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The map label for this gene is msrA [H]

Identifier: 226948669

GI number: 226948669

Start: 1624805

End: 1625443

Strand: Reverse

Name: msrA [H]

Synonym: CLM_1565

Alternate gene names: 226948669

Gene position: 1625443-1624805 (Counterclockwise)

Preceding gene: 226948683

Following gene: 226948665

Centisome position: 39.12

GC content: 26.45

Gene sequence:

>639_bases
ATGTTAGAAGGAAACCACATAAAAAAAGCTTATTTTTCTATGGGTTGCTTTTGGTCAGTAGAAGCTTTATTTGATTCTTT
AGATGGTGTTGTTAAAACCTATGTTGGATATACTGGTGGAAATACACTATTTCCTACTTACAATAGTATAGGAGATCATT
TAGAAACTTTAGAAGTATACTACGACTCCAGTAAAATAGCCTTTGAAAATCTACTAACTATTTTTGAAAAAAATCATAAT
TATATTGTAAGACCTAATCTATTACAATATTATTCTGCTATTTTCTATAATAATGAAAATGAAAAAGAGCTTTGTTTAGA
TTGGAAGAAAAATAAAAAAGAAGAATTAAAGACGGAAGTTTTAACTAGAATTTCCCCTATAGAAAAATTTTATTATGCGG
AATTTTATCACCAAAAATATTATGTTCAATTAGAACCTGTAATTATGTCTAATTTAAGATCCAAATTTTCTACTGGTAAT
GATTTAATATCTTCTCCTTTATGCCATAAATTAAATGCATACTTAGCAGGTTATGGTTCTCTAAAAGAGCTAAATAAGGA
AATTGAAGACTTTAATCTTTCCGAGGATGCTAAAAACAGATTATTATCTATTGTAGAAGGTTTTAATAATAGTAAATAA

Upstream 100 bases:

>100_bases
ATAATATTATTTTCAATACTTTGCAACTATTTTTTGCTTATTTTCTTATTTATTTTTTTATATTTAAAATTTCATTTTTT
TATAATTAGGAGGGTGGAAA

Downstream 100 bases:

>100_bases
AATTAATTTTAAAATTAAAGTGATTTTTTTATTTTACATTAATTATTACTACTAAAAATTAGAAGAGTTGTCTGAAAATA
AATTTTATTTTCAGGCAACC

Product: putative methionine-S-sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MLEGNHIKKAYFSMGCFWSVEALFDSLDGVVKTYVGYTGGNTLFPTYNSIGDHLETLEVYYDSSKIAFENLLTIFEKNHN
YIVRPNLLQYYSAIFYNNENEKELCLDWKKNKKEELKTEVLTRISPIEKFYYAEFYHQKYYVQLEPVIMSNLRSKFSTGN
DLISSPLCHKLNAYLAGYGSLKELNKEIEDFNLSEDAKNRLLSIVEGFNNSK

Sequences:

>Translated_212_residues
MLEGNHIKKAYFSMGCFWSVEALFDSLDGVVKTYVGYTGGNTLFPTYNSIGDHLETLEVYYDSSKIAFENLLTIFEKNHN
YIVRPNLLQYYSAIFYNNENEKELCLDWKKNKKEELKTEVLTRISPIEKFYYAEFYHQKYYVQLEPVIMSNLRSKFSTGN
DLISSPLCHKLNAYLAGYGSLKELNKEIEDFNLSEDAKNRLLSIVEGFNNSK
>Mature_212_residues
MLEGNHIKKAYFSMGCFWSVEALFDSLDGVVKTYVGYTGGNTLFPTYNSIGDHLETLEVYYDSSKIAFENLLTIFEKNHN
YIVRPNLLQYYSAIFYNNENEKELCLDWKKNKKEELKTEVLTRISPIEKFYYAEFYHQKYYVQLEPVIMSNLRSKFSTGN
DLISSPLCHKLNAYLAGYGSLKELNKEIEDFNLSEDAKNRLLSIVEGFNNSK

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=144, Percent_Identity=37.5, Blast_Score=85, Evalue=5e-17,
Organism=Homo sapiens, GI208609995, Length=144, Percent_Identity=36.8055555555556, Blast_Score=84, Evalue=9e-17,
Organism=Escherichia coli, GI1790665, Length=145, Percent_Identity=37.9310344827586, Blast_Score=85, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17533973, Length=196, Percent_Identity=35.7142857142857, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24664627, Length=194, Percent_Identity=39.6907216494845, Blast_Score=138, Evalue=3e-33,
Organism=Drosophila melanogaster, GI45553131, Length=190, Percent_Identity=39.4736842105263, Blast_Score=134, Evalue=5e-32,
Organism=Drosophila melanogaster, GI24664631, Length=194, Percent_Identity=39.1752577319588, Blast_Score=129, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 24685; Mature: 24685

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEGNHIKKAYFSMGCFWSVEALFDSLDGVVKTYVGYTGGNTLFPTYNSIGDHLETLEVY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHH
YDSSKIAFENLLTIFEKNHNYIVRPNLLQYYSAIFYNNENEKELCLDWKKNKKEELKTEV
CCCCHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHH
LTRISPIEKFYYAEFYHQKYYVQLEPVIMSNLRSKFSTGNDLISSPLCHKLNAYLAGYGS
HHHHHHHHHHHHHHHHHCEEEEEEHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHCCCC
LKELNKEIEDFNLSEDAKNRLLSIVEGFNNSK
HHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLEGNHIKKAYFSMGCFWSVEALFDSLDGVVKTYVGYTGGNTLFPTYNSIGDHLETLEVY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHH
YDSSKIAFENLLTIFEKNHNYIVRPNLLQYYSAIFYNNENEKELCLDWKKNKKEELKTEV
CCCCHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHH
LTRISPIEKFYYAEFYHQKYYVQLEPVIMSNLRSKFSTGNDLISSPLCHKLNAYLAGYGS
HHHHHHHHHHHHHHHHHCEEEEEEHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHCCCC
LKELNKEIEDFNLSEDAKNRLLSIVEGFNNSK
HHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]