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The map label for this gene is walR [H]

Identifier: 226948075

GI number: 226948075

Start: 996521

End: 997234

Strand: Direct

Name: walR [H]

Synonym: CLM_0936

Alternate gene names: 226948075

Gene position: 996521-997234 (Clockwise)

Preceding gene: 226948074

Following gene: 226948076

Centisome position: 23.98

GC content: 28.15

Gene sequence:

>714_bases
GTGACAAAAATATTATTAGTAGAAGATGATACGGCTTTAGCCATTGGAGTGGAATATACATTAAAACAAGAAAACTATGA
AGTTAAAAGAGCTAAAAATTTAAAAGAGGCTAGAGAGATTTTAAAAGAAGAGGAGTTAGATTTAATTTTATTAGATTTAA
TGTTACCAGATGGAAGTGGATATGATTTTTGTAGTGAAGTAAGAGAAGAAAGTCTAATTCCAGTAATATTTATGACTGCC
TGTGATGAAGAAGCTAATGTGGTTTTAGGATTAGACATGGGAGGCGATGACTATATAACAAAGCCCATTAGAATAAGAGA
ACTTTTATCTAGAATAAATGCGGTTTTAAGAAGAAGAGCTAAAGAAGCAGAATCAAAAAATAAGAATATAAAAGAAGATA
ATATAAAAAATAATAAAATAATTTCTAAGGACATAATAATAGAACCCTTGAAAGCAAAAGTTTTCAAAGGAGAGGAAGAA
ATTTTATTAACAGCAGGGGAATATAAATTACTTTTAATATTAGTAGAAAACAAGGGTAATGTGTTATCTAGGAATGTTTT
ATTAGAAAGAATTTGGGATGTAGATGGAAGTTTTGTAGATGGAAACACATTAAATGTTTATATAAAAAGGTTAAGAGAAA
AAATAGAAAAAGATCCTAAAAAGCCTGAATATATAGAAACTGTAAGAGGTATAGGTTATAGATGGAGTGAGTAA

Upstream 100 bases:

>100_bases
AATAGGTTCTTTTTTTATACTAAAATGTTAAATTATTTTTATTTTAAATAACTATAGTATAAATTATAATTAAATAAGTA
ATATTAGGGGGGGGGATTTT

Downstream 100 bases:

>100_bases
AATTGCTTTATGAGAATGTAAAACAATCATTGTAAACTCCATTTAATATCTTAACTCAGTGTAAAGTAAGTTGTGGAATT
TTCAGTAGATAATTGTTATA

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 236

Protein sequence:

>237_residues
MTKILLVEDDTALAIGVEYTLKQENYEVKRAKNLKEAREILKEEELDLILLDLMLPDGSGYDFCSEVREESLIPVIFMTA
CDEEANVVLGLDMGGDDYITKPIRIRELLSRINAVLRRRAKEAESKNKNIKEDNIKNNKIISKDIIIEPLKAKVFKGEEE
ILLTAGEYKLLLILVENKGNVLSRNVLLERIWDVDGSFVDGNTLNVYIKRLREKIEKDPKKPEYIETVRGIGYRWSE

Sequences:

>Translated_237_residues
MTKILLVEDDTALAIGVEYTLKQENYEVKRAKNLKEAREILKEEELDLILLDLMLPDGSGYDFCSEVREESLIPVIFMTA
CDEEANVVLGLDMGGDDYITKPIRIRELLSRINAVLRRRAKEAESKNKNIKEDNIKNNKIISKDIIIEPLKAKVFKGEEE
ILLTAGEYKLLLILVENKGNVLSRNVLLERIWDVDGSFVDGNTLNVYIKRLREKIEKDPKKPEYIETVRGIGYRWSE
>Mature_236_residues
TKILLVEDDTALAIGVEYTLKQENYEVKRAKNLKEAREILKEEELDLILLDLMLPDGSGYDFCSEVREESLIPVIFMTAC
DEEANVVLGLDMGGDDYITKPIRIRELLSRINAVLRRRAKEAESKNKNIKEDNIKNNKIISKDIIIEPLKAKVFKGEEEI
LLTAGEYKLLLILVENKGNVLSRNVLLERIWDVDGSFVDGNTLNVYIKRLREKIEKDPKKPEYIETVRGIGYRWSE

Specific function: Member of the two-component regulatory system walK/walR that regulates genes involved in autolysis, biofilm formation and cell wall metabolism [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786911, Length=235, Percent_Identity=33.6170212765957, Blast_Score=143, Evalue=1e-35,
Organism=Escherichia coli, GI1786599, Length=237, Percent_Identity=36.2869198312236, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1789809, Length=235, Percent_Identity=36.1702127659575, Blast_Score=137, Evalue=6e-34,
Organism=Escherichia coli, GI1790552, Length=232, Percent_Identity=34.9137931034483, Blast_Score=124, Evalue=5e-30,
Organism=Escherichia coli, GI1788394, Length=233, Percent_Identity=33.4763948497854, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1786784, Length=232, Percent_Identity=32.3275862068966, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI87082012, Length=232, Percent_Identity=31.8965517241379, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI1790863, Length=242, Percent_Identity=31.404958677686, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI1789402, Length=236, Percent_Identity=31.7796610169492, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1790860, Length=231, Percent_Identity=31.1688311688312, Blast_Score=111, Evalue=4e-26,
Organism=Escherichia coli, GI1787229, Length=233, Percent_Identity=32.1888412017167, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1787375, Length=237, Percent_Identity=30.379746835443, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI145693140, Length=237, Percent_Identity=28.6919831223629, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI2367329, Length=233, Percent_Identity=30.0429184549356, Blast_Score=97, Evalue=9e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27271; Mature: 27140

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKILLVEDDTALAIGVEYTLKQENYEVKRAKNLKEAREILKEEELDLILLDLMLPDGSG
CCEEEEEECCCEEEEEEEEEEECCCCHHHHHCCHHHHHHHHHHCCCCEEEEEEECCCCCC
YDFCSEVREESLIPVIFMTACDEEANVVLGLDMGGDDYITKPIRIRELLSRINAVLRRRA
CHHHHHHHHCCCCCEEEEEECCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHH
KEAESKNKNIKEDNIKNNKIISKDIIIEPLKAKVFKGEEEILLTAGEYKLLLILVENKGN
HHHHHHCCCCCCCCCCCCEEECHHHEEECHHHHHCCCCCEEEEEECCEEEEEEEEECCCC
VLSRNVLLERIWDVDGSFVDGNTLNVYIKRLREKIEKDPKKPEYIETVRGIGYRWSE
CHHHHHHHHHHHCCCCCEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TKILLVEDDTALAIGVEYTLKQENYEVKRAKNLKEAREILKEEELDLILLDLMLPDGSG
CEEEEEECCCEEEEEEEEEEECCCCHHHHHCCHHHHHHHHHHCCCCEEEEEEECCCCCC
YDFCSEVREESLIPVIFMTACDEEANVVLGLDMGGDDYITKPIRIRELLSRINAVLRRRA
CHHHHHHHHCCCCCEEEEEECCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHH
KEAESKNKNIKEDNIKNNKIISKDIIIEPLKAKVFKGEEEILLTAGEYKLLLILVENKGN
HHHHHHCCCCCCCCCCCCEEECHHHEEECHHHHHCCCCCEEEEEECCEEEEEEEEECCCC
VLSRNVLLERIWDVDGSFVDGNTLNVYIKRLREKIEKDPKKPEYIETVRGIGYRWSE
CHHHHHHHHHHHCCCCCEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA