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The map label for this gene is yfnA [H]

Identifier: 226947622

GI number: 226947622

Start: 498209

End: 499660

Strand: Direct

Name: yfnA [H]

Synonym: CLM_0459

Alternate gene names: 226947622

Gene position: 498209-499660 (Clockwise)

Preceding gene: 226947621

Following gene: 226947624

Centisome position: 11.99

GC content: 34.37

Gene sequence:

>1452_bases
ATGTCTAAGGGAAACGACGTCAGTAGCAGTGATCAAAATTTTGAAAGGGTTTTATCGAAAAAGGATATTATGGCTTTAGC
CTTTGGAGCTATGATTGGCTGGGGCTGGGTTGTATTAACAGGTCCATGGATACAGAAAGCAGGAAGCATGGGTGCTATAT
TGGCCTTTATAATAGGCGGAATCGTAGTATTATTTGTAGGACTCACCTATGCAGAACTTACATCAGCTATGCCAAAGTGT
GGGGGAGACTTGGTATTTAGCTATAGAGCACTGGGGAAAAAAGCAGCTTTTATATGTACTTGGGGCATGATTTTAGGATA
TATTTCTGTTGTAGCCTTTGAAGCAGTTGCATTCCCTTCAGTATTAGAGAATTTATTTTCTTTTTCTTATTTAAAAGGTT
ATATGTACACCATTGCAGGCTATGATATATATGCTTCTTGGGCATTAATAGGTTCTATAAGTGCCATAATTATAACAATA
GTAAATTACTTTGGAGCAAAACCAGCAGCTTTTATGCAAACTGTAGTAACAGTTATGATTGCTTGTGTAGGGATTGCATT
GTTTACAGGAAGCTTATTTAATGGAAGTATACAAAATATGTCACCTATGTTTGTTACAGGTACTTCAGGAAAGGGGATTT
TAGCAGTAGCTATAATGACTCCTTTTATGTATGTAGGCTTTGATGTAATACCACAGGCAGCAGAAGAAATAAATGTACCT
TTTAAGAAAATAGGAAAAATACTAATTTTATCAGTAATTATGGCAGTAGTTTGGTATGCTATGATAATTTATAGCACATC
AGTAGCATTAAATTCTAGCGAAATAAATAGTTCAAGCTTAGTAGCTGCAGATGCTATGAAAAAGATGTTCGGAAATAGTG
TGGCAGCATCAAAAATATTGATACTAGCTGGCATAGGTGGAATTTTAACCAGTTGGAATTCTTTTTTTATGGGCGGAAGT
AGAGCTATATATTCTATGGCAGAGGCTGGAATGTTACCAAAATTTTTAGCTAAAATACACCCTAAATATAAAACACCAAC
TAACGCTATAGTATTAATAGGATTAGTATCAAGCATTGCACCATTCTTTGGAGAGAAGATGCTAGTATGGCTTAGTAATG
CAGGTGGATTTGGTATATTAATATCTTATTTACTTGTATCTATATCCTTCTTAGTATTAAGAAAGAAGGAACCTGATATG
GAAAGACCTTATAAAGTAAGACATCCTAAGTTTGTAGGTACTATGGCTATAGTTTTATGTATAGGAATGCTTTTAATGTT
TATGCCAGGTTTACCATCAGGACTTAGCTGGCCTTATGAATGGGGAATAATATTAGCATGGTTTTTACTTGGAGGTATAT
TCTATTTAGCTGCAGCTAATAAAGCCTCAAATGAATCCAAGCATACTAAATATAAAGACGATTATTATACAAATAAAAAA
GTTAGTGTATAG

Upstream 100 bases:

>100_bases
ATGGTTAAGTTGCAAGTTGTAACTTATACCTTATAATATTATTAAATAATCCTAATATTAAAATATTAAAAAATTAACTA
TAAATTGAAGGGGGATCATT

Downstream 100 bases:

>100_bases
TTAATTTATAAATTGAAGAAAAAACAAACAAAAGTGTAATAAGAGGAAAGTGCGATGCACTTTCCTCTTATTGTGGAATT
ATTCTATTGAATAATTCTTT

Product: amino acid permease family protein

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 483; Mature: 482

Protein sequence:

>483_residues
MSKGNDVSSSDQNFERVLSKKDIMALAFGAMIGWGWVVLTGPWIQKAGSMGAILAFIIGGIVVLFVGLTYAELTSAMPKC
GGDLVFSYRALGKKAAFICTWGMILGYISVVAFEAVAFPSVLENLFSFSYLKGYMYTIAGYDIYASWALIGSISAIIITI
VNYFGAKPAAFMQTVVTVMIACVGIALFTGSLFNGSIQNMSPMFVTGTSGKGILAVAIMTPFMYVGFDVIPQAAEEINVP
FKKIGKILILSVIMAVVWYAMIIYSTSVALNSSEINSSSLVAADAMKKMFGNSVAASKILILAGIGGILTSWNSFFMGGS
RAIYSMAEAGMLPKFLAKIHPKYKTPTNAIVLIGLVSSIAPFFGEKMLVWLSNAGGFGILISYLLVSISFLVLRKKEPDM
ERPYKVRHPKFVGTMAIVLCIGMLLMFMPGLPSGLSWPYEWGIILAWFLLGGIFYLAAANKASNESKHTKYKDDYYTNKK
VSV

Sequences:

>Translated_483_residues
MSKGNDVSSSDQNFERVLSKKDIMALAFGAMIGWGWVVLTGPWIQKAGSMGAILAFIIGGIVVLFVGLTYAELTSAMPKC
GGDLVFSYRALGKKAAFICTWGMILGYISVVAFEAVAFPSVLENLFSFSYLKGYMYTIAGYDIYASWALIGSISAIIITI
VNYFGAKPAAFMQTVVTVMIACVGIALFTGSLFNGSIQNMSPMFVTGTSGKGILAVAIMTPFMYVGFDVIPQAAEEINVP
FKKIGKILILSVIMAVVWYAMIIYSTSVALNSSEINSSSLVAADAMKKMFGNSVAASKILILAGIGGILTSWNSFFMGGS
RAIYSMAEAGMLPKFLAKIHPKYKTPTNAIVLIGLVSSIAPFFGEKMLVWLSNAGGFGILISYLLVSISFLVLRKKEPDM
ERPYKVRHPKFVGTMAIVLCIGMLLMFMPGLPSGLSWPYEWGIILAWFLLGGIFYLAAANKASNESKHTKYKDDYYTNKK
VSV
>Mature_482_residues
SKGNDVSSSDQNFERVLSKKDIMALAFGAMIGWGWVVLTGPWIQKAGSMGAILAFIIGGIVVLFVGLTYAELTSAMPKCG
GDLVFSYRALGKKAAFICTWGMILGYISVVAFEAVAFPSVLENLFSFSYLKGYMYTIAGYDIYASWALIGSISAIIITIV
NYFGAKPAAFMQTVVTVMIACVGIALFTGSLFNGSIQNMSPMFVTGTSGKGILAVAIMTPFMYVGFDVIPQAAEEINVPF
KKIGKILILSVIMAVVWYAMIIYSTSVALNSSEINSSSLVAADAMKKMFGNSVAASKILILAGIGGILTSWNSFFMGGSR
AIYSMAEAGMLPKFLAKIHPKYKTPTNAIVLIGLVSSIAPFFGEKMLVWLSNAGGFGILISYLLVSISFLVLRKKEPDME
RPYKVRHPKFVGTMAIVLCIGMLLMFMPGLPSGLSWPYEWGIILAWFLLGGIFYLAAANKASNESKHTKYKDDYYTNKKV
SV

