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The map label for this gene is 226948371

Identifier: 226948371

GI number: 226948371

Start: 1307753

End: 1309261

Strand: Reverse

Name: 226948371

Synonym: CLM_1254

Alternate gene names: NA

Gene position: 1309261-1307753 (Counterclockwise)

Preceding gene: 226948375

Following gene: 226948369

Centisome position: 31.51

GC content: 29.03

Gene sequence:

>1509_bases
ATGGAAATAAAATTCTTAGGAGCAGCTTCTTGTGTAACAGGTTCCTGCCACTTATTAAAAATAAAAGATAAAAATATTCT
TTTAGACTGTGGTGCTTATCAAGGCAAAGACGATGAAGGAGATAGAAATTTTTCTTTTAAATTCGATATTAAAGATATAG
ATTGTGTAATACTCTCTCACGCTCATATAGATCACAGTGGACGAATTCCTTTTTTATATAAACTAGGCTATAGAGGAAAA
GTTATCTCTACTAAAGCTACTGCAGACCTATGCTCCATTATGCTTCCTGACAGCGGTCATATATTAGAATCAGAAGTTGA
ATGGAAAAACAGAAAAAGAATTCGTAGTGGTCTACCTCCTATAGAACCTTTATATACTTTAAAAACAGCTCAAATGAGTA
CATCCCTTTTTGAAGGTTACAATTACGATGAATATATAGAAATATTTTCTAATCTCAAAATAAGATTTTTAGATTCTGGT
CATCTCTTAGGCTCTGCTATAACTGAATTATATATAACTGAAAATGATAAAGAATTTAAAATTGTTTATTCTGGAGATCT
TGGCAATACAAATTTGCCTATACTAAAAGATCCTGTTCAAGTAGATTATGCAGATTATGTGCTAATGGAAACAACCTATG
GAAATAGACTTCATGATAACATAAATTCCCAATTAAAGCAATTGATTCATATCGTAAAGGATACCTTTAAAAGAAGAGGT
AATGTTATTATTCCTTCCTTTGCAGTGGGTAGAACTCAAGAAGTAATATACGCATTAAATAAATATGTGGAAAGTAATAT
ATTAAAAAATATCAAAGTCTACGTAGATAGCCCTTTAGCTTCAGAAGCTACTAAAATATTTAATGAATACACTACCGAAT
TTGATGAAGATGCTCAAAAGTTATTAAAGGAAGGTGATAATCCTCTAGAATTTAATGGTCTTTACTTTACTAATTCTCCT
CAAGAATCTATGGAATTAAATAAAATAAAAACTGGTGCTATTATAATATCTGCTAGTGGAATGTGTGAAGCTGGTAGAAT
TCGTCATCATCTGAAACATAATCTTTGGAGAAAAGAATGTTCTATAGTATTTGTAGGTTATCAAGCCGAGGGAACTTTAG
GTCAAAAAATATTAAGCGGTGCTAAAAAAATAAAATTATTTGGTGAAGAGATTGCTGTAAATGCTGAAATATATAATCTA
CCATCATTATCTGGTCATGCTGACAAAAATGGCCTATTGAATTGGCTAGAAAATTTTAAAGAAAAACCTAAGGAAGTTAT
ATTGATCCATGGTGAAAAAGCTTCTAGAGATTATTTTAAAAATCTGTTAATTGAAAAAAACTATAATACCTTTTGTCCTA
ATATAGGTGATATATATTCAAGTGAATTTAAAGGTCAAAGAAAAAGTGTAGTTAAAAATAAAATAACTAATTTATTGAAT
TCCTTAGAGGATATAGACTCATTAAATAAAGAAGATTTATTAAACTTGATTAAAAAAGAAATATATTAA

Upstream 100 bases:

>100_bases
AATTATTTATATTATTTTTAAATACATATATATTTTTCAATAAAATAATATTAAAATATTCTTACAAGTATTAATTAATC
ATTAGAACAGGAGGGATCAT

Downstream 100 bases:

>100_bases
AAACAAAACCATTTTATCTATTAAATTTTAAAACTATCTATATATTAAAAAGAAAGAGGCTGTCTCAAAATAGATTTAAA
TTTGTTCTGAGATAGTCTCT

Product: metallo-beta-lactamase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 502; Mature: 502

