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The map label for this gene is tkt [H]

Identifier: 226225211

GI number: 226225211

Start: 2704495

End: 2706510

Strand: Reverse

Name: tkt [H]

Synonym: Lm4b_02633

Alternate gene names: 226225211

Gene position: 2706510-2704495 (Counterclockwise)

Preceding gene: 226225212

Following gene: 226225210

Centisome position: 92.92

GC content: 45.39

Gene sequence:

>2016_bases
TTGAAAAAAACATTAGATAGACAAGCCGTGGACACGATTCGTTCGTTATCCATTGATATGATTGAGAAAGCAAATTCAGG
ACACCCAGGAATGCCGATGGGAGCAGCTCCAATGGCGTATATGCTATTTGCGAAACATTTAGTATTCAACCCAGCCAACC
CAGAATGGTTTAACCGCGATCGCTTTGTTTTATCAGCAGGACACGGGTCTGCGCTACTTTATAGCATGCTTCATTTATTT
GGTTATGATGTAAAAATGGAAGACTTAAAACAGTTCCGTCAATTAGATAGTTTGACACCAGGACACCCTGAATTTGGATG
GACTGCTGGAGTCGATGCAACGAGTGGCCCGCTTGGACAAGGGATTGGTATGGCGGCTGGAATGGCGCTTGCAGAGTCTC
ATTTAGCGGCGGAGTATAACCAACCAAATTATCCAATTGTCGACCATTATACGTATGCGATTTGTGGTGACGGAGACTTG
ATGGAAGGCGTGGCATCAGAAACAGCCTCACTTGCAGGACATTTAGGACTTGGGAAATTAATCGTATTGTACGATTCCAA
TGATATTTGTTTAGATGGAGATTTAAGCGCAACGTTCAGTGAAAATGCAGCAGACCGTTTCCGCGCATACGGCTGGCAAG
TTTTACGTGTAGAAGATGGCAACAATTTAGCGGCAATTCAAGAAAAAATTGTTCAAGCAAAATTAGAAACATCGAAACCA
ACGCTAATCGAAGTGAAAACAGTCATCGGTTACGGCGCACCAACAAAAGCAGGCAGCTCCGCAAGTCACGGTGCTCCGCT
CGGTGAAAAAGAAGCAAATGGTGCAAAAGAGCATTACGAATGGGCAGAAGAACCTTTCACAGTACCAGCCGAAGTTCGTG
ATTACTTAAGAAATTACAAAGCTCGCGGGGAAAAACTAGAGGGTGCTTGGAACACAATGCTCGCTAATTACAAAAAAGAA
TTCCCAGAACTTGCAAGTCAATTAGACCGCGTGTTAGCGGGAGAAGTAGCTGCCGATTGGAACGCTAATTTGCCAACTTT
TGAAGCAGGCACAAATGTTGCAACGCGCTCTGCTTCTGGGAAAATGATTAACGCAATTGCAGCCGAATTACCGGAACTTT
TCGGGGGATCCGCTGACTTAGGTTGCTCGAACAAAACATTTATTGATGCGAGCCCAGCATATAGCATTCAAGACCCAGCT
GGTAAAAATATCTGGTTCGGTGTGCGCGAATTTGCGATGGGAGCAATGTTAAACGGAATGGCACTTCATAGCGGTTTGCG
AGTGTTTGGCTCGACTTTCTTCGTCTTCTCAGACTATGTCCGCCCAGCAATGCGGATGGCTGCTTTAATGCAACTTCCAG
TAACGTATGTATTCACGCATGACAGTATCGCTGTAGGTGAAGACGGCCCGACACATGAACCAATCGAACAACTAGCCTCG
CTTCGTGCTATGCCAGGCCTAACAGTTATTCGCCCAGCCGATGCCAAAGAAACCCGCGCTGCTTGGGAAATTGCCGCAAC
TAACACAAATGGTCCAATCGCACTTGTATTATCACGCCAAGACTTACCAGTGCTTGAAAATGCACAAGAAGAAGTGGATG
CAGGTGTAGATAAAGGTGCTTATATCGTAGCACCAGCAAATAGTTCCAAACCAGACGCTATCATTATCGCAACAGGATCA
GAAGTGTCCCTTGCAATTGAAGCGAAAGCCGAACTTGCGAAAAAAGATATCGACGTTTCCGTTGTTAGTTTATCCAGCTG
GGAACGCTTTGAAAAAACAACCGATGCTTATAAAGAAAGCATTTTACCAAAAGAAGTCACAGCGAGATTTGCGATTGAAG
CAGGAGCAACATTCGGTTGGAAAGAATTTATTGGGTCAGAAGGCGATATGTTAGGAATCGATCACTTCGGCGCATCTGCC
CCTGCGAAAGATTTGTTTAACGCTTATGGATTTACACCAGAAAATGTGGCGGATCGTGTCGAAGCTGTGATTGCGAAAGC
CGGTGTGCGCGTATGA

Upstream 100 bases:

>100_bases
CCGAGATAAAACGAGTTATGCAGAAAGACTAGTACACATTTGGTCAGATGTAGAAAAACATGTGTAATAAAGCACAAACA
ATTTAAGGGAGATGACAGTT

Downstream 100 bases:

>100_bases
CATTCGTAGCGCCATCATTACTCGCAGCTGATTATATGAACATGGCAAACTCCATTAAAGAAGCAGAACATGCCGGAGCT
GACTACCTTCATATCGATGT

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 671; Mature: 671

Protein sequence:

>671_residues
MKKTLDRQAVDTIRSLSIDMIEKANSGHPGMPMGAAPMAYMLFAKHLVFNPANPEWFNRDRFVLSAGHGSALLYSMLHLF
GYDVKMEDLKQFRQLDSLTPGHPEFGWTAGVDATSGPLGQGIGMAAGMALAESHLAAEYNQPNYPIVDHYTYAICGDGDL
MEGVASETASLAGHLGLGKLIVLYDSNDICLDGDLSATFSENAADRFRAYGWQVLRVEDGNNLAAIQEKIVQAKLETSKP
TLIEVKTVIGYGAPTKAGSSASHGAPLGEKEANGAKEHYEWAEEPFTVPAEVRDYLRNYKARGEKLEGAWNTMLANYKKE
FPELASQLDRVLAGEVAADWNANLPTFEAGTNVATRSASGKMINAIAAELPELFGGSADLGCSNKTFIDASPAYSIQDPA
GKNIWFGVREFAMGAMLNGMALHSGLRVFGSTFFVFSDYVRPAMRMAALMQLPVTYVFTHDSIAVGEDGPTHEPIEQLAS
LRAMPGLTVIRPADAKETRAAWEIAATNTNGPIALVLSRQDLPVLENAQEEVDAGVDKGAYIVAPANSSKPDAIIIATGS
EVSLAIEAKAELAKKDIDVSVVSLSSWERFEKTTDAYKESILPKEVTARFAIEAGATFGWKEFIGSEGDMLGIDHFGASA
PAKDLFNAYGFTPENVADRVEAVIAKAGVRV

Sequences:

