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The map label for this gene is cobK [H]

Identifier: 226948224

GI number: 226948224

Start: 1141970

End: 1142737

Strand: Direct

Name: cobK [H]

Synonym: CLM_1101

Alternate gene names: 226948224

Gene position: 1141970-1142737 (Clockwise)

Preceding gene: 226948223

Following gene: 226948225

Centisome position: 27.48

GC content: 25.78

Gene sequence:

>768_bases
ATGATAGCTTTAATATTAGGTACTTCAGAAGGAAGAGAGATACTTTCTCTACTAAATAAGTTTACAGATAATATATTAAT
ATCTACAGCAACAGCTTATGGCGGAGAAATTTTAAAGGATTATAAATATAAAAAATTAAATACCAAACCTTTAAATAAAG
AAAGGCTTTTAAATATGCTAAAAGAAAATCAAGTAAATATATTAATTGATGCTTCTCATCCCTATGCTTTAGAAGTAACT
AAAAATGCTAGAGAAGTATCAAAAGATTTAAATATAGAATATGTAAGATATGAAAGACCATCCTCAGCAGAGGAATTTAA
GCAAAATAAAAAAGTAGTATTTTTAGAGGATTATAAAGATTTAAATGAGGCTTTAAAAAATATAAAAGGTAATATATTAA
ATACTTCTGGTAGTAGAAATATGGATAAAATTTTAGATTTAAAACTAGAAAATAGAATTATCCATAGAGTGCTTCCATCT
GTAAAAGTTTTAGAAGATTGCTTTAATTTAGGGGTAAAAGTAGAGGATCTTATGGCTATAAAGGGACCTATAAGTAAAGA
GTTAAATAAAGCCTTTATAAAGGATTATGATGCCAAGGCATTAATATTAAAAGATAGTGGACCACAAGGTGGTACAGAGG
AAAAAATATTAGCCTGTCTAGAGTGTGATATATATGCTTTGGTAATAAAAAGAAAGAAAATAAATTATGAAAGAGAATTT
AATAATATAGAGATTTTAGTTGAATACATAAGTTCAATGATCAATTAA

Upstream 100 bases:

>100_bases
CTATTAGCATGTTATAGACATAAAAGAGTATAAAACGAAAGGAAGTGGGCTTTAGTAGGAGTTTGGTACTAAAAATACAC
TCTCTCACTAAAAATAAATT

Downstream 100 bases:

>100_bases
CAATGATTAAGTATTAATATTGTTTAACTTGAAAATAATTTAATAGATTAAAAACTTAATATTGGGGGAAGAAAACAAGA
TGAAAACTAAAAGATTAGTT

Product: cobalt-precorrin-6x reductase

Products: Precorrin 6A; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MIALILGTSEGREILSLLNKFTDNILISTATAYGGEILKDYKYKKLNTKPLNKERLLNMLKENQVNILIDASHPYALEVT
KNAREVSKDLNIEYVRYERPSSAEEFKQNKKVVFLEDYKDLNEALKNIKGNILNTSGSRNMDKILDLKLENRIIHRVLPS
VKVLEDCFNLGVKVEDLMAIKGPISKELNKAFIKDYDAKALILKDSGPQGGTEEKILACLECDIYALVIKRKKINYEREF
NNIEILVEYISSMIN

Sequences:

>Translated_255_residues
MIALILGTSEGREILSLLNKFTDNILISTATAYGGEILKDYKYKKLNTKPLNKERLLNMLKENQVNILIDASHPYALEVT
KNAREVSKDLNIEYVRYERPSSAEEFKQNKKVVFLEDYKDLNEALKNIKGNILNTSGSRNMDKILDLKLENRIIHRVLPS
VKVLEDCFNLGVKVEDLMAIKGPISKELNKAFIKDYDAKALILKDSGPQGGTEEKILACLECDIYALVIKRKKINYEREF
NNIEILVEYISSMIN
>Mature_255_residues
MIALILGTSEGREILSLLNKFTDNILISTATAYGGEILKDYKYKKLNTKPLNKERLLNMLKENQVNILIDASHPYALEVT
KNAREVSKDLNIEYVRYERPSSAEEFKQNKKVVFLEDYKDLNEALKNIKGNILNTSGSRNMDKILDLKLENRIIHRVLPS
VKVLEDCFNLGVKVEDLMAIKGPISKELNKAFIKDYDAKALILKDSGPQGGTEEKILACLECDIYALVIKRKKINYEREF
NNIEILVEYISSMIN

Specific function: Catalyzes the reduction of the macrocycle of cobalt- precorrin-6X into cobalt-precorrin-6Y [H]

COG id: COG2099

COG function: function code H; Precorrin-6x reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin-6x reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003723 [H]

Pfam domain/function: PF02571 CbiJ [H]

EC number: 1.3.1.54

Molecular weight: Translated: 29146; Mature: 29146

Theoretical pI: Translated: 8.39; Mature: 8.39

Prosite motif: PS51014 COBK_CBIJ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIALILGTSEGREILSLLNKFTDNILISTATAYGGEILKDYKYKKLNTKPLNKERLLNML
CEEEEEECCCCHHHHHHHHHHHCCEEEEEHHHHCHHHHHHHHHCCCCCCCCCHHHHHHHH
KENQVNILIDASHPYALEVTKNAREVSKDLNIEYVRYERPSSAEEFKQNKKVVFLEDYKD
HCCCEEEEEECCCCEEEEECCCHHHHHHCCCEEEEEECCCCCHHHHHHCCCEEEEHHHHH
LNEALKNIKGNILNTSGSRNMDKILDLKLENRIIHRVLPSVKVLEDCFNLGVKVEDLMAI
HHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHH
KGPISKELNKAFIKDYDAKALILKDSGPQGGTEEKILACLECDIYALVIKRKKINYEREF
CCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHCCHHEEEHHHHHCCHHHHC
NNIEILVEYISSMIN
CHHHHHHHHHHHHCC
>Mature Secondary Structure
MIALILGTSEGREILSLLNKFTDNILISTATAYGGEILKDYKYKKLNTKPLNKERLLNML
CEEEEEECCCCHHHHHHHHHHHCCEEEEEHHHHCHHHHHHHHHCCCCCCCCCHHHHHHHH
KENQVNILIDASHPYALEVTKNAREVSKDLNIEYVRYERPSSAEEFKQNKKVVFLEDYKD
HCCCEEEEEECCCCEEEEECCCHHHHHHCCCEEEEEECCCCCHHHHHHCCCEEEEHHHHH
LNEALKNIKGNILNTSGSRNMDKILDLKLENRIIHRVLPSVKVLEDCFNLGVKVEDLMAI
HHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHH
KGPISKELNKAFIKDYDAKALILKDSGPQGGTEEKILACLECDIYALVIKRKKINYEREF
CCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHCCHHEEEHHHHHCCHHHHC
NNIEILVEYISSMIN
CHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Precorrin 6B; NADP+

Specific reaction: precorrin-6B + NADP+ = precorrin-6A + NADPH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]