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The map label for this gene is mrpB [H]

Identifier: 226224931

GI number: 226224931

Start: 2429298

End: 2429723

Strand: Direct

Name: mrpB [H]

Synonym: Lm4b_02351

Alternate gene names: 226224931

Gene position: 2429298-2429723 (Clockwise)

Preceding gene: 226224930

Following gene: 226224932

Centisome position: 83.4

GC content: 39.2

Gene sequence:

>426_bases
ATGATGAAAACGAATGATGTTCTACTGAGAAATGTAACGAAAGTAGTTGCTTTCATTATTTTCTTATTCTCACTCCATTT
ATTCTTTGCAGGACATTATAATCCTGGTGGCGGGTTTGTGGCCGGGCTTACAACGGCTGGTGCTATTACATTAACACTAC
TTGCTTATGATACAAAAACAGTGGCTAGTATGCTTAATATCAATACGATTATGCTTACTGGGGTTGGACTTGTATTTGCC
CTTGGTACTGGAATGATTGGGATTTTTACAGGAGATCCTTTCTTAACGCATAAATTTGGTCATGTTGATTTGCCCATTTT
AGGAGATACTGCGTTACACACGGCGACTTTGTTTGACCTTGGGGTTTACTTAGTTGTTGTCGGTGTAACACTTACGATAA
TTCAAACGATTGGGGAGAGTGACTGA

Upstream 100 bases:

>100_bases
TTCCGTGGTTTTGATACGATGTTTGAGACAGCTGTGCTTTCGATTGCGGCGATTGGTATTTACGCGATGATTAAATTACG
ACTGACGAAACGAGGTGAGA

Downstream 100 bases:

>100_bases
TGGAACTATTAATGTCTATATTAATCGGCTTGATTTTTGCAGCTGCTGTCTACTTAATTCTCTCTAAAAGTTTGCTACGG
ATTATTATTGGAACGGCTGT

Product: putative monovalent cation/H+ antiporter subunit B

Products: NA

Alternate protein names: Mrp complex subunit B; Multiple resistance and pH homeostasis protein B [H]

Number of amino acids: Translated: 141; Mature: 141

Protein sequence:

>141_residues
MMKTNDVLLRNVTKVVAFIIFLFSLHLFFAGHYNPGGGFVAGLTTAGAITLTLLAYDTKTVASMLNINTIMLTGVGLVFA
LGTGMIGIFTGDPFLTHKFGHVDLPILGDTALHTATLFDLGVYLVVVGVTLTIIQTIGESD

Sequences:

>Translated_141_residues
MMKTNDVLLRNVTKVVAFIIFLFSLHLFFAGHYNPGGGFVAGLTTAGAITLTLLAYDTKTVASMLNINTIMLTGVGLVFA
LGTGMIGIFTGDPFLTHKFGHVDLPILGDTALHTATLFDLGVYLVVVGVTLTIIQTIGESD
>Mature_141_residues
MMKTNDVLLRNVTKVVAFIIFLFSLHLFFAGHYNPGGGFVAGLTTAGAITLTLLAYDTKTVASMLNINTIMLTGVGLVFA
LGTGMIGIFTGDPFLTHKFGHVDLPILGDTALHTATLFDLGVYLVVVGVTLTIIQTIGESD

Specific function: Mrp complex is a Na(+)/H(+) antiporter that is considered to be the major Na(+) excretion system in B.subtilis. Has a major role in Na(+) resistance and a minor role in Na(+)- and K(+)-dependent pH homeostasis as compared to TetB. MrpA may be the actual N

COG id: COG2111

COG function: function code P; Multisubunit Na+/H+ antiporter, MnhB subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CPA3 antiporters (TC 2.A.63) subunit B family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005281
- InterPro:   IPR007182 [H]

Pfam domain/function: PF04039 MnhB [H]

EC number: NA

Molecular weight: Translated: 14934; Mature: 14934

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKTNDVLLRNVTKVVAFIIFLFSLHLFFAGHYNPGGGFVAGLTTAGAITLTLLAYDTKT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHEEEEEHHHHHH
VASMLNINTIMLTGVGLVFALGTGMIGIFTGDPFLTHKFGHVDLPILGDTALHTATLFDL
HHHHHCCHHHHHHHHHHHHHHHCCEEEEEECCCHHEEECCCCCCCEECCHHHHHHHHHHH
GVYLVVVGVTLTIIQTIGESD
HHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MMKTNDVLLRNVTKVVAFIIFLFSLHLFFAGHYNPGGGFVAGLTTAGAITLTLLAYDTKT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHEEEEEHHHHHH
VASMLNINTIMLTGVGLVFALGTGMIGIFTGDPFLTHKFGHVDLPILGDTALHTATLFDL
HHHHHCCHHHHHHHHHHHHHHHCCEEEEEECCCHHEEECCCCCCCEECCHHHHHHHHHHH
GVYLVVVGVTLTIIQTIGESD
HHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9274030; 9384377; 10198001; 11356194 [H]