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The map label for this gene is cobB [H]

Identifier: 226948197

GI number: 226948197

Start: 1122059

End: 1123381

Strand: Direct

Name: cobB [H]

Synonym: CLM_1072

Alternate gene names: 226948197

Gene position: 1122059-1123381 (Clockwise)

Preceding gene: 226948196

Following gene: 226948198

Centisome position: 27.0

GC content: 26.91

Gene sequence:

>1323_bases
ATGAGAAGTATAATAATATCTTCCAATAGTAGTGGTGGAGGAAAAACTACAGTAACTTTAGGGCTTATGAAGGCTTTAAT
TAAAAAAGATTATAAAGTTCAAGGCTATAAAGTTGGTCCTGATTATATAGATCCTGCCTTTCATTCTTATGTAACAGAAA
ATAGTTCTAGAAATTTAGATTTGTTTTTAATGGGAGAGGATGGTGTTAAAGCATCCTATAGCAGAGGTAAAGGTGATTTA
GGAGTAATAGAAGGGGTAATGGGATTGTATGATGGAAAAGGGATAGATACAAAATATTCTACAGCACATGTATCAAAGGT
TTTAAATTTACCAGTGGTTTTAGTATTAACTCCAAAGGCTCAAAGTGCTACTTTATGTGCAGAAATTATGGGAATATTAA
ATTATGAAAAGATAAATATAGTTGGAGTAATTTTTAATAAAGTAAGTGAAAACTATTATAAATTACTTAAGAGATTAGTT
GAAGAAAATTGTGGATTAAAAGTATTTGGATATGTACCAAAGGAAGAAAAATTAGAATTGAAAAGTAGACATTTAGGTCT
TATACAAAGTAGTGAAATAAAAGATTTAGAAGAAAAAATAGATATATGTAGTGAATTAATTTTAAAATATGTAGATATAG
AAAATTTAATAAATCACTTTGAAAAAACAGAAAAATATAAAGATAATTTTTACTTAGAAAACAAAAATCTAAATATAGGC
ATACCTTATGATAAAGCTTTTAGTTTTTATTATAAAGAGAACATAGAACTATTGGAAAACATAGGTAATATAAAATATTT
TAGTCCTATGAAGGATGAAGAATTGCCAGAGTATTTAGATTTTTTATATATAGGTGGGGGATACCCAGAGGTTTTTATAA
AGGAATTAAGAGAAAACAAATCCATGTTAAGTAGTATAAATAAAGAATTAAATAATGGACTCCCATGTTATGCGGAATGT
GGAGGACTTATGTATTTAACAGAAGGCATAGAAGATTTAGAGGGAGATTATAAAGAAGCAGTAGGATTCTTTAAAGGTAA
ATGTCATATGACTAAAAAACTTCAAAACTTTGGGTATGCTGAAATAGAAGTGGAAAAGGAAAATAAAATATTACCTAAAG
GGTTAAAAATTAATTGTCATGAATTTCATAAATCTTATGTGGATTTAAAAGAGGATAAAATATATGAACTTACTAAAAAT
CTCTATGATGATTCTACAAAAAAATGGAGTTGCGGATATATAAAAAATAATACGTTGGCAGCATATGCTCATGTACATTT
CTTCGGAAATATGGATTTTGTAAGAAATTTATTTAATAGATAA

Upstream 100 bases:

>100_bases
CTCTGTACTCTGTACTCTGTACTCTGTACTCTGTACTCTGTACTCTGTACTCTGTACTCTGTACTCTGTACTCTGTACTC
TGTATCAAAGGGGTGTTTTT

Downstream 100 bases:

>100_bases
AAAGAAAATTAGAGAGGTAAGGGTATGAAAGATTATATAAAAAAACCAATGGATATAGAAAAAAGAAGTTTTGAAATAAT
AGAAGAAGAGATTGGTAAGA

Product: cobyrinic acid a,c-diamide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MRSIIISSNSSGGGKTTVTLGLMKALIKKDYKVQGYKVGPDYIDPAFHSYVTENSSRNLDLFLMGEDGVKASYSRGKGDL
GVIEGVMGLYDGKGIDTKYSTAHVSKVLNLPVVLVLTPKAQSATLCAEIMGILNYEKINIVGVIFNKVSENYYKLLKRLV
EENCGLKVFGYVPKEEKLELKSRHLGLIQSSEIKDLEEKIDICSELILKYVDIENLINHFEKTEKYKDNFYLENKNLNIG
IPYDKAFSFYYKENIELLENIGNIKYFSPMKDEELPEYLDFLYIGGGYPEVFIKELRENKSMLSSINKELNNGLPCYAEC
GGLMYLTEGIEDLEGDYKEAVGFFKGKCHMTKKLQNFGYAEIEVEKENKILPKGLKINCHEFHKSYVDLKEDKIYELTKN
LYDDSTKKWSCGYIKNNTLAAYAHVHFFGNMDFVRNLFNR

Sequences:

