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The map label for this gene is pepC

Identifier: 226224883

GI number: 226224883

Start: 2371289

End: 2372614

Strand: Direct

Name: pepC

Synonym: Lm4b_02302

Alternate gene names: 226224883

Gene position: 2371289-2372614 (Clockwise)

Preceding gene: 226224878

Following gene: 226224897

Centisome position: 81.41

GC content: 34.92

Gene sequence:

>1326_bases
ATGCATACAGAATTAACATTTGAGCAATTAGAAAGTTTTTCTCGAAAATGGCGTGAAAATCCAGATAAATTGGTATTTCA
AGCTAGTATTATCAAGAATGGGATTAAAGCAGCAACTGAGAATCCTGCATCAAAAGTTAGCATTCAACCTGTCTTTTCCC
ACGAAGTTGCTACAGATAAAGTTTCTAATCAACAACAAAGTGGAAGATGCTGGATGTTTGCAGCATTAAATACGTTTCGC
CATAAATTAAACGGAACGCTTGGTTTGAAGGATTTTGAGTTATCACAGAATTATACTAATTTTTGGGACAAACTTGAGAA
AGCAAATTACTTTTTAGAGAATATAATTGAAACAGCAAGTGAGGATGAAGATAGTCGATTAGTTTCGTGGTTGCTTGATA
CACCCCAACAAGATGGTGGGCAGTGGGATATGTTAGTTTCAATTATTGAAAAATATGGAGTGGTTCCAAAGTCAGCTATG
CCTGAAACGTTTCAAAGTAGTAAGTCTGCTGATTTAAACCATCTATTAAATGAAAGACTTCGTACGGATGCGGTTATTTT
GAGAAATGCTATTGCTGAGAAGAAAGATACTGCAGATTTGAAAGAAGAAATGCTTGCTGAGGTCTATCAACTCTTAGTTA
TGACTCTAGGCGAACCACCTAAAGTATTCAATTTTGAGTATCGAAATAAAGACAATGAATTTAAACAAGAATTACAAATT
ACACCTAAAGATTTTTATGAACGCTATGTAGATATGGATTTGAAAGATTATATTCCACTTATTAATGCACCGACCAAAGA
TAAACCTTTTAATCAAGCTTTTACAGTGGAATATTTAGGCAACATTGTAAATGGTACACCTATTAAGTATTTGAATGTAG
AAATGGATGTCTTGAAAAAAGCTGCTGCTGATCAGATTAAAGATGGGGAAACAGTTTGGTTTGGATGTGATGTTGGACAA
CTTTCAGAACGGAATACCGGTATTATGGATACGGATATTTTCTTGCTTAATCAGACTTTTGGCTTTAAAACTGCGATGAC
TAAAGCTGAACGCCTGGATTATAAACACAGTATGCTTACACATGCGATGGTATTAACTGGAGTGAACATTGCTAATGGAG
AAGTAAATCGCTGGAAAGTGGAAAATAGTTGGGGAGAAAAAATTGGTAATAATGGTTATTTTGTTGCTAGCGATGCTTGG
ATGGATGAGTTTACATTCCAAGTAGTGGTGCATAAAAAATATCTATCTAAGGAATTAATTGAATCCTTTAACCAAAAGCC
AATTGTGTTAAAACCTTGGGATCCAATGGGTTCGCTCGCACTTTAA

Upstream 100 bases:

>100_bases
AATCCTTCACAATTATTCATTCAGCGTTTTTCTTATACAGTTCTAATTTTTAGCAGTATACTTGGTTAGAAGATAATTTT
CATTTTAGGAGGAGTTATTC

Downstream 100 bases:

>100_bases
AATGCGAATTCGGAAATGATTTTTATTCCATTCATTTGAAAAAGAGCTGCTGCTACGCCGGTACCATCTTTTATTTTTCC
TGAGAAGGTACCGTCGTAAA

Product: aminopeptidase C

Products: NA

Alternate protein names: Bleomycin hydrolase [H]

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MHTELTFEQLESFSRKWRENPDKLVFQASIIKNGIKAATENPASKVSIQPVFSHEVATDKVSNQQQSGRCWMFAALNTFR
HKLNGTLGLKDFELSQNYTNFWDKLEKANYFLENIIETASEDEDSRLVSWLLDTPQQDGGQWDMLVSIIEKYGVVPKSAM
PETFQSSKSADLNHLLNERLRTDAVILRNAIAEKKDTADLKEEMLAEVYQLLVMTLGEPPKVFNFEYRNKDNEFKQELQI
TPKDFYERYVDMDLKDYIPLINAPTKDKPFNQAFTVEYLGNIVNGTPIKYLNVEMDVLKKAAADQIKDGETVWFGCDVGQ
LSERNTGIMDTDIFLLNQTFGFKTAMTKAERLDYKHSMLTHAMVLTGVNIANGEVNRWKVENSWGEKIGNNGYFVASDAW
MDEFTFQVVVHKKYLSKELIESFNQKPIVLKPWDPMGSLAL

Sequences:

>Translated_441_residues
MHTELTFEQLESFSRKWRENPDKLVFQASIIKNGIKAATENPASKVSIQPVFSHEVATDKVSNQQQSGRCWMFAALNTFR
HKLNGTLGLKDFELSQNYTNFWDKLEKANYFLENIIETASEDEDSRLVSWLLDTPQQDGGQWDMLVSIIEKYGVVPKSAM
PETFQSSKSADLNHLLNERLRTDAVILRNAIAEKKDTADLKEEMLAEVYQLLVMTLGEPPKVFNFEYRNKDNEFKQELQI
TPKDFYERYVDMDLKDYIPLINAPTKDKPFNQAFTVEYLGNIVNGTPIKYLNVEMDVLKKAAADQIKDGETVWFGCDVGQ
LSERNTGIMDTDIFLLNQTFGFKTAMTKAERLDYKHSMLTHAMVLTGVNIANGEVNRWKVENSWGEKIGNNGYFVASDAW
MDEFTFQVVVHKKYLSKELIESFNQKPIVLKPWDPMGSLAL
>Mature_441_residues
MHTELTFEQLESFSRKWRENPDKLVFQASIIKNGIKAATENPASKVSIQPVFSHEVATDKVSNQQQSGRCWMFAALNTFR
HKLNGTLGLKDFELSQNYTNFWDKLEKANYFLENIIETASEDEDSRLVSWLLDTPQQDGGQWDMLVSIIEKYGVVPKSAM
PETFQSSKSADLNHLLNERLRTDAVILRNAIAEKKDTADLKEEMLAEVYQLLVMTLGEPPKVFNFEYRNKDNEFKQELQI
TPKDFYERYVDMDLKDYIPLINAPTKDKPFNQAFTVEYLGNIVNGTPIKYLNVEMDVLKKAAADQIKDGETVWFGCDVGQ
LSERNTGIMDTDIFLLNQTFGFKTAMTKAERLDYKHSMLTHAMVLTGVNIANGEVNRWKVENSWGEKIGNNGYFVASDAW
MDEFTFQVVVHKKYLSKELIESFNQKPIVLKPWDPMGSLAL

Specific function: Unknown

COG id: COG3579

COG function: function code E; Aminopeptidase C

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C1 family [H]

Homologues:

Organism=Homo sapiens, GI4557367, Length=449, Percent_Identity=38.7527839643653, Blast_Score=347, Evalue=1e-95,
Organism=Saccharomyces cerevisiae, GI6324090, Length=408, Percent_Identity=37.7450980392157, Blast_Score=283, Evalue=5e-77,
Organism=Drosophila melanogaster, GI161077632, Length=442, Percent_Identity=39.5927601809955, Blast_Score=322, Evalue=3e-88,
Organism=Drosophila melanogaster, GI24640588, Length=403, Percent_Identity=41.6873449131514, Blast_Score=322, Evalue=4e-88,
Organism=Drosophila melanogaster, GI161077630, Length=363, Percent_Identity=41.3223140495868, Blast_Score=287, Evalue=1e-77,
Organism=Drosophila melanogaster, GI20130175, Length=463, Percent_Identity=25.2699784017279, Blast_Score=172, Evalue=5e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000169
- InterPro:   IPR004134 [H]

Pfam domain/function: PF03051 Peptidase_C1_2 [H]

EC number: =3.4.22.40 [H]

Molecular weight: Translated: 50617; Mature: 50617

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00139 THIOL_PROTEASE_CYS ; PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHTELTFEQLESFSRKWRENPDKLVFQASIIKNGIKAATENPASKVSIQPVFSHEVATDK
CCCCCCHHHHHHHHHHHHCCCHHEEEHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHH
VSNQQQSGRCWMFAALNTFRHKLNGTLGLKDFELSQNYTNFWDKLEKANYFLENIIETAS
HCCCCCCCCEEEEHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
EDEDSRLVSWLLDTPQQDGGQWDMLVSIIEKYGVVPKSAMPETFQSSKSADLNHLLNERL
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCHHHHHHHHHH
RTDAVILRNAIAEKKDTADLKEEMLAEVYQLLVMTLGEPPKVFNFEYRNKDNEFKQELQI
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHCC
TPKDFYERYVDMDLKDYIPLINAPTKDKPFNQAFTVEYLGNIVNGTPIKYLNVEMDVLKK
CHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCEEEHHHHHHHCCCCCEEEEECHHHHHHH
AAADQIKDGETVWFGCDVGQLSERNTGIMDTDIFLLNQTFGFKTAMTKAERLDYKHSMLT
HHHHHCCCCCEEEEECCCCCCCCCCCCCEECEEEEEECCCCHHHHHHHHHHHHHHHHHHH
HAMVLTGVNIANGEVNRWKVENSWGEKIGNNGYFVASDAWMDEFTFQVVVHKKYLSKELI
HHHHHHCCEECCCCCCEEEECCCHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHH
ESFNQKPIVLKPWDPMGSLAL
HHCCCCCEEEECCCCCCCCCC
>Mature Secondary Structure
MHTELTFEQLESFSRKWRENPDKLVFQASIIKNGIKAATENPASKVSIQPVFSHEVATDK
CCCCCCHHHHHHHHHHHHCCCHHEEEHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHH
VSNQQQSGRCWMFAALNTFRHKLNGTLGLKDFELSQNYTNFWDKLEKANYFLENIIETAS
HCCCCCCCCEEEEHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
EDEDSRLVSWLLDTPQQDGGQWDMLVSIIEKYGVVPKSAMPETFQSSKSADLNHLLNERL
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCHHHHHHHHHH
RTDAVILRNAIAEKKDTADLKEEMLAEVYQLLVMTLGEPPKVFNFEYRNKDNEFKQELQI
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHCC
TPKDFYERYVDMDLKDYIPLINAPTKDKPFNQAFTVEYLGNIVNGTPIKYLNVEMDVLKK
CHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCEEEHHHHHHHCCCCCEEEEECHHHHHHH
AAADQIKDGETVWFGCDVGQLSERNTGIMDTDIFLLNQTFGFKTAMTKAERLDYKHSMLT
HHHHHCCCCCEEEEECCCCCCCCCCCCCEECEEEEEECCCCHHHHHHHHHHHHHHHHHHH
HAMVLTGVNIANGEVNRWKVENSWGEKIGNNGYFVASDAWMDEFTFQVVVHKKYLSKELI
HHHHHHCCEECCCCCCEEEECCCHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHH
ESFNQKPIVLKPWDPMGSLAL
HHCCCCCEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]