Click here to switch to the map view.

The map label for this gene is tmk

Identifier: 226225244

GI number: 226225244

Start: 2739528

End: 2740154

Strand: Reverse

Name: tmk

Synonym: Lm4b_02666

Alternate gene names: 226225244

Gene position: 2740154-2739528 (Counterclockwise)

Preceding gene: 226225245

Following gene: 226225243

Centisome position: 94.08

GC content: 43.7

Gene sequence:

>627_bases
ATGAAAGCAATTTTTATTACACTCGAAGGCCCAGATGGCTCTGGTAAAACAACAGTAGGAACACTACTTAATCAAAAAAT
GACGGAAGCTGGCATTGATTTTATTAAAACGCGCGAACCAGGTGGCAGCCCGATTTCAGAAAAAGTAAGAAATATCGTGC
TCGGAATTGGCAATGAAGAAATGGACCCAAAAACAGAAGTACTACTTATTGCGGGAGCGCGCCGTCAACATGTCGTTGAA
ACAATCCGTCCAGCTCTAGCGGCAGGGAAAACAGTACTGTGTGACCGTTTCATGGATAGCTCTCTTGCGTATCAAGGTGC
CGGACGTGACATGAATATGGAACAAGTTTTACAAGTGAATTTATATGCGATTGAGGATACATTGCCTGACCGGACGTACT
ATCTCGATGTGCCTGCCGAAGTCGGTTTAGCTAGAATCGCCGCTAATAAGGGCCGTGAAGTCAATCGCTTGGATAAAGAA
GATATTACCTACCACGAAAAAGTCCAAGCTGGCTACGAAAAAGTCATCAACATGTTCCCGGAACGTTTTATGCGAGTGGA
CGCTACAAAGACACCAGAAGAAATCACAGAAACTATTTTAGCCGACATTTTACGACAATTAGCCTAA

Upstream 100 bases:

>100_bases
CAAGGCGGCGAAAAACTAGCCGAGAATTACATCCGTGTATTCCGCTAATTTATGCTATAATCAAACAGAAAGCGACACGA
AAGGGAAAGGAAATTACTAA

Downstream 100 bases:

>100_bases
CATCTAGTGGGACTTCAACACCTTGCCACAAGTGCATATCGCTCTTTAAAATGGCGTTTGTTTGCTATAATAGAAAAAAA
GATAGATTTTTAGGAAGGGT

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MKAIFITLEGPDGSGKTTVGTLLNQKMTEAGIDFIKTREPGGSPISEKVRNIVLGIGNEEMDPKTEVLLIAGARRQHVVE
TIRPALAAGKTVLCDRFMDSSLAYQGAGRDMNMEQVLQVNLYAIEDTLPDRTYYLDVPAEVGLARIAANKGREVNRLDKE
DITYHEKVQAGYEKVINMFPERFMRVDATKTPEEITETILADILRQLA

Sequences:

>Translated_208_residues
MKAIFITLEGPDGSGKTTVGTLLNQKMTEAGIDFIKTREPGGSPISEKVRNIVLGIGNEEMDPKTEVLLIAGARRQHVVE
TIRPALAAGKTVLCDRFMDSSLAYQGAGRDMNMEQVLQVNLYAIEDTLPDRTYYLDVPAEVGLARIAANKGREVNRLDKE
DITYHEKVQAGYEKVINMFPERFMRVDATKTPEEITETILADILRQLA
>Mature_208_residues
MKAIFITLEGPDGSGKTTVGTLLNQKMTEAGIDFIKTREPGGSPISEKVRNIVLGIGNEEMDPKTEVLLIAGARRQHVVE
TIRPALAAGKTVLCDRFMDSSLAYQGAGRDMNMEQVLQVNLYAIEDTLPDRTYYLDVPAEVGLARIAANKGREVNRLDKE
DITYHEKVQAGYEKVINMFPERFMRVDATKTPEEITETILADILRQLA

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787340, Length=203, Percent_Identity=36.4532019704434, Blast_Score=117, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 23098; Mature: 23098

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAIFITLEGPDGSGKTTVGTLLNQKMTEAGIDFIKTREPGGSPISEKVRNIVLGIGNEE
CEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCHHEECCCCCCCCHHHHHHHHHHCCCCCC
MDPKTEVLLIAGARRQHVVETIRPALAAGKTVLCDRFMDSSLAYQGAGRDMNMEQVLQVN
CCCCCEEEEEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
LYAIEDTLPDRTYYLDVPAEVGLARIAANKGREVNRLDKEDITYHEKVQAGYEKVINMFP
EEEEECCCCCCEEEEECCHHHHHHHHHHCCCCCCCCCCCHHCHHHHHHHHHHHHHHHHHH
ERFMRVDATKTPEEITETILADILRQLA
HHHHHCCCCCCHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MKAIFITLEGPDGSGKTTVGTLLNQKMTEAGIDFIKTREPGGSPISEKVRNIVLGIGNEE
CEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCHHEECCCCCCCCHHHHHHHHHHCCCCCC
MDPKTEVLLIAGARRQHVVETIRPALAAGKTVLCDRFMDSSLAYQGAGRDMNMEQVLQVN
CCCCCEEEEEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
LYAIEDTLPDRTYYLDVPAEVGLARIAANKGREVNRLDKEDITYHEKVQAGYEKVINMFP
EEEEECCCCCCEEEEECCHHHHHHHHHHCCCCCCCCCCCHHCHHHHHHHHHHHHHHHHHH
ERFMRVDATKTPEEITETILADILRQLA
HHHHHCCCCCCHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]