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The map label for this gene is licC [H]

Identifier: 226225336

GI number: 226225336

Start: 2840291

End: 2841586

Strand: Reverse

Name: licC [H]

Synonym: Lm4b_02759

Alternate gene names: 226225336

Gene position: 2841586-2840291 (Counterclockwise)

Preceding gene: 226225337

Following gene: 226225335

Centisome position: 97.56

GC content: 38.5

Gene sequence:

>1296_bases
TTGAAAAAGTTCATCGAGAAATTAAGTTGGTTATCGCAGAAGCTTGGAAATCAAATTCATTTAAAGTCTATGCGTGATGC
ATTTGCTACTATTTTACCTTTTATTATGTTAGCAGGATTCATGGTTTTAATTAATAACGTGATTATTAAGCCGGATGGTT
TTATGTCGGCGATCATCAGTTCCGAAACACTTACGACTTGGCAGGGGCTAGGTAACAGTATTGTGAACGGGACTTTAGGA
ATTATTACTATTTTGATTGGAGCTTCAGTTGCTTACTTTTTAGCGCAAAACCGGAAGTTTGAAAATCCGTTTGCACCTGC
ATTAATGACCATTGCACTGATTGTTATTTTTATCCCAGCTGTGACAGAAATTGTGCCAATTGGTGCAGAGAAATCTGTGG
AAGTTGCTGGAGTATTGCCAATAGCCTTGATGGGTTCGGCGGGAATGTTCGTTGGGATTGTAACGGCGCTTCTTGCAACA
GAAGTATTCATTCGTCTTTCTAAGAGTGAGAAAATGAAAATCCATATTTCTGGGGATAGCGTACCTCCAGCCGTAATTAA
ATCATTCAATGTGCTTATTCCGACAATGTTAACAATACTTATTTTTGCGTTTATTTCATTCTTAGTAGTGACATTATTCA
GCTTGAATTTGTATTCTTTAATTAGCGCAATTATTCAAGAACCATTAACATTCTTAGTTACAAGTGTTCCAGGGTTCCTA
ACGTTAATGACGATTTCACAAATGCTTTATTCTATCGGTATTGCTGGAAGTGGGATTTTAGGGCCGATTATGGACCCAGT
TCTTTTGGCAAATATGCAAGAAAATATGACAGCATTTGCGAATCACACAGAGATTCCTCATATTATTAATACTACTTTCC
GTGATGTTTTTGGCGTTATGGGAGGCGGCGGAAATACTATTGCGCTGTTAATAGCAATTTTTATTTGGTCAAAACGAAAA
GATTATCGCGAAATAGCTACTTTATCGGCAGCTCCTGGTCTATTTAATATCAATGAACCGGTAGTATTTGGCCTTCCGAT
TGTTTATAACTTGAGTTTGATGATTCCGTTCATTATTTCAACACCGCTTTGCTTATGTTTAGCCTACTTCGCGACAAAGC
TGCATATGATTTCAGAAGTAGTCGTAATGGTTCCGTGGACGACACCAGTTGTTGCTTCCGGCTTCCTTGCAACAGGTGGG
GACTGGCGTGCTGCAGTATTCCAAATTTTCTTGATTGGCGTCTGCGTACTTCTTTACCTACCATTCTTAAAAGCCAATGA
CAGAATTAAAGCCTAA

Upstream 100 bases:

>100_bases
TTTATTTCCGCATGTAAAATACAGATGCGGAAAAAGACTAGATTTATTTAACAAAAAGAAAGCGCTACACTTATTGTAAT
ATCAAAGGAGGTATAAAAAA

Downstream 100 bases:

>100_bases
TTGGAGGGATTTTTATGAAAAATATTATGTTGATGTGTAATGCGGGAATGTCTACAAGCGTTTTAGTGAGGAAAATGGAA
CGCGTTGTAGAAGAACGTAA

Product: cellobiose phosphotransferase system enzyme IIC

Products: pyruvate; diacetylchitobiose-6-phosphate [Cytoplasm]; cellobiose-6-phosphate [Cytoplasm] [C]

Alternate protein names: EIIC-Lic; PTS system lichenan-specific EIIC component [H]

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MKKFIEKLSWLSQKLGNQIHLKSMRDAFATILPFIMLAGFMVLINNVIIKPDGFMSAIISSETLTTWQGLGNSIVNGTLG
IITILIGASVAYFLAQNRKFENPFAPALMTIALIVIFIPAVTEIVPIGAEKSVEVAGVLPIALMGSAGMFVGIVTALLAT
EVFIRLSKSEKMKIHISGDSVPPAVIKSFNVLIPTMLTILIFAFISFLVVTLFSLNLYSLISAIIQEPLTFLVTSVPGFL
TLMTISQMLYSIGIAGSGILGPIMDPVLLANMQENMTAFANHTEIPHIINTTFRDVFGVMGGGGNTIALLIAIFIWSKRK
DYREIATLSAAPGLFNINEPVVFGLPIVYNLSLMIPFIISTPLCLCLAYFATKLHMISEVVVMVPWTTPVVASGFLATGG
DWRAAVFQIFLIGVCVLLYLPFLKANDRIKA

Sequences:

