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The map label for this gene is lip2 [H]

Identifier: 226224695

GI number: 226224695

Start: 2167690

End: 2168733

Strand: Reverse

Name: lip2 [H]

Synonym: Lm4b_02110

Alternate gene names: 226224695

Gene position: 2168733-2167690 (Counterclockwise)

Preceding gene: 226224699

Following gene: 226224694

Centisome position: 74.46

GC content: 39.27

Gene sequence:

>1044_bases
GTGAAAAATACAATAAAATGGATCGCTATCGGTTTTGCTGGGATCATTCTACTTCCATTATTAATCGTTTTCTTTATTTA
CAAAAAAGCGGTTGGGAAAAAAGAATATAATCCCGAGGTACTGGAGAATTTAGATGAAGCTTCACAGGAATTTGTGAAAA
ACACTTCACCGTTATCCGACGTAGATTCGCGATATAAATATATGAGACTAGCGACAAAAGCATTACCTTCAGCAAAAGAT
ATCGAAATTGGCGATGTTGAAAATAAAAAAATTGATGGCCCGGCTGGCAAAATTCCAATTAGAATTTATACGCCGCAAGA
AGACGGACCTTTTGAAATTATCGTTTACTATCATGGTGGCGGATTTGTTCTAGGCGGACTGCAAACGCATGACGCGATTG
CCAGAAAACTTGTTCAAACAACAGGCGCTCGCGTTGTTACTGTTGATTACCGACTTGCTCCAGAAAATCCATTCCCAGCA
GCAGTGGAAGATGCCTATGCCGCGCTACTATGGGTTCAAAATCATCGTACTAGCTTGCGAGCTAAATCCTCAGACATTAT
CGTTGCAGGAGATAGCGTAGGAGGAAACTTAGCAACCGTTGTGACTCAAATTGCTAAATCAAAAGGTAAACCAAATATCA
CTGCTCAAATTTTACTTTATCCAGCGACAGATATTTTCAGTCGTGATGCGTCTGTTCTTTATCCTTCAATGGATGAATTT
GCAGAAGGCTACGTGCTTACGAAAGAATCATTAGATAAATTCTTTAAATTATATATTGCGAATGCAAGCGATCGTAAATA
CGATCCACTCGTTGCACCAATACGTAGCAAAGATTTAGTCGGACTTCCAAAAACATTTATTGCGACTGCTGAATTTGATC
CACTTAGAGATCAAGGGGAAGCATATGCGAAGAAATTAAAAGACGCCGGCGTAGAAGTATTTGCCAAACGCTTTGAAAAA
GTTCCACATGGCTTCATGACAACTAACTCAGAAGCGACCGATGAGACATACGAATTGATTAGCGAGTTTTTAGAAGAAAA
ATAA

Upstream 100 bases:

>100_bases
TTTCAAATAAAAATAATCATTTCAAATAGTAATAAATTGGTTCCTGTTCGTAAAACTGCTATACTTGTTAATGAAGTTAT
ATTGAAGGAGTTGAGCGAAT

Downstream 100 bases:

>100_bases
ATCCATGAATCCACTCTTTTATTAGAGTGGATTTTTTTGTTGACAAAGAAATTTTTTCGTGAGAGAATGACTTACGAACG
GTCGTCAGTTTTTGCGAGAG

Product: lipase

Products: NA

Alternate protein names: Triacylglycerol lipase [H]

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MKNTIKWIAIGFAGIILLPLLIVFFIYKKAVGKKEYNPEVLENLDEASQEFVKNTSPLSDVDSRYKYMRLATKALPSAKD
IEIGDVENKKIDGPAGKIPIRIYTPQEDGPFEIIVYYHGGGFVLGGLQTHDAIARKLVQTTGARVVTVDYRLAPENPFPA
AVEDAYAALLWVQNHRTSLRAKSSDIIVAGDSVGGNLATVVTQIAKSKGKPNITAQILLYPATDIFSRDASVLYPSMDEF
AEGYVLTKESLDKFFKLYIANASDRKYDPLVAPIRSKDLVGLPKTFIATAEFDPLRDQGEAYAKKLKDAGVEVFAKRFEK
VPHGFMTTNSEATDETYELISEFLEEK

Sequences:

>Translated_347_residues
MKNTIKWIAIGFAGIILLPLLIVFFIYKKAVGKKEYNPEVLENLDEASQEFVKNTSPLSDVDSRYKYMRLATKALPSAKD
IEIGDVENKKIDGPAGKIPIRIYTPQEDGPFEIIVYYHGGGFVLGGLQTHDAIARKLVQTTGARVVTVDYRLAPENPFPA
AVEDAYAALLWVQNHRTSLRAKSSDIIVAGDSVGGNLATVVTQIAKSKGKPNITAQILLYPATDIFSRDASVLYPSMDEF
AEGYVLTKESLDKFFKLYIANASDRKYDPLVAPIRSKDLVGLPKTFIATAEFDPLRDQGEAYAKKLKDAGVEVFAKRFEK
VPHGFMTTNSEATDETYELISEFLEEK
>Mature_347_residues
MKNTIKWIAIGFAGIILLPLLIVFFIYKKAVGKKEYNPEVLENLDEASQEFVKNTSPLSDVDSRYKYMRLATKALPSAKD
IEIGDVENKKIDGPAGKIPIRIYTPQEDGPFEIIVYYHGGGFVLGGLQTHDAIARKLVQTTGARVVTVDYRLAPENPFPA
AVEDAYAALLWVQNHRTSLRAKSSDIIVAGDSVGGNLATVVTQIAKSKGKPNITAQILLYPATDIFSRDASVLYPSMDEF
AEGYVLTKESLDKFFKLYIANASDRKYDPLVAPIRSKDLVGLPKTFIATAEFDPLRDQGEAYAKKLKDAGVEVFAKRFEK
VPHGFMTTNSEATDETYELISEFLEEK

Specific function: Has An Esterase Activity. Triacetyl Glycerol (Triacetin) Is A Substrate Of The Enzyme. [C]

COG id: COG0657

COG function: function code I; Esterase/lipase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'GDXG' lipolytic enzyme family [H]

Homologues:

Organism=Homo sapiens, GI206597554, Length=295, Percent_Identity=31.864406779661, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI68299767, Length=309, Percent_Identity=28.4789644012945, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI157041239, Length=291, Percent_Identity=28.8659793814433, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI21328446, Length=111, Percent_Identity=38.7387387387387, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI61966717, Length=277, Percent_Identity=23.826714801444, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI1786682, Length=235, Percent_Identity=31.4893617021277, Blast_Score=105, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17567059, Length=300, Percent_Identity=28, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI72001146, Length=309, Percent_Identity=25.5663430420712, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71996133, Length=314, Percent_Identity=26.1146496815287, Blast_Score=101, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17540028, Length=176, Percent_Identity=28.4090909090909, Blast_Score=85, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI115533410, Length=90, Percent_Identity=35.5555555555556, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI115533412, Length=90, Percent_Identity=35.5555555555556, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24656084, Length=89, Percent_Identity=37.0786516853933, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24656076, Length=89, Percent_Identity=37.0786516853933, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI20130169, Length=89, Percent_Identity=37.0786516853933, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013094
- InterPro:   IPR002168 [H]

Pfam domain/function: PF07859 Abhydrolase_3 [H]

EC number: =3.1.1.3 [H]

Molecular weight: Translated: 38471; Mature: 38471

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNTIKWIAIGFAGIILLPLLIVFFIYKKAVGKKEYNPEVLENLDEASQEFVKNTSPLSD
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHH
VDSRYKYMRLATKALPSAKDIEIGDVENKKIDGPAGKIPIRIYTPQEDGPFEIIVYYHGG
HHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEEEECC
GFVLGGLQTHDAIARKLVQTTGARVVTVDYRLAPENPFPAAVEDAYAALLWVQNHRTSLR
CEEECCCCHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCHHHHHHHHHHHEEECCCCHHE
AKSSDIIVAGDSVGGNLATVVTQIAKSKGKPNITAQILLYPATDIFSRDASVLYPSMDEF
ECCCCEEEECCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECHHHHCCCCCEECCCHHHH
AEGYVLTKESLDKFFKLYIANASDRKYDPLVAPIRSKDLVGLPKTFIATAEFDPLRDQGE
HCCEEEEHHHHHHHHHHHEECCCCCCCCCEECCCCCCCCCCCCHHHEEECCCCCCHHHHH
AYAKKLKDAGVEVFAKRFEKVPHGFMTTNSEATDETYELISEFLEEK
HHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MKNTIKWIAIGFAGIILLPLLIVFFIYKKAVGKKEYNPEVLENLDEASQEFVKNTSPLSD
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHH
VDSRYKYMRLATKALPSAKDIEIGDVENKKIDGPAGKIPIRIYTPQEDGPFEIIVYYHGG
HHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEEEECC
GFVLGGLQTHDAIARKLVQTTGARVVTVDYRLAPENPFPAAVEDAYAALLWVQNHRTSLR
CEEECCCCHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCHHHHHHHHHHHEEECCCCHHE
AKSSDIIVAGDSVGGNLATVVTQIAKSKGKPNITAQILLYPATDIFSRDASVLYPSMDEF
ECCCCEEEECCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECHHHHCCCCCEECCCHHHH
AEGYVLTKESLDKFFKLYIANASDRKYDPLVAPIRSKDLVGLPKTFIATAEFDPLRDQGE
HCCEEEEHHHHHHHHHHHEECCCCCCCCCEECCCCCCCCCCCCHHHEEECCCCCCHHHHH
AYAKKLKDAGVEVFAKRFEKVPHGFMTTNSEATDETYELISEFLEEK
HHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1907455 [H]