>Translated_671_residues
MKKTLDRQAVDTIRSLSIDMIEKANSGHPGMPMGAAPMAYMLFAKHLVFNPANPEWFNRDRFVLSAGHGSALLYSMLHLF
GYDVKMEDLKQFRQLDSLTPGHPEFGWTAGVDATSGPLGQGIGMAAGMALAESHLAAEYNQPNYPIVDHYTYAICGDGDL
MEGVASETASLAGHLGLGKLIVLYDSNDICLDGDLSATFSENAADRFRAYGWQVLRVEDGNNLAAIQEKIVQAKLETSKP
TLIEVKTVIGYGAPTKAGSSASHGAPLGEKEANGAKEHYEWAEEPFTVPAEVRDYLRNYKARGEKLEGAWNTMLANYKKE
FPELASQLDRVLAGEVAADWNANLPTFEAGTNVATRSASGKMINAIAAELPELFGGSADLGCSNKTFIDASPAYSIQDPA
GKNIWFGVREFAMGAMLNGMALHSGLRVFGSTFFVFSDYVRPAMRMAALMQLPVTYVFTHDSIAVGEDGPTHEPIEQLAS
LRAMPGLTVIRPADAKETRAAWEIAATNTNGPIALVLSRQDLPVLENAQEEVDAGVDKGAYIVAPANSSKPDAIIIATGS
EVSLAIEAKAELAKKDIDVSVVSLSSWERFEKTTDAYKESILPKEVTARFAIEAGATFGWKEFIGSEGDMLGIDHFGASA
PAKDLFNAYGFTPENVADRVEAVIAKAGVRV
>Mature_671_residues
MKKTLDRQAVDTIRSLSIDMIEKANSGHPGMPMGAAPMAYMLFAKHLVFNPANPEWFNRDRFVLSAGHGSALLYSMLHLF
GYDVKMEDLKQFRQLDSLTPGHPEFGWTAGVDATSGPLGQGIGMAAGMALAESHLAAEYNQPNYPIVDHYTYAICGDGDL
MEGVASETASLAGHLGLGKLIVLYDSNDICLDGDLSATFSENAADRFRAYGWQVLRVEDGNNLAAIQEKIVQAKLETSKP
TLIEVKTVIGYGAPTKAGSSASHGAPLGEKEANGAKEHYEWAEEPFTVPAEVRDYLRNYKARGEKLEGAWNTMLANYKKE
FPELASQLDRVLAGEVAADWNANLPTFEAGTNVATRSASGKMINAIAAELPELFGGSADLGCSNKTFIDASPAYSIQDPA
GKNIWFGVREFAMGAMLNGMALHSGLRVFGSTFFVFSDYVRPAMRMAALMQLPVTYVFTHDSIAVGEDGPTHEPIEQLAS
LRAMPGLTVIRPADAKETRAAWEIAATNTNGPIALVLSRQDLPVLENAQEEVDAGVDKGAYIVAPANSSKPDAIIIATGS
EVSLAIEAKAELAKKDIDVSVVSLSSWERFEKTTDAYKESILPKEVTARFAIEAGATFGWKEFIGSEGDMLGIDHFGASA
PAKDLFNAYGFTPENVADRVEAVIAKAGVRV

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=682, Percent_Identity=24.7800586510264, Blast_Score=156, Evalue=7e-38,
Organism=Homo sapiens, GI4507521, Length=682, Percent_Identity=24.7800586510264, Blast_Score=156, Evalue=7e-38,
Organism=Homo sapiens, GI133778974, Length=580, Percent_Identity=26.0344827586207, Blast_Score=138, Evalue=2e-32,
Organism=Homo sapiens, GI225637459, Length=581, Percent_Identity=23.2358003442341, Blast_Score=113, Evalue=5e-25,
Organism=Homo sapiens, GI225637461, Length=508, Percent_Identity=24.0157480314961, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI225637463, Length=508, Percent_Identity=24.0157480314961, Blast_Score=111, Evalue=2e-24,
Organism=Escherichia coli, GI48994911, Length=664, Percent_Identity=47.5903614457831, Blast_Score=621, Evalue=1e-179,
Organism=Escherichia coli, GI1788808, Length=663, Percent_Identity=46.7571644042232, Blast_Score=612, Evalue=1e-176,
Organism=Caenorhabditis elegans, GI17539652, Length=583, Percent_Identity=27.4442538593482, Blast_Score=163, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6325331, Length=671, Percent_Identity=47.6900149031297, Blast_Score=588, Evalue=1e-169,
Organism=Saccharomyces cerevisiae, GI6319593, Length=673, Percent_Identity=45.1708766716196, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI45551847, Length=574, Percent_Identity=28.397212543554, Blast_Score=176, Evalue=6e-44,
Organism=Drosophila melanogaster, GI45550715, Length=574, Percent_Identity=28.397212543554, Blast_Score=176, Evalue=6e-44,
Organism=Drosophila melanogaster, GI24666278, Length=557, Percent_Identity=29.0843806104129, Blast_Score=169, Evalue=7e-42,
Organism=Drosophila melanogaster, GI24645119, Length=546, Percent_Identity=28.3882783882784, Blast_Score=164, Evalue=3e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 72182; Mature: 72182

