Click here to switch to the map view.

The map label for this gene is mycB [H]

Identifier: 226947533

GI number: 226947533

Start: 358533

End: 363017

Strand: Direct

Name: mycB [H]

Synonym: CLM_0369

Alternate gene names: 226947533

Gene position: 358533-363017 (Clockwise)

Preceding gene: 226947532

Following gene: 226947534

Centisome position: 8.63

GC content: 26.09

Gene sequence:

>4485_bases
ATGAAGAATAATGAGAAGCATTATTATAATTTAACTCATCCACAAAAGAGAATATGGTACATAGATAAAGTGAATTTAGA
CTCTCCACTTCATAATATTGGTGGATGTCTAAATATATACGGGAATATATGTATTGACAAGATGGAGGATACTATTAATA
TTATAATAAAAAATAACGAGGGATTAAGATTAAGATTTAAAGAAAAAGATGGACAACCAGTTCAGTATATTCAGGAGTTT
AAAAAAGAAAAAATAGAGTTTTTAGATTTTAGTAAGTGTATAAATCCAAGAGAAGAATATGAAAAATGGTCGGAAAATTT
ATTCAAAACAAACTCTTTTATAGAAAATAATCAATTGTATTATTTTGCTATATATAAAATAAGTAGAAAAGAATATGGAG
TGTTATTAAATATTCATCATATTATATCTGATGGATGGTCTATTAATCTTATAGAAAAGCAAATATGTAAAATATACAGT
AAATTGATAAATAATGAAGATATTTCTCTTAATGAATATTACTCATATGTAGATTTTGTACATGAAGAACAAAAATATTT
AAAGTCAGATCGTTTTATAAAAAATAAAAATTTTTGGAGAGAAAAATTTAAGGACATATCTGAAGAATTTTTATATAAAA
CCTCTAGTAGTTTAGAAGGAAAAAGGCAGTGTTTTAATATTGATATTAATTTATCAAATAAGATAAAGAAATTTATTGAT
AATAAAAAATATTCACTAAACACTTTTTTTATAGTAATTTTACTTATATATATAAATAAAACTACATATAAGAAAGATTT
GATAATAGGTACACCAGTATTTAATAGAACGGGAAAAAATCAAAAAAGTACGGTAGGTATGTTTACAAGCACAGTACCTT
TTAGATTTACATTAGATACTGAATTAACTGTAGAGAATTTAATGAAGCTAATTAATAGAGAGTTAAAATTTTGTTTTTTA
AATCAAAAATATCCTTACGATCTTTTAGTTAAAGATTTAGAGTTAAGTAAGTTAGGATATGATAGTTTATTTAAAATGTG
TGTAAATTATTATAATTCAAACTATGTTAATGATATTAATGGAAATAAAGCGGAGGTTAAAGAATATTATTGTGGAAATC
AAAGTTACTCACTACAACTAACTGTTAAGGAGTGGGAAGAGAATAATATAACATTAAATTTTGACTTTAAAACATTAGAA
TATACAGACCAAGAAATTAAAACAATGTATAAATCTATGATTAATATAATTAATCAAGTAATAGAGAATGAGCAACTTAA
AGTAAATCAAATAAAGCTTCTTAATAAAGAAGAAAGAAATTCTAAGGTGTATGATTTAAATTCAACAACTAATTATTATC
CACAGAAAGCAGTATGTGAACTTTTTGAAGAACAAGTAATGAAAACACCAAATAAGGTTGTAGTAGAGTTTAAAGAAAAA
ACATTAACTTATAAGGAGCTTAATGAAAAGGCAAATCAATTAGCAAATCACTTAAGAGAAAAAGGCATAGATAAAAAATC
AATAGTATCAATTATGGAGACTCATTCAATAGAACTTATTATAAGTATTTTAGGCGTCCTAAAGACGGGCGCTGCTTATT
TACCTATTGATCCCAATTATCCTGTAGAAAGAATAAACTATATGCTTGAAGATTCAAAAAGTAATATGCTGTTAACTAAT
TTTAAGGTAACAGATGAAATTAAATTCAAAGGAAACATAATTAATATAAATAATGAAGATTTACAAGGATATAGCAAAAT
CAATTTACCAGAAGCTAACAGTTTAAGCGATTTAGTTTATATTATATATACATCTGGGTCAACGGGAAAACCAAAAGGTG
TAATGATTGAACACCAAGGGCTTACAAACTACATATGGTGGGCTAATAAGATGTATTTAAAAGATGAAGATGAAGGTATG
GCCTTATATTCTTCAATATCCTTTGATTTAACAGTAACTTCTATCTTTACACCATTAATTTCAGGAAATAAGATTATAAT
TTATGATAATGATGAAACAGAATTCGTTTTATATAAAATATTAAGAGAAAATAAGGCAACAGTGGTAAAGCTTACTCCTG
CACATTTAACTTTATTAAAGGATATGGATAATACAAAATCTAGTATAAAGAGATTTATCGTAGGTGGAGAAGATTTAAAG
GTAAAATTAGCAAAAGAAGTTTGTAATAGTTTTGGTAAAAATATAAAGATATACAATGAATATGGACCAACAGAAACTGT
GGTTGGATGCATGATATACAAATATGATGAAGACAAAGATAAGGGAGTATCAGTACCAATTGGGCGTCCTGCAGACAATG
TGCAAATTTATGTATTAGATAATGAATTAAACCCAGTTTCAACAGGTTTTGTTGGGGAACTATATATTTCTGGAGATGGA
GTTGCTAGAGGATATTTAAACAGAGAAGGATTAACCCATGAGAGATTTATTGAAAACTCATTTATTAAAGGAAAAAGGAT
GTATAAAACTGGTGATACAGCTAGGTATCTAGAAAATGGATCTATTGAGTATGTAGGAAGAATTGATAACCAAGTAAAAA
TAAGAGGTCACAGAATTGAACTTGGGGAGATAGAGAGATATTTAATAGAAAATGAATGTGTTAAAGACGCAGTTGTTGTT
TATAAAGAAGACTCATCAAAAAACAAGTTCTTAAATGCTTATTTGGTTGCTAAAAAGGAGATTACAGATTTACAGTTAAA
AGAATGGCTTTTAAAGTTCTTGCCTAAATATATGCTTCCAACCAATTTTGTATTCATGGGAAAACTTCCATTAACTTTAA
ATGGAAAAGTAAATTATGCGCTACTTCCAGAACCGGAAACAGTTGAGAGAGAATTTATAAAATATGCAACATTAGCTGAA
AAAGAGCTAGTTAAAGCAATGGAAGAAATATTAAGTATAGAAAATATAAGTATGAATGATAACTACTATCAGCTTGGTGG
TGATTCTATAAAAGCTATTCAAATTTCATCGAAACTTAAAAATATTGGATTGAATATTAAAGTGAAAGATATATTAGCTT
ATGATTCTATAGAGGAGATATCAGCCGCCATAGAAGAAAGTGAAATTATTAGATTAATAAGCCAAGATAAAAGTGAAGGA
ACTGTTGAAAAAACACCTATAGTAGAATGGTTTTTTAATCAAAAATTTTCTAATGAAAGCTTTTATAATCAATATGTACT
ACTAGAGTATAAAGGAAAATTAGATATAAATAAGGTTATAATTGTTGTAAATAAATTGATTGAACATCATGATGCTTTAA
GAATTAATTATAATAAAAGAAGTAATGAGTTATATTACAATGACAAGAAGTATAATGAAATACATGCTTTTAAATATTTT
AATTTATCTGAATATTCCTACAAAGATCAATGTAAGAATATAAAAAAATTAATAAATGAAACTAATTCTAGTATTAATAT
AGAAAATAGTAGTTTATTCAATGTAGTAATGATGGATTTAGAGGATAATAGACAGGCTTTACTATTTACAGCTCACCACT
TAATAATAGATGGTGTTTCTTGGAGAGTAATATTAGATGATTTCATAACCATCTTAAAACAATTGGATGAAGGTAGTAAG
ATAAGATTACCTTTAAAAACTCATTCATATAAAGAATGGTCAGAAGCTTTACAAACTTATAGAAGGAATGATTTTAGTGA
AGAAGTTGGTTATTGGAAATCAATACTAGATAAAGAAATCAGTTATAACGTAGATTACAATAATGAAGAAGATATTGTTG
AAACATCTAATATTTTAAGTAAAGAAATAGATGAAGAAACATTTAGTAGTTTAATACAAAAAGTTGATGAAATCTATAAT
ATGGATCTAAATGAAGCTTTAATAATTGGATTAGTGCTTACACTTAATAAGTTAACTAAGAAGGATGAAATAATAGTTGA
ACTTGAAAGACATGGAAGAGAGGCAATAAATGATTATATTGATGTATCTAGAACTGTTGGATGGTTTACAAGTATGTACC
CTGCATATTTTAGCATAGAGCATGAAGATATAGAGGATAATATTAAATCATTAAAGGAACAGTTTAGGAATATACCTAAC
AATGGATTTAATTATAGCATTCTTAAATTCTTAAACAAGAAACTTAAAGGACAAGAAAGTAAATATGTAAGATTCAATTA
TCTTGGAGACTTTGACAATATAATTGATAAAGAAAAGCTGAATATATCAGATATTGAATTTGGATTATGTAGTGATGACA
AAAACTCATTGACGGCCCTCATAGACATTACTGCAATAATAATAAATAAAAAATTAAAAGTAACTGCTGAATATAGTAAA
AGGAGATTTAAGGATGAAATAGTAGAAAAATTCATTGAAAGCTATATAGAAACATTAAAATTAATCCTAGATAAATGTTC
AAATAAGGGTTTTAAAGAATTTACCCCATCAGATTTTGATGCTGTTGATATATCGCAAGAAGATTTAGATGCTCTTTTTG
ATTAA

Upstream 100 bases:

>100_bases
ATAAAAATAAGATTTAAAATCTTTAGATTATAAAATGATGGCAGATTCATTAAATAAATAGTTTCAAAAAAAGATAAAAG
ACATGTTAAGGGGAATTGAT

Downstream 100 bases:

>100_bases
AAATTAATAATGCAATATATATCCAGGTTGTCAGGATGGTTTTAGTTAATATTACTGTGGTTTAAAGTAAATAGTGATTT
CAATATTTAATATTACAGTT

Product: nonribosomal peptide synthetase subunit

Products: pyrophosphate; AMP; enterobactin; pyrophosphate; L-Seryl-AMP [C]

Alternate protein names: ATP-dependent tyrosine adenylase; TyrA; Tyrosine activase; ATP-dependent asparagine adenylase 2; AsnA 2; Asparagine activase 2; ATP-dependent glutamine adenylase; GlnA; Glutamine activase; ATP-dependent proline adenylase; ProA; Proline activase [H]

Number of amino acids: Translated: 1494; Mature: 1494

Protein sequence:

>1494_residues
MKNNEKHYYNLTHPQKRIWYIDKVNLDSPLHNIGGCLNIYGNICIDKMEDTINIIIKNNEGLRLRFKEKDGQPVQYIQEF
KKEKIEFLDFSKCINPREEYEKWSENLFKTNSFIENNQLYYFAIYKISRKEYGVLLNIHHIISDGWSINLIEKQICKIYS
KLINNEDISLNEYYSYVDFVHEEQKYLKSDRFIKNKNFWREKFKDISEEFLYKTSSSLEGKRQCFNIDINLSNKIKKFID
NKKYSLNTFFIVILLIYINKTTYKKDLIIGTPVFNRTGKNQKSTVGMFTSTVPFRFTLDTELTVENLMKLINRELKFCFL
NQKYPYDLLVKDLELSKLGYDSLFKMCVNYYNSNYVNDINGNKAEVKEYYCGNQSYSLQLTVKEWEENNITLNFDFKTLE
YTDQEIKTMYKSMINIINQVIENEQLKVNQIKLLNKEERNSKVYDLNSTTNYYPQKAVCELFEEQVMKTPNKVVVEFKEK
TLTYKELNEKANQLANHLREKGIDKKSIVSIMETHSIELIISILGVLKTGAAYLPIDPNYPVERINYMLEDSKSNMLLTN
FKVTDEIKFKGNIININNEDLQGYSKINLPEANSLSDLVYIIYTSGSTGKPKGVMIEHQGLTNYIWWANKMYLKDEDEGM
ALYSSISFDLTVTSIFTPLISGNKIIIYDNDETEFVLYKILRENKATVVKLTPAHLTLLKDMDNTKSSIKRFIVGGEDLK
VKLAKEVCNSFGKNIKIYNEYGPTETVVGCMIYKYDEDKDKGVSVPIGRPADNVQIYVLDNELNPVSTGFVGELYISGDG
VARGYLNREGLTHERFIENSFIKGKRMYKTGDTARYLENGSIEYVGRIDNQVKIRGHRIELGEIERYLIENECVKDAVVV
YKEDSSKNKFLNAYLVAKKEITDLQLKEWLLKFLPKYMLPTNFVFMGKLPLTLNGKVNYALLPEPETVEREFIKYATLAE
KELVKAMEEILSIENISMNDNYYQLGGDSIKAIQISSKLKNIGLNIKVKDILAYDSIEEISAAIEESEIIRLISQDKSEG
TVEKTPIVEWFFNQKFSNESFYNQYVLLEYKGKLDINKVIIVVNKLIEHHDALRINYNKRSNELYYNDKKYNEIHAFKYF
NLSEYSYKDQCKNIKKLINETNSSINIENSSLFNVVMMDLEDNRQALLFTAHHLIIDGVSWRVILDDFITILKQLDEGSK
IRLPLKTHSYKEWSEALQTYRRNDFSEEVGYWKSILDKEISYNVDYNNEEDIVETSNILSKEIDEETFSSLIQKVDEIYN
MDLNEALIIGLVLTLNKLTKKDEIIVELERHGREAINDYIDVSRTVGWFTSMYPAYFSIEHEDIEDNIKSLKEQFRNIPN
NGFNYSILKFLNKKLKGQESKYVRFNYLGDFDNIIDKEKLNISDIEFGLCSDDKNSLTALIDITAIIINKKLKVTAEYSK
RRFKDEIVEKFIESYIETLKLILDKCSNKGFKEFTPSDFDAVDISQEDLDALFD

Sequences:

>Translated_1494_residues
MKNNEKHYYNLTHPQKRIWYIDKVNLDSPLHNIGGCLNIYGNICIDKMEDTINIIIKNNEGLRLRFKEKDGQPVQYIQEF
KKEKIEFLDFSKCINPREEYEKWSENLFKTNSFIENNQLYYFAIYKISRKEYGVLLNIHHIISDGWSINLIEKQICKIYS
KLINNEDISLNEYYSYVDFVHEEQKYLKSDRFIKNKNFWREKFKDISEEFLYKTSSSLEGKRQCFNIDINLSNKIKKFID
NKKYSLNTFFIVILLIYINKTTYKKDLIIGTPVFNRTGKNQKSTVGMFTSTVPFRFTLDTELTVENLMKLINRELKFCFL
NQKYPYDLLVKDLELSKLGYDSLFKMCVNYYNSNYVNDINGNKAEVKEYYCGNQSYSLQLTVKEWEENNITLNFDFKTLE
YTDQEIKTMYKSMINIINQVIENEQLKVNQIKLLNKEERNSKVYDLNSTTNYYPQKAVCELFEEQVMKTPNKVVVEFKEK
TLTYKELNEKANQLANHLREKGIDKKSIVSIMETHSIELIISILGVLKTGAAYLPIDPNYPVERINYMLEDSKSNMLLTN
FKVTDEIKFKGNIININNEDLQGYSKINLPEANSLSDLVYIIYTSGSTGKPKGVMIEHQGLTNYIWWANKMYLKDEDEGM
ALYSSISFDLTVTSIFTPLISGNKIIIYDNDETEFVLYKILRENKATVVKLTPAHLTLLKDMDNTKSSIKRFIVGGEDLK
VKLAKEVCNSFGKNIKIYNEYGPTETVVGCMIYKYDEDKDKGVSVPIGRPADNVQIYVLDNELNPVSTGFVGELYISGDG
VARGYLNREGLTHERFIENSFIKGKRMYKTGDTARYLENGSIEYVGRIDNQVKIRGHRIELGEIERYLIENECVKDAVVV
YKEDSSKNKFLNAYLVAKKEITDLQLKEWLLKFLPKYMLPTNFVFMGKLPLTLNGKVNYALLPEPETVEREFIKYATLAE
KELVKAMEEILSIENISMNDNYYQLGGDSIKAIQISSKLKNIGLNIKVKDILAYDSIEEISAAIEESEIIRLISQDKSEG
TVEKTPIVEWFFNQKFSNESFYNQYVLLEYKGKLDINKVIIVVNKLIEHHDALRINYNKRSNELYYNDKKYNEIHAFKYF
NLSEYSYKDQCKNIKKLINETNSSINIENSSLFNVVMMDLEDNRQALLFTAHHLIIDGVSWRVILDDFITILKQLDEGSK
IRLPLKTHSYKEWSEALQTYRRNDFSEEVGYWKSILDKEISYNVDYNNEEDIVETSNILSKEIDEETFSSLIQKVDEIYN
MDLNEALIIGLVLTLNKLTKKDEIIVELERHGREAINDYIDVSRTVGWFTSMYPAYFSIEHEDIEDNIKSLKEQFRNIPN
NGFNYSILKFLNKKLKGQESKYVRFNYLGDFDNIIDKEKLNISDIEFGLCSDDKNSLTALIDITAIIINKKLKVTAEYSK
RRFKDEIVEKFIESYIETLKLILDKCSNKGFKEFTPSDFDAVDISQEDLDALFD
