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The map label for this gene is nrdA [H]

Identifier: 226224762

GI number: 226224762

Start: 2237902

End: 2240193

Strand: Reverse

Name: nrdA [H]

Synonym: Lm4b_02180

Alternate gene names: 226224762

Gene position: 2240193-2237902 (Counterclockwise)

Preceding gene: 226224764

Following gene: 226224761

Centisome position: 76.91

GC content: 37.57

Gene sequence:

>2292_bases
ATGAAATGGGGATTGCAAATGACAACTTACATAGTAAAAGACGGGGGAAACAGAAAGCTACCTTTTGACAAAAGCCGATT
GGATGGATATTTAGAGAAAATCCATGAAGAATTTCCGAAACTTGATTTGGAGGATTACAAACGTAAGGTTTTTAATTTTG
TAGAGAAGAAGGAAGATTATGCGGCTGACGAATTAGTCGATTATTTAATTAGGGAAGCAGAAGCTCGTACTGATATTCAT
ATTCCTGAATGGGAACATTTCGCAGCACGCCTTTATTTAAATAAATTATATAAAAAAGCAAGTAAAAATCGTTTCTATAA
TGATGATGATAAATATGGTTCGTACGTTGGACTACAAGAGAGTCTAGGCGAACGTGGTATTTATTCTGGCAATATTCTAA
AAAATTATTCTAAAGAAGATTTGATTGCAGCAGGGAAATTAATTGACCCTGAAAAAGATAAATTATTCACTTATAATGGT
TTGTATTTACTTGCGACTCGTTACTTAGCGACTGACTCTGAACGTAATGTGTATGAGTTGCCACAAGAACGTTGGTTAAC
TATCGCACTTTATTTAATGCAAAATGAACCAAAAGAAAAACGGATGAAACTAGTAGAAGAAGCTTACTGGGCTTTAAGTA
ATTTATATATGACTGTTGCAACACCGACACTTGCAAATGCTGGAAAAGTTGGCGGTCAATTGTCTAGTTGTTTCATTGAT
ACTGTAGATGATAGCTTGCAAGGTATTTATGACAGTAATACAGACGTCGCTAGAGTTTCTAAGCACGGTGGTGGTGTTGG
CGCATATCTTGGGTATGTTCGTTCAACAGGAGCTGCTATCCGCGGCGTCAAAGGCGCAAGTGGTGGCGTTATTCCTTGGA
TTAAACAATTAAACAATACTGCGGTTAGCGTAGATCAATTAGGTCAACGTAAAGGCGCGATTGCAGTTTATTTAGATGTT
TTCCATAAAGATATCGAATCTTTCCTTGATTTGCGATTAAACAATGGTGACCAACGTTTACGCGCACATGATGTATTCAC
TGCAGTTTGTATCCCTGATATTTTCATGGAAGCTGTAGAACGTCGTGGCGAGTGGTATTTGTTTGATCCACATGAAGTAA
AAGCGAAAAAAGGCTGGTACCTACAAGATTTCTACGATGAATCAAAAGGTGAAGGTACTTTCCGTGAAAAATATGAAGAA
CTAGTAGCAGATGAAACAATTAGCAAAAAAATTGTTAAAGCTATTGATATCATGAAACGTATTATGATGAGTCAATTAGA
AACAGGGAATCCATTCATGTTTTACCGTGATGAAGTAAACAGAATGAACCCTAATAAACATGAAGGCATGGTGTATTCTA
GTAACTTATGTACAGAAATCATGCAAAATATGAGCCCAACAAAAATGATTCAAGAAATTATTTCTGGAGATCAAATTGTT
ATCACAAAACAAGCGGGAGATTTTGTTGTATGTAACTTATCTTCTGTTAACCTAGGTCGTGCGGTTGTTGCTGAAGAAGG
TACTTTAGAACGTTTAATCGAAGTAGAAGTACGGATGTTAGATAACGTTATCGACTTAAACGAACTACCAGTACCACAAG
CTACTATCACGAACCAAAAGTACCGTTCTATCGGACTTGGAACATTTGGTTGGCACCATCTGCTTGCTCTTAAAAATATC
GCTTGGGACTCAGAAGAAGCGGAGAAATATGCCGATGAATTATATGAACAAATTAACTATTTAGCTATTCGCGCAAGTAA
CAAACTAGCGCAAGAAAAAGGTGCTTATAAAGTCTTTAAAGGCAGTGACTGGAATACTGGAGAATACTTCGCGCGTCGTA
ACTATAATTCACCTGAATGGCAAGAATTAGCAAAAGAAGTAGCAGAAAAAGGTTTGCGTAATGCATATCTTGTAGCTGTA
GCACCAAATATGAGTACAGCTCAAATTGCTGGATCCACTGCTTCAATCGACCCAATTTACAGTGCATTCTACTATGAAGA
GAAAAAAGATTACCGTCGTCCAGTTATTGCACCGGACTTAAACTTAAGCACATACCCATACTACGAAAAAGGTGCTTACA
AAGTTGACCAATTCGCAAGCGTTCGTCAAAACGGTCGTCGTCAACGTCACGTAGACCAATCACTAAGCTTTAACTTCTAT
GTACCAAGTGGTATCAAAGCAAGTAAACTACTTGAACTACACATGACGGCTTGGAATGAAGGACTTAAAACAACTTACTA
TGTTCGCTCTAACGATATCGATGTTGAAGAGTGCGAATGGTGCTCAAGCTGA

Upstream 100 bases:

>100_bases
TAAAAGTTAATTTTTTTGCTCCATGGAACGACCACAATAGTTCAGCGGACGAATAAAAAGCGCAAAGTGAATCAGATATT
TTTACAACGAGGAAAAAAGG

Downstream 100 bases:

>100_bases
TACATCTCTAAAATACTTTACACTTAGTACAAAATGAAAGGGAGGGCTTGCCTAGATGGCTAACCAAAAAGAACAACTGA
CACGTATTAAAATTTTAGAA

Product: ribonucleotide-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: Ribonucleotide reductase [H]

Number of amino acids: Translated: 763; Mature: 763

Protein sequence:

>763_residues
MKWGLQMTTYIVKDGGNRKLPFDKSRLDGYLEKIHEEFPKLDLEDYKRKVFNFVEKKEDYAADELVDYLIREAEARTDIH
IPEWEHFAARLYLNKLYKKASKNRFYNDDDKYGSYVGLQESLGERGIYSGNILKNYSKEDLIAAGKLIDPEKDKLFTYNG
LYLLATRYLATDSERNVYELPQERWLTIALYLMQNEPKEKRMKLVEEAYWALSNLYMTVATPTLANAGKVGGQLSSCFID
TVDDSLQGIYDSNTDVARVSKHGGGVGAYLGYVRSTGAAIRGVKGASGGVIPWIKQLNNTAVSVDQLGQRKGAIAVYLDV
FHKDIESFLDLRLNNGDQRLRAHDVFTAVCIPDIFMEAVERRGEWYLFDPHEVKAKKGWYLQDFYDESKGEGTFREKYEE
LVADETISKKIVKAIDIMKRIMMSQLETGNPFMFYRDEVNRMNPNKHEGMVYSSNLCTEIMQNMSPTKMIQEIISGDQIV
ITKQAGDFVVCNLSSVNLGRAVVAEEGTLERLIEVEVRMLDNVIDLNELPVPQATITNQKYRSIGLGTFGWHHLLALKNI
AWDSEEAEKYADELYEQINYLAIRASNKLAQEKGAYKVFKGSDWNTGEYFARRNYNSPEWQELAKEVAEKGLRNAYLVAV
APNMSTAQIAGSTASIDPIYSAFYYEEKKDYRRPVIAPDLNLSTYPYYEKGAYKVDQFASVRQNGRRQRHVDQSLSFNFY
VPSGIKASKLLELHMTAWNEGLKTTYYVRSNDIDVEECEWCSS

Sequences:

>Translated_763_residues
MKWGLQMTTYIVKDGGNRKLPFDKSRLDGYLEKIHEEFPKLDLEDYKRKVFNFVEKKEDYAADELVDYLIREAEARTDIH
IPEWEHFAARLYLNKLYKKASKNRFYNDDDKYGSYVGLQESLGERGIYSGNILKNYSKEDLIAAGKLIDPEKDKLFTYNG
LYLLATRYLATDSERNVYELPQERWLTIALYLMQNEPKEKRMKLVEEAYWALSNLYMTVATPTLANAGKVGGQLSSCFID
TVDDSLQGIYDSNTDVARVSKHGGGVGAYLGYVRSTGAAIRGVKGASGGVIPWIKQLNNTAVSVDQLGQRKGAIAVYLDV
FHKDIESFLDLRLNNGDQRLRAHDVFTAVCIPDIFMEAVERRGEWYLFDPHEVKAKKGWYLQDFYDESKGEGTFREKYEE
LVADETISKKIVKAIDIMKRIMMSQLETGNPFMFYRDEVNRMNPNKHEGMVYSSNLCTEIMQNMSPTKMIQEIISGDQIV
ITKQAGDFVVCNLSSVNLGRAVVAEEGTLERLIEVEVRMLDNVIDLNELPVPQATITNQKYRSIGLGTFGWHHLLALKNI
AWDSEEAEKYADELYEQINYLAIRASNKLAQEKGAYKVFKGSDWNTGEYFARRNYNSPEWQELAKEVAEKGLRNAYLVAV
APNMSTAQIAGSTASIDPIYSAFYYEEKKDYRRPVIAPDLNLSTYPYYEKGAYKVDQFASVRQNGRRQRHVDQSLSFNFY
VPSGIKASKLLELHMTAWNEGLKTTYYVRSNDIDVEECEWCSS
>Mature_763_residues
MKWGLQMTTYIVKDGGNRKLPFDKSRLDGYLEKIHEEFPKLDLEDYKRKVFNFVEKKEDYAADELVDYLIREAEARTDIH
IPEWEHFAARLYLNKLYKKASKNRFYNDDDKYGSYVGLQESLGERGIYSGNILKNYSKEDLIAAGKLIDPEKDKLFTYNG
LYLLATRYLATDSERNVYELPQERWLTIALYLMQNEPKEKRMKLVEEAYWALSNLYMTVATPTLANAGKVGGQLSSCFID
TVDDSLQGIYDSNTDVARVSKHGGGVGAYLGYVRSTGAAIRGVKGASGGVIPWIKQLNNTAVSVDQLGQRKGAIAVYLDV
FHKDIESFLDLRLNNGDQRLRAHDVFTAVCIPDIFMEAVERRGEWYLFDPHEVKAKKGWYLQDFYDESKGEGTFREKYEE
LVADETISKKIVKAIDIMKRIMMSQLETGNPFMFYRDEVNRMNPNKHEGMVYSSNLCTEIMQNMSPTKMIQEIISGDQIV
ITKQAGDFVVCNLSSVNLGRAVVAEEGTLERLIEVEVRMLDNVIDLNELPVPQATITNQKYRSIGLGTFGWHHLLALKNI
AWDSEEAEKYADELYEQINYLAIRASNKLAQEKGAYKVFKGSDWNTGEYFARRNYNSPEWQELAKEVAEKGLRNAYLVAV
APNMSTAQIAGSTASIDPIYSAFYYEEKKDYRRPVIAPDLNLSTYPYYEKGAYKVDQFASVRQNGRRQRHVDQSLSFNFY
VPSGIKASKLLELHMTAWNEGLKTTYYVRSNDIDVEECEWCSS

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=718, Percent_Identity=31.6155988857939, Blast_Score=310, Evalue=3e-84,
Organism=Escherichia coli, GI1789030, Length=676, Percent_Identity=31.9526627218935, Blast_Score=276, Evalue=3e-75,
Organism=Escherichia coli, GI2367133, Length=690, Percent_Identity=27.6811594202899, Blast_Score=236, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI17555242, Length=795, Percent_Identity=30.6918238993711, Blast_Score=303, Evalue=3e-82,
Organism=Saccharomyces cerevisiae, GI6320914, Length=792, Percent_Identity=30.4292929292929, Blast_Score=308, Evalue=2e-84,
Organism=Saccharomyces cerevisiae, GI6322123, Length=722, Percent_Identity=31.4404432132964, Blast_Score=307, Evalue=4e-84,
Organism=Drosophila melanogaster, GI17352481, Length=786, Percent_Identity=29.7709923664122, Blast_Score=302, Evalue=8e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013346
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 87396; Mature: 87396

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: PS51161 ATP_CONE ; PS00089 RIBORED_LARGE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKWGLQMTTYIVKDGGNRKLPFDKSRLDGYLEKIHEEFPKLDLEDYKRKVFNFVEKKEDY
CCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHC
AADELVDYLIREAEARTDIHIPEWEHFAARLYLNKLYKKASKNRFYNDDDKYGSYVGLQE
CHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHH
SLGERGIYSGNILKNYSKEDLIAAGKLIDPEKDKLFTYNGLYLLATRYLATDSERNVYEL
HHCCCCCCCCHHHHCCCHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHHHCCCCCCHHHC
PQERWLTIALYLMQNEPKEKRMKLVEEAYWALSNLYMTVATPTLANAGKVGGQLSSCFID
CHHHHEEEEEEEHHCCCHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCHHHHHHH
TVDDSLQGIYDSNTDVARVSKHGGGVGAYLGYVRSTGAAIRGVKGASGGVIPWIKQLNNT
HHHHHHHHCCCCCCCHHHHHHCCCCHHHHHHHHHHCCHHHCCCCCCCCCCCHHHHHHCCC
AVSVDQLGQRKGAIAVYLDVFHKDIESFLDLRLNNGDQRLRAHDVFTAVCIPDIFMEAVE
EEEHHHHCCCCCCEEEHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
RRGEWYLFDPHEVKAKKGWYLQDFYDESKGEGTFREKYEELVADETISKKIVKAIDIMKR
CCCCEEEECCHHHHHCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IMMSQLETGNPFMFYRDEVNRMNPNKHEGMVYSSNLCTEIMQNMSPTKMIQEIISGDQIV
HHHHHCCCCCCEEEEECHHCCCCCCCCCCEEEEHHHHHHHHHCCCHHHHHHHHHCCCEEE
ITKQAGDFVVCNLSSVNLGRAVVAEEGTLERLIEVEVRMLDNVIDLNELPVPQATITNQK
EEECCCCEEEEEECCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCH
YRSIGLGTFGWHHLLALKNIAWDSEEAEKYADELYEQINYLAIRASNKLAQEKGAYKVFK
HHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEEEEECCCHHHHHCCCEEEEE
GSDWNTGEYFARRNYNSPEWQELAKEVAEKGLRNAYLVAVAPNMSTAQIAGSTASIDPIY
CCCCCCCHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHCCCCCCCCCHHH
SAFYYEEKKDYRRPVIAPDLNLSTYPYYEKGAYKVDQFASVRQNGRRQRHVDQSLSFNFY
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHCCEEEEE
VPSGIKASKLLELHMTAWNEGLKTTYYVRSNDIDVEECEWCSS
CCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHCCCC
>Mature Secondary Structure
MKWGLQMTTYIVKDGGNRKLPFDKSRLDGYLEKIHEEFPKLDLEDYKRKVFNFVEKKEDY
CCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHC
AADELVDYLIREAEARTDIHIPEWEHFAARLYLNKLYKKASKNRFYNDDDKYGSYVGLQE
CHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHH
SLGERGIYSGNILKNYSKEDLIAAGKLIDPEKDKLFTYNGLYLLATRYLATDSERNVYEL
HHCCCCCCCCHHHHCCCHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHHHCCCCCCHHHC
PQERWLTIALYLMQNEPKEKRMKLVEEAYWALSNLYMTVATPTLANAGKVGGQLSSCFID
CHHHHEEEEEEEHHCCCHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCHHHHHHH
TVDDSLQGIYDSNTDVARVSKHGGGVGAYLGYVRSTGAAIRGVKGASGGVIPWIKQLNNT
HHHHHHHHCCCCCCCHHHHHHCCCCHHHHHHHHHHCCHHHCCCCCCCCCCCHHHHHHCCC
AVSVDQLGQRKGAIAVYLDVFHKDIESFLDLRLNNGDQRLRAHDVFTAVCIPDIFMEAVE
EEEHHHHCCCCCCEEEHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
RRGEWYLFDPHEVKAKKGWYLQDFYDESKGEGTFREKYEELVADETISKKIVKAIDIMKR
CCCCEEEECCHHHHHCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IMMSQLETGNPFMFYRDEVNRMNPNKHEGMVYSSNLCTEIMQNMSPTKMIQEIISGDQIV
HHHHHCCCCCCEEEEECHHCCCCCCCCCCEEEEHHHHHHHHHCCCHHHHHHHHHCCCEEE
ITKQAGDFVVCNLSSVNLGRAVVAEEGTLERLIEVEVRMLDNVIDLNELPVPQATITNQK
EEECCCCEEEEEECCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCH
YRSIGLGTFGWHHLLALKNIAWDSEEAEKYADELYEQINYLAIRASNKLAQEKGAYKVFK
HHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEEEEECCCHHHHHCCCEEEEE
GSDWNTGEYFARRNYNSPEWQELAKEVAEKGLRNAYLVAVAPNMSTAQIAGSTASIDPIY
CCCCCCCHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHCCCCCCCCCHHH
SAFYYEEKKDYRRPVIAPDLNLSTYPYYEKGAYKVDQFASVRQNGRRQRHVDQSLSFNFY
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHCCEEEEE
VPSGIKASKLLELHMTAWNEGLKTTYYVRSNDIDVEECEWCSS
CCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9665876 [H]