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The map label for this gene is fhuB [H]

Identifier: 226947946

GI number: 226947946

Start: 866483

End: 867523

Strand: Direct

Name: fhuB [H]

Synonym: CLM_0804

Alternate gene names: 226947946

Gene position: 866483-867523 (Clockwise)

Preceding gene: 226947945

Following gene: 226947947

Centisome position: 20.85

GC content: 37.56

Gene sequence:

>1041_bases
ATGAAAAAACCAATGGAGAAGGTAAATATAAACATAAATAAAAAAGATCATATACGGAAGATGTGGTTTATTGTATTAGG
AGGATTAGGATTACTTGCTTTTATTATGATGTTTTCTACAACTAAGGGGGCAGAGAATATCCCCTTAGCTTCCCTATGGG
ATGCTTTATTTCATTTTAATGGGAAGGAAATGAATCATCTTGTTATAGTCAATCTACGTATTCCTCGTGTTATAGCAAGT
GCCTTAGTTGGTGCAGCTCTTGCTGTTTCAGGAGCTATTATGCAAGGAACTACAGGAAATCCCCTTGCTGATTCAGGATT
ATTAGGGTTAAATGCTGGAGCGGCTTTTGCTCTTTCTATATGTTTTGCCTTCTTTCCCGGAATGAAATATATCCATATTA
TTTTATTTTCCTTTTTAGGAGCAGCTTTTGGAGCTGTATTAGTTAATGGTATTGCTTCTATGAAAAGAGGTGGACAAACA
CCCATTAGGCTTGTATTGGCAGGGGCAGCTGTTAGTACATTACTTGTGGCTATGAGCCAGGGTATTGCTCTTTATTTTAA
TGTAGCTCAAAGCATCATGTTTTGGACTGTTGGTGGTGTTGCAGGTTCTAATTGGGAACAGGTTAGGATAATGCTTCCGT
GGATAATAGGAGGACTCATAGGAGCGGTGGCCCTATCACCTTATATTTCTATTTTAAGCTTAGGACAGGATGTTGCAAAG
GGATTGGGAATAAATATAAAGGTAATAAATCTATTCTCTTCACTTATAGTTCTTATATTGGTAGGAGCTTCAGTATCTGT
AGTGGGTTCAGTTGGATTTGTGGGATTGATTGTTCCTCATATTGCACGTTTTTTTGTTGGGATGGATTATAAACTAATTA
TTCCTTCTACAGCAGTAATGGGAGCTTTGCTGGTAGTATTGGCTGACCTAGGAGCGAGAACTTTAAACCCTCCTTTTGAA
ACTCCCATAGGAGCTATAATTTCTCTTATTGGTGTACCATTATTTTTAAATTTGGCTCGTAGGCAAAGGAGTGCAATATA
A

Upstream 100 bases:

>100_bases
AATAAACTTTCATTGGCAAATTAAATGTAATCTAAATGGAAGTTATCCATTGGTTTGGCATAATAAGAATAGTTTACAGT
AATAAGGAGGTAGCAGTTAT

Downstream 100 bases:

>100_bases
TGAAAGAACAACAACAAATAATTGAAGCATATAAACGTAAGGTAGCCATTCGTAATACATTAATTGTAATTGGATGCATT
TTATTACTAGCAATTTCTTT

Product: ferrichrome transport system permease FhuB

Products: ADP; phosphate; iron dicitrate [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein B; Ferrichrome transport system permease protein fhuB; Iron(III)-hydroxamate import system permease protein fhuB [H]

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MKKPMEKVNININKKDHIRKMWFIVLGGLGLLAFIMMFSTTKGAENIPLASLWDALFHFNGKEMNHLVIVNLRIPRVIAS
ALVGAALAVSGAIMQGTTGNPLADSGLLGLNAGAAFALSICFAFFPGMKYIHIILFSFLGAAFGAVLVNGIASMKRGGQT
PIRLVLAGAAVSTLLVAMSQGIALYFNVAQSIMFWTVGGVAGSNWEQVRIMLPWIIGGLIGAVALSPYISILSLGQDVAK
GLGINIKVINLFSSLIVLILVGASVSVVGSVGFVGLIVPHIARFFVGMDYKLIIPSTAVMGALLVVLADLGARTLNPPFE
TPIGAIISLIGVPLFLNLARRQRSAI

Sequences:

>Translated_346_residues
MKKPMEKVNININKKDHIRKMWFIVLGGLGLLAFIMMFSTTKGAENIPLASLWDALFHFNGKEMNHLVIVNLRIPRVIAS
ALVGAALAVSGAIMQGTTGNPLADSGLLGLNAGAAFALSICFAFFPGMKYIHIILFSFLGAAFGAVLVNGIASMKRGGQT
PIRLVLAGAAVSTLLVAMSQGIALYFNVAQSIMFWTVGGVAGSNWEQVRIMLPWIIGGLIGAVALSPYISILSLGQDVAK
GLGINIKVINLFSSLIVLILVGASVSVVGSVGFVGLIVPHIARFFVGMDYKLIIPSTAVMGALLVVLADLGARTLNPPFE
TPIGAIISLIGVPLFLNLARRQRSAI
>Mature_346_residues
MKKPMEKVNININKKDHIRKMWFIVLGGLGLLAFIMMFSTTKGAENIPLASLWDALFHFNGKEMNHLVIVNLRIPRVIAS
ALVGAALAVSGAIMQGTTGNPLADSGLLGLNAGAAFALSICFAFFPGMKYIHIILFSFLGAAFGAVLVNGIASMKRGGQT
PIRLVLAGAAVSTLLVAMSQGIALYFNVAQSIMFWTVGGVAGSNWEQVRIMLPWIIGGLIGAVALSPYISILSLGQDVAK
GLGINIKVINLFSSLIVLILVGASVSVVGSVGFVGLIVPHIARFFVGMDYKLIIPSTAVMGALLVVLADLGARTLNPPFE
TPIGAIISLIGVPLFLNLARRQRSAI

Specific function: Part of the ABC transporter complex fhuBGCD involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790741, Length=292, Percent_Identity=36.3013698630137, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI1786805, Length=302, Percent_Identity=34.1059602649007, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1790740, Length=295, Percent_Identity=30.8474576271186, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1786347, Length=355, Percent_Identity=30.7042253521127, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1788004, Length=292, Percent_Identity=32.5342465753425, Blast_Score=111, Evalue=9e-26,
Organism=Escherichia coli, GI1786804, Length=306, Percent_Identity=31.0457516339869, Blast_Score=94, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 36493; Mature: 36493

Theoretical pI: Translated: 10.90; Mature: 10.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKPMEKVNININKKDHIRKMWFIVLGGLGLLAFIMMFSTTKGAENIPLASLWDALFHFN
CCCCCHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCC
GKEMNHLVIVNLRIPRVIASALVGAALAVSGAIMQGTTGNPLADSGLLGLNAGAAFALSI
CCCCCEEEEEEECHHHHHHHHHHHHHHHHHCHHEECCCCCCCCCCCCEECCCHHHHHHHH
CFAFFPGMKYIHIILFSFLGAAFGAVLVNGIASMKRGGQTPIRLVLAGAAVSTLLVAMSQ
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHC
GIALYFNVAQSIMFWTVGGVAGSNWEQVRIMLPWIIGGLIGAVALSPYISILSLGQDVAK
CHHHHHHHHHHHHHHHCCCCCCCCHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLGINIKVINLFSSLIVLILVGASVSVVGSVGFVGLIVPHIARFFVGMDYKLIIPSTAVM
CCCCEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHH
GALLVVLADLGARTLNPPFETPIGAIISLIGVPLFLNLARRQRSAI
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKPMEKVNININKKDHIRKMWFIVLGGLGLLAFIMMFSTTKGAENIPLASLWDALFHFN
CCCCCHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCC
GKEMNHLVIVNLRIPRVIASALVGAALAVSGAIMQGTTGNPLADSGLLGLNAGAAFALSI
CCCCCEEEEEEECHHHHHHHHHHHHHHHHHCHHEECCCCCCCCCCCCEECCCHHHHHHHH
CFAFFPGMKYIHIILFSFLGAAFGAVLVNGIASMKRGGQTPIRLVLAGAAVSTLLVAMSQ
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHC
GIALYFNVAQSIMFWTVGGVAGSNWEQVRIMLPWIIGGLIGAVALSPYISILSLGQDVAK
CHHHHHHHHHHHHHHHCCCCCCCCHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLGINIKVINLFSSLIVLILVGASVSVVGSVGFVGLIVPHIARFFVGMDYKLIIPSTAVM
CCCCEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHH
GALLVVLADLGARTLNPPFETPIGAIISLIGVPLFLNLARRQRSAI
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron dicitrate [Periplasm]; H2O [C]

Specific reaction: ATP + iron dicitrate [Periplasm] + H2O = ADP + phosphate + iron dicitrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377; 8388528 [H]