>Mature_1494_residues
MKNNEKHYYNLTHPQKRIWYIDKVNLDSPLHNIGGCLNIYGNICIDKMEDTINIIIKNNEGLRLRFKEKDGQPVQYIQEF
KKEKIEFLDFSKCINPREEYEKWSENLFKTNSFIENNQLYYFAIYKISRKEYGVLLNIHHIISDGWSINLIEKQICKIYS
KLINNEDISLNEYYSYVDFVHEEQKYLKSDRFIKNKNFWREKFKDISEEFLYKTSSSLEGKRQCFNIDINLSNKIKKFID
NKKYSLNTFFIVILLIYINKTTYKKDLIIGTPVFNRTGKNQKSTVGMFTSTVPFRFTLDTELTVENLMKLINRELKFCFL
NQKYPYDLLVKDLELSKLGYDSLFKMCVNYYNSNYVNDINGNKAEVKEYYCGNQSYSLQLTVKEWEENNITLNFDFKTLE
YTDQEIKTMYKSMINIINQVIENEQLKVNQIKLLNKEERNSKVYDLNSTTNYYPQKAVCELFEEQVMKTPNKVVVEFKEK
TLTYKELNEKANQLANHLREKGIDKKSIVSIMETHSIELIISILGVLKTGAAYLPIDPNYPVERINYMLEDSKSNMLLTN
FKVTDEIKFKGNIININNEDLQGYSKINLPEANSLSDLVYIIYTSGSTGKPKGVMIEHQGLTNYIWWANKMYLKDEDEGM
ALYSSISFDLTVTSIFTPLISGNKIIIYDNDETEFVLYKILRENKATVVKLTPAHLTLLKDMDNTKSSIKRFIVGGEDLK
VKLAKEVCNSFGKNIKIYNEYGPTETVVGCMIYKYDEDKDKGVSVPIGRPADNVQIYVLDNELNPVSTGFVGELYISGDG
VARGYLNREGLTHERFIENSFIKGKRMYKTGDTARYLENGSIEYVGRIDNQVKIRGHRIELGEIERYLIENECVKDAVVV
YKEDSSKNKFLNAYLVAKKEITDLQLKEWLLKFLPKYMLPTNFVFMGKLPLTLNGKVNYALLPEPETVEREFIKYATLAE
KELVKAMEEILSIENISMNDNYYQLGGDSIKAIQISSKLKNIGLNIKVKDILAYDSIEEISAAIEESEIIRLISQDKSEG
TVEKTPIVEWFFNQKFSNESFYNQYVLLEYKGKLDINKVIIVVNKLIEHHDALRINYNKRSNELYYNDKKYNEIHAFKYF
NLSEYSYKDQCKNIKKLINETNSSINIENSSLFNVVMMDLEDNRQALLFTAHHLIIDGVSWRVILDDFITILKQLDEGSK
IRLPLKTHSYKEWSEALQTYRRNDFSEEVGYWKSILDKEISYNVDYNNEEDIVETSNILSKEIDEETFSSLIQKVDEIYN
MDLNEALIIGLVLTLNKLTKKDEIIVELERHGREAINDYIDVSRTVGWFTSMYPAYFSIEHEDIEDNIKSLKEQFRNIPN
NGFNYSILKFLNKKLKGQESKYVRFNYLGDFDNIIDKEKLNISDIEFGLCSDDKNSLTALIDITAIIINKKLKVTAEYSK
RRFKDEIVEKFIESYIETLKLILDKCSNKGFKEFTPSDFDAVDISQEDLDALFD

Specific function: This protein is a multifunctional enzyme, able to activate and polymerize the amino acids Tyr, Asn, Gln and Pro as part of the synthesis of mycosubtilin. The Asn and Gln residues are further epimerized to the D-isomer form. The activation sites for these

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 4 acyl carrier domains [H]

Homologues:

Organism=Homo sapiens, GI28416953, Length=580, Percent_Identity=24.6551724137931, Blast_Score=105, Evalue=4e-22,
Organism=Homo sapiens, GI45580730, Length=625, Percent_Identity=22.24, Blast_Score=101, Evalue=5e-21,
Organism=Homo sapiens, GI13375727, Length=527, Percent_Identity=23.9089184060721, Blast_Score=99, Evalue=4e-20,
Organism=Homo sapiens, GI42544132, Length=501, Percent_Identity=23.9520958083832, Blast_Score=88, Evalue=6e-17,
Organism=Homo sapiens, GI38505220, Length=526, Percent_Identity=21.6730038022814, Blast_Score=80, Evalue=1e-14,
Organism=Homo sapiens, GI115511026, Length=536, Percent_Identity=22.0149253731343, Blast_Score=79, Evalue=3e-14,
Organism=Homo sapiens, GI122937307, Length=507, Percent_Identity=20.7100591715976, Blast_Score=75, Evalue=7e-13,
Organism=Homo sapiens, GI156151445, Length=586, Percent_Identity=20.9897610921502, Blast_Score=68, Evalue=9e-11,
Organism=Escherichia coli, GI1786801, Length=1065, Percent_Identity=24.7887323943662, Blast_Score=367, Evalue=1e-102,
Organism=Escherichia coli, GI145693145, Length=517, Percent_Identity=25.531914893617, Blast_Score=123, Evalue=7e-29,
Organism=Escherichia coli, GI1790505, Length=604, Percent_Identity=23.1788079470199, Blast_Score=116, Evalue=1e-26,
Organism=Escherichia coli, GI1786810, Length=504, Percent_Identity=23.4126984126984, Blast_Score=100, Evalue=7e-22,
Organism=Escherichia coli, GI221142682, Length=492, Percent_Identity=22.3577235772358, Blast_Score=100, Evalue=1e-21,
Organism=Escherichia coli, GI1788107, Length=538, Percent_Identity=21.7472118959108, Blast_Score=99, Evalue=2e-21,
Organism=Escherichia coli, GI1789201, Length=366, Percent_Identity=25.1366120218579, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17556356, Length=921, Percent_Identity=23.4527687296417, Blast_Score=151, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17550940, Length=1017, Percent_Identity=22.1238938053097, Blast_Score=142, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71994690, Length=616, Percent_Identity=21.9155844155844, Blast_Score=100, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI71994694, Length=584, Percent_Identity=22.0890410958904, Blast_Score=98, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17531443, Length=478, Percent_Identity=22.8033472803347, Blast_Score=98, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17538037, Length=496, Percent_Identity=23.5887096774194, Blast_Score=98, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71994703, Length=566, Percent_Identity=22.2614840989399, Blast_Score=96, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17560140, Length=553, Percent_Identity=23.5081374321881, Blast_Score=96, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17560308, Length=555, Percent_Identity=22.3423423423423, Blast_Score=91, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17558820, Length=476, Percent_Identity=24.5798319327731, Blast_Score=86, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17557194, Length=503, Percent_Identity=22.2664015904573, Blast_Score=86, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI32564420, Length=415, Percent_Identity=22.8915662650602, Blast_Score=74, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI32564422, Length=416, Percent_Identity=22.8365384615385, Blast_Score=74, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17551278, Length=480, Percent_Identity=25, Blast_Score=73, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71996755, Length=472, Percent_Identity=20.7627118644068, Blast_Score=70, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6319591, Length=827, Percent_Identity=25.0302297460701, Blast_Score=209, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6319699, Length=520, Percent_Identity=21.5384615384615, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24648676, Length=636, Percent_Identity=29.559748427673, Blast_Score=239, Evalue=8e-63,
Organism=Drosophila melanogaster, GI24582852, Length=580, Percent_Identity=23.1034482758621, Blast_Score=83, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24581924, Length=519, Percent_Identity=23.121387283237, Blast_Score=77, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR009081
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR001242
- InterPro:   IPR010060
- InterPro:   IPR006163
- InterPro:   IPR006162 [H]

Pfam domain/function: PF00501 AMP-binding; PF00668 Condensation; PF00550 PP-binding [H]

EC number: 2.7.7.- [C]

