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The map label for this gene is norB [H]

Identifier: 226225368

GI number: 226225368

Start: 2869979

End: 2871379

Strand: Reverse

Name: norB [H]

Synonym: Lm4b_02791

Alternate gene names: 226225368

Gene position: 2871379-2869979 (Counterclockwise)

Preceding gene: 226225369

Following gene: 226225367

Centisome position: 98.58

GC content: 40.54

Gene sequence:

>1401_bases
ATGACTTCAACAGCGTATAAAGGTACAAATAAACTTATTGTTGGGATTGTTTTCGGGGTTATCACGTTTTGGCTTTTCGC
ACAATCAATGGTGAATATCGTTCCGGCCGTGCAATCTGACCTTGGAATTTCCTCTGATTTACTTAGTATTGCCATCAGTT
TAACCGCGCTATTTTCAGGTATTTTTATCGTTGTAGCGGGCGGTATGGCTGACAAATTTGGTCGTGTGAAATTAACTTAT
ATCGGACTTATTCTTAGTATCATCGGTTCACTGTTACTTGTTGTCACTCAAGGGGCGACGTTACTTATTATCGGCCGTAT
TATTCAAGGACTTTCAGCTGCTTGTATTATGCCAGCAACCCTGGCCTTAATGAAAACTTATTTTGAAGGGGCTGATAGAC
AAAGAGCGCTTAGTTACTGGTCGATTGGCTCATGGGGTGGATCAGGTATTTGTTCATTCGCAGGTGGAGCTATCGCAACA
TACATGGGCTGGCGCTGGATTTTCATTATTTCCATCGTATTCGCACTGCTTGGAATGCTACTTATTAAAGGTACTCCAGA
AAGTAAAGTCGTTCAAAATACAAAAGCAAAATTTGATTCATTTGGTCTTGTTCTTTTTGTTATCGCAATGGTTTGCTTAA
ATCTTATTATCACTCGTGGTTCCACATTTGGCTGGACAAGCCCAATTACTATTACAATGCTCGTTGTTTTCCTTATTTCT
GCGGGATTATTTTTCCGGGTGGAATTACGACAAGCGAACGGATTTATTGATTTCTCGTTATTTAAAAATAAAGCTTATAC
TGGTGCGACACTTTCCAACTTCTTGTTAAATGCAGCTGCTGGAACACTAGTTGTTGCAAATACTTATGTGCAAATTGGTC
GCGGTTTTACAGCATTCCAATCCGGTTTACTTTCTATCGGTTACCTTGTCTGTGTGCTTGGAATGATTCGTATTGGTGAA
AAAATTCTTCAACGAGTTGGCGCGCGTAAACCAATGATTTTAGGCTCTGGTATTACGGCTGTTGGTATTGCTTTAATGGC
GCTCACTTTTATTCCAGGAACCCTTTATACGGTGCTTGTGTTTATCGGTTTTGCTTTATTCGGGATTGGACTTGGTATGT
ATGCAACTCCTTCCACAGATACAGCTATCTCTAATGCTCCAGAAGATAAAGTCGGAGTAGCATCAGGTATTTACAAAATG
GCAAGTTCGTTAGGTGGCTCATTCGGTGTGGCAATTTCTGCTACGATTTATGGTGTGATTGCACTTTCTGGAAATATTGA
TTTAGCCGCAATGGTGGGGCTTTTAACTAACGTCGGTTTTTGTGTCGTGTCACTTATTTCCGTTGCTATAACAACACCGT
CTGCGAAAAAAGCGCTCGAATTAAAAGCCGCAAAAGAATAG

Upstream 100 bases:

>100_bases
ATCATCATCCAAAATTTGACATCAATGAAGATTCATTATTAATTGCATCAAAAGCCATGGGAGCTTGTGTTGTAGATTAC
TTAAAAGGAGAGAATAACTA

Downstream 100 bases:

>100_bases
GAGGTTGGATTTATCATGCGTACCAAGTTAATGAATATGCTTCAGGAACGAAAAGATGAAATCACTCAGATTAGACGTCA
TTTGCACGAACATCCTGAAT

Product: transmembrane efflux protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MTSTAYKGTNKLIVGIVFGVITFWLFAQSMVNIVPAVQSDLGISSDLLSIAISLTALFSGIFIVVAGGMADKFGRVKLTY
IGLILSIIGSLLLVVTQGATLLIIGRIIQGLSAACIMPATLALMKTYFEGADRQRALSYWSIGSWGGSGICSFAGGAIAT
YMGWRWIFIISIVFALLGMLLIKGTPESKVVQNTKAKFDSFGLVLFVIAMVCLNLIITRGSTFGWTSPITITMLVVFLIS
AGLFFRVELRQANGFIDFSLFKNKAYTGATLSNFLLNAAAGTLVVANTYVQIGRGFTAFQSGLLSIGYLVCVLGMIRIGE
KILQRVGARKPMILGSGITAVGIALMALTFIPGTLYTVLVFIGFALFGIGLGMYATPSTDTAISNAPEDKVGVASGIYKM
ASSLGGSFGVAISATIYGVIALSGNIDLAAMVGLLTNVGFCVVSLISVAITTPSAKKALELKAAKE

Sequences:

>Translated_466_residues
MTSTAYKGTNKLIVGIVFGVITFWLFAQSMVNIVPAVQSDLGISSDLLSIAISLTALFSGIFIVVAGGMADKFGRVKLTY
IGLILSIIGSLLLVVTQGATLLIIGRIIQGLSAACIMPATLALMKTYFEGADRQRALSYWSIGSWGGSGICSFAGGAIAT
YMGWRWIFIISIVFALLGMLLIKGTPESKVVQNTKAKFDSFGLVLFVIAMVCLNLIITRGSTFGWTSPITITMLVVFLIS
AGLFFRVELRQANGFIDFSLFKNKAYTGATLSNFLLNAAAGTLVVANTYVQIGRGFTAFQSGLLSIGYLVCVLGMIRIGE
KILQRVGARKPMILGSGITAVGIALMALTFIPGTLYTVLVFIGFALFGIGLGMYATPSTDTAISNAPEDKVGVASGIYKM
ASSLGGSFGVAISATIYGVIALSGNIDLAAMVGLLTNVGFCVVSLISVAITTPSAKKALELKAAKE
>Mature_465_residues
TSTAYKGTNKLIVGIVFGVITFWLFAQSMVNIVPAVQSDLGISSDLLSIAISLTALFSGIFIVVAGGMADKFGRVKLTYI
GLILSIIGSLLLVVTQGATLLIIGRIIQGLSAACIMPATLALMKTYFEGADRQRALSYWSIGSWGGSGICSFAGGAIATY
MGWRWIFIISIVFALLGMLLIKGTPESKVVQNTKAKFDSFGLVLFVIAMVCLNLIITRGSTFGWTSPITITMLVVFLISA
GLFFRVELRQANGFIDFSLFKNKAYTGATLSNFLLNAAAGTLVVANTYVQIGRGFTAFQSGLLSIGYLVCVLGMIRIGEK
ILQRVGARKPMILGSGITAVGIALMALTFIPGTLYTVLVFIGFALFGIGLGMYATPSTDTAISNAPEDKVGVASGIYKMA
SSLGGSFGVAISATIYGVIALSGNIDLAAMVGLLTNVGFCVVSLISVAITTPSAKKALELKAAKE

Specific function: Multidrug efflux pump that acts independently of norA and is one of the factors that confers resistance against diverse quinolones and chemical compounds [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Escherichia coli, GI1789042, Length=418, Percent_Identity=27.0334928229665, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1788710, Length=394, Percent_Identity=24.8730964467005, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790195, Length=402, Percent_Identity=25.3731343283582, Blast_Score=89, Evalue=8e-19,
Organism=Escherichia coli, GI1788392, Length=419, Percent_Identity=25.0596658711217, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI87081983, Length=360, Percent_Identity=25.8333333333333, Blast_Score=85, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 48918; Mature: 48787

Theoretical pI: Translated: 10.10; Mature: 10.10

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSTAYKGTNKLIVGIVFGVITFWLFAQSMVNIVPAVQSDLGISSDLLSIAISLTALFSG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
IFIVVAGGMADKFGRVKLTYIGLILSIIGSLLLVVTQGATLLIIGRIIQGLSAACIMPAT
HHHHHCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHH
LALMKTYFEGADRQRALSYWSIGSWGGSGICSFAGGAIATYMGWRWIFIISIVFALLGML
HHHHHHHHCCCCHHHHHHHCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
LIKGTPESKVVQNTKAKFDSFGLVLFVIAMVCLNLIITRGSTFGWTSPITITMLVVFLIS
HHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHC
AGLFFRVELRQANGFIDFSLFKNKAYTGATLSNFLLNAAAGTLVVANTYVQIGRGFTAFQ
CCCEEEEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEHHHHHHCCCHHHHH
SGLLSIGYLVCVLGMIRIGEKILQRVGARKPMILGSGITAVGIALMALTFIPGTLYTVLV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHCCHHHHHHHH
FIGFALFGIGLGMYATPSTDTAISNAPEDKVGVASGIYKMASSLGGSFGVAISATIYGVI
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHEEE
ALSGNIDLAAMVGLLTNVGFCVVSLISVAITTPSAKKALELKAAKE
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCC
>Mature Secondary Structure 
TSTAYKGTNKLIVGIVFGVITFWLFAQSMVNIVPAVQSDLGISSDLLSIAISLTALFSG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
IFIVVAGGMADKFGRVKLTYIGLILSIIGSLLLVVTQGATLLIIGRIIQGLSAACIMPAT
HHHHHCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHH
LALMKTYFEGADRQRALSYWSIGSWGGSGICSFAGGAIATYMGWRWIFIISIVFALLGML
HHHHHHHHCCCCHHHHHHHCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
LIKGTPESKVVQNTKAKFDSFGLVLFVIAMVCLNLIITRGSTFGWTSPITITMLVVFLIS
HHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHC
AGLFFRVELRQANGFIDFSLFKNKAYTGATLSNFLLNAAAGTLVVANTYVQIGRGFTAFQ
CCCEEEEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEHHHHHHCCCHHHHH
SGLLSIGYLVCVLGMIRIGEKILQRVGARKPMILGSGITAVGIALMALTFIPGTLYTVLV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHCCHHHHHHHH
FIGFALFGIGLGMYATPSTDTAISNAPEDKVGVASGIYKMASSLGGSFGVAISATIYGVI
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHEEE
ALSGNIDLAAMVGLLTNVGFCVVSLISVAITTPSAKKALELKAAKE
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA