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The map label for this gene is flp [H]

Identifier: 226948084

GI number: 226948084

Start: 1006146

End: 1007594

Strand: Direct

Name: flp [H]

Synonym: CLM_0947

Alternate gene names: 226948084

Gene position: 1006146-1007594 (Clockwise)

Preceding gene: 226948083

Following gene: 226948085

Centisome position: 24.21

GC content: 40.37

Gene sequence:

>1449_bases
ATGAAAAAGACTATTGTTTTTGTATTAACGATACTTATATTATTCTCAGGATTCGCAACACAAAGTTATCCGTTGTCAAA
TGCGCAATCTGCGGCAATACAAGCGTTGCTGGATGATGCCTGTCGTATATCAGGTGTGCCAGGAATGTCAATTTCAATAC
TTGCTGATGATGAAGTATTCTACTTTTCTTCTGGGTATGCAGATCGTGAAAAGGGACTGTCGGCAAGTGAAAATACGCTA
TATGAGCTGGCTTCGGTCAGCAAAGCTTTTACAGGCATAGGTATTCTGCTGATGGAAAAACAAGGACTGCTGTCAATGAC
TGACCCCATTCAAAAGTATTTACCTTGGTTTACGTTAAAGCATCAGGGGAAACCCATTGATATACAAAGTATTACACTCA
ATAACTTTTTACACCATACTAGCGGCTTAACAAATGGAAGTTATAGTCAAATCATTCCACAAGGCAATACGCCAGATATG
TTGCAAAAAACCGTAGAAATGCTCGTAGATGCTGAATTGTCATTCTTTCCTGGTGAGCAGTATAATTACGGAACTGTTAA
TTATGACGTATTAGGTCTGGTTATTGAAATTGTGTCGGGTCGGAGATATGAAGACTACATGAAAAAACAAGTGTTTCAGC
CGTTAGGGCTACACCAGACGTATGTTTACAAAGAAGATGCTCAAGCTACTAAACAATTGGCACAGGGCTACCGCTCTTCC
TTCTTTATGACGACCCCATATGATGCACCAGATTATGCTGGGAATAAACCCGCGGGCTACATCATTTCTTGCGCCAAAGA
TATGGCGCGTTGGATGGGCATACAGATGGGTATTGTTCATGATATACCCGAAATATTCCATGAGATTATCGAGAAGTCCC
ATCATGGGGACATGTCTGTTCCAGATGTCAACGGAATGTTTTATGCGGCGGGGTGGTCAGTAAATTCCCAACAAACAATT
ATTGAACACTCAGGGGGCAACCCCAATTTTGCAACCGAAGTGGAAATACTGCCAAACGAACGCACAGCCGTTTGCTTGCT
GACCAACGGTGCAAATACCAATAGAAATTTAGTGCTAAAAATTAAGGAGATATTGGATGGTAATCTTTCTCAGTCGTATG
AAATAAGCGGTACACAGTTTCTTGATATCACTTTGTCGTCTGCCACAATTATTTGTTGCCTGTTGGCTGTTCTGTTCTTT
CTTTTAGGATTACGCAGAAAGAAAATGAATGAGCGACAGCCAATGACAAAAAAGAGAATAATCGTAACAGTTATTTTGCT
GATTGCTACGATTGCCCTGTGTATAATGTGCTGTGCCTTCGATTGGTCAACGATACTTATTTGGCAAACATATAGTGTTC
TTACAGCTTTGATTTCATCGGCATTATTAACTGGAAGCATTACATGGTTTGTATACACTCACGGATATAATACCTCGCTC
CGAAAATAA

Upstream 100 bases:

>100_bases
GGATGTAAGATTGAGAAGTGAATTAAATTTGTAAATTCCAATTTGATATTGAGTAATATAAATTAGAATTTAGTTTAGTA
GTTGTAACTAAGGAGAGCTT

Downstream 100 bases:

>100_bases
TCATAATGTTAAGTAATTAAATTCCAGTTTAAGGTTGAGTAATATAAATAGTAAATTTGTTTAATACACACTTATAGTGC
AATAAAATGGCATGTAAAAT

Product: beta-lactamase

Products: A Substituted Beta- Amino Acid. [C]

Alternate protein names: FmtA-like protein [H]

Number of amino acids: Translated: 482; Mature: 482

Protein sequence:

>482_residues
MKKTIVFVLTILILFSGFATQSYPLSNAQSAAIQALLDDACRISGVPGMSISILADDEVFYFSSGYADREKGLSASENTL
YELASVSKAFTGIGILLMEKQGLLSMTDPIQKYLPWFTLKHQGKPIDIQSITLNNFLHHTSGLTNGSYSQIIPQGNTPDM
LQKTVEMLVDAELSFFPGEQYNYGTVNYDVLGLVIEIVSGRRYEDYMKKQVFQPLGLHQTYVYKEDAQATKQLAQGYRSS
FFMTTPYDAPDYAGNKPAGYIISCAKDMARWMGIQMGIVHDIPEIFHEIIEKSHHGDMSVPDVNGMFYAAGWSVNSQQTI
IEHSGGNPNFATEVEILPNERTAVCLLTNGANTNRNLVLKIKEILDGNLSQSYEISGTQFLDITLSSATIICCLLAVLFF
LLGLRRKKMNERQPMTKKRIIVTVILLIATIALCIMCCAFDWSTILIWQTYSVLTALISSALLTGSITWFVYTHGYNTSL
RK

Sequences:

>Translated_482_residues
MKKTIVFVLTILILFSGFATQSYPLSNAQSAAIQALLDDACRISGVPGMSISILADDEVFYFSSGYADREKGLSASENTL
YELASVSKAFTGIGILLMEKQGLLSMTDPIQKYLPWFTLKHQGKPIDIQSITLNNFLHHTSGLTNGSYSQIIPQGNTPDM
LQKTVEMLVDAELSFFPGEQYNYGTVNYDVLGLVIEIVSGRRYEDYMKKQVFQPLGLHQTYVYKEDAQATKQLAQGYRSS
FFMTTPYDAPDYAGNKPAGYIISCAKDMARWMGIQMGIVHDIPEIFHEIIEKSHHGDMSVPDVNGMFYAAGWSVNSQQTI
IEHSGGNPNFATEVEILPNERTAVCLLTNGANTNRNLVLKIKEILDGNLSQSYEISGTQFLDITLSSATIICCLLAVLFF
LLGLRRKKMNERQPMTKKRIIVTVILLIATIALCIMCCAFDWSTILIWQTYSVLTALISSALLTGSITWFVYTHGYNTSL
RK
>Mature_482_residues
MKKTIVFVLTILILFSGFATQSYPLSNAQSAAIQALLDDACRISGVPGMSISILADDEVFYFSSGYADREKGLSASENTL
YELASVSKAFTGIGILLMEKQGLLSMTDPIQKYLPWFTLKHQGKPIDIQSITLNNFLHHTSGLTNGSYSQIIPQGNTPDM
LQKTVEMLVDAELSFFPGEQYNYGTVNYDVLGLVIEIVSGRRYEDYMKKQVFQPLGLHQTYVYKEDAQATKQLAQGYRSS
FFMTTPYDAPDYAGNKPAGYIISCAKDMARWMGIQMGIVHDIPEIFHEIIEKSHHGDMSVPDVNGMFYAAGWSVNSQQTI
IEHSGGNPNFATEVEILPNERTAVCLLTNGANTNRNLVLKIKEILDGNLSQSYEISGTQFLDITLSSATIICCLLAVLFF
LLGLRRKKMNERQPMTKKRIIVTVILLIATIALCIMCCAFDWSTILIWQTYSVLTALISSALLTGSITWFVYTHGYNTSL
RK

Specific function: Its precise function is unknown. Has no penicillin- binding activity and is not involved in methicillin resistance [H]

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1790593, Length=233, Percent_Identity=30.4721030042918, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI87082101, Length=242, Percent_Identity=27.2727272727273, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1786574, Length=407, Percent_Identity=23.5872235872236, Blast_Score=74, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI115533026, Length=268, Percent_Identity=26.865671641791, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17550934, Length=187, Percent_Identity=26.7379679144385, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17565630, Length=198, Percent_Identity=28.2828282828283, Blast_Score=68, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: 3.5.2.6 [C]

Molecular weight: Translated: 53662; Mature: 53662

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKTIVFVLTILILFSGFATQSYPLSNAQSAAIQALLDDACRISGVPGMSISILADDEVF
CCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCEE
YFSSGYADREKGLSASENTLYELASVSKAFTGIGILLMEKQGLLSMTDPIQKYLPWFTLK
EEECCCCHHHCCCCCCHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHCCCEEEE
HQGKPIDIQSITLNNFLHHTSGLTNGSYSQIIPQGNTPDMLQKTVEMLVDAELSFFPGEQ
CCCCCCEEEEEHHHHHHHHHCCCCCCCHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCC
YNYGTVNYDVLGLVIEIVSGRRYEDYMKKQVFQPLGLHQTYVYKEDAQATKQLAQGYRSS
CCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHCC
FFMTTPYDAPDYAGNKPAGYIISCAKDMARWMGIQMGIVHDIPEIFHEIIEKSHHGDMSV
EEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCC
PDVNGMFYAAGWSVNSQQTIIEHSGGNPNFATEVEILPNERTAVCLLTNGANTNRNLVLK
CCCCCEEEEECCCCCCCCEEEEECCCCCCCEEEEEECCCCCEEEEEEECCCCCCCEEEEE
IKEILDGNLSQSYEISGTQFLDITLSSATIICCLLAVLFFLLGLRRKKMNERQPMTKKRI
EHHHHCCCCCCCEECCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
IVTVILLIATIALCIMCCAFDWSTILIWQTYSVLTALISSALLTGSITWFVYTHGYNTSL
HHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCC
RK
CC
>Mature Secondary Structure
MKKTIVFVLTILILFSGFATQSYPLSNAQSAAIQALLDDACRISGVPGMSISILADDEVF
CCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCEE
YFSSGYADREKGLSASENTLYELASVSKAFTGIGILLMEKQGLLSMTDPIQKYLPWFTLK
EEECCCCHHHCCCCCCHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHCCCEEEE
HQGKPIDIQSITLNNFLHHTSGLTNGSYSQIIPQGNTPDMLQKTVEMLVDAELSFFPGEQ
CCCCCCEEEEEHHHHHHHHHCCCCCCCHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCC
YNYGTVNYDVLGLVIEIVSGRRYEDYMKKQVFQPLGLHQTYVYKEDAQATKQLAQGYRSS
CCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHCC
FFMTTPYDAPDYAGNKPAGYIISCAKDMARWMGIQMGIVHDIPEIFHEIIEKSHHGDMSV
EEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCC
PDVNGMFYAAGWSVNSQQTIIEHSGGNPNFATEVEILPNERTAVCLLTNGANTNRNLVLK
CCCCCEEEEECCCCCCCCEEEEECCCCCCCEEEEEECCCCCEEEEEEECCCCCCCEEEEE
IKEILDGNLSQSYEISGTQFLDITLSSATIICCLLAVLFFLLGLRRKKMNERQPMTKKRI
EHHHHCCCCCCCEECCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
IVTVILLIATIALCIMCCAFDWSTILIWQTYSVLTALISSALLTGSITWFVYTHGYNTSL
HHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCC
RK
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: A Beta-Lactam; H2O [C]

Specific reaction: A Beta-Lactam + H2O = A Substituted Beta- Amino Acid. [C]

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA