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The map label for this gene is serS

Identifier: 226225298

GI number: 226225298

Start: 2791903

End: 2793186

Strand: Reverse

Name: serS

Synonym: Lm4b_02721

Alternate gene names: 226225298

Gene position: 2793186-2791903 (Counterclockwise)

Preceding gene: 226225299

Following gene: 226225297

Centisome position: 95.9

GC content: 40.5

Gene sequence:

>1284_bases
ATGTTAGATGTTAAATTGTTACGTAATAATTTTGATGAAGTAAAGCAGAAATTACAAAATCGCGGGGAAGACCTTGGTGA
ATTCGAGAAATTTGGTGAGTTAGATAAACGTCGCCGTACGCTAATCGTGGAGACAGAAGCGCTGAAAAGTCAGCGTAATG
AAGTGTCTCAAGAAATCGCTAAATTAAAACGCGAAAAACAAGACGCAGATGCTAAAATTGAAGAGATGCGTGTCGTTGGT
GATCGTATTAAAACATTAGACATCGAGCTAAGAGAAATCGACGAGAAGTTAGATATGATTTTAATGTCGATTCCAAATAT
TCCGCATGAGTCTACTCCGGTTGGTGAATCGGAAGACGATAACGTGGAAATTCGCAAGTGGGGCGAAGTACGCGAATTTG
ATTTTGAACCAAAAGCTCACTGGGACTTAGGAACAGACTTAGATATTCTTGATTTTGAAAATGCTGCGAAAGTAACTGGT
AGCCGTTTTGTCTTTTATAAAAAATTAGGTGCAAGACTGGAACGGGCGCTAATTAACTTTATGATGGACTTGCACTCGAA
TGAACATGGCTATGAAGAAATGTTACCACCGTACATGGTGAACCGTGCGAGCATGACTGGAACTGGTCAATTGCCGAAAT
TTGAAGAAGATGCTTTCTTAATTGAAGCAGAAGATTATTTCCTTATTCCAACAGCGGAAGTACCAGTAACAAACTACCAC
CGCGAAGACATTTTAAAAGCAGAAGATTTACCAAGAAAATATACAGCATTTAGCGCATGTTTCCGTTCTGAAGCGGGATC
TGCTGGTCGTGATACGCGCGGCTTAATTCGCCAGCATCAATTTAACAAAGTGGAATTAGTTCAATTTGTTAAACCAGAAG
ATTCCTACGCGGCGCTTGAAAAATTAACTGGAAACGCAGAAGAAGTATTGCGTCGCCTAGAATTACCATATCGCGTATTA
AGCATGTGTACGGCTGATTTAGGCTTCACTGCTGCTAAAAAATATGATTTAGAAGTTTGGATTCCAAGCTATAATTCTTA
CCGTGAGATTTCTTCTTGCAGTAATTTTGAAAGCTTCCAAGCAAGACGCGCTAACATTCGTTTCCGCCGTGAACCAGGGA
GCAAACCGGAATACGTGCATACATTAAATGGTTCCGGGTTAGCACTAGGTCGTACAGTCGCTGCTATTTTGGAAAACTAC
CAAGATGCAGATGGTTCTGTACGCATTCCGAAAGTATTGCAAGGCTACATGGGCGGTATCGAGAAAATAGAATTACCAAA
ATAA

Upstream 100 bases:

>100_bases
GTCCCAATAAGGGTGGCAACGCGGTTAACTCTCGTCCCTTTCCTGTTAATTCGGGAAAGTACGGGAGTTTTTATATGGAA
AAAATAAAGGAGGAGTTAGC

Downstream 100 bases:

>100_bases
TATGGAAGAAGGAACTGTAATGGCGAACCTTAGCGAATTACCAAACATTGGCAAAGTACTGGAGCAGGATTTAATCAAAG
CGGGAATAAAAACTCCCGTC

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MLDVKLLRNNFDEVKQKLQNRGEDLGEFEKFGELDKRRRTLIVETEALKSQRNEVSQEIAKLKREKQDADAKIEEMRVVG
DRIKTLDIELREIDEKLDMILMSIPNIPHESTPVGESEDDNVEIRKWGEVREFDFEPKAHWDLGTDLDILDFENAAKVTG
SRFVFYKKLGARLERALINFMMDLHSNEHGYEEMLPPYMVNRASMTGTGQLPKFEEDAFLIEAEDYFLIPTAEVPVTNYH
REDILKAEDLPRKYTAFSACFRSEAGSAGRDTRGLIRQHQFNKVELVQFVKPEDSYAALEKLTGNAEEVLRRLELPYRVL
SMCTADLGFTAAKKYDLEVWIPSYNSYREISSCSNFESFQARRANIRFRREPGSKPEYVHTLNGSGLALGRTVAAILENY
QDADGSVRIPKVLQGYMGGIEKIELPK

Sequences:

>Translated_427_residues
MLDVKLLRNNFDEVKQKLQNRGEDLGEFEKFGELDKRRRTLIVETEALKSQRNEVSQEIAKLKREKQDADAKIEEMRVVG
DRIKTLDIELREIDEKLDMILMSIPNIPHESTPVGESEDDNVEIRKWGEVREFDFEPKAHWDLGTDLDILDFENAAKVTG
SRFVFYKKLGARLERALINFMMDLHSNEHGYEEMLPPYMVNRASMTGTGQLPKFEEDAFLIEAEDYFLIPTAEVPVTNYH
REDILKAEDLPRKYTAFSACFRSEAGSAGRDTRGLIRQHQFNKVELVQFVKPEDSYAALEKLTGNAEEVLRRLELPYRVL
SMCTADLGFTAAKKYDLEVWIPSYNSYREISSCSNFESFQARRANIRFRREPGSKPEYVHTLNGSGLALGRTVAAILENY
QDADGSVRIPKVLQGYMGGIEKIELPK
>Mature_427_residues
MLDVKLLRNNFDEVKQKLQNRGEDLGEFEKFGELDKRRRTLIVETEALKSQRNEVSQEIAKLKREKQDADAKIEEMRVVG
DRIKTLDIELREIDEKLDMILMSIPNIPHESTPVGESEDDNVEIRKWGEVREFDFEPKAHWDLGTDLDILDFENAAKVTG
SRFVFYKKLGARLERALINFMMDLHSNEHGYEEMLPPYMVNRASMTGTGQLPKFEEDAFLIEAEDYFLIPTAEVPVTNYH
REDILKAEDLPRKYTAFSACFRSEAGSAGRDTRGLIRQHQFNKVELVQFVKPEDSYAALEKLTGNAEEVLRRLELPYRVL
SMCTADLGFTAAKKYDLEVWIPSYNSYREISSCSNFESFQARRANIRFRREPGSKPEYVHTLNGSGLALGRTVAAILENY
QDADGSVRIPKVLQGYMGGIEKIELPK

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=335, Percent_Identity=37.0149253731343, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI8923421, Length=402, Percent_Identity=30.3482587064677, Blast_Score=189, Evalue=5e-48,
Organism=Homo sapiens, GI225579074, Length=341, Percent_Identity=32.5513196480938, Blast_Score=186, Evalue=3e-47,
Organism=Escherichia coli, GI1787120, Length=430, Percent_Identity=52.093023255814, Blast_Score=442, Evalue=1e-125,
Organism=Caenorhabditis elegans, GI17539260, Length=466, Percent_Identity=30.68669527897, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17542084, Length=326, Percent_Identity=30.9815950920245, Blast_Score=130, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6320226, Length=392, Percent_Identity=33.6734693877551, Blast_Score=221, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6321799, Length=413, Percent_Identity=30.7506053268765, Blast_Score=210, Evalue=3e-55,
Organism=Drosophila melanogaster, GI24581334, Length=371, Percent_Identity=34.7708894878706, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI17737985, Length=346, Percent_Identity=30.9248554913295, Blast_Score=149, Evalue=4e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 49108; Mature: 49108

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDVKLLRNNFDEVKQKLQNRGEDLGEFEKFGELDKRRRTLIVETEALKSQRNEVSQEIA
CCCHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHH
KLKREKQDADAKIEEMRVVGDRIKTLDIELREIDEKLDMILMSIPNIPHESTPVGESEDD
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
NVEIRKWGEVREFDFEPKAHWDLGTDLDILDFENAAKVTGSRFVFYKKLGARLERALINF
CEEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHCCCHHHHHHHHHHHHHHHHHHH
MMDLHSNEHGYEEMLPPYMVNRASMTGTGQLPKFEEDAFLIEAEDYFLIPTAEVPVTNYH
HHHHCCCCCCHHHCCCHHHHCCCCCCCCCCCCCCCCCEEEEEECCEEEEECCCCCCCCCC
REDILKAEDLPRKYTAFSACFRSEAGSAGRDTRGLIRQHQFNKVELVQFVKPEDSYAALE
HHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEHHHEECCCHHHHHHH
KLTGNAEEVLRRLELPYRVLSMCTADLGFTAAKKYDLEVWIPSYNSYREISSCSNFESFQ
HHCCCHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEEEEEEECCCCCHHHHHHHCCHHHHH
ARRANIRFRREPGSKPEYVHTLNGSGLALGRTVAAILENYQDADGSVRIPKVLQGYMGGI
HHHCCCEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCEECHHHHHHHHCCC
EKIELPK
CEECCCC
>Mature Secondary Structure
MLDVKLLRNNFDEVKQKLQNRGEDLGEFEKFGELDKRRRTLIVETEALKSQRNEVSQEIA
CCCHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHH
KLKREKQDADAKIEEMRVVGDRIKTLDIELREIDEKLDMILMSIPNIPHESTPVGESEDD
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
NVEIRKWGEVREFDFEPKAHWDLGTDLDILDFENAAKVTGSRFVFYKKLGARLERALINF
CEEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHCCCHHHHHHHHHHHHHHHHHHH
MMDLHSNEHGYEEMLPPYMVNRASMTGTGQLPKFEEDAFLIEAEDYFLIPTAEVPVTNYH
HHHHCCCCCCHHHCCCHHHHCCCCCCCCCCCCCCCCCEEEEEECCEEEEECCCCCCCCCC
REDILKAEDLPRKYTAFSACFRSEAGSAGRDTRGLIRQHQFNKVELVQFVKPEDSYAALE
HHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEHHHEECCCHHHHHHH
KLTGNAEEVLRRLELPYRVLSMCTADLGFTAAKKYDLEVWIPSYNSYREISSCSNFESFQ
HHCCCHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEEEEEEECCCCCHHHHHHHCCHHHHH
ARRANIRFRREPGSKPEYVHTLNGSGLALGRTVAAILENYQDADGSVRIPKVLQGYMGGI
HHHCCCEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCEECHHHHHHHHCCC
EKIELPK
CEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]