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The map label for this gene is upp

Identifier: 226947368

GI number: 226947368

Start: 174874

End: 175503

Strand: Direct

Name: upp

Synonym: CLM_0188

Alternate gene names: 226947368

Gene position: 174874-175503 (Clockwise)

Preceding gene: 226947367

Following gene: 226947370

Centisome position: 4.21

GC content: 33.33

Gene sequence:

>630_bases
ATGAGTAAAGTAACACAAATAGCACATCCATTAATTCTTCATAAATTAGCCTTAATTAGAGATAAAAATACTGGTTCTAA
AGATTTTAGGGAGTTAGTAGAAGAAGTAGCTATGCTTATGGCTTATGAAGTTACAAGAGATTTACAATTAAAGGAAGTTG
AGATTGAAACTCCTATATGCAAAACAAAATGTAAAATGCTATCAGGTAAAAAAGTAGCAATAGTTCCAATATTAAGAGCA
GGACTTGGAATGGTTGGTGGCATGACTAGCTTAATACCAGCAGCAAAAGTTGGACACATAGGACTTTATCGTGATGAGGA
AACTTTAAAACCTGTAGAATATTTCTGTAAATTACCTCAAGATATTGGTGATAGAGATGTAATTGTTACAGATCCAATGC
TAGCTACAGGAGGATCTGCAAAAGATGCAATAACATTATTAAAACAAAAGGGAGCAAAACATATAAGATTAATGTGTCTT
GTAGCAGCTCCAGAAGGAATTAAAGAAGTTATGGATGAACATCCAGATGTAGATATATATGTAGCTTCTGTAGATGAAAA
ACTTAATGAAAAGGGCTATGTAGTTCCAGGTTTAGGAGATGCAGGAGACAGACTATACGGAACAAAATAA

Upstream 100 bases:

>100_bases
TCTTAAATGCTGAATTCCAAGGTGGAAGGCATGAAAACAGAATTAACAAAATGATGGGAATAGAAAAATAATATAAAAGA
TAACTAGGAGGAAAATATAA

Downstream 100 bases:

>100_bases
GTAAATTATTATTTAAAAGCTCTTAAAGGTTAATAATTAAAACAATAAATACTTTTAGTAAATAGATAACTATAAAAATA
AAGAATAGTAATTATTTTTA

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MSKVTQIAHPLILHKLALIRDKNTGSKDFRELVEEVAMLMAYEVTRDLQLKEVEIETPICKTKCKMLSGKKVAIVPILRA
GLGMVGGMTSLIPAAKVGHIGLYRDEETLKPVEYFCKLPQDIGDRDVIVTDPMLATGGSAKDAITLLKQKGAKHIRLMCL
VAAPEGIKEVMDEHPDVDIYVASVDEKLNEKGYVVPGLGDAGDRLYGTK

Sequences:

>Translated_209_residues
MSKVTQIAHPLILHKLALIRDKNTGSKDFRELVEEVAMLMAYEVTRDLQLKEVEIETPICKTKCKMLSGKKVAIVPILRA
GLGMVGGMTSLIPAAKVGHIGLYRDEETLKPVEYFCKLPQDIGDRDVIVTDPMLATGGSAKDAITLLKQKGAKHIRLMCL
VAAPEGIKEVMDEHPDVDIYVASVDEKLNEKGYVVPGLGDAGDRLYGTK
>Mature_208_residues
SKVTQIAHPLILHKLALIRDKNTGSKDFRELVEEVAMLMAYEVTRDLQLKEVEIETPICKTKCKMLSGKKVAIVPILRAG
LGMVGGMTSLIPAAKVGHIGLYRDEETLKPVEYFCKLPQDIGDRDVIVTDPMLATGGSAKDAITLLKQKGAKHIRLMCLV
AAPEGIKEVMDEHPDVDIYVASVDEKLNEKGYVVPGLGDAGDRLYGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family

Homologues:

Organism=Homo sapiens, GI301129207, Length=195, Percent_Identity=29.2307692307692, Blast_Score=88, Evalue=4e-18,
Organism=Homo sapiens, GI57863312, Length=195, Percent_Identity=29.2307692307692, Blast_Score=88, Evalue=6e-18,
Organism=Homo sapiens, GI21450816, Length=170, Percent_Identity=29.4117647058824, Blast_Score=75, Evalue=3e-14,
Organism=Escherichia coli, GI87082118, Length=207, Percent_Identity=49.7584541062802, Blast_Score=221, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17539892, Length=201, Percent_Identity=25.8706467661692, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17539894, Length=201, Percent_Identity=25.8706467661692, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6321920, Length=197, Percent_Identity=36.5482233502538, Blast_Score=117, Evalue=1e-27,
Organism=Drosophila melanogaster, GI45550449, Length=196, Percent_Identity=30.6122448979592, Blast_Score=90, Evalue=8e-19,
Organism=Drosophila melanogaster, GI28573516, Length=196, Percent_Identity=30.6122448979592, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28573514, Length=196, Percent_Identity=30.6122448979592, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28573512, Length=196, Percent_Identity=30.6122448979592, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21358379, Length=173, Percent_Identity=26.5895953757225, Blast_Score=67, Evalue=7e-12,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): UPP_CLOB1 (A7FQG8)

Other databases:

- EMBL:   CP000726
- RefSeq:   YP_001382552.1
- ProteinModelPortal:   A7FQG8
- SMR:   A7FQG8
- STRING:   A7FQG8
- GeneID:   5396334
- GenomeReviews:   CP000726_GR
- KEGG:   cba:CLB_0181
- eggNOG:   COG0035
- HOGENOM:   HBG326432
- OMA:   IQHKLSH
- ProtClustDB:   PRK00129
- BioCyc:   CBOT441770:CLB_0181-MONOMER
- HAMAP:   MF_01218_B
- InterPro:   IPR000836
- InterPro:   IPR005765
- TIGRFAMs:   TIGR01091

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 22869; Mature: 22738

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: NA

Important sites: BINDING 79-79 BINDING 104-104 BINDING 194-194 BINDING 200-200

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKVTQIAHPLILHKLALIRDKNTGSKDFRELVEEVAMLMAYEVTRDLQLKEVEIETPIC
CCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCHH
KTKCKMLSGKKVAIVPILRAGLGMVGGMTSLIPAAKVGHIGLYRDEETLKPVEYFCKLPQ
HHHHHHHCCCCEEEHHHHHHHHHHHCCHHHHHCHHHHCCEEEECCCHHHHHHHHHHHCCC
DIGDRDVIVTDPMLATGGSAKDAITLLKQKGAKHIRLMCLVAAPEGIKEVMDEHPDVDIY
CCCCCCEEEECCCEECCCCHHHHHHHHHHCCCCEEEEEEEEECCHHHHHHHHCCCCCEEE
VASVDEKLNEKGYVVPGLGDAGDRLYGTK
EEECCHHHCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
SKVTQIAHPLILHKLALIRDKNTGSKDFRELVEEVAMLMAYEVTRDLQLKEVEIETPIC
CCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCHH
KTKCKMLSGKKVAIVPILRAGLGMVGGMTSLIPAAKVGHIGLYRDEETLKPVEYFCKLPQ
HHHHHHHCCCCEEEHHHHHHHHHHHCCHHHHHCHHHHCCEEEECCCHHHHHHHHHHHCCC
DIGDRDVIVTDPMLATGGSAKDAITLLKQKGAKHIRLMCLVAAPEGIKEVMDEHPDVDIY
CCCCCCEEEECCCEECCCCHHHHHHHHHHCCCCEEEEEEEEECCHHHHHHHHCCCCCEEE
VASVDEKLNEKGYVVPGLGDAGDRLYGTK
EEECCHHHCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA