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The map label for this gene is isdE [H]

Identifier: 226224792

GI number: 226224792

Start: 2277388

End: 2278260

Strand: Reverse

Name: isdE [H]

Synonym: Lm4b_02210

Alternate gene names: 226224792

Gene position: 2278260-2277388 (Counterclockwise)

Preceding gene: 226224793

Following gene: 226224791

Centisome position: 78.22

GC content: 39.63

Gene sequence:

>873_bases
ATGAGGAAAATGGCTGTCATATCTTTGATGTTATTACTTTTTTTAGTTGGCTGTGGAAAGGAAGAGGCGGCTCAAAAGCC
TGAACAAAAATCGGAGAAGGAGCCAAAAATTGTGGCGACTACGGTAGCGATTACGGAAATTATGGATAAACTTGATTTGC
CACTCGTTGGAATTCCGACTAGTTCTAAAAAACTTCCGGAGCGTTATGCAGATGTAAAGGAAACTGGGTCGCCTATGGGG
CCTGATTTGGAAATTATTCGGATGTTGAAGCCAGACATGGTCCTTTCAACGAAAACGCTAGAAGCGGACTTAAAGGCTGG
GTTTGAAGGGGCCGATTTAAAAGCGGACTTTCTAGACTTTACGAGTATTGCCTCGATGCAAACAGAAATTAAAAAACTTG
GAGCAGAATTTGATCGTAAAGAAGAAGCGGCTAAATTAAATGGTGATTTAACGAATGAGATTGATAAGGTGAAGACGAGC
GTGGCGAAAAAGAAAAAGCCAACTGTTCTTATTCTGATGGGGGTTCCGGGCAGCTACTTAGTTGTAACGGAACATGCGTA
TATTGGTGATTTGGTCAAACTTGCTGGTGGAGAAAATGTCATTAAGGACCAAAAAGTAGAATATTTAGCTTCTAATACAG
AATACTTACAAAGTGCCAATCCTGATATTATTTTGCGGGCGGCTCATGGTATGCCTGCTGAAGTGGTTAAAATGTTTGAC
GAGGAATTTAAAACAAATGATATTTGGAAACATTTTGATGCGGTGAAAAATAATCGGGTGTATGATTTGGATGAAAATTT
ATTTGGTATGACAGCGAGTTTGAATGCACCAGAAGCACTACAGGAAATGGAAAAGATGCTTTATGACAATTAA

Upstream 100 bases:

>100_bases
AAAGATTGAGTTAATAAAATTAGTAAAAGCGAGTTAGGTCGGGGGTTTCCTTTGCTTAACTCGCTTTACCGATTTTATTT
TATAAATGGGGGAATTAGTG

Downstream 100 bases:

>100_bases
GCAAAAAAGTTCTTTTGGGGCTGTAATTATTTTATTGATTGGGACTATTTTGTGGGCAGTTCAGGCGGGAAGTTTGTCGA
TGTCGATTCCAGCTTTTTTG

Product: ferrichrome ABC transporter (binding protein)

Products: NA

Alternate protein names: Iron-regulated surface determinant protein E; Staphylococcal iron-regulated protein F [H]

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MRKMAVISLMLLLFLVGCGKEEAAQKPEQKSEKEPKIVATTVAITEIMDKLDLPLVGIPTSSKKLPERYADVKETGSPMG
PDLEIIRMLKPDMVLSTKTLEADLKAGFEGADLKADFLDFTSIASMQTEIKKLGAEFDRKEEAAKLNGDLTNEIDKVKTS
VAKKKKPTVLILMGVPGSYLVVTEHAYIGDLVKLAGGENVIKDQKVEYLASNTEYLQSANPDIILRAAHGMPAEVVKMFD
EEFKTNDIWKHFDAVKNNRVYDLDENLFGMTASLNAPEALQEMEKMLYDN

Sequences:

>Translated_290_residues
MRKMAVISLMLLLFLVGCGKEEAAQKPEQKSEKEPKIVATTVAITEIMDKLDLPLVGIPTSSKKLPERYADVKETGSPMG
PDLEIIRMLKPDMVLSTKTLEADLKAGFEGADLKADFLDFTSIASMQTEIKKLGAEFDRKEEAAKLNGDLTNEIDKVKTS
VAKKKKPTVLILMGVPGSYLVVTEHAYIGDLVKLAGGENVIKDQKVEYLASNTEYLQSANPDIILRAAHGMPAEVVKMFD
EEFKTNDIWKHFDAVKNNRVYDLDENLFGMTASLNAPEALQEMEKMLYDN
>Mature_290_residues
MRKMAVISLMLLLFLVGCGKEEAAQKPEQKSEKEPKIVATTVAITEIMDKLDLPLVGIPTSSKKLPERYADVKETGSPMG
PDLEIIRMLKPDMVLSTKTLEADLKAGFEGADLKADFLDFTSIASMQTEIKKLGAEFDRKEEAAKLNGDLTNEIDKVKTS
VAKKKKPTVLILMGVPGSYLVVTEHAYIGDLVKLAGGENVIKDQKVEYLASNTEYLQSANPDIILRAAHGMPAEVVKMFD
EEFKTNDIWKHFDAVKNNRVYDLDENLFGMTASLNAPEALQEMEKMLYDN

Specific function: Involved in heme (porphyrin) scavenging. Binds Fe(2+) and Fe(3+) heme but the largest fraction is Fe(2+) heme. Functions as a high-affinity heme binding protein and probably has a role in relaying heme-iron from cell wall-anchored isd proteins receptors t

COG id: COG0614

COG function: function code P; ABC-type Fe3+-hydroxamate transport system, periplasmic component

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Fe/B12 periplasmic-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019957
- InterPro:   IPR002491 [H]

Pfam domain/function: PF01497 Peripla_BP_2 [H]

EC number: NA

Molecular weight: Translated: 32176; Mature: 32176

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50983 FE_B12_PBP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKMAVISLMLLLFLVGCGKEEAAQKPEQKSEKEPKIVATTVAITEIMDKLDLPLVGIPT
CCHHHHHHHHHHHHHHCCCCHHHHCCCHHHHCCCCCEEHHHHHHHHHHHHHCCCEEECCC
SSKKLPERYADVKETGSPMGPDLEIIRMLKPDMVLSTKTLEADLKAGFEGADLKADFLDF
CCHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCEEEHHHHHHHHHCCCCCCCCCHHHHHH
TSIASMQTEIKKLGAEFDRKEEAAKLNGDLTNEIDKVKTSVAKKKKPTVLILMGVPGSYL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCEE
VVTEHAYIGDLVKLAGGENVIKDQKVEYLASNTEYLQSANPDIILRAAHGMPAEVVKMFD
EEECCHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHCCCCCEEEEECCCCHHHHHHHHH
EEFKTNDIWKHFDAVKNNRVYDLDENLFGMTASLNAPEALQEMEKMLYDN
HHHCCHHHHHHHHHHHCCCEEECCCCCCCEEECCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MRKMAVISLMLLLFLVGCGKEEAAQKPEQKSEKEPKIVATTVAITEIMDKLDLPLVGIPT
CCHHHHHHHHHHHHHHCCCCHHHHCCCHHHHCCCCCEEHHHHHHHHHHHHHCCCEEECCC
SSKKLPERYADVKETGSPMGPDLEIIRMLKPDMVLSTKTLEADLKAGFEGADLKADFLDF
CCHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCEEEHHHHHHHHHCCCCCCCCCHHHHHH
TSIASMQTEIKKLGAEFDRKEEAAKLNGDLTNEIDKVKTSVAKKKKPTVLILMGVPGSYL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCEE
VVTEHAYIGDLVKLAGGENVIKDQKVEYLASNTEYLQSANPDIILRAAHGMPAEVVKMFD
EEECCHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHCCCCCEEEEECCCCHHHHHHHHH
EEFKTNDIWKHFDAVKNNRVYDLDENLFGMTASLNAPEALQEMEKMLYDN
HHHCCHHHHHHHHHHHCCCEEECCCCCCCEEECCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA