Click here to switch to the map view.

The map label for this gene is gntK [H]

Identifier: 226225263

GI number: 226225263

Start: 2754799

End: 2756313

Strand: Reverse

Name: gntK [H]

Synonym: Lm4b_02686

Alternate gene names: 226225263

Gene position: 2756313-2754799 (Counterclockwise)

Preceding gene: 226225264

Following gene: 226225262

Centisome position: 94.63

GC content: 41.06

Gene sequence:

>1515_bases
TTGACGAGTAAACCATACATAATGGGCGTAGACATTGGAACTTCAAGCACAAAGGCAGTACTTTTTAATCAACGAGGAGA
AGTGATTTTCCGGCAGGCGACGCATTATGAACTAATAACGGATGAAACTGGGAAAGCGGAAGAGAGCCCCACGGAAATTT
TCGAAGCAGTTTTATCATCTATTCAAGCTGTGATGAAAAATGTGAATAAAGAAGAATTAGCGGGGATTTCGTTTAGTTCT
GCGATGCATAGTTTAATTATGGTTGGAAGTAATGGAGAGCTTTTGACTGAATGTATCACTTGGGCGGACGGACGAAGCAG
TGAGACGCTTGAAAAAGTAAAAAGGGATAATTACTTATTCCAACTGTATGAGGCCACAGGAACGCCGATACACCCTATGA
GCCCCTTTGCCAAAATTTGCTGGTTGAAGGAGGAAAAGCCTACTTTATTTAAACGCACAGAAAAATTTGTTGATATTAAA
TCCTATATTTTATACCGATTATTTGGTGTTTGGGTGATGGATGAATCGTTAGCATCGGGGACTGGACTATATAACATTAT
GGAGCACGACTGGGAATTTGAAGCAATGGAAATTGTCAAATTGACTCCTGATCTCTTGCCAAAAGTTGTACCAGAAACAT
ATCAATTAACTGGTGTGAAAAAAGAATACGCTGAATTAATGGGAATCCCAGAAAATTTACCATTCATTGTAGGAGGTAGT
GACGGGGCGCTAGCTAATATTGGTATTCAAGCGACCGGCCAAAATGATGTTACGATTACAGTAGGCACAAGTGGTGCAGT
TCGCAAACTTACCAATCAATTCCAAATAGATTCTCGTGGTCGGACATTTTGTTATGGAGCTGGTGATGGATACTTTATCG
CAGGTGGCGCAGTGAACAATGGTGGAAAAGTAGTCGAATGGGGTCTGCAACAATTTGGTTCTGAAGAGGAAATTAAGGGG
CGAGACTTCGCAAGCTTTATTGCAAAAATGGAGGAAGTTCCTCCAGGGGCTACGGGTCTTTTATTCCAGCCATATTTACT
AGGTGAGCGCGCACCATTTTGGACTAATGATATTCGCGGAGGTTTTGTTGGGCTGACGATTAATCATACAAAAGCCCATT
TTATTCGAGCGATTTTGGAAGGTGTTGCTTTCAATCTTGCAGAAGTTTATGAGGCAGTTTCGGCTCCAGATGACATTATT
TACGTCACAGGTGGGATTTCTGCGCATGATGGTTGGTGTAGACTTCTAGCGGATATTTTGAACCGTGAGATACGTGTTCC
GCATACGATAGAAGGCTCGAGTTTAGGAGCAGCAATTATTGGTATGCGCTCACTCGGAATTTTGAAAGATTTGAATCTAA
AACATACGCTGCCTATTAAAGCGGTATATCATCCAAGTGAGAACGTCCTTAAATACGCGGAATTACGTCTGATTTTTAAA
CAAGTAAGCACACAGTTAATGTCGAGCTACAGCCAATTAAATAGTTGGCAAAAGAAGTTTGATATTAACAGCTAA

Upstream 100 bases:

>100_bases
CTCTAGCTTTTTTGTTTGGCAAAAAAGCTAAGTAGCCTAGCCCCAAATTTTCTTCTATTTGACGTATAATAAAAAGAAAC
GAAAACGCGGGGTGAATTGT

Downstream 100 bases:

>100_bases
ATTTTGGATTTCATGATATAATCACTAAAAGAAAAGTGATAACGAGGGGGAGAAACCATGAATAAAAAAATAGTATGGAT
AGCTTTAACATTAGTAGGTA

Product: gluconate kinase

Products: NA

Alternate protein names: Gluconate kinase [H]

Number of amino acids: Translated: 504; Mature: 503

Protein sequence:

>504_residues
MTSKPYIMGVDIGTSSTKAVLFNQRGEVIFRQATHYELITDETGKAEESPTEIFEAVLSSIQAVMKNVNKEELAGISFSS
AMHSLIMVGSNGELLTECITWADGRSSETLEKVKRDNYLFQLYEATGTPIHPMSPFAKICWLKEEKPTLFKRTEKFVDIK
SYILYRLFGVWVMDESLASGTGLYNIMEHDWEFEAMEIVKLTPDLLPKVVPETYQLTGVKKEYAELMGIPENLPFIVGGS
DGALANIGIQATGQNDVTITVGTSGAVRKLTNQFQIDSRGRTFCYGAGDGYFIAGGAVNNGGKVVEWGLQQFGSEEEIKG
RDFASFIAKMEEVPPGATGLLFQPYLLGERAPFWTNDIRGGFVGLTINHTKAHFIRAILEGVAFNLAEVYEAVSAPDDII
YVTGGISAHDGWCRLLADILNREIRVPHTIEGSSLGAAIIGMRSLGILKDLNLKHTLPIKAVYHPSENVLKYAELRLIFK
QVSTQLMSSYSQLNSWQKKFDINS

Sequences:

>Translated_504_residues
MTSKPYIMGVDIGTSSTKAVLFNQRGEVIFRQATHYELITDETGKAEESPTEIFEAVLSSIQAVMKNVNKEELAGISFSS
AMHSLIMVGSNGELLTECITWADGRSSETLEKVKRDNYLFQLYEATGTPIHPMSPFAKICWLKEEKPTLFKRTEKFVDIK
SYILYRLFGVWVMDESLASGTGLYNIMEHDWEFEAMEIVKLTPDLLPKVVPETYQLTGVKKEYAELMGIPENLPFIVGGS
DGALANIGIQATGQNDVTITVGTSGAVRKLTNQFQIDSRGRTFCYGAGDGYFIAGGAVNNGGKVVEWGLQQFGSEEEIKG
RDFASFIAKMEEVPPGATGLLFQPYLLGERAPFWTNDIRGGFVGLTINHTKAHFIRAILEGVAFNLAEVYEAVSAPDDII
YVTGGISAHDGWCRLLADILNREIRVPHTIEGSSLGAAIIGMRSLGILKDLNLKHTLPIKAVYHPSENVLKYAELRLIFK
QVSTQLMSSYSQLNSWQKKFDINS
>Mature_503_residues
TSKPYIMGVDIGTSSTKAVLFNQRGEVIFRQATHYELITDETGKAEESPTEIFEAVLSSIQAVMKNVNKEELAGISFSSA
MHSLIMVGSNGELLTECITWADGRSSETLEKVKRDNYLFQLYEATGTPIHPMSPFAKICWLKEEKPTLFKRTEKFVDIKS
YILYRLFGVWVMDESLASGTGLYNIMEHDWEFEAMEIVKLTPDLLPKVVPETYQLTGVKKEYAELMGIPENLPFIVGGSD
GALANIGIQATGQNDVTITVGTSGAVRKLTNQFQIDSRGRTFCYGAGDGYFIAGGAVNNGGKVVEWGLQQFGSEEEIKGR
DFASFIAKMEEVPPGATGLLFQPYLLGERAPFWTNDIRGGFVGLTINHTKAHFIRAILEGVAFNLAEVYEAVSAPDDIIY
VTGGISAHDGWCRLLADILNREIRVPHTIEGSSLGAAIIGMRSLGILKDLNLKHTLPIKAVYHPSENVLKYAELRLIFKQ
VSTQLMSSYSQLNSWQKKFDINS

Specific function: Unknown

COG id: COG1070

COG function: function code G; Sugar (pentulose and hexulose) kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI88196792, Length=504, Percent_Identity=23.015873015873, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI42794763, Length=450, Percent_Identity=24.8888888888889, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI4504007, Length=460, Percent_Identity=25.2173913043478, Blast_Score=99, Evalue=9e-21,
Organism=Homo sapiens, GI189409120, Length=460, Percent_Identity=25.2173913043478, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI41393575, Length=456, Percent_Identity=24.780701754386, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI1789987, Length=491, Percent_Identity=25.050916496945, Blast_Score=148, Evalue=1e-36,
Organism=Escherichia coli, GI1790005, Length=476, Percent_Identity=25.2100840336134, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1790361, Length=509, Percent_Identity=25.147347740668, Blast_Score=128, Evalue=7e-31,
Organism=Escherichia coli, GI1789168, Length=457, Percent_Identity=23.8512035010941, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1787789, Length=478, Percent_Identity=23.8493723849372, Blast_Score=111, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17535599, Length=457, Percent_Identity=24.507658643326, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71986140, Length=506, Percent_Identity=20.5533596837945, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71986147, Length=238, Percent_Identity=24.3697478991597, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21357867, Length=527, Percent_Identity=23.9089184060721, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24656367, Length=517, Percent_Identity=23.9845261121857, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI17864214, Length=477, Percent_Identity=23.6897274633124, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24656372, Length=360, Percent_Identity=26.6666666666667, Blast_Score=99, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24654573, Length=403, Percent_Identity=23.8213399503722, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24657106, Length=493, Percent_Identity=22.3123732251521, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24657102, Length=493, Percent_Identity=22.3123732251521, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24655555, Length=458, Percent_Identity=22.2707423580786, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24655560, Length=458, Percent_Identity=22.2707423580786, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24655570, Length=458, Percent_Identity=22.2707423580786, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24655574, Length=458, Percent_Identity=22.2707423580786, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24655565, Length=458, Percent_Identity=22.2707423580786, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI45552909, Length=282, Percent_Identity=25.531914893617, Blast_Score=70, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR006002 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.12 [H]

Molecular weight: Translated: 55759; Mature: 55628

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00933 FGGY_KINASES_1 ; PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSKPYIMGVDIGTSSTKAVLFNQRGEVIFRQATHYELITDETGKAEESPTEIFEAVLSS
CCCCCEEEEEECCCCCCEEEEEECCCCEEEEECCCEEEEECCCCCCCCCHHHHHHHHHHH
IQAVMKNVNKEELAGISFSSAMHSLIMVGSNGELLTECITWADGRSSETLEKVKRDNYLF
HHHHHHCCCHHHHCCCCHHHHHCEEEEECCCCHHHHHHHHCCCCCCHHHHHHHHCCCEEE
QLYEATGTPIHPMSPFAKICWLKEEKPTLFKRTEKFVDIKSYILYRLFGVWVMDESLASG
EEEECCCCCCCCCCHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCC
TGLYNIMEHDWEFEAMEIVKLTPDLLPKVVPETYQLTGVKKEYAELMGIPENLPFIVGGS
CCEEHHHHCCCCCCHHHHHHCCHHHHHHHCCCCEEECCCHHHHHHHHCCCCCCCEEEECC
DGALANIGIQATGQNDVTITVGTSGAVRKLTNQFQIDSRGRTFCYGAGDGYFIAGGAVNN
CCCEEEEEEEECCCCCEEEEECCCHHHHHHHHHEEECCCCCEEEEECCCCEEEECCEECC
GGKVVEWGLQQFGSEEEIKGRDFASFIAKMEEVPPGATGLLFQPYLLGERAPFWTNDIRG
CCCEEEHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEECHHHCCCCCCCCCCCCCC
GFVGLTINHTKAHFIRAILEGVAFNLAEVYEAVSAPDDIIYVTGGISAHDGWCRLLADIL
CEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHH
NREIRVPHTIEGSSLGAAIIGMRSLGILKDLNLKHTLPIKAVYHPSENVLKYAELRLIFK
CCCCCCCCEECCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHH
QVSTQLMSSYSQLNSWQKKFDINS
HHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TSKPYIMGVDIGTSSTKAVLFNQRGEVIFRQATHYELITDETGKAEESPTEIFEAVLSS
CCCCEEEEEECCCCCCEEEEEECCCCEEEEECCCEEEEECCCCCCCCCHHHHHHHHHHH
IQAVMKNVNKEELAGISFSSAMHSLIMVGSNGELLTECITWADGRSSETLEKVKRDNYLF
HHHHHHCCCHHHHCCCCHHHHHCEEEEECCCCHHHHHHHHCCCCCCHHHHHHHHCCCEEE
QLYEATGTPIHPMSPFAKICWLKEEKPTLFKRTEKFVDIKSYILYRLFGVWVMDESLASG
EEEECCCCCCCCCCHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCC
TGLYNIMEHDWEFEAMEIVKLTPDLLPKVVPETYQLTGVKKEYAELMGIPENLPFIVGGS
CCEEHHHHCCCCCCHHHHHHCCHHHHHHHCCCCEEECCCHHHHHHHHCCCCCCCEEEECC
DGALANIGIQATGQNDVTITVGTSGAVRKLTNQFQIDSRGRTFCYGAGDGYFIAGGAVNN
CCCEEEEEEEECCCCCEEEEECCCHHHHHHHHHEEECCCCCEEEEECCCCEEEECCEECC
GGKVVEWGLQQFGSEEEIKGRDFASFIAKMEEVPPGATGLLFQPYLLGERAPFWTNDIRG
CCCEEEHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEECHHHCCCCCCCCCCCCCC
GFVGLTINHTKAHFIRAILEGVAFNLAEVYEAVSAPDDIIYVTGGISAHDGWCRLLADIL
CEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHH
NREIRVPHTIEGSSLGAAIIGMRSLGILKDLNLKHTLPIKAVYHPSENVLKYAELRLIFK
CCCCCCCCEECCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHH
QVSTQLMSSYSQLNSWQKKFDINS
HHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8535972 [H]