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The map label for this gene is yclK [H]

Identifier: 226948076

GI number: 226948076

Start: 997406

End: 998668

Strand: Direct

Name: yclK [H]

Synonym: CLM_0937

Alternate gene names: 226948076

Gene position: 997406-998668 (Clockwise)

Preceding gene: 226948075

Following gene: 226948077

Centisome position: 24.0

GC content: 24.07

Gene sequence:

>1263_bases
TTGTTAAAGTATTTTAGAAATCCTGAAATTAAAGAATTAACTTTTAAATTCAGCATAATATTTATTTTATTTGCTATATT
AACTACAATTTTTATAAAAGGAGAACTTAATAAATTAAATAAAGATTACATAAATCAAAATACCTTGATAGTAGGAAATA
TATTATCAAAACATCCAGAATTGGAAGAAGAAATAATACTTTCTTTAAAAAGTAATGAGGATGCAACATATAATGAAGAA
AAAAATTATAAAATAGGAAAAAATATTTTAGAAAAATATTCATATGATGAAAATTTAGAACTTTATAAAAATCCAGTATT
AAAGAATTTTAGCATAAATTTTATATATAGAACTATAATTTATTTTGGTTTAGCTATTTTTATTATATACATCATAATAT
ATGATAAGTTTAAGTATTTTTATAAAAGAGCGGAAGTGTTTACTAAAGCCGCAGAAGAAATAATGGATGGCCATTTTAGT
AAGTTTGTAGATGAAAATAAAGAAGGGGATTTTTATATTCTTTCTTCTAAATTTAATTTAATGTCAAACAGATTAGAGGA
ATCTTTATTAAACTTAAAAAAAGAAAAGATATTTTTAAAAAACATAATATCAGATATTTCTCATCAATTAAAAACCCCTC
TATCCTCTTTAATAATGTTTAATGAACTAATGAAGGATGAAAGTATGCCAATAGAAGATAGGGAAAATTTTTTAAAACTT
AGTGATGAACAGTTAAAAAGAATGGAATGGCTCATTATAAATCTTTTGAAAATAGGTAGACTAGAGGCAGGAGTAGTAGA
ATTTAAAAGAGAAAATAATCCCTTGTATGTGACGATAAATAAAGCATTAGCAGGTCTTAGTGAGAAGGCTAAAGAAAAAT
CCCAACAGGTAATAGTTGATATAGATGAAGATGTATATTTTAAGCATGATATGGATTGGACAGCAGAAGCTATTTCCAAT
ATTATAAAAAATTCTATAGAACATACAGATAATTATGGACAAATAAAAATAAGTTGTGAAGAAACACCAATATCTTTAAC
TATAAGTATAAAAGATAACGGAGAAGGAATACCAGAAAAATTGCAAAATAAAATATTTGAAAGATTTTATAAAGGAGAAA
ACTCAGTTAATCCTTCTAGTATAGGAATAGGGCTTTCTCTTACCAAATCTATAATAGAATCTCAAAATGGAAGTATAATT
GTAGAAAGCGAAATGGGAGAAGGAACGGAATTTATAATAACATTCTTAAAAACTATAGTATAA

Upstream 100 bases:

>100_bases
TGTGGAATTTTCAGTAGATAATTGTTATATAAATATTAAAACTATAAAATATTATATTAAATCTTTATAAATTAATTTAG
TACAACTGAGGGGGATAATT

Downstream 100 bases:

>100_bases
AAGATATAAGAGATATCAAAATTAAATCTATTTTAGATATTCTTAAGTGAAATAGTAAAATTTAATAGTGAAGATGGTTC
ATTCTTACTTAGAATTTGAT

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MLKYFRNPEIKELTFKFSIIFILFAILTTIFIKGELNKLNKDYINQNTLIVGNILSKHPELEEEIILSLKSNEDATYNEE
KNYKIGKNILEKYSYDENLELYKNPVLKNFSINFIYRTIIYFGLAIFIIYIIIYDKFKYFYKRAEVFTKAAEEIMDGHFS
KFVDENKEGDFYILSSKFNLMSNRLEESLLNLKKEKIFLKNIISDISHQLKTPLSSLIMFNELMKDESMPIEDRENFLKL
SDEQLKRMEWLIINLLKIGRLEAGVVEFKRENNPLYVTINKALAGLSEKAKEKSQQVIVDIDEDVYFKHDMDWTAEAISN
IIKNSIEHTDNYGQIKISCEETPISLTISIKDNGEGIPEKLQNKIFERFYKGENSVNPSSIGIGLSLTKSIIESQNGSII
VESEMGEGTEFIITFLKTIV

Sequences:

>Translated_420_residues
MLKYFRNPEIKELTFKFSIIFILFAILTTIFIKGELNKLNKDYINQNTLIVGNILSKHPELEEEIILSLKSNEDATYNEE
KNYKIGKNILEKYSYDENLELYKNPVLKNFSINFIYRTIIYFGLAIFIIYIIIYDKFKYFYKRAEVFTKAAEEIMDGHFS
KFVDENKEGDFYILSSKFNLMSNRLEESLLNLKKEKIFLKNIISDISHQLKTPLSSLIMFNELMKDESMPIEDRENFLKL
SDEQLKRMEWLIINLLKIGRLEAGVVEFKRENNPLYVTINKALAGLSEKAKEKSQQVIVDIDEDVYFKHDMDWTAEAISN
IIKNSIEHTDNYGQIKISCEETPISLTISIKDNGEGIPEKLQNKIFERFYKGENSVNPSSIGIGLSLTKSIIESQNGSII
VESEMGEGTEFIITFLKTIV
>Mature_420_residues
MLKYFRNPEIKELTFKFSIIFILFAILTTIFIKGELNKLNKDYINQNTLIVGNILSKHPELEEEIILSLKSNEDATYNEE
KNYKIGKNILEKYSYDENLELYKNPVLKNFSINFIYRTIIYFGLAIFIIYIIIYDKFKYFYKRAEVFTKAAEEIMDGHFS
KFVDENKEGDFYILSSKFNLMSNRLEESLLNLKKEKIFLKNIISDISHQLKTPLSSLIMFNELMKDESMPIEDRENFLKL
SDEQLKRMEWLIINLLKIGRLEAGVVEFKRENNPLYVTINKALAGLSEKAKEKSQQVIVDIDEDVYFKHDMDWTAEAISN
IIKNSIEHTDNYGQIKISCEETPISLTISIKDNGEGIPEKLQNKIFERFYKGENSVNPSSIGIGLSLTKSIIESQNGSII
VESEMGEGTEFIITFLKTIV

Specific function: Could be member of the two-component regulatory system yclK/yclJ. Potentially phosphorylates yclJ [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=216, Percent_Identity=28.2407407407407, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788393, Length=254, Percent_Identity=24.0157480314961, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1789149, Length=221, Percent_Identity=28.9592760180996, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1787374, Length=216, Percent_Identity=24.537037037037, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1790861, Length=303, Percent_Identity=23.4323432343234, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788713, Length=228, Percent_Identity=22.8070175438596, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1786783, Length=247, Percent_Identity=24.6963562753036, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1786912, Length=249, Percent_Identity=22.0883534136546, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790436, Length=235, Percent_Identity=20.4255319148936, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790346, Length=278, Percent_Identity=21.9424460431655, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI48994928, Length=241, Percent_Identity=24.896265560166, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1788279, Length=203, Percent_Identity=28.5714285714286, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI145693157, Length=216, Percent_Identity=25.9259259259259, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787894, Length=274, Percent_Identity=24.0875912408759, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1788549, Length=240, Percent_Identity=23.3333333333333, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48835; Mature: 48835

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKYFRNPEIKELTFKFSIIFILFAILTTIFIKGELNKLNKDYINQNTLIVGNILSKHPE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEHHHHCCCC
LEEEIILSLKSNEDATYNEEKNYKIGKNILEKYSYDENLELYKNPVLKNFSINFIYRTII
CCHHHHEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHCCCCCCCHHHHHHHHHH
YFGLAIFIIYIIIYDKFKYFYKRAEVFTKAAEEIMDGHFSKFVDENKEGDFYILSSKFNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCHHH
MSNRLEESLLNLKKEKIFLKNIISDISHQLKTPLSSLIMFNELMKDESMPIEDRENFLKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHC
SDEQLKRMEWLIINLLKIGRLEAGVVEFKRENNPLYVTINKALAGLSEKAKEKSQQVIVD
CHHHHHHHHHHHHHHHHHCCHHHHHHHHEECCCCEEEEEHHHHHCHHHHHHHCCCEEEEE
IDEDVYFKHDMDWTAEAISNIIKNSIEHTDNYGQIKISCEETPISLTISIKDNGEGIPEK
CCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEEECCCCCCCCHH
LQNKIFERFYKGENSVNPSSIGIGLSLTKSIIESQNGSIIVESEMGEGTEFIITFLKTIV
HHHHHHHHHHCCCCCCCCHHCCCHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHC
>Mature Secondary Structure
MLKYFRNPEIKELTFKFSIIFILFAILTTIFIKGELNKLNKDYINQNTLIVGNILSKHPE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEHHHHCCCC
LEEEIILSLKSNEDATYNEEKNYKIGKNILEKYSYDENLELYKNPVLKNFSINFIYRTII
CCHHHHEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHCCCCCCCHHHHHHHHHH
YFGLAIFIIYIIIYDKFKYFYKRAEVFTKAAEEIMDGHFSKFVDENKEGDFYILSSKFNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCHHH
MSNRLEESLLNLKKEKIFLKNIISDISHQLKTPLSSLIMFNELMKDESMPIEDRENFLKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHC
SDEQLKRMEWLIINLLKIGRLEAGVVEFKRENNPLYVTINKALAGLSEKAKEKSQQVIVD
CHHHHHHHHHHHHHHHHHCCHHHHHHHHEECCCCEEEEEHHHHHCHHHHHHHCCCEEEEE
IDEDVYFKHDMDWTAEAISNIIKNSIEHTDNYGQIKISCEETPISLTISIKDNGEGIPEK
CCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEEECCCCCCCCHH
LQNKIFERFYKGENSVNPSSIGIGLSLTKSIIESQNGSIIVESEMGEGTEFIITFLKTIV
HHHHHHHHHHCCCCCCCCHHCCCHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]