>Translated_431_residues
MKKFIEKLSWLSQKLGNQIHLKSMRDAFATILPFIMLAGFMVLINNVIIKPDGFMSAIISSETLTTWQGLGNSIVNGTLG
IITILIGASVAYFLAQNRKFENPFAPALMTIALIVIFIPAVTEIVPIGAEKSVEVAGVLPIALMGSAGMFVGIVTALLAT
EVFIRLSKSEKMKIHISGDSVPPAVIKSFNVLIPTMLTILIFAFISFLVVTLFSLNLYSLISAIIQEPLTFLVTSVPGFL
TLMTISQMLYSIGIAGSGILGPIMDPVLLANMQENMTAFANHTEIPHIINTTFRDVFGVMGGGGNTIALLIAIFIWSKRK
DYREIATLSAAPGLFNINEPVVFGLPIVYNLSLMIPFIISTPLCLCLAYFATKLHMISEVVVMVPWTTPVVASGFLATGG
DWRAAVFQIFLIGVCVLLYLPFLKANDRIKA
>Mature_431_residues
MKKFIEKLSWLSQKLGNQIHLKSMRDAFATILPFIMLAGFMVLINNVIIKPDGFMSAIISSETLTTWQGLGNSIVNGTLG
IITILIGASVAYFLAQNRKFENPFAPALMTIALIVIFIPAVTEIVPIGAEKSVEVAGVLPIALMGSAGMFVGIVTALLAT
EVFIRLSKSEKMKIHISGDSVPPAVIKSFNVLIPTMLTILIFAFISFLVVTLFSLNLYSLISAIIQEPLTFLVTSVPGFL
TLMTISQMLYSIGIAGSGILGPIMDPVLLANMQENMTAFANHTEIPHIINTTFRDVFGVMGGGGNTIALLIAIFIWSKRK
DYREIATLSAAPGLFNINEPVVFGLPIVYNLSLMIPFIISTPLCLCLAYFATKLHMISEVVVMVPWTTPVVASGFLATGG
DWRAAVFQIFLIGVCVLLYLPFLKANDRIKA

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system i

COG id: COG1455

COG function: function code G; Phosphotransferase system cellobiose-specific component IIC

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-3 domain [H]

Homologues:

Organism=Escherichia coli, GI1788032, Length=438, Percent_Identity=29.6803652968037, Blast_Score=172, Evalue=4e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003352
- InterPro:   IPR004796
- InterPro:   IPR004501 [H]

Pfam domain/function: PF02378 PTS_EIIC [H]

EC number: NA

Molecular weight: Translated: 46740; Mature: 46740

Theoretical pI: Translated: 8.77; Mature: 8.77

Prosite motif: PS51105 PTS_EIIC_TYPE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKFIEKLSWLSQKLGNQIHLKSMRDAFATILPFIMLAGFMVLINNVIIKPDGFMSAIIS
CHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHC
SETLTTWQGLGNSIVNGTLGIITILIGASVAYFLAQNRKFENPFAPALMTIALIVIFIPA
CCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
VTEIVPIGAEKSVEVAGVLPIALMGSAGMFVGIVTALLATEVFIRLSKSEKMKIHISGDS
HHHHHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
VPPAVIKSFNVLIPTMLTILIFAFISFLVVTLFSLNLYSLISAIIQEPLTFLVTSVPGFL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLMTISQMLYSIGIAGSGILGPIMDPVLLANMQENMTAFANHTEIPHIINTTFRDVFGVM
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
GGGGNTIALLIAIFIWSKRKDYREIATLSAAPGLFNINEPVVFGLPIVYNLSLMIPFIIS
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHHHHHHH
TPLCLCLAYFATKLHMISEVVVMVPWTTPVVASGFLATGGDWRAAVFQIFLIGVCVLLYL
HHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
PFLKANDRIKA
HHHCCCCCCCC
>Mature Secondary Structure
MKKFIEKLSWLSQKLGNQIHLKSMRDAFATILPFIMLAGFMVLINNVIIKPDGFMSAIIS
CHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHC
SETLTTWQGLGNSIVNGTLGIITILIGASVAYFLAQNRKFENPFAPALMTIALIVIFIPA
CCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
VTEIVPIGAEKSVEVAGVLPIALMGSAGMFVGIVTALLATEVFIRLSKSEKMKIHISGDS
HHHHHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
VPPAVIKSFNVLIPTMLTILIFAFISFLVVTLFSLNLYSLISAIIQEPLTFLVTSVPGFL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLMTISQMLYSIGIAGSGILGPIMDPVLLANMQENMTAFANHTEIPHIINTTFRDVFGVM
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
GGGGNTIALLIAIFIWSKRKDYREIATLSAAPGLFNINEPVVFGLPIVYNLSLMIPFIIS
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHHHHHHH
TPLCLCLAYFATKLHMISEVVVMVPWTTPVVASGFLATGGDWRAAVFQIFLIGVCVLLYL
HHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
PFLKANDRIKA
HHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: diacetylchitobiose [Periplasm]; phosphoenolpyruvate; cellobiose [Periplasm] [C]

Specific reaction: phosphoenolpyruvate + diacetylchitobiose [Periplasm] = pyruvate + diacetylchitobiose-6-phosphate [Cytoplasm] phosphoenolpyruvate + cellobiose [Periplasm] = cellobiose-6-phosphate [Cytoplasm] + pyruvate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8990303; 8969509; 9384377 [H]