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The map label for this gene is ctaB

Identifier: 226224663

GI number: 226224663

Start: 2138540

End: 2139445

Strand: Reverse

Name: ctaB

Synonym: Lm4b_02078

Alternate gene names: 226224663

Gene position: 2139445-2138540 (Counterclockwise)

Preceding gene: 226224666

Following gene: 226224662

Centisome position: 73.45

GC content: 38.08

Gene sequence:

>906_bases
GTGAATCAGATAGAAAAGACTGGGGAGTTATCGGCGAGTAGATTTACTGTCCGTGATTTTACCGAGCTTGTGAAAATTGG
TATCGTGAATTCCAATACGATTACTGCTTTTACAGGAATGTGGTTAGCCTTTCAGTTAAATGGAATTTCTTTTATTCAAA
ATGTAGACGTGATATTTTTTACTATCGTCGGTTCAGCACTTATCGTAGCTGCTTCGGGCGCTTTTAACAATGTCATCGAC
CGTGATATTGACGGAATTATGGAAAGAACAAAAAACAGACCAACGATGACCGGGAAAATTTCTGGTAAACGAGCGCTAAT
GGTTGCGCTTGTGCTAGGTGTTGTCGGTACAATTATGTTATTTATGACAACTTGGCAAGCAGGAGTTCTTGGCGTTATCG
GGGTCTTTTTGTATGTAGTCGTTTATTCGCTATATGCAAAAAGAAAACTAGTTAGTAATACTGTAATTGGTAGTTTTTCA
GGCGCTGTCCCGCCGCTGATTGGTTGGTTTGCAGTCGAACCATCATTTAGCATCGTACCAATCATGCTGTTTCTCGTAAT
GTTTTGTTGGCAACCGCCGCATTTTTATGCGATTGCGATTAAACGGAAAGAGGAATACGCAGCTGCTGGAATTCCAATGT
TACCAGTAGTAAAAGGCATTGAACGTACAAAGAAAAGCATGTTTTTCTGGGTGATTTTATTAACTATCCTACCGTTCTTT
ATGTTTGAACTTGGCATCGTTTATGTTGTTTTAGCAACGTTACTGAATATCGGTTGGTTAGCACTTAGTATTTACGGCTT
TAAAATGGAAGATAGTATTAAATGGGCTAAATGGATGTTCGTTTACTCATTAAATTACATGACAATTTTATTCGTAGCAA
TGGTAGTTATTTCGATTTTCTTATAA

Upstream 100 bases:

>100_bases
TTATTGACAAAAGGGGCGTATTTTTCACATAATAAGGGTATAGGATATCTATCAGTTCGCAATCACTGGTTTATATCAGC
AAGTGTTAGGGGGAGAAAAA

Downstream 100 bases:

>100_bases
AAATAAAAAACAATTACGAAGAAGCGTGCAATACGCGTTTCCTTGTAATTGTTTTTTTTATGATTTTTAAAGCTTTTCAA
ATGATAATAGTATTGGTAAA

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MNQIEKTGELSASRFTVRDFTELVKIGIVNSNTITAFTGMWLAFQLNGISFIQNVDVIFFTIVGSALIVAASGAFNNVID
RDIDGIMERTKNRPTMTGKISGKRALMVALVLGVVGTIMLFMTTWQAGVLGVIGVFLYVVVYSLYAKRKLVSNTVIGSFS
GAVPPLIGWFAVEPSFSIVPIMLFLVMFCWQPPHFYAIAIKRKEEYAAAGIPMLPVVKGIERTKKSMFFWVILLTILPFF
MFELGIVYVVLATLLNIGWLALSIYGFKMEDSIKWAKWMFVYSLNYMTILFVAMVVISIFL

Sequences:

>Translated_301_residues
MNQIEKTGELSASRFTVRDFTELVKIGIVNSNTITAFTGMWLAFQLNGISFIQNVDVIFFTIVGSALIVAASGAFNNVID
RDIDGIMERTKNRPTMTGKISGKRALMVALVLGVVGTIMLFMTTWQAGVLGVIGVFLYVVVYSLYAKRKLVSNTVIGSFS
GAVPPLIGWFAVEPSFSIVPIMLFLVMFCWQPPHFYAIAIKRKEEYAAAGIPMLPVVKGIERTKKSMFFWVILLTILPFF
MFELGIVYVVLATLLNIGWLALSIYGFKMEDSIKWAKWMFVYSLNYMTILFVAMVVISIFL
>Mature_301_residues
MNQIEKTGELSASRFTVRDFTELVKIGIVNSNTITAFTGMWLAFQLNGISFIQNVDVIFFTIVGSALIVAASGAFNNVID
RDIDGIMERTKNRPTMTGKISGKRALMVALVLGVVGTIMLFMTTWQAGVLGVIGVFLYVVVYSLYAKRKLVSNTVIGSFS
GAVPPLIGWFAVEPSFSIVPIMLFLVMFCWQPPHFYAIAIKRKEEYAAAGIPMLPVVKGIERTKKSMFFWVILLTILPFF
MFELGIVYVVLATLLNIGWLALSIYGFKMEDSIKWAKWMFVYSLNYMTILFVAMVVISIFL

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group [H]

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI17921982, Length=163, Percent_Identity=33.1288343558282, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI1786631, Length=284, Percent_Identity=40.4929577464789, Blast_Score=177, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI71998235, Length=234, Percent_Identity=26.4957264957265, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6325085, Length=161, Percent_Identity=31.055900621118, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI19921064, Length=234, Percent_Identity=29.4871794871795, Blast_Score=89, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006369
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.-

Molecular weight: Translated: 33652; Mature: 33652

Theoretical pI: Translated: 10.00; Mature: 10.00

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQIEKTGELSASRFTVRDFTELVKIGIVNSNTITAFTGMWLAFQLNGISFIQNVDVIFF
CCCCCCCCCCCCCCEEHHHHHHHHHHHCCCCCCCHHHHHHEEEEEECCHHHHHHHHHHHH
TIVGSALIVAASGAFNNVIDRDIDGIMERTKNRPTMTGKISGKRALMVALVLGVVGTIML
HHHHHHHHHEECCHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHH
FMTTWQAGVLGVIGVFLYVVVYSLYAKRKLVSNTVIGSFSGAVPPLIGWFAVEPSFSIVP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHEEECCCCCHHH
IMLFLVMFCWQPPHFYAIAIKRKEEYAAAGIPMLPVVKGIERTKKSMFFWVILLTILPFF
HHHHHHHHHCCCCCEEEEEEEECHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MFELGIVYVVLATLLNIGWLALSIYGFKMEDSIKWAKWMFVYSLNYMTILFVAMVVISIF
HHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
L
C
>Mature Secondary Structure
MNQIEKTGELSASRFTVRDFTELVKIGIVNSNTITAFTGMWLAFQLNGISFIQNVDVIFF
CCCCCCCCCCCCCCEEHHHHHHHHHHHCCCCCCCHHHHHHEEEEEECCHHHHHHHHHHHH
TIVGSALIVAASGAFNNVIDRDIDGIMERTKNRPTMTGKISGKRALMVALVLGVVGTIML
HHHHHHHHHEECCHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHH
FMTTWQAGVLGVIGVFLYVVVYSLYAKRKLVSNTVIGSFSGAVPPLIGWFAVEPSFSIVP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHEEECCCCCHHH
IMLFLVMFCWQPPHFYAIAIKRKEEYAAAGIPMLPVVKGIERTKKSMFFWVILLTILPFF
HHHHHHHHHCCCCCEEEEEEEECHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MFELGIVYVVLATLLNIGWLALSIYGFKMEDSIKWAKWMFVYSLNYMTILFVAMVVISIF
HHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
L
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]