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The map label for this gene is mtlR [H]

Identifier: 226224745

GI number: 226224745

Start: 2222729

End: 2224186

Strand: Reverse

Name: mtlR [H]

Synonym: Lm4b_02162

Alternate gene names: 226224745

Gene position: 2224186-2222729 (Counterclockwise)

Preceding gene: 226224749

Following gene: 226224744

Centisome position: 76.36

GC content: 32.65

Gene sequence:

>1458_bases
ATGCTTCTAACCAAATCGGAGCATGCATTAATTAACTTGTTCTTAACGAAAAACGATTTTTTGACAGCAAAGCAATTAGC
TGAAATTCTAGACGTTTCCTCTAAAACGATTTATCGCAAGATTAAAAACATCAATGAGACAACTGGAAGAAAGGATATCA
TCATTTCTGAAAAGGGGCGTGGTTTTAAGTTAGATTATAAAGCTTACATACAAGCTAAATTAGAAACGACAGGTGATATT
TTTGGCTATACACCAACAGAAAGACGTGAAAAAATCTTGCTGCAAGTATTGTTTAAATCACCAAAGTACTTGAATGTAAC
AGAGCTGTATGAAGATTATTATGTTGGGTATAATTCAATCAAAAATGATTTCTCTCTTTTAAATCAAGCCATCGAGAAAT
ATGATTTGGCTCTTGAAAAAAGGCAAAAAGAAATACGGGTTGTTGGCACTGAAGAAAACATCCGGACCGCCATTAATGAA
GTGATTAACAACTTGGATTTATCGACCTATGATGATTTGAAAACAGAATACAGTGATCTCAATAAAGCTGACGTTCAGTT
TATTGTGCGGCAAATGGAGTTGATTGAGAACAAGCTGATGATTAGCATTCCGTATCCGTATGATATTAATATCTTTTCAC
ATTTGTATATTTTAATCAACCGTTTCCGTCAAGGGGAAGTAGAAGATTTTAAAGAAAGTGATGATGCTTATATCGTCACA
AATGAAAAATTGCATACGATTGCTGTAGAAGCCATTGATGCAATTGAACAATATTTGAAAATGAAGCTACCGGAGAGAGA
GACTTTCCATTTTTTACAATACTTGATTTCTTCTCGTTTTAACCATGAAATCGAATTAGTTCCAGGTAAAATTTTACCGA
TTGTGGAAGAGATGACTGATTTTTATATTGAACAAGTGGCTGCTAAAATTAATATGCCGATTAATAAAAAGCAATTAAAG
ATCGAGCTATTGAGCCATATGAAGCCAATGGTAAACCGAATGAATCATCAAATTAATATAAAGAATAATTTGTTAAGCGA
CATCAAATTAGAGTATGGCAGACTATTTGAAATCATCAAAGAAACTGCAAATGATGTAGCAAAAACCTTTAAATTAAATA
CAATTTCTGATGATGAAGTTGGCTATATTACCATATATTTTGCGAAACACATGGAAGCGTCTCCTCTAGTCAAACGAATT
ATCATTATGTGTTCAAGCGGCATCGGGACGTCAGAACTTTTGAAAGTAAAGGTTCAAAAAGCTTTTCCAGATGTTGAAAT
AGTAGACGTTTTATCATCTACAAGATTCAAAAATAACTTGCAAGACTATCAGAATATTGATTTTATTCTAACAACAATTA
ATGCAGAAAGTACGAAAGAAATCCCATCGTTACTTGTAAGTGCGATGTTTACCGAGAAAGATAAAATAATGGTAAAAAAA
CTGATGGAAAGTTTATAG

Upstream 100 bases:

>100_bases
TCACAAACTCAGCCAAAAAATTGTCTAGTGTAGTGGACATAACTTGTTGTAACCGTTTTCTTTTATTTGTGTATAATAGA
GCGTAGAGGGAGGTGATGAA

Downstream 100 bases:

>100_bases
GAGGCGAATTCATGGATATCCAAGATTTAGATATTAGTAAAGTAATAAGCCCAGCACTTGTAAATTTAGACTTACAAGCT
ACAAGTAAATTAGAAGTCAT

Product: transcription regulator

Products: NA

Alternate protein names: Mannitol operon transcriptional activator; Mtl operon transcriptional activator; Putative phosphotransferase enzyme IIB component; Putative PTS system EIIB component; Putative phosphotransferase enzyme IIA component; Putative PTS system EIIA component [H]

Number of amino acids: Translated: 485; Mature: 485

Protein sequence:

>485_residues
MLLTKSEHALINLFLTKNDFLTAKQLAEILDVSSKTIYRKIKNINETTGRKDIIISEKGRGFKLDYKAYIQAKLETTGDI
FGYTPTERREKILLQVLFKSPKYLNVTELYEDYYVGYNSIKNDFSLLNQAIEKYDLALEKRQKEIRVVGTEENIRTAINE
VINNLDLSTYDDLKTEYSDLNKADVQFIVRQMELIENKLMISIPYPYDINIFSHLYILINRFRQGEVEDFKESDDAYIVT
NEKLHTIAVEAIDAIEQYLKMKLPERETFHFLQYLISSRFNHEIELVPGKILPIVEEMTDFYIEQVAAKINMPINKKQLK
IELLSHMKPMVNRMNHQINIKNNLLSDIKLEYGRLFEIIKETANDVAKTFKLNTISDDEVGYITIYFAKHMEASPLVKRI
IIMCSSGIGTSELLKVKVQKAFPDVEIVDVLSSTRFKNNLQDYQNIDFILTTINAESTKEIPSLLVSAMFTEKDKIMVKK
LMESL

Sequences:

>Translated_485_residues
MLLTKSEHALINLFLTKNDFLTAKQLAEILDVSSKTIYRKIKNINETTGRKDIIISEKGRGFKLDYKAYIQAKLETTGDI
FGYTPTERREKILLQVLFKSPKYLNVTELYEDYYVGYNSIKNDFSLLNQAIEKYDLALEKRQKEIRVVGTEENIRTAINE
VINNLDLSTYDDLKTEYSDLNKADVQFIVRQMELIENKLMISIPYPYDINIFSHLYILINRFRQGEVEDFKESDDAYIVT
NEKLHTIAVEAIDAIEQYLKMKLPERETFHFLQYLISSRFNHEIELVPGKILPIVEEMTDFYIEQVAAKINMPINKKQLK
IELLSHMKPMVNRMNHQINIKNNLLSDIKLEYGRLFEIIKETANDVAKTFKLNTISDDEVGYITIYFAKHMEASPLVKRI
IIMCSSGIGTSELLKVKVQKAFPDVEIVDVLSSTRFKNNLQDYQNIDFILTTINAESTKEIPSLLVSAMFTEKDKIMVKK
LMESL
>Mature_485_residues
MLLTKSEHALINLFLTKNDFLTAKQLAEILDVSSKTIYRKIKNINETTGRKDIIISEKGRGFKLDYKAYIQAKLETTGDI
FGYTPTERREKILLQVLFKSPKYLNVTELYEDYYVGYNSIKNDFSLLNQAIEKYDLALEKRQKEIRVVGTEENIRTAINE
VINNLDLSTYDDLKTEYSDLNKADVQFIVRQMELIENKLMISIPYPYDINIFSHLYILINRFRQGEVEDFKESDDAYIVT
NEKLHTIAVEAIDAIEQYLKMKLPERETFHFLQYLISSRFNHEIELVPGKILPIVEEMTDFYIEQVAAKINMPINKKQLK
IELLSHMKPMVNRMNHQINIKNNLLSDIKLEYGRLFEIIKETANDVAKTFKLNTISDDEVGYITIYFAKHMEASPLVKRI
IIMCSSGIGTSELLKVKVQKAFPDVEIVDVLSSTRFKNNLQDYQNIDFILTTINAESTKEIPSLLVSAMFTEKDKIMVKK
LMESL

Specific function: Positively regulates the expression of the mtlAFD operon involved in the uptake and catabolism of mannitol [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIB type-2 domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013196
- InterPro:   IPR007737
- InterPro:   IPR011608
- InterPro:   IPR016152
- InterPro:   IPR002178
- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR011991 [H]

Pfam domain/function: PF08279 HTH_11; PF05043 Mga; PF00874 PRD; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 56380; Mature: 56380

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS51099 PTS_EIIB_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLTKSEHALINLFLTKNDFLTAKQLAEILDVSSKTIYRKIKNINETTGRKDIIISEKGR
CCCCCCCCEEEEEEEECCCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEEEECCCC
GFKLDYKAYIQAKLETTGDIFGYTPTERREKILLQVLFKSPKYLNVTELYEDYYVGYNSI
CEEEEHHHEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCHHHH
KNDFSLLNQAIEKYDLALEKRQKEIRVVGTEENIRTAINEVINNLDLSTYDDLKTEYSDL
HHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCC
NKADVQFIVRQMELIENKLMISIPYPYDINIFSHLYILINRFRQGEVEDFKESDDAYIVT
CHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCHHHCCCCCEEEEE
NEKLHTIAVEAIDAIEQYLKMKLPERETFHFLQYLISSRFNHEIELVPGKILPIVEEMTD
CCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHH
FYIEQVAAKINMPINKKQLKIELLSHMKPMVNRMNHQINIKNNLLSDIKLEYGRLFEIIK
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHH
ETANDVAKTFKLNTISDDEVGYITIYFAKHMEASPLVKRIIIMCSSGIGTSELLKVKVQK
HHHHHHHHHEECCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHH
AFPDVEIVDVLSSTRFKNNLQDYQNIDFILTTINAESTKEIPSLLVSAMFTEKDKIMVKK
HCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHCCHHHHHHHH
LMESL
HHHHC
>Mature Secondary Structure
MLLTKSEHALINLFLTKNDFLTAKQLAEILDVSSKTIYRKIKNINETTGRKDIIISEKGR
CCCCCCCCEEEEEEEECCCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEEEECCCC
GFKLDYKAYIQAKLETTGDIFGYTPTERREKILLQVLFKSPKYLNVTELYEDYYVGYNSI
CEEEEHHHEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCHHHH
KNDFSLLNQAIEKYDLALEKRQKEIRVVGTEENIRTAINEVINNLDLSTYDDLKTEYSDL
HHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCC
NKADVQFIVRQMELIENKLMISIPYPYDINIFSHLYILINRFRQGEVEDFKESDDAYIVT
CHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCHHHCCCCCEEEEE
NEKLHTIAVEAIDAIEQYLKMKLPERETFHFLQYLISSRFNHEIELVPGKILPIVEEMTD
CCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHH
FYIEQVAAKINMPINKKQLKIELLSHMKPMVNRMNHQINIKNNLLSDIKLEYGRLFEIIK
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHH
ETANDVAKTFKLNTISDDEVGYITIYFAKHMEASPLVKRIIIMCSSGIGTSELLKVKVQK
HHHHHHHHHEECCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHH
AFPDVEIVDVLSSTRFKNNLQDYQNIDFILTTINAESTKEIPSLLVSAMFTEKDKIMVKK
HCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHCCHHHHHHHH
LMESL
HHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]