Protein sequence:

>502_residues
MEIKFLGAASCVTGSCHLLKIKDKNILLDCGAYQGKDDEGDRNFSFKFDIKDIDCVILSHAHIDHSGRIPFLYKLGYRGK
VISTKATADLCSIMLPDSGHILESEVEWKNRKRIRSGLPPIEPLYTLKTAQMSTSLFEGYNYDEYIEIFSNLKIRFLDSG
HLLGSAITELYITENDKEFKIVYSGDLGNTNLPILKDPVQVDYADYVLMETTYGNRLHDNINSQLKQLIHIVKDTFKRRG
NVIIPSFAVGRTQEVIYALNKYVESNILKNIKVYVDSPLASEATKIFNEYTTEFDEDAQKLLKEGDNPLEFNGLYFTNSP
QESMELNKIKTGAIIISASGMCEAGRIRHHLKHNLWRKECSIVFVGYQAEGTLGQKILSGAKKIKLFGEEIAVNAEIYNL
PSLSGHADKNGLLNWLENFKEKPKEVILIHGEKASRDYFKNLLIEKNYNTFCPNIGDIYSSEFKGQRKSVVKNKITNLLN
SLEDIDSLNKEDLLNLIKKEIY

Sequences:

>Translated_502_residues
MEIKFLGAASCVTGSCHLLKIKDKNILLDCGAYQGKDDEGDRNFSFKFDIKDIDCVILSHAHIDHSGRIPFLYKLGYRGK
VISTKATADLCSIMLPDSGHILESEVEWKNRKRIRSGLPPIEPLYTLKTAQMSTSLFEGYNYDEYIEIFSNLKIRFLDSG
HLLGSAITELYITENDKEFKIVYSGDLGNTNLPILKDPVQVDYADYVLMETTYGNRLHDNINSQLKQLIHIVKDTFKRRG
NVIIPSFAVGRTQEVIYALNKYVESNILKNIKVYVDSPLASEATKIFNEYTTEFDEDAQKLLKEGDNPLEFNGLYFTNSP
QESMELNKIKTGAIIISASGMCEAGRIRHHLKHNLWRKECSIVFVGYQAEGTLGQKILSGAKKIKLFGEEIAVNAEIYNL
PSLSGHADKNGLLNWLENFKEKPKEVILIHGEKASRDYFKNLLIEKNYNTFCPNIGDIYSSEFKGQRKSVVKNKITNLLN
SLEDIDSLNKEDLLNLIKKEIY
>Mature_502_residues
MEIKFLGAASCVTGSCHLLKIKDKNILLDCGAYQGKDDEGDRNFSFKFDIKDIDCVILSHAHIDHSGRIPFLYKLGYRGK
VISTKATADLCSIMLPDSGHILESEVEWKNRKRIRSGLPPIEPLYTLKTAQMSTSLFEGYNYDEYIEIFSNLKIRFLDSG
HLLGSAITELYITENDKEFKIVYSGDLGNTNLPILKDPVQVDYADYVLMETTYGNRLHDNINSQLKQLIHIVKDTFKRRG
NVIIPSFAVGRTQEVIYALNKYVESNILKNIKVYVDSPLASEATKIFNEYTTEFDEDAQKLLKEGDNPLEFNGLYFTNSP
QESMELNKIKTGAIIISASGMCEAGRIRHHLKHNLWRKECSIVFVGYQAEGTLGQKILSGAKKIKLFGEEIAVNAEIYNL
PSLSGHADKNGLLNWLENFKEKPKEVILIHGEKASRDYFKNLLIEKNYNTFCPNIGDIYSSEFKGQRKSVVKNKITNLLN
SLEDIDSLNKEDLLNLIKKEIY

Specific function: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro) [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI33300633, Length=475, Percent_Identity=26.5263157894737, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI7706427, Length=448, Percent_Identity=26.3392857142857, Blast_Score=154, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI32564696, Length=473, Percent_Identity=27.906976744186, Blast_Score=154, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI32566029, Length=440, Percent_Identity=27.5, Blast_Score=150, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6323307, Length=464, Percent_Identity=22.8448275862069, Blast_Score=129, Evalue=1e-30,
Organism=Drosophila melanogaster, GI21358523, Length=471, Percent_Identity=26.963906581741, Blast_Score=155, Evalue=7e-38,
Organism=Drosophila melanogaster, GI24648013, Length=454, Percent_Identity=26.2114537444934, Blast_Score=150, Evalue=3e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 57015; Mature: 57015

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIKFLGAASCVTGSCHLLKIKDKNILLDCGAYQGKDDEGDRNFSFKFDIKDIDCVILSH
CEEEEEECCCCCCCCEEEEEEECCEEEEECCCCCCCCCCCCCCEEEEEECCCCEEEEEEE
AHIDHSGRIPFLYKLGYRGKVISTKATADLCSIMLPDSGHILESEVEWKNRKRIRSGLPP
EECCCCCCCCEEEEECCCCEEEECHHHHHHHHEECCCCCCEECCHHHHHHHHHHHHCCCC
IEPLYTLKTAQMSTSLFEGYNYDEYIEIFSNLKIRFLDSGHLLGSAITELYITENDKEFK
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCEEEEEECCCHHHHHHHEEEEECCCCEEE
IVYSGDLGNTNLPILKDPVQVDYADYVLMETTYGNRLHDNINSQLKQLIHIVKDTFKRRG
EEEECCCCCCCCCEECCCCEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCC
NVIIPSFAVGRTQEVIYALNKYVESNILKNIKVYVDSPLASEATKIFNEYTTEFDEDAQK
CEEEECCCCCCHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
LLKEGDNPLEFNGLYFTNSPQESMELNKIKTGAIIISASGMCEAGRIRHHLKHNLWRKEC
HHHCCCCCEEECCEEEECCCHHHHHHHEEECCEEEEEECCCCCHHHHHHHHHHHHHHCCC
SIVFVGYQAEGTLGQKILSGAKKIKLFGEEIAVNAEIYNLPSLSGHADKNGLLNWLENFK
CEEEEEEECCCHHHHHHHCCHHHEEEECCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHH
EKPKEVILIHGEKASRDYFKNLLIEKNYNTFCPNIGDIYSSEFKGQRKSVVKNKITNLLN
CCCCEEEEEECCCCCHHHHHHHHEECCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHH
SLEDIDSLNKEDLLNLIKKEIY
HHHHHHCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MEIKFLGAASCVTGSCHLLKIKDKNILLDCGAYQGKDDEGDRNFSFKFDIKDIDCVILSH
CEEEEEECCCCCCCCEEEEEEECCEEEEECCCCCCCCCCCCCCEEEEEECCCCEEEEEEE
AHIDHSGRIPFLYKLGYRGKVISTKATADLCSIMLPDSGHILESEVEWKNRKRIRSGLPP
EECCCCCCCCEEEEECCCCEEEECHHHHHHHHEECCCCCCEECCHHHHHHHHHHHHCCCC
IEPLYTLKTAQMSTSLFEGYNYDEYIEIFSNLKIRFLDSGHLLGSAITELYITENDKEFK
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCEEEEEECCCHHHHHHHEEEEECCCCEEE
IVYSGDLGNTNLPILKDPVQVDYADYVLMETTYGNRLHDNINSQLKQLIHIVKDTFKRRG
EEEECCCCCCCCCEECCCCEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCC
NVIIPSFAVGRTQEVIYALNKYVESNILKNIKVYVDSPLASEATKIFNEYTTEFDEDAQK
CEEEECCCCCCHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
LLKEGDNPLEFNGLYFTNSPQESMELNKIKTGAIIISASGMCEAGRIRHHLKHNLWRKEC
HHHCCCCCEEECCEEEECCCHHHHHHHEEECCEEEEEECCCCCHHHHHHHHHHHHHHCCC
SIVFVGYQAEGTLGQKILSGAKKIKLFGEEIAVNAEIYNLPSLSGHADKNGLLNWLENFK
CEEEEEEECCCHHHHHHHCCHHHEEEECCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHH
EKPKEVILIHGEKASRDYFKNLLIEKNYNTFCPNIGDIYSSEFKGQRKSVVKNKITNLLN
CCCCEEEEEECCCCCHHHHHHHHEECCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHH
SLEDIDSLNKEDLLNLIKKEIY
HHHHHHCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA