Click here to switch to the map view.

The map label for this gene is lysA

Identifier: 226224557

GI number: 226224557

Start: 2020320

End: 2021630

Strand: Reverse

Name: lysA

Synonym: Lm4b_01971

Alternate gene names: 226224557

Gene position: 2021630-2020320 (Counterclockwise)

Preceding gene: 226224558

Following gene: 226224556

Centisome position: 69.41

GC content: 40.27

Gene sequence:

>1311_bases
GTGACGTTTGAACGGCTTGGAACAATGAATGTAAATGCAGAAGGACATCTCGAAATTGGAGGGGTGGACACTTTAAAGCT
TACTGAAAAATATGGTACGCCACTTTACGTTTATGATGTAGCGCTAATCCGTGACCGAGCAAGAGGATTTAAGAAAACAT
TCGAGGAACTAGGCGTAAAAGCACAAGTGGCTTATGCGAGCAAAGCATTTTCTGCAGTAGCGATTTATCAGCTGATGGCC
GAAGAAGGTTTATCACTAGATGTTGTTTCAGGCGGAGAACTTTATACAGCAATTAAAGCAAATTTTCCTCCTGAGAGAAT
TCATTTTCACGGAAATAATAAAAGTGCAGAAGAAATACATATGGCGCTTGACTATGGCATCGGTTGTTTTGTTATCGATA
ATTATTATGAAATTAGTTTATTAGAAGATATATTAATAGAACGAAATGAAAAGGCATCGGTTTTAATTCGCGTGACACCG
GGGATAGAAGCTCATACACATGACTATATTTTAACAGGCCAAGATGATTCGAAATTTGGATTTGGACTTACAAATGGACA
AGCTGAAAAAGCGATTAAACAAGTGCTTCATGCAAGTGCGTCCTTTGATTTAATTGGCCTACACTGTCATATTGGGTCGC
AAATTTTTGAAACAACGGGTTTTAAATTAGCGGCTCGTCGTATTATGGATAAATTAGTTGAATGGCACCAAACTCTGGGA
TTTGATTCCAAAGTACTTAATCTTGGTGGCGGTTTCGGTGTCCGTTATACGGCAGAAGATGAACCTCTTGAACCTAGCGA
ATATGTGCGCCAAATTATGGATGAAGTGCGGGATGTGGCTAATAATAACGATATTGATATTCCAGAAATTTGGATTGAGC
CAGGTCGTTCCCTTGTTGGTGAAGCAGGTACAACACTTTATAAAGTTGGATCGCGTAAAGAAGTTCCGGGAATTCGGAAT
TATATCGCAGTTGACGGCGGCATGTCTGATAATATCCGTCCAGCGTTATATGATGCGCATTACGATGCTGTTCTTGCGGC
AAACCCAGAGAAAGTCGCAGAAGAAACAGTGGCTATCGCAGGAAAATGCTGTGAGTCTGGTGATATGTTAATATGGGACT
TACCACTACCGAAATCAAACGCCGGTGAAGTTTTGGCGGTATTTTGTACTGGAGCCTATGGTTATGCGATGGCAAGTAAT
TATAACCGTATCCCAAGACCACCAGTTGTTTTTGTGGAAAACGGAGTCGATAAATTAATCGTTGCCCGCGAAACATATGA
AAATTTAGTGCAAAATGATCTTTCATTATAG

Upstream 100 bases:

>100_bases
TATTTGATAATATTTTCAGATAGTTATTGTCGCTCGGCTTCTTAGTGTGCTACTATATAAAAGAACTTTTAAAAATCTAT
AATGTAAAGGTGGGATTGGC

Downstream 100 bases:

>100_bases
TAGGGCGGGACAGATATGGTAGAAATGAATTTTAAAGTGGACGCGTTTGAAGGACCGCTTGACTTACTTCTTCATTTAAT
TGGACAACTAGAAGTCGATA

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MTFERLGTMNVNAEGHLEIGGVDTLKLTEKYGTPLYVYDVALIRDRARGFKKTFEELGVKAQVAYASKAFSAVAIYQLMA
EEGLSLDVVSGGELYTAIKANFPPERIHFHGNNKSAEEIHMALDYGIGCFVIDNYYEISLLEDILIERNEKASVLIRVTP
GIEAHTHDYILTGQDDSKFGFGLTNGQAEKAIKQVLHASASFDLIGLHCHIGSQIFETTGFKLAARRIMDKLVEWHQTLG
FDSKVLNLGGGFGVRYTAEDEPLEPSEYVRQIMDEVRDVANNNDIDIPEIWIEPGRSLVGEAGTTLYKVGSRKEVPGIRN
YIAVDGGMSDNIRPALYDAHYDAVLAANPEKVAEETVAIAGKCCESGDMLIWDLPLPKSNAGEVLAVFCTGAYGYAMASN
YNRIPRPPVVFVENGVDKLIVARETYENLVQNDLSL

Sequences:

>Translated_436_residues
MTFERLGTMNVNAEGHLEIGGVDTLKLTEKYGTPLYVYDVALIRDRARGFKKTFEELGVKAQVAYASKAFSAVAIYQLMA
EEGLSLDVVSGGELYTAIKANFPPERIHFHGNNKSAEEIHMALDYGIGCFVIDNYYEISLLEDILIERNEKASVLIRVTP
GIEAHTHDYILTGQDDSKFGFGLTNGQAEKAIKQVLHASASFDLIGLHCHIGSQIFETTGFKLAARRIMDKLVEWHQTLG
FDSKVLNLGGGFGVRYTAEDEPLEPSEYVRQIMDEVRDVANNNDIDIPEIWIEPGRSLVGEAGTTLYKVGSRKEVPGIRN
YIAVDGGMSDNIRPALYDAHYDAVLAANPEKVAEETVAIAGKCCESGDMLIWDLPLPKSNAGEVLAVFCTGAYGYAMASN
YNRIPRPPVVFVENGVDKLIVARETYENLVQNDLSL
>Mature_435_residues
TFERLGTMNVNAEGHLEIGGVDTLKLTEKYGTPLYVYDVALIRDRARGFKKTFEELGVKAQVAYASKAFSAVAIYQLMAE
EGLSLDVVSGGELYTAIKANFPPERIHFHGNNKSAEEIHMALDYGIGCFVIDNYYEISLLEDILIERNEKASVLIRVTPG
IEAHTHDYILTGQDDSKFGFGLTNGQAEKAIKQVLHASASFDLIGLHCHIGSQIFETTGFKLAARRIMDKLVEWHQTLGF
DSKVLNLGGGFGVRYTAEDEPLEPSEYVRQIMDEVRDVANNNDIDIPEIWIEPGRSLVGEAGTTLYKVGSRKEVPGIRNY
IAVDGGMSDNIRPALYDAHYDAVLAANPEKVAEETVAIAGKCCESGDMLIWDLPLPKSNAGEVLAVFCTGAYGYAMASNY
NRIPRPPVVFVENGVDKLIVARETYENLVQNDLSL

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=371, Percent_Identity=25.3369272237197, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI22538418, Length=416, Percent_Identity=25, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI21361583, Length=416, Percent_Identity=25, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI1789203, Length=417, Percent_Identity=31.4148681055156, Blast_Score=155, Evalue=4e-39,
Organism=Drosophila melanogaster, GI24586472, Length=401, Percent_Identity=23.1920199501247, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 48056; Mature: 47925

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFERLGTMNVNAEGHLEIGGVDTLKLTEKYGTPLYVYDVALIRDRARGFKKTFEELGVK
CCHHHCCEEECCCCCEEEECCCEEEEEHHHCCCEEEEEHHHHHHHHHHHHHHHHHHCCCE
AQVAYASKAFSAVAIYQLMAEEGLSLDVVSGGELYTAIKANFPPERIHFHGNNKSAEEIH
EEEEHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEEECCCCHHHEEEECCCCCHHHHH
MALDYGIGCFVIDNYYEISLLEDILIERNEKASVLIRVTPGIEAHTHDYILTGQDDSKFG
HHHHCCCEEEEECCCEEHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCEEEECCCCCCCC
FGLTNGQAEKAIKQVLHASASFDLIGLHCHIGSQIFETTGFKLAARRIMDKLVEWHQTLG
CCCCCCHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHCCHHHHHHHHHHHHHHHHHHCC
FDSKVLNLGGGFGVRYTAEDEPLEPSEYVRQIMDEVRDVANNNDIDIPEIWIEPGRSLVG
CCCEEEECCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHC
EAGTTLYKVGSRKEVPGIRNYIAVDGGMSDNIRPALYDAHYDAVLAANPEKVAEETVAIA
CCCCEEEECCCCCCCCCCCCEEEECCCCCCCCCCEEECCCCCEEEECCHHHHHHHHHHHH
GKCCESGDMLIWDLPLPKSNAGEVLAVFCTGAYGYAMASNYNRIPRPPVVFVENGVDKLI
HHCCCCCCEEEEECCCCCCCCCCEEEEEECCCCHHHHHCCCCCCCCCCEEEEECCCCCEE
VARETYENLVQNDLSL
EEHHHHHHHHHHHCCC
>Mature Secondary Structure 
TFERLGTMNVNAEGHLEIGGVDTLKLTEKYGTPLYVYDVALIRDRARGFKKTFEELGVK
CHHHCCEEECCCCCEEEECCCEEEEEHHHCCCEEEEEHHHHHHHHHHHHHHHHHHCCCE
AQVAYASKAFSAVAIYQLMAEEGLSLDVVSGGELYTAIKANFPPERIHFHGNNKSAEEIH
EEEEHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEEECCCCHHHEEEECCCCCHHHHH
MALDYGIGCFVIDNYYEISLLEDILIERNEKASVLIRVTPGIEAHTHDYILTGQDDSKFG
HHHHCCCEEEEECCCEEHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCEEEECCCCCCCC
FGLTNGQAEKAIKQVLHASASFDLIGLHCHIGSQIFETTGFKLAARRIMDKLVEWHQTLG
CCCCCCHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHCCHHHHHHHHHHHHHHHHHHCC
FDSKVLNLGGGFGVRYTAEDEPLEPSEYVRQIMDEVRDVANNNDIDIPEIWIEPGRSLVG
CCCEEEECCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHC
EAGTTLYKVGSRKEVPGIRNYIAVDGGMSDNIRPALYDAHYDAVLAANPEKVAEETVAIA
CCCCEEEECCCCCCCCCCCCEEEECCCCCCCCCCEEECCCCCEEEECCHHHHHHHHHHHH
GKCCESGDMLIWDLPLPKSNAGEVLAVFCTGAYGYAMASNYNRIPRPPVVFVENGVDKLI
HHCCCCCCEEEEECCCCCCCCCCEEEEEECCCCHHHHHCCCCCCCCCCEEEEECCCCCEE
VARETYENLVQNDLSL
EEHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8215365 [H]