Molecular weight: Translated: 174562; Mature: 174562

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS50075 ACP_DOMAIN ; PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNNEKHYYNLTHPQKRIWYIDKVNLDSPLHNIGGCLNIYGNICIDKMEDTINIIIKNNE
CCCCCCCEEECCCCCCEEEEEEEECCCCCHHHHCCHHHHHCCCEEECCCCEEEEEEECCC
GLRLRFKEKDGQPVQYIQEFKKEKIEFLDFSKCINPREEYEKWSENLFKTNSFIENNQLY
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEECCCEE
YFAIYKISRKEYGVLLNIHHIISDGWSINLIEKQICKIYSKLINNEDISLNEYYSYVDFV
EEEEEEECCCCCCEEEEEEHHHCCCCEEEHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
HEEQKYLKSDRFIKNKNFWREKFKDISEEFLYKTSSSLEGKRQCFNIDINLSNKIKKFID
HHHHHHHHHCCEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECHHHHHHHHC
NKKYSLNTFFIVILLIYINKTTYKKDLIIGTPVFNRTGKNQKSTVGMFTSTVPFRFTLDT
CCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCEEEEEEECCCEEEEECC
ELTVENLMKLINRELKFCFLNQKYPYDLLVKDLELSKLGYDSLFKMCVNYYNSNYVNDIN
CCCHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEECCC
GNKAEVKEYYCGNQSYSLQLTVKEWEENNITLNFDFKTLEYTDQEIKTMYKSMINIINQV
CCHHHHHHHHCCCCCEEEEEEEEECCCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHHH
IENEQLKVNQIKLLNKEERNSKVYDLNSTTNYYPQKAVCELFEEQVMKTPNKVVVEFKEK
HCCCCEEEEHEEEECCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEHHH
TLTYKELNEKANQLANHLREKGIDKKSIVSIMETHSIELIISILGVLKTGAAYLPIDPNY
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCC
PVERINYMLEDSKSNMLLTNFKVTDEIKFKGNIININNEDLQGYSKINLPEANSLSDLVY
CHHHHHHHHCCCCCCEEEEEEEEEEEEEEECCEEECCCCCCCCCCEECCCCCCCCCCEEE
IIYTSGSTGKPKGVMIEHQGLTNYIWWANKMYLKDEDEGMALYSSISFDLTVTSIFTPLI
EEEECCCCCCCCCEEEECCCCCCEEEECCEEEEECCCCCEEEEEEEEEEEEHHHHHHHHH
SGNKIIIYDNDETEFVLYKILRENKATVVKLTPAHLTLLKDMDNTKSSIKRFIVGGEDLK
CCCEEEEEECCCCHHHHHHHHHCCCCEEEEECHHHHHHHHHCCCHHHHHHHHHCCCCCCE
VKLAKEVCNSFGKNIKIYNEYGPTETVVGCMIYKYDEDKDKGVSVPIGRPADNVQIYVLD
EHHHHHHHHHHCCCEEEEECCCCCHHEEEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEE
NELNPVSTGFVGELYISGDGVARGYLNREGLTHERFIENSFIKGKRMYKTGDTARYLENG
CCCCCCCCCCEEEEEECCCCCEECCCCCCCCCHHHHHHHHHCCCCEEEECCCHHHHHCCC
SIEYVGRIDNQVKIRGHRIELGEIERYLIENECVKDAVVVYKEDSSKNKFLNAYLVAKKE
CEEEEEECCCEEEEEEEEEEHHHHHHHHHHHHHHCCEEEEEECCCCCCCEEEEEEEEHHC
ITDLQLKEWLLKFLPKYMLPTNFVFMGKLPLTLNGKVNYALLPEPETVEREFIKYATLAE
CHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEECCCEEEEECCCCCHHHHHHHHHHHHHH
KELVKAMEEILSIENISMNDNYYQLGGDSIKAIQISSKLKNIGLNIKVKDILAYDSIEEI
HHHHHHHHHHHHHCCCCCCCCEEEECCCCEEEEEEHHHHHHCCCCEEEEHHHHHCCHHHH
SAAIEESEIIRLISQDKSEGTVEKTPIVEWFFNQKFSNESFYNQYVLLEYKGKLDINKVI
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCEEEEEECCCCCHHHHH
IVVNKLIEHHDALRINYNKRSNELYYNDKKYNEIHAFKYFNLSEYSYKDQCKNIKKLINE
HHHHHHHHCCCCEEEEECCCCCCEEECCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHC
TNSSINIENSSLFNVVMMDLEDNRQALLFTAHHLIIDGVSWRVILDDFITILKQLDEGSK
CCCEEEECCCCEEEEEEEEECCCCEEEEEEEEEHEEECCCCCHHHHHHHHHHHHCCCCCE
IRLPLKTHSYKEWSEALQTYRRNDFSEEVGYWKSILDKEISYNVDYNNEEDIVETSNILS
EEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHH
KEIDEETFSSLIQKVDEIYNMDLNEALIIGLVLTLNKLTKKDEIIVELERHGREAINDYI
HHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEEEHHCCHHHHHHHH
DVSRTVGWFTSMYPAYFSIEHEDIEDNIKSLKEQFRNIPNNGFNYSILKFLNKKLKGQES
HHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCC
KYVRFNYLGDFDNIIDKEKLNISDIEFGLCSDDKNSLTALIDITAIIINKKLKVTAEYSK
CEEEEEECCCHHHHHCCCCCCCCCCEEEECCCCCCCEEEHEEEEEEEECCCEEEEEHHHH
RRFKDEIVEKFIESYIETLKLILDKCSNKGFKEFTPSDFDAVDISQEDLDALFD
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCCHHHHHHHCC
>Mature Secondary Structure
MKNNEKHYYNLTHPQKRIWYIDKVNLDSPLHNIGGCLNIYGNICIDKMEDTINIIIKNNE
CCCCCCCEEECCCCCCEEEEEEEECCCCCHHHHCCHHHHHCCCEEECCCCEEEEEEECCC
GLRLRFKEKDGQPVQYIQEFKKEKIEFLDFSKCINPREEYEKWSENLFKTNSFIENNQLY
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEECCCEE
YFAIYKISRKEYGVLLNIHHIISDGWSINLIEKQICKIYSKLINNEDISLNEYYSYVDFV
EEEEEEECCCCCCEEEEEEHHHCCCCEEEHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
HEEQKYLKSDRFIKNKNFWREKFKDISEEFLYKTSSSLEGKRQCFNIDINLSNKIKKFID
HHHHHHHHHCCEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECHHHHHHHHC
NKKYSLNTFFIVILLIYINKTTYKKDLIIGTPVFNRTGKNQKSTVGMFTSTVPFRFTLDT
CCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCEEEEEEECCCEEEEECC
ELTVENLMKLINRELKFCFLNQKYPYDLLVKDLELSKLGYDSLFKMCVNYYNSNYVNDIN
CCCHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEECCC
GNKAEVKEYYCGNQSYSLQLTVKEWEENNITLNFDFKTLEYTDQEIKTMYKSMINIINQV
CCHHHHHHHHCCCCCEEEEEEEEECCCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHHH
IENEQLKVNQIKLLNKEERNSKVYDLNSTTNYYPQKAVCELFEEQVMKTPNKVVVEFKEK
HCCCCEEEEHEEEECCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEHHH
TLTYKELNEKANQLANHLREKGIDKKSIVSIMETHSIELIISILGVLKTGAAYLPIDPNY
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCC
PVERINYMLEDSKSNMLLTNFKVTDEIKFKGNIININNEDLQGYSKINLPEANSLSDLVY
CHHHHHHHHCCCCCCEEEEEEEEEEEEEEECCEEECCCCCCCCCCEECCCCCCCCCCEEE
IIYTSGSTGKPKGVMIEHQGLTNYIWWANKMYLKDEDEGMALYSSISFDLTVTSIFTPLI
EEEECCCCCCCCCEEEECCCCCCEEEECCEEEEECCCCCEEEEEEEEEEEEHHHHHHHHH
SGNKIIIYDNDETEFVLYKILRENKATVVKLTPAHLTLLKDMDNTKSSIKRFIVGGEDLK
CCCEEEEEECCCCHHHHHHHHHCCCCEEEEECHHHHHHHHHCCCHHHHHHHHHCCCCCCE
VKLAKEVCNSFGKNIKIYNEYGPTETVVGCMIYKYDEDKDKGVSVPIGRPADNVQIYVLD
EHHHHHHHHHHCCCEEEEECCCCCHHEEEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEE
NELNPVSTGFVGELYISGDGVARGYLNREGLTHERFIENSFIKGKRMYKTGDTARYLENG
CCCCCCCCCCEEEEEECCCCCEECCCCCCCCCHHHHHHHHHCCCCEEEECCCHHHHHCCC
SIEYVGRIDNQVKIRGHRIELGEIERYLIENECVKDAVVVYKEDSSKNKFLNAYLVAKKE
CEEEEEECCCEEEEEEEEEEHHHHHHHHHHHHHHCCEEEEEECCCCCCCEEEEEEEEHHC
ITDLQLKEWLLKFLPKYMLPTNFVFMGKLPLTLNGKVNYALLPEPETVEREFIKYATLAE
CHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEECCCEEEEECCCCCHHHHHHHHHHHHHH
KELVKAMEEILSIENISMNDNYYQLGGDSIKAIQISSKLKNIGLNIKVKDILAYDSIEEI
HHHHHHHHHHHHHCCCCCCCCEEEECCCCEEEEEEHHHHHHCCCCEEEEHHHHHCCHHHH
SAAIEESEIIRLISQDKSEGTVEKTPIVEWFFNQKFSNESFYNQYVLLEYKGKLDINKVI
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCEEEEEECCCCCHHHHH
IVVNKLIEHHDALRINYNKRSNELYYNDKKYNEIHAFKYFNLSEYSYKDQCKNIKKLINE
HHHHHHHHCCCCEEEEECCCCCCEEECCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHC
TNSSINIENSSLFNVVMMDLEDNRQALLFTAHHLIIDGVSWRVILDDFITILKQLDEGSK
CCCEEEECCCCEEEEEEEEECCCCEEEEEEEEEHEEECCCCCHHHHHHHHHHHHCCCCCE
IRLPLKTHSYKEWSEALQTYRRNDFSEEVGYWKSILDKEISYNVDYNNEEDIVETSNILS
EEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHH
KEIDEETFSSLIQKVDEIYNMDLNEALIIGLVLTLNKLTKKDEIIVELERHGREAINDYI
HHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEEEHHCCHHHHHHHH
DVSRTVGWFTSMYPAYFSIEHEDIEDNIKSLKEQFRNIPNNGFNYSILKFLNKKLKGQES
HHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCC
KYVRFNYLGDFDNIIDKEKLNISDIEFGLCSDDKNSLTALIDITAIIINKKLKVTAEYSK
CEEEEEECCCHHHHHCCCCCCCCCCEEEECCCCCCCEEEHEEEEEEEECCCEEEEEHHHH
RRFKDEIVEKFIESYIETLKLILDKCSNKGFKEFTPSDFDAVDISQEDLDALFD
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Phosphopantetheine. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 6 ATP; L-serine; 2,3-dihydroxybenzoate [C]

Specific reaction: 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Seryl-AMP 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Ser

General reaction: Transferases; Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10557314 [H]