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The map label for this gene is gluP [H]

Identifier: 226947631

GI number: 226947631

Start: 505633

End: 506655

Strand: Direct

Name: gluP [H]

Synonym: CLM_0468

Alternate gene names: 226947631

Gene position: 505633-506655 (Clockwise)

Preceding gene: 226947630

Following gene: 226947634

Centisome position: 12.17

GC content: 25.12

Gene sequence:

>1023_bases
GTGATTGGTATAGATAATTTTATAAAGGGCATTATAGAAAAGCTTATGAGTACAAACAATTACAATGTTATGGAGATAAA
TACTAATACAGGACTAGAGAGTAATTGGATAGCTGTTAAAGATAAAGAAGATTTTTATAATGTATTAATTTTTTCTAGTA
ACTTTGCAATAAAAAATTTAGATAAGGAATATATAGAAGAGTATATTAAGTCTTTGCTTGCGGATAAACCCATAAATTTA
AACATAGCTATACTAATGGATGAAGAAATAGATGGCTCTTTTATTAGTTCTTTAGATAGTAATTTAATTAAAGATATTTC
CTTTATAGTGGATTATAATAATAGAAATATAGTATATGCGGGAGAAGGCACTAGAAGTATTGTAGAGGACATAGTAAGTG
TTCCAGAACAAAGAGAGAATATTTATTATAATGAAAATGATGCAAATAGCAATAAAAAAGCTACTATTACTAAAATAATA
ATAGGTATAAATATTTTTATGTATCTAATAACAGCTTTTTTATCAGGAAGTATATTTACTAGTGATATTAAAGTACTAAT
ATTTCTAGGAGCAAAAGTAAATTCTTTTATAAATAATGGAGAATATTATAGGCTAATAACAGCAATGTTTTTACATGGAG
GATTAATACATTTAGCATTAAATATGTATGCATTAAATGCTATAGGTCCATTGGTAGAAATTTATTTTGGTAAAGTAAAA
TATTTAATTATTTATTTTATATCTGGAATATTAAGTTCTTATTTTAGTTATTTATTTTCATCTTCAGTGTCCATAGGAGC
TTCAGGAGCTATATTTGGTATATTAGGAGCTACTTTAATAATAGCTTATGCAAATAGGAAAAAAGGCGGGAAAGAATTTT
TAAATAATATAATATCAGTTATAGTTGTTAACTTAATACTAGGGTTTTCTATCCCCAATGTGGATAACTTTGGACATATC
GGTGGATTAATTGGAGGAGTAATTATAACACTTGTTCTTTTTTTATATTCAAAGAATAAATAA

Upstream 100 bases:

>100_bases
TAAATTATATGTTGTGCTTATTTGTATAATAATATATATTGGGTAATATAAAGAAAATTTTTTAATGGTGTCTAAAAGTA
ATTATTATTTTTATTAGGAT

Downstream 100 bases:

>100_bases
CGAAATTTCAAAATGTAGAGAATTAAATTAAAAAGTACCTTTAGTGAATGAATATCTATAAAAACAAGTAATACTAACAT
TTGTATACTAATTATTTTTT

Product: peptidase, S54

Products: NA

Alternate protein names: Intramembrane serine protease [H]

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MIGIDNFIKGIIEKLMSTNNYNVMEINTNTGLESNWIAVKDKEDFYNVLIFSSNFAIKNLDKEYIEEYIKSLLADKPINL
NIAILMDEEIDGSFISSLDSNLIKDISFIVDYNNRNIVYAGEGTRSIVEDIVSVPEQRENIYYNENDANSNKKATITKII
IGINIFMYLITAFLSGSIFTSDIKVLIFLGAKVNSFINNGEYYRLITAMFLHGGLIHLALNMYALNAIGPLVEIYFGKVK
YLIIYFISGILSSYFSYLFSSSVSIGASGAIFGILGATLIIAYANRKKGGKEFLNNIISVIVVNLILGFSIPNVDNFGHI
GGLIGGVIITLVLFLYSKNK

Sequences:

>Translated_340_residues
MIGIDNFIKGIIEKLMSTNNYNVMEINTNTGLESNWIAVKDKEDFYNVLIFSSNFAIKNLDKEYIEEYIKSLLADKPINL
NIAILMDEEIDGSFISSLDSNLIKDISFIVDYNNRNIVYAGEGTRSIVEDIVSVPEQRENIYYNENDANSNKKATITKII
IGINIFMYLITAFLSGSIFTSDIKVLIFLGAKVNSFINNGEYYRLITAMFLHGGLIHLALNMYALNAIGPLVEIYFGKVK
YLIIYFISGILSSYFSYLFSSSVSIGASGAIFGILGATLIIAYANRKKGGKEFLNNIISVIVVNLILGFSIPNVDNFGHI
GGLIGGVIITLVLFLYSKNK
>Mature_340_residues
MIGIDNFIKGIIEKLMSTNNYNVMEINTNTGLESNWIAVKDKEDFYNVLIFSSNFAIKNLDKEYIEEYIKSLLADKPINL
NIAILMDEEIDGSFISSLDSNLIKDISFIVDYNNRNIVYAGEGTRSIVEDIVSVPEQRENIYYNENDANSNKKATITKII
IGINIFMYLITAFLSGSIFTSDIKVLIFLGAKVNSFINNGEYYRLITAMFLHGGLIHLALNMYALNAIGPLVEIYFGKVK
YLIIYFISGILSSYFSYLFSSSVSIGASGAIFGILGATLIIAYANRKKGGKEFLNNIISVIVVNLILGFSIPNVDNFGHI
GGLIGGVIITLVLFLYSKNK

Specific function: Rhomboid-type serine protease that catalyzes intramembrane proteolysis. Important for normal cell division and sporulation. May act as a glucose exporter [H]

COG id: COG0705

COG function: function code R; Uncharacterized membrane protein (homolog of Drosophila rhomboid)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 TPR repeats [H]

Homologues:

Organism=Caenorhabditis elegans, GI133901888, Length=143, Percent_Identity=34.965034965035, Blast_Score=78, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI115532986, Length=143, Percent_Identity=34.965034965035, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002610
- InterPro:   IPR022764
- InterPro:   IPR001440
- InterPro:   IPR013026
- InterPro:   IPR011990
- InterPro:   IPR019734 [H]

Pfam domain/function: PF01694 Rhomboid; PF00515 TPR_1 [H]

EC number: =3.4.21.105 [H]

Molecular weight: Translated: 37812; Mature: 37812

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGIDNFIKGIIEKLMSTNNYNVMEINTNTGLESNWIAVKDKEDFYNVLIFSSNFAIKNL
CCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEEECCCCEEEEEEEECCCCHHCC
DKEYIEEYIKSLLADKPINLNIAILMDEEIDGSFISSLDSNLIKDISFIVDYNNRNIVYA
CHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHEEEECCCEEEEE
GEGTRSIVEDIVSVPEQRENIYYNENDANSNKKATITKIIIGINIFMYLITAFLSGSIFT
CCCHHHHHHHHHHCCHHHCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEC
SDIKVLIFLGAKVNSFINNGEYYRLITAMFLHGGLIHLALNMYALNAIGPLVEIYFGKVK
CCEEEEEEECCHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
YLIIYFISGILSSYFSYLFSSSVSIGASGAIFGILGATLIIAYANRKKGGKEFLNNIISV
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
IVVNLILGFSIPNVDNFGHIGGLIGGVIITLVLFLYSKNK
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIGIDNFIKGIIEKLMSTNNYNVMEINTNTGLESNWIAVKDKEDFYNVLIFSSNFAIKNL
CCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEEECCCCEEEEEEEECCCCHHCC
DKEYIEEYIKSLLADKPINLNIAILMDEEIDGSFISSLDSNLIKDISFIVDYNNRNIVYA
CHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHEEEECCCEEEEE
GEGTRSIVEDIVSVPEQRENIYYNENDANSNKKATITKIIIGINIFMYLITAFLSGSIFT
CCCHHHHHHHHHHCCHHHCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEC
SDIKVLIFLGAKVNSFINNGEYYRLITAMFLHGGLIHLALNMYALNAIGPLVEIYFGKVK
CCEEEEEEECCHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
YLIIYFISGILSSYFSYLFSSSVSIGASGAIFGILGATLIIAYANRKKGGKEFLNNIISV
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
IVVNLILGFSIPNVDNFGHIGGLIGGVIITLVLFLYSKNK
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]