Specific function: Permease That Is Involved In The Transport Across The Cytoplasmic Membrane Of Lysine. [C]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI4507047, Length=445, Percent_Identity=25.8426966292135, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI114326544, Length=419, Percent_Identity=24.8210023866348, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI114326550, Length=419, Percent_Identity=24.8210023866348, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI181337167, Length=398, Percent_Identity=25.3768844221106, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI258614003, Length=425, Percent_Identity=26.5882352941176, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI258614005, Length=425, Percent_Identity=26.5882352941176, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI258645169, Length=425, Percent_Identity=25.1764705882353, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI7657683, Length=388, Percent_Identity=25.2577319587629, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI33286428, Length=389, Percent_Identity=25.706940874036, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI110347453, Length=416, Percent_Identity=24.2788461538462, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI71979932, Length=424, Percent_Identity=24.2924528301887, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI186910308, Length=406, Percent_Identity=24.384236453202, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI186910306, Length=406, Percent_Identity=24.384236453202, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI186910304, Length=406, Percent_Identity=24.384236453202, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI9790235, Length=322, Percent_Identity=24.5341614906832, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1788480, Length=437, Percent_Identity=22.6544622425629, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI87082250, Length=354, Percent_Identity=25.7062146892655, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1786789, Length=449, Percent_Identity=22.9398663697105, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17532491, Length=399, Percent_Identity=28.0701754385965, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17531343, Length=417, Percent_Identity=26.378896882494, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17533459, Length=406, Percent_Identity=27.0935960591133, Blast_Score=99, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17540018, Length=440, Percent_Identity=25.6818181818182, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI32566699, Length=360, Percent_Identity=24.1666666666667, Blast_Score=66, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71993915, Length=365, Percent_Identity=25.7534246575342, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6321629, Length=448, Percent_Identity=23.2142857142857, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24668806, Length=435, Percent_Identity=27.3563218390805, Blast_Score=109, Evalue=5e-24,
Organism=Drosophila melanogaster, GI21356285, Length=435, Percent_Identity=27.3563218390805, Blast_Score=109, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24668802, Length=435, Percent_Identity=27.3563218390805, Blast_Score=109, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24666159, Length=423, Percent_Identity=26.7139479905437, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI221512776, Length=423, Percent_Identity=26.7139479905437, Blast_Score=104, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24667468, Length=421, Percent_Identity=26.3657957244656, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI281366235, Length=409, Percent_Identity=26.8948655256724, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI116007820, Length=409, Percent_Identity=26.8948655256724, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI116007818, Length=409, Percent_Identity=26.8948655256724, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI85725152, Length=409, Percent_Identity=26.8948655256724, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21357367, Length=462, Percent_Identity=24.4588744588745, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI221331183, Length=420, Percent_Identity=25.2380952380952, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI17647653, Length=420, Percent_Identity=25.2380952380952, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24664379, Length=420, Percent_Identity=25.2380952380952, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI161077963, Length=445, Percent_Identity=26.2921348314607, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24641995, Length=429, Percent_Identity=23.5431235431235, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24641993, Length=429, Percent_Identity=23.5431235431235, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45550968, Length=410, Percent_Identity=22.6829268292683, Blast_Score=69, Evalue=9e-12,
Organism=Drosophila melanogaster, GI19921172, Length=410, Percent_Identity=22.6829268292683, Blast_Score=69, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24651635, Length=388, Percent_Identity=23.7113402061856, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24651633, Length=388, Percent_Identity=23.7113402061856, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR015606 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 52249; Mature: 52118

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKGNDVSSSDQNFERVLSKKDIMALAFGAMIGWGWVVLTGPWIQKAGSMGAILAFIIGG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECHHHHHCCCHHHHHHHHHHH
IVVLFVGLTYAELTSAMPKCGGDLVFSYRALGKKAAFICTWGMILGYISVVAFEAVAFPS
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLENLFSFSYLKGYMYTIAGYDIYASWALIGSISAIIITIVNYFGAKPAAFMQTVVTVMI
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
ACVGIALFTGSLFNGSIQNMSPMFVTGTSGKGILAVAIMTPFMYVGFDVIPQAAEEINVP
HHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
FKKIGKILILSVIMAVVWYAMIIYSTSVALNSSEINSSSLVAADAMKKMFGNSVAASKIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHCCCHHHHHHH
ILAGIGGILTSWNSFFMGGSRAIYSMAEAGMLPKFLAKIHPKYKTPTNAIVLIGLVSSIA
HHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
PFFGEKMLVWLSNAGGFGILISYLLVSISFLVLRKKEPDMERPYKVRHPKFVGTMAIVLC
HHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHH
IGMLLMFMPGLPSGLSWPYEWGIILAWFLLGGIFYLAAANKASNESKHTKYKDDYYTNKK
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
VSV
CCC
>Mature Secondary Structure 
SKGNDVSSSDQNFERVLSKKDIMALAFGAMIGWGWVVLTGPWIQKAGSMGAILAFIIGG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECHHHHHCCCHHHHHHHHHHH
IVVLFVGLTYAELTSAMPKCGGDLVFSYRALGKKAAFICTWGMILGYISVVAFEAVAFPS
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLENLFSFSYLKGYMYTIAGYDIYASWALIGSISAIIITIVNYFGAKPAAFMQTVVTVMI
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
ACVGIALFTGSLFNGSIQNMSPMFVTGTSGKGILAVAIMTPFMYVGFDVIPQAAEEINVP
HHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
FKKIGKILILSVIMAVVWYAMIIYSTSVALNSSEINSSSLVAADAMKKMFGNSVAASKIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHCCCHHHHHHH
ILAGIGGILTSWNSFFMGGSRAIYSMAEAGMLPKFLAKIHPKYKTPTNAIVLIGLVSSIA
HHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
PFFGEKMLVWLSNAGGFGILISYLLVSISFLVLRKKEPDMERPYKVRHPKFVGTMAIVLC
HHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHH
IGMLLMFMPGLPSGLSWPYEWGIILAWFLLGGIFYLAAANKASNESKHTKYKDDYYTNKK
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
VSV
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9141694; 9384377 [H]