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The map label for this gene is yuxJ [H]

Identifier: 226224929

GI number: 226224929

Start: 2425350

End: 2426561

Strand: Direct

Name: yuxJ [H]

Synonym: Lm4b_02349

Alternate gene names: 226224929

Gene position: 2425350-2426561 (Clockwise)

Preceding gene: 226224927

Following gene: 226224930

Centisome position: 83.27

GC content: 42.16

Gene sequence:

>1212_bases
ATGACAACTCGAACACGGAATTTGTACATCTTAATGCTGGCAAACCTTTTGATGTCAGCCAGTATGACAATGATTATGCC
TTTTTTATCTCTTTACATTGAAACATTTGGTGATTATAGCAATGCTTACGTGCAAAGGTGGGCCGGTTATATTTTTGGCG
TAACATTTTTAATTGCCTTTATCTTTTCGCCGATTTGGGGACGTATTGGTGATAAGCACGGTTATAAAGGGATTTTGATT
CTGACTTCAGTTGGTTTATCGATTTGTATCTTTCTGATGGGATTTGCGCATTCTGTCACTTACTTACTGATTTTACGAAT
TTTCATGGGGGTTGTGACTGGCTTTATTGGCGTTAGTAATGCCTTTATTGCACGGCAAACTCCTCGTAATGAAGCTGGAA
AAATTCTCGGTACTTTGCAACTCGGAGGCGTGACTGGGATGCTGTTTGGTCCCTTGATTGGCGGCGCGATGGCGGATTTA
TTTGGCTTTAAAGATACCTTTACAATTACCGGAATTGCGATGATGGTTGCGGCTTTAATTGTCGCTTTTGGTGTCAAGGA
AATTCGTACAGAAGAACAAAAAGAAGCTGCCAAAGTCGTTTATTCTCGTCGTGCAGTTTTAAAACAAATTTTTACGCTAC
GAGTTCTATTCACGGTGATGGTTATTACAGCACTTATCCAAATTGCGAACTTTAGTGTTCAACCGTTGCTTGCGCTTTAT
GTAGGAGATATGACGCAATCAGACAATATTGCTTTCTTGTCCGGGCTGGCGTTTTCTGCGACGGGATTCGGGAACTTGGT
GATGACGCGAAAATGGGGACAGCTTGGAGACAAATATGGGTATGAGAAAATACTGAATATCTTGTTGATTATGGCGGCTG
TTTTTGTTATTCCACAGGCATTCGCGACGAATCTTTGGGTGTTCATTTTCTTCCGCTTTTTATTCGGTATTGCGATTGGT
GGAATGGTTCCTTGTACGACAGCTTATATTCGGCTTGCGGCGCCTGGTGTTATGCAAGGCGAAATGCTTGGCTATAATCA
AAGTGCTCGCTTTTTAGGAAATGTTATCGGACCAATCCTCGGTGGGACGCTCGCTGGTTTCACAGGAATTCCGAGTGTGT
TCTTATTTATGAGTTTTATGTTCCTCGTGGCATTTTTCATTTTGCTTTATGCCCTTCATTCCGACCGGAAACGGCATGTG
AACGTGGATTGA

Upstream 100 bases:

>100_bases
CCAAAAATGCACATCCTTCACTTTATTTTTCATTCGCTATCTTTTATTCTATAATGAAAAGGACAGTTTTAACAATAATA
CGAATAGAGATGATTCTTTT

Downstream 100 bases:

>100_bases
ATTTGACAAACCTAAGTTTTTTCTTAGGTTTGTTTTTTTGTTCTTCCTATTAAATTGTTTTTTAAATTTCGGTAAATTGA
TTTATAAAGTTAAGTTTCCT

Product: multi-drug resistance efflux pump

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: ORF1 [H]

Number of amino acids: Translated: 403; Mature: 402

Protein sequence:

>403_residues
MTTRTRNLYILMLANLLMSASMTMIMPFLSLYIETFGDYSNAYVQRWAGYIFGVTFLIAFIFSPIWGRIGDKHGYKGILI
LTSVGLSICIFLMGFAHSVTYLLILRIFMGVVTGFIGVSNAFIARQTPRNEAGKILGTLQLGGVTGMLFGPLIGGAMADL
FGFKDTFTITGIAMMVAALIVAFGVKEIRTEEQKEAAKVVYSRRAVLKQIFTLRVLFTVMVITALIQIANFSVQPLLALY
VGDMTQSDNIAFLSGLAFSATGFGNLVMTRKWGQLGDKYGYEKILNILLIMAAVFVIPQAFATNLWVFIFFRFLFGIAIG
GMVPCTTAYIRLAAPGVMQGEMLGYNQSARFLGNVIGPILGGTLAGFTGIPSVFLFMSFMFLVAFFILLYALHSDRKRHV
NVD

Sequences:

>Translated_403_residues
MTTRTRNLYILMLANLLMSASMTMIMPFLSLYIETFGDYSNAYVQRWAGYIFGVTFLIAFIFSPIWGRIGDKHGYKGILI
LTSVGLSICIFLMGFAHSVTYLLILRIFMGVVTGFIGVSNAFIARQTPRNEAGKILGTLQLGGVTGMLFGPLIGGAMADL
FGFKDTFTITGIAMMVAALIVAFGVKEIRTEEQKEAAKVVYSRRAVLKQIFTLRVLFTVMVITALIQIANFSVQPLLALY
VGDMTQSDNIAFLSGLAFSATGFGNLVMTRKWGQLGDKYGYEKILNILLIMAAVFVIPQAFATNLWVFIFFRFLFGIAIG
GMVPCTTAYIRLAAPGVMQGEMLGYNQSARFLGNVIGPILGGTLAGFTGIPSVFLFMSFMFLVAFFILLYALHSDRKRHV
NVD
>Mature_402_residues
TTRTRNLYILMLANLLMSASMTMIMPFLSLYIETFGDYSNAYVQRWAGYIFGVTFLIAFIFSPIWGRIGDKHGYKGILIL
TSVGLSICIFLMGFAHSVTYLLILRIFMGVVTGFIGVSNAFIARQTPRNEAGKILGTLQLGGVTGMLFGPLIGGAMADLF
GFKDTFTITGIAMMVAALIVAFGVKEIRTEEQKEAAKVVYSRRAVLKQIFTLRVLFTVMVITALIQIANFSVQPLLALYV
GDMTQSDNIAFLSGLAFSATGFGNLVMTRKWGQLGDKYGYEKILNILLIMAAVFVIPQAFATNLWVFIFFRFLFGIAIGG
MVPCTTAYIRLAAPGVMQGEMLGYNQSARFLGNVIGPILGGTLAGFTGIPSVFLFMSFMFLVAFFILLYALHSDRKRHVN
VD

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI1787291, Length=396, Percent_Identity=34.5959595959596, Blast_Score=230, Evalue=1e-61,
Organism=Saccharomyces cerevisiae, GI6319871, Length=150, Percent_Identity=28, Blast_Score=63, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 44329; Mature: 44198

Theoretical pI: Translated: 10.10; Mature: 10.10

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TTRTRNLYILMLANLLMSASMTMIMPFLSLYIETFGDYSNAYVQRWAGYIFGVTFLIAF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
IFSPIWGRIGDKHGYKGILILTSVGLSICIFLMGFAHSVTYLLILRIFMGVVTGFIGVSN
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AFIARQTPRNEAGKILGTLQLGGVTGMLFGPLIGGAMADLFGFKDTFTITGIAMMVAALI
HHHCCCCCCCCHHHEEEEEEECCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
VAFGVKEIRTEEQKEAAKVVYSRRAVLKQIFTLRVLFTVMVITALIQIANFSVQPLLALY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
VGDMTQSDNIAFLSGLAFSATGFGNLVMTRKWGQLGDKYGYEKILNILLIMAAVFVIPQA
HCCCCCCCCCHHHHCCHHHCCCCCCHHEECCHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
FATNLWVFIFFRFLFGIAIGGMVPCTTAYIRLAAPGVMQGEMLGYNQSARFLGNVIGPIL
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
GGTLAGFTGIPSVFLFMSFMFLVAFFILLYALHSDRKRHVNVD
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9274030; 9384377; 10568751; 7961491 [H]