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKTLDRQAVDTIRSLSIDMIEKANSGHPGMPMGAAPMAYMLFAKHLVFNPANPEWFNRD
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
RFVLSAGHGSALLYSMLHLFGYDVKMEDLKQFRQLDSLTPGHPEFGWTAGVDATSGPLGQ
EEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
GIGMAAGMALAESHLAAEYNQPNYPIVDHYTYAICGDGDLMEGVASETASLAGHLGLGKL
CHHHHHHHHHHHHHHHHHCCCCCCCEEECEEEEEECCCHHHHHHHHHHHHHHHCCCCCEE
IVLYDSNDICLDGDLSATFSENAADRFRAYGWQVLRVEDGNNLAAIQEKIVQAKLETSKP
EEEECCCCEEECCCCCCCCCCHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHCCCCC
TLIEVKTVIGYGAPTKAGSSASHGAPLGEKEANGAKEHYEWAEEPFTVPAEVRDYLRNYK
CEEEEEEHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHH
ARGEKLEGAWNTMLANYKKEFPELASQLDRVLAGEVAADWNANLPTFEAGTNVATRSASG
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCCCC
KMINAIAAELPELFGGSADLGCSNKTFIDASPAYSIQDPAGKNIWFGVREFAMGAMLNGM
HHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
ALHSGLRVFGSTFFVFSDYVRPAMRMAALMQLPVTYVFTHDSIAVGEDGPTHEPIEQLAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCEEECCCCCCHHHHHHHHH
LRAMPGLTVIRPADAKETRAAWEIAATNTNGPIALVLSRQDLPVLENAQEEVDAGVDKGA
HHCCCCCEEECCCCCCHHHCEEEEEEECCCCCEEEEEECCCCCHHHCCHHHHHCCCCCCE
YIVAPANSSKPDAIIIATGSEVSLAIEAKAELAKKDIDVSVVSLSSWERFEKTTDAYKES
EEEECCCCCCCCEEEEEECCCEEEEEECHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHH
ILPKEVTARFAIEAGATFGWKEFIGSEGDMLGIDHFGASAPAKDLFNAYGFTPENVADRV
CCCHHHHHHEEEECCCCCCHHHHHCCCCCEEEECCCCCCCCHHHHHHHCCCCHHHHHHHH
EAVIAKAGVRV
HHHHHHCCCCC
>Mature Secondary Structure
MKKTLDRQAVDTIRSLSIDMIEKANSGHPGMPMGAAPMAYMLFAKHLVFNPANPEWFNRD
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
RFVLSAGHGSALLYSMLHLFGYDVKMEDLKQFRQLDSLTPGHPEFGWTAGVDATSGPLGQ
EEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
GIGMAAGMALAESHLAAEYNQPNYPIVDHYTYAICGDGDLMEGVASETASLAGHLGLGKL
CHHHHHHHHHHHHHHHHHCCCCCCCEEECEEEEEECCCHHHHHHHHHHHHHHHCCCCCEE
IVLYDSNDICLDGDLSATFSENAADRFRAYGWQVLRVEDGNNLAAIQEKIVQAKLETSKP
EEEECCCCEEECCCCCCCCCCHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHCCCCC
TLIEVKTVIGYGAPTKAGSSASHGAPLGEKEANGAKEHYEWAEEPFTVPAEVRDYLRNYK
CEEEEEEHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHH
ARGEKLEGAWNTMLANYKKEFPELASQLDRVLAGEVAADWNANLPTFEAGTNVATRSASG
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCCCC
KMINAIAAELPELFGGSADLGCSNKTFIDASPAYSIQDPAGKNIWFGVREFAMGAMLNGM
HHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
ALHSGLRVFGSTFFVFSDYVRPAMRMAALMQLPVTYVFTHDSIAVGEDGPTHEPIEQLAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCEEECCCCCCHHHHHHHHH
LRAMPGLTVIRPADAKETRAAWEIAATNTNGPIALVLSRQDLPVLENAQEEVDAGVDKGA
HHCCCCCEEECCCCCCHHHCEEEEEEECCCCCEEEEEECCCCCHHHCCHHHHHCCCCCCE
YIVAPANSSKPDAIIIATGSEVSLAIEAKAELAKKDIDVSVVSLSSWERFEKTTDAYKES
EEEECCCCCCCCEEEEEECCCEEEEEECHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHH
ILPKEVTARFAIEAGATFGWKEFIGSEGDMLGIDHFGASAPAKDLFNAYGFTPENVADRV
CCCHHHHHHEEEECCCCCCHHHHHCCCCCEEEECCCCCCCCHHHHHHHCCCCHHHHHHHH
EAVIAKAGVRV
HHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969507; 9384377; 9068642 [H]