>Translated_440_residues
MRSIIISSNSSGGGKTTVTLGLMKALIKKDYKVQGYKVGPDYIDPAFHSYVTENSSRNLDLFLMGEDGVKASYSRGKGDL
GVIEGVMGLYDGKGIDTKYSTAHVSKVLNLPVVLVLTPKAQSATLCAEIMGILNYEKINIVGVIFNKVSENYYKLLKRLV
EENCGLKVFGYVPKEEKLELKSRHLGLIQSSEIKDLEEKIDICSELILKYVDIENLINHFEKTEKYKDNFYLENKNLNIG
IPYDKAFSFYYKENIELLENIGNIKYFSPMKDEELPEYLDFLYIGGGYPEVFIKELRENKSMLSSINKELNNGLPCYAEC
GGLMYLTEGIEDLEGDYKEAVGFFKGKCHMTKKLQNFGYAEIEVEKENKILPKGLKINCHEFHKSYVDLKEDKIYELTKN
LYDDSTKKWSCGYIKNNTLAAYAHVHFFGNMDFVRNLFNR
>Mature_440_residues
MRSIIISSNSSGGGKTTVTLGLMKALIKKDYKVQGYKVGPDYIDPAFHSYVTENSSRNLDLFLMGEDGVKASYSRGKGDL
GVIEGVMGLYDGKGIDTKYSTAHVSKVLNLPVVLVLTPKAQSATLCAEIMGILNYEKINIVGVIFNKVSENYYKLLKRLV
EENCGLKVFGYVPKEEKLELKSRHLGLIQSSEIKDLEEKIDICSELILKYVDIENLINHFEKTEKYKDNFYLENKNLNIG
IPYDKAFSFYYKENIELLENIGNIKYFSPMKDEELPEYLDFLYIGGGYPEVFIKELRENKSMLSSINKELNNGLPCYAEC
GGLMYLTEGIEDLEGDYKEAVGFFKGKCHMTKKLQNFGYAEIEVEKENKILPKGLKINCHEFHKSYVDLKEDKIYELTKN
LYDDSTKKWSCGYIKNNTLAAYAHVHFFGNMDFVRNLFNR

Specific function: Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation [H]

COG id: COG1797

COG function: function code H; Cobyrinic acid a,c-diamide synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002586
- InterPro:   IPR004484
- InterPro:   IPR017929
- InterPro:   IPR011698 [H]

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3 [H]

EC number: NA

Molecular weight: Translated: 50242; Mature: 50242

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSIIISSNSSGGGKTTVTLGLMKALIKKDYKVQGYKVGPDYIDPAFHSYVTENSSRNLD
CCEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHCCCCCCCEE
LFLMGEDGVKASYSRGKGDLGVIEGVMGLYDGKGIDTKYSTAHVSKVLNLPVVLVLTPKA
EEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCEEEEECCCC
QSATLCAEIMGILNYEKINIVGVIFNKVSENYYKLLKRLVEENCGLKVFGYVPKEEKLEL
CHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHH
KSRHLGLIQSSEIKDLEEKIDICSELILKYVDIENLINHFEKTEKYKDNFYLENKNLNIG
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCEEEECCCEEEE
IPYDKAFSFYYKENIELLENIGNIKYFSPMKDEELPEYLDFLYIGGGYPEVFIKELRENK
CCHHHHHHHHHHCCHHHHHCCCCCEEECCCCCCHHHHHHHEEEECCCCHHHHHHHHHHHH
SMLSSINKELNNGLPCYAECGGLMYLTEGIEDLEGDYKEAVGFFKGKCHMTKKLQNFGYA
HHHHHHHHHHHCCCCCHHHCCCEEEEHHCHHHHCCCHHHHHHHHCCHHHHHHHHHHCCCE
EIEVEKENKILPKGLKINCHEFHKSYVDLKEDKIYELTKNLYDDSTKKWSCGYIKNNTLA
EEEEECCCCCCCCCCEECHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEECCEEECCCEE
AYAHVHFFGNMDFVRNLFNR
EEEEEEEECCHHHHHHHHCC
>Mature Secondary Structure
MRSIIISSNSSGGGKTTVTLGLMKALIKKDYKVQGYKVGPDYIDPAFHSYVTENSSRNLD
CCEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHCCCCCCCEE
LFLMGEDGVKASYSRGKGDLGVIEGVMGLYDGKGIDTKYSTAHVSKVLNLPVVLVLTPKA
EEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCEEEEECCCC
QSATLCAEIMGILNYEKINIVGVIFNKVSENYYKLLKRLVEENCGLKVFGYVPKEEKLEL
CHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHH
KSRHLGLIQSSEIKDLEEKIDICSELILKYVDIENLINHFEKTEKYKDNFYLENKNLNIG
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCEEEECCCEEEE
IPYDKAFSFYYKENIELLENIGNIKYFSPMKDEELPEYLDFLYIGGGYPEVFIKELRENK
CCHHHHHHHHHHCCHHHHHCCCCCEEECCCCCCHHHHHHHEEEECCCCHHHHHHHHHHHH
SMLSSINKELNNGLPCYAECGGLMYLTEGIEDLEGDYKEAVGFFKGKCHMTKKLQNFGYA
HHHHHHHHHHHCCCCCHHHCCCEEEEHHCHHHHCCCHHHHHHHHCCHHHHHHHHHHCCCE
EIEVEKENKILPKGLKINCHEFHKSYVDLKEDKIYELTKNLYDDSTKKWSCGYIKNNTLA
EEEEECCCCCCCCCCEECHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEECCEEECCCEE
AYAHVHFFGNMDFVRNLFNR
EEEEEEEECCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12552129 [H]