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The map label for this gene is hgdC [H]

Identifier: 226948884

GI number: 226948884

Start: 1826960

End: 1827721

Strand: Direct

Name: hgdC [H]

Synonym: CLM_1794

Alternate gene names: 226948884

Gene position: 1826960-1827721 (Clockwise)

Preceding gene: 226948883

Following gene: 226948885

Centisome position: 43.97

GC content: 32.15

Gene sequence:

>762_bases
ATGAGATTATTAGGAATAGACCTTGGAAGTAGAGAAGTTAAGATTGTTTTAATGGAAAACAATATTATAGTTCAAAAGAA
AAAAGTAAGTACCATGAAATTTTATAGAGATTACTGCAGCTTTCATGGCAAGATTGTAGTAGATTTAGAAAAACTTAATA
TAAAAGGAATAGATAAAGCGATATCAACGGGTTATGGAAAAAATAATACGGATTTAGAATTTTTTACACCTATAAATGAG
ATAAAAGCCCATGTTTATGGTGGGATCTATCAAAGTAATTTAAAGGATTTTATACTTTTAGATGTAGGTGGTCAGGACGT
TAAGGTGGTAAAGGTAGAAAAGGGCGTTGCAACAGATTTGGAGCTTAATGAAAAATGTGCTGCTTCCTGTGGAAGATACT
TGGAGAATATGGCAAATGTACTTGAAATATCCCTAGATGAAATGAGCCAGTACTCGGAAAATCCCGTGGATTTAAATTCC
ACCTGTGCAGTATTTTCTGAATCAGAATTAATTGGAAAAATAGCCGAAGGGGTACACATAGAAAGGTTATGTGCTGGGGT
TAATTACTCTTTGTATAAAAGGCTACAACCTCTTTTAAGTAAGTTTAGGGGGAAGAAATTAGTTATAACCGGTGGTGTTG
CAAATAACCATTCAATAAAAAAATATTTAAATAATGATTATGAAGAAATAGTATCCGTAAAAGATCCTCAGTTTAATGGG
GCTATTGGATGTTGTTATTACGGAAGCAAATTTTTAAAATAA

Upstream 100 bases:

>100_bases
AATTTTTATCTTAATATATTTTTGGATTTAAAGCAAAAGTAACAGACAGTATATAAAAGAAGTTCATGTTTTCTTTATAT
TTAATGAAGGAGGGGAATTA

Downstream 100 bases:

>100_bases
ACTTAGGAGGAAAAAACATGTATACTTTAAAAGTAGAACATAATTTTGATAGTGCTCATTTTCTTGCAGGTTATGAAGGT
AAATGTGGAAATATTCATGG

Product: 2-hydroxyglutaryl-CoA dehydratase subunit A

Products: NA

Alternate protein names: 2-hydroxyglutaryl-CoA dehydratase component A [H]

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MRLLGIDLGSREVKIVLMENNIIVQKKKVSTMKFYRDYCSFHGKIVVDLEKLNIKGIDKAISTGYGKNNTDLEFFTPINE
IKAHVYGGIYQSNLKDFILLDVGGQDVKVVKVEKGVATDLELNEKCAASCGRYLENMANVLEISLDEMSQYSENPVDLNS
TCAVFSESELIGKIAEGVHIERLCAGVNYSLYKRLQPLLSKFRGKKLVITGGVANNHSIKKYLNNDYEEIVSVKDPQFNG
AIGCCYYGSKFLK

Sequences:

>Translated_253_residues
MRLLGIDLGSREVKIVLMENNIIVQKKKVSTMKFYRDYCSFHGKIVVDLEKLNIKGIDKAISTGYGKNNTDLEFFTPINE
IKAHVYGGIYQSNLKDFILLDVGGQDVKVVKVEKGVATDLELNEKCAASCGRYLENMANVLEISLDEMSQYSENPVDLNS
TCAVFSESELIGKIAEGVHIERLCAGVNYSLYKRLQPLLSKFRGKKLVITGGVANNHSIKKYLNNDYEEIVSVKDPQFNG
AIGCCYYGSKFLK
>Mature_253_residues
MRLLGIDLGSREVKIVLMENNIIVQKKKVSTMKFYRDYCSFHGKIVVDLEKLNIKGIDKAISTGYGKNNTDLEFFTPINE
IKAHVYGGIYQSNLKDFILLDVGGQDVKVVKVEKGVATDLELNEKCAASCGRYLENMANVLEISLDEMSQYSENPVDLNS
TCAVFSESELIGKIAEGVHIERLCAGVNYSLYKRLQPLLSKFRGKKLVITGGVANNHSIKKYLNNDYEEIVSVKDPQFNG
AIGCCYYGSKFLK

Specific function: Required for the activation of (R)-2-hydroxyglutaryl-CoA dehydratase. This protein is extremely sensitive towards oxygen [H]

COG id: COG1924

COG function: function code I; Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To E.coli yjiL and M.jannaschii MJ0004 and MJ0800 [H]

Homologues:

Organism=Escherichia coli, GI87082426, Length=255, Percent_Identity=29.8039215686275, Blast_Score=102, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002731
- InterPro:   IPR008275 [H]

Pfam domain/function: PF01869 BcrAD_BadFG [H]

EC number: NA

Molecular weight: Translated: 28289; Mature: 28289

Theoretical pI: Translated: 8.02; Mature: 8.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLGIDLGSREVKIVLMENNIIVQKKKVSTMKFYRDYCSFHGKIVVDLEKLNIKGIDKA
CEEEEECCCCCEEEEEEEECCEEEEEHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHH
ISTGYGKNNTDLEFFTPINEIKAHVYGGIYQSNLKDFILLDVGGQDVKVVKVEKGVATDL
HHCCCCCCCCCEEEECCHHHHHHHHHCCHHHCCCCEEEEEEECCCCEEEEEECCCCCCCC
ELNEKCAASCGRYLENMANVLEISLDEMSQYSENPVDLNSTCAVFSESELIGKIAEGVHI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECHHHHHHHHHCCCCH
ERLCAGVNYSLYKRLQPLLSKFRGKKLVITGGVANNHSIKKYLNNDYEEIVSVKDPQFNG
HHHHHCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHCCCHHHHHCCCCCCCCC
AIGCCYYGSKFLK
CEEEEECCHHHCC
>Mature Secondary Structure
MRLLGIDLGSREVKIVLMENNIIVQKKKVSTMKFYRDYCSFHGKIVVDLEKLNIKGIDKA
CEEEEECCCCCEEEEEEEECCEEEEEHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHH
ISTGYGKNNTDLEFFTPINEIKAHVYGGIYQSNLKDFILLDVGGQDVKVVKVEKGVATDL
HHCCCCCCCCCEEEECCHHHHHHHHHCCHHHCCCCEEEEEEECCCCEEEEEECCCCCCCC
ELNEKCAASCGRYLENMANVLEISLDEMSQYSENPVDLNSTCAVFSESELIGKIAEGVHI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECHHHHHHHHHCCCCH
ERLCAGVNYSLYKRLQPLLSKFRGKKLVITGGVANNHSIKKYLNNDYEEIVSVKDPQFNG
HHHHHCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHCCCHHHHHCCCCCCCCC
AIGCCYYGSKFLK
CEEEEECCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8365476; 2659350; 7607244; 11106419; 11243821 [H]