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The map label for this gene is yaaO [H]

Identifier: 226225245

GI number: 226225245

Start: 2740207

End: 2741586

Strand: Reverse

Name: yaaO [H]

Synonym: Lm4b_02667

Alternate gene names: 226225245

Gene position: 2741586-2740207 (Counterclockwise)

Preceding gene: 226225251

Following gene: 226225244

Centisome position: 94.13

GC content: 43.84

Gene sequence:

>1380_bases
ATGAGGAATCAATCTAAAATGCCTTTAGTGGAACGGTTAGATGCTCATGCTAAGTCTTGCCCAATATCACTCCATGTGCC
AGGACACAAAAGCGGAGCCATTTATCCAGATGCATGGCAAAAATTTTTGAAATGGGACGTAACAGAAATTACTGGAATGG
ATGATTTGCATCACCCAGAAGATGTGATTTTGGAAGCAGAGGAGTTACTTGCGGAATGTTATGGAAGCAAAAAAAGCTAC
TTTTTAGTCAATGGGACAAGCGGAGGAAGCTTGGCAGTTATTATGGCGACGTTGAAGCACGGGGAGAAAGTTTTAGTGCC
AAGAGATGCTCATAAATCAATCTTGCATGGAATCGAACTGGCAGGCGGAGAACCGATTTTCTTAACCCCAGCGACAAACA
AAGAAGTTGGCGTCGCGAGTGGCGTGACAACCGAACTTCTCGAAGAAACATTACATAATCACCCAGATATAAAACTATGT
ATTTTCACTTATCCGAGCTATTATGGAACGACTTTTAACTTGCAAAAATGTATTCGCATTGCGCATGATTTTGGTGCGGT
TGTGTTTGTTGATGAAGCGCACGGAGCCCACTTTTTAACAAGTTCTGAATTTCCGAAAAGTGCAGTGGAGCTTGGTGCGG
ATGTGGTTGTTCAGTCGGCGCATAAGACGTTGCCGGCGCTAACGATGGGTTCCTATTTACATGTGGTGAATGATTTACCG
ATTTTTGAAAAACTACCTTATTACCTGCAAGTATTCCAAACGAGCAGCCCATCTTATTTAATTATGGCGTCACTTGATGC
GGCGAGGAAATATGCGGCAACTTACACAGCGGCGGACGTCGAAGCTTTTTGGAAAATGCGTGCCAGATGGATTAAATGGC
TGAAGAAGAATAAATTTGACGTTATTTTGCCAGATGATCCGCTTAAAATCATCGTGCGCAAAACAGGCTACACGGGCTAC
GAACTGCAAGCAATTTTTGAAGAAAGCTCTTATTTCCCAGAGCTTGCCGATGAGTCACAGGTATTACTGATTTTACCATT
AATTAAAAAAGGGATTGATTTCACGCCTATTAGCCGGATTCATTCTCCGGTGAAAAAAGAAATCGCGAAAGAACCATATG
AAATGTCAGCGCCTTTTGCGTCAGGTCTTGCGCTAACTTACGAAGAAATGCACGCACGCGCGACCGAATTCGTATTACTA
GATGAAGCTACGACACGCGTTTCGGCTGAAACAATTTCGCTCTATCCGCCGGGAATCCCAGCAATCATCCGCGGAGAAAG
CATCACAGAAAAGCATATCCGCGAACTAAAAAACATTCGCACACGCCACTACCAAGGCGGCGAAAAACTAGCCGAGAATT
ACATCCGTGTATTCCGCTAA

Upstream 100 bases:

>100_bases
ATACAACTTATAAAATGAAAACGCTTTAAAACTGCAAGAATATGTCATAAACCCAGCAAAATGGTACAATGAAGGAGAGA
ATTTGAAAAGGGGAATTGTT

Downstream 100 bases:

>100_bases
TTTATGCTATAATCAAACAGAAAGCGACACGAAAGGGAAAGGAAATTACTAAATGAAAGCAATTTTTATTACACTCGAAG
GCCCAGATGGCTCTGGTAAA

Product: lysine decarboxylase

Products: Agmatine; CO2 [C]

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MRNQSKMPLVERLDAHAKSCPISLHVPGHKSGAIYPDAWQKFLKWDVTEITGMDDLHHPEDVILEAEELLAECYGSKKSY
FLVNGTSGGSLAVIMATLKHGEKVLVPRDAHKSILHGIELAGGEPIFLTPATNKEVGVASGVTTELLEETLHNHPDIKLC
IFTYPSYYGTTFNLQKCIRIAHDFGAVVFVDEAHGAHFLTSSEFPKSAVELGADVVVQSAHKTLPALTMGSYLHVVNDLP
IFEKLPYYLQVFQTSSPSYLIMASLDAARKYAATYTAADVEAFWKMRARWIKWLKKNKFDVILPDDPLKIIVRKTGYTGY
ELQAIFEESSYFPELADESQVLLILPLIKKGIDFTPISRIHSPVKKEIAKEPYEMSAPFASGLALTYEEMHARATEFVLL
DEATTRVSAETISLYPPGIPAIIRGESITEKHIRELKNIRTRHYQGGEKLAENYIRVFR

Sequences:

>Translated_459_residues
MRNQSKMPLVERLDAHAKSCPISLHVPGHKSGAIYPDAWQKFLKWDVTEITGMDDLHHPEDVILEAEELLAECYGSKKSY
FLVNGTSGGSLAVIMATLKHGEKVLVPRDAHKSILHGIELAGGEPIFLTPATNKEVGVASGVTTELLEETLHNHPDIKLC
IFTYPSYYGTTFNLQKCIRIAHDFGAVVFVDEAHGAHFLTSSEFPKSAVELGADVVVQSAHKTLPALTMGSYLHVVNDLP
IFEKLPYYLQVFQTSSPSYLIMASLDAARKYAATYTAADVEAFWKMRARWIKWLKKNKFDVILPDDPLKIIVRKTGYTGY
ELQAIFEESSYFPELADESQVLLILPLIKKGIDFTPISRIHSPVKKEIAKEPYEMSAPFASGLALTYEEMHARATEFVLL
DEATTRVSAETISLYPPGIPAIIRGESITEKHIRELKNIRTRHYQGGEKLAENYIRVFR
>Mature_459_residues
MRNQSKMPLVERLDAHAKSCPISLHVPGHKSGAIYPDAWQKFLKWDVTEITGMDDLHHPEDVILEAEELLAECYGSKKSY
FLVNGTSGGSLAVIMATLKHGEKVLVPRDAHKSILHGIELAGGEPIFLTPATNKEVGVASGVTTELLEETLHNHPDIKLC
IFTYPSYYGTTFNLQKCIRIAHDFGAVVFVDEAHGAHFLTSSEFPKSAVELGADVVVQSAHKTLPALTMGSYLHVVNDLP
IFEKLPYYLQVFQTSSPSYLIMASLDAARKYAATYTAADVEAFWKMRARWIKWLKKNKFDVILPDDPLKIIVRKTGYTGY
ELQAIFEESSYFPELADESQVLLILPLIKKGIDFTPISRIHSPVKKEIAKEPYEMSAPFASGLALTYEEMHARATEFVLL
DEATTRVSAETISLYPPGIPAIIRGESITEKHIRELKNIRTRHYQGGEKLAENYIRVFR

Specific function: Adc Can Be Found In Two Forms: Biodegradative And Biosynthetic. The Biodegradative Form May Play A Role In Regulating pH By Consuming Proteins. [C]

COG id: COG1982

COG function: function code E; Arginine/lysine/ornithine decarboxylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-I family [H]

Homologues:

Organism=Escherichia coli, GI221142684, Length=303, Percent_Identity=25.7425742574257, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1786384, Length=289, Percent_Identity=26.643598615917, Blast_Score=75, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000310
- InterPro:   IPR008286
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF01276 OKR_DC_1; PF03711 OKR_DC_1_C [H]

EC number: 4.1.1.19 [C]

Molecular weight: Translated: 51405; Mature: 51405

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNQSKMPLVERLDAHAKSCPISLHVPGHKSGAIYPDAWQKFLKWDVTEITGMDDLHHPE
CCCCCCCCHHHHHHHHHHHCCEEEECCCCCCCCCCHHHHHHHHHCCHHHHCCCCCCCCCH
DVILEAEELLAECYGSKKSYFLVNGTSGGSLAVIMATLKHGEKVLVPRDAHKSILHGIEL
HHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEEEHHCCCEEEECCHHHHHHHHHHEE
AGGEPIFLTPATNKEVGVASGVTTELLEETLHNHPDIKLCIFTYPSYYGTTFNLQKCIRI
CCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHH
AHDFGAVVFVDEAHGAHFLTSSEFPKSAVELGADVVVQSAHKTLPALTMGSYLHVVNDLP
HHHCCEEEEEECCCCCEEEECCCCCHHHHHHCHHHHHHHHHHHCCHHHHHHHHHHHHCCC
IFEKLPYYLQVFQTSSPSYLIMASLDAARKYAATYTAADVEAFWKMRARWIKWLKKNKFD
HHHHCCHHEEEEECCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
VILPDDPLKIIVRKTGYTGYELQAIFEESSYFPELADESQVLLILPLIKKGIDFTPISRI
EEECCCCEEEEEEECCCCCEEEHEEECCCCCCCCCCCCCCEEEEEEHHHCCCCCCCHHHH
HSPVKKEIAKEPYEMSAPFASGLALTYEEMHARATEFVLLDEATTRVSAETISLYPPGIP
HHHHHHHHHCCCCCCCCCCCCCCEEEHHHHHCCHHEEEEEECCCCEEEEEEEEECCCCCC
AIIRGESITEKHIRELKNIRTRHYQGGEKLAENYIRVFR
EEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MRNQSKMPLVERLDAHAKSCPISLHVPGHKSGAIYPDAWQKFLKWDVTEITGMDDLHHPE
CCCCCCCCHHHHHHHHHHHCCEEEECCCCCCCCCCHHHHHHHHHCCHHHHCCCCCCCCCH
DVILEAEELLAECYGSKKSYFLVNGTSGGSLAVIMATLKHGEKVLVPRDAHKSILHGIEL
HHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEEEHHCCCEEEECCHHHHHHHHHHEE
AGGEPIFLTPATNKEVGVASGVTTELLEETLHNHPDIKLCIFTYPSYYGTTFNLQKCIRI
CCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHH
AHDFGAVVFVDEAHGAHFLTSSEFPKSAVELGADVVVQSAHKTLPALTMGSYLHVVNDLP
HHHCCEEEEEECCCCCEEEECCCCCHHHHHHCHHHHHHHHHHHCCHHHHHHHHHHHHCCC
IFEKLPYYLQVFQTSSPSYLIMASLDAARKYAATYTAADVEAFWKMRARWIKWLKKNKFD
HHHHCCHHEEEEECCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
VILPDDPLKIIVRKTGYTGYELQAIFEESSYFPELADESQVLLILPLIKKGIDFTPISRI
EEECCCCEEEEEEECCCCCEEEHEEECCCCCCCCCCCCCCEEEEEEHHHCCCCCCCHHHH
HSPVKKEIAKEPYEMSAPFASGLALTYEEMHARATEFVLLDEATTRVSAETISLYPPGIP
HHHHHHHHHCCCCCCCCCCCCCCEEEHHHHHCCHHEEEEEECCCCEEEEEEEEECCCCCC
AIIRGESITEKHIRELKNIRTRHYQGGEKLAENYIRVFR
EEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: 2-Norpyridoxal phosphate; 6-Methylpyridoxal phosphate; Pyridoxal 5'-phosphate [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.65 {L-Arg}} 1.2 {L-canavanine}} [C]

Substrates: L-Arginine; H+ [C]

Specific reaction: L-Arginine + H+ --> Agmatine + CO2 [C]

General reaction: Decarboxylation [C]

Inhibitor: 2-Nor-2-butyl pyridoxalphosphate; 5-Deoxypyridoxal; Ag+; Agmatine; Citrulline; Guanidine; Guanidinoacetic acid; L-2-Amino-3-guanidinopropanoate; L-2-Amino-4-guanidinobutyrate; L-2-Amino-5-guanidinopentanoate; L-2-Amino-6-guanidinohexanoate; L-2-Chloro-5-g

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377 [H]