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The map label for this gene is aroB

Identifier: 226224531

GI number: 226224531

Start: 1989910

End: 1991007

Strand: Reverse

Name: aroB

Synonym: Lm4b_01944

Alternate gene names: 226224531

Gene position: 1991007-1989910 (Counterclockwise)

Preceding gene: 226224532

Following gene: 226224530

Centisome position: 68.36

GC content: 41.35

Gene sequence:

>1098_bases
ATGCCAGAAATTACAGTCCGTGCTAAAAGTAAAACATACCCAGTATATATTAATGAATTCGCATTAGAAGATGTCCGGGA
AAAGTGGACGGAGAGCCTAGCTAAATTTTCCCACGTGTTTGTTTTGACGGACGAGCATGTGGCGGAACTTCATAAAGCAA
AGCTTGACGCGGTTCTCGCTGATTTACCTGTAGTCACTTATTATGTGGCGCCAAATGGGGAAGAAGCGAAAACGTTTCGT
GTATATGAAGATGTGATGACAAAATTGATTGAAACAGGTCTTGATCGTAAAGCGGTTTTAATTGCTTTTGGTGGAGGCGT
TATTGGTGATTTAGGTGGTTTTGTTGCGGCTACGTATATGAGGGGCATTCCTTTTTATCAGGTGCCTACGACGGTTCTTG
CGCATGATAGTGCCGTGGGTGGCAAGGTTGCGATCAATCATCCGCTTGGCAAAAACATGATTGGGAACTTTTACCAGCCA
GAAGCAGTCATTTATGATACCCAGTTCTTTGCTACCTTGCCAGAACGGGAAATGCGCTCTGGTTTTGCGGAAATGATTAA
ACATGCGCTTATTAGCGATCAGACGTTACTACGGGCCTTAATGGATACATTTACGGAGCCGAAAGACTTTTATACGAAGG
ATTTGACGCCGTTTTTACAACGTGGGATTGAAATTAAAGCAAATATCGTTGCGCAAGATGAAACCGAGCAAGGCGTGCGC
GCTTATTTGAATTTTGGTCACACATTTGGTCATGCACTTGAAGCCTACGGAAACTTTGGCAAGTGGCTGCACGGCGAGGC
GATTACTTATGGGATGATTTATGCACTCACGATGAGTGAGACAATTTACGGACTGGATTTCGATTTAGCAGAATTTAAAA
CGTGGCTAAAACAGTTAGGCTATGATACGACATTTGATGCAACTGTTCCATTTAATAAAATACTGGAAAATATGCGTCAT
GATAAAAAAACAACTTTTAATGAAATAAGTATGGTTTTACTCGAAGAAATTGGAAAACCGGTTATTTTTAAAGCGGAAGA
TGATTTGATTTTTGAAACTTACAAACGTGTGATGCGAAATGGAGGGAATGGCATTTGA

Upstream 100 bases:

>100_bases
AAGTTGCAGTTGCTGTGTTAGAAAAATTTGATGGTGATCGTTTTGACACACTTAAAAAACATGTGGAGGAACACCGAAAC
TTAACGAAGGAGTTTTAAAC

Downstream 100 bases:

>100_bases
GAGCAATTCGAGGGGCAACGACAATAGAAACTAACTCACCGGAAGCAATTTATGCAGCGACGAAAGAATTATTTGAAGAA
ATTTTAACGCAAAATGAAAT

Product: 3-dehydroquinate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 365; Mature: 364

Protein sequence:

>365_residues
MPEITVRAKSKTYPVYINEFALEDVREKWTESLAKFSHVFVLTDEHVAELHKAKLDAVLADLPVVTYYVAPNGEEAKTFR
VYEDVMTKLIETGLDRKAVLIAFGGGVIGDLGGFVAATYMRGIPFYQVPTTVLAHDSAVGGKVAINHPLGKNMIGNFYQP
EAVIYDTQFFATLPEREMRSGFAEMIKHALISDQTLLRALMDTFTEPKDFYTKDLTPFLQRGIEIKANIVAQDETEQGVR
AYLNFGHTFGHALEAYGNFGKWLHGEAITYGMIYALTMSETIYGLDFDLAEFKTWLKQLGYDTTFDATVPFNKILENMRH
DKKTTFNEISMVLLEEIGKPVIFKAEDDLIFETYKRVMRNGGNGI

Sequences:

>Translated_365_residues
MPEITVRAKSKTYPVYINEFALEDVREKWTESLAKFSHVFVLTDEHVAELHKAKLDAVLADLPVVTYYVAPNGEEAKTFR
VYEDVMTKLIETGLDRKAVLIAFGGGVIGDLGGFVAATYMRGIPFYQVPTTVLAHDSAVGGKVAINHPLGKNMIGNFYQP
EAVIYDTQFFATLPEREMRSGFAEMIKHALISDQTLLRALMDTFTEPKDFYTKDLTPFLQRGIEIKANIVAQDETEQGVR
AYLNFGHTFGHALEAYGNFGKWLHGEAITYGMIYALTMSETIYGLDFDLAEFKTWLKQLGYDTTFDATVPFNKILENMRH
DKKTTFNEISMVLLEEIGKPVIFKAEDDLIFETYKRVMRNGGNGI
>Mature_364_residues
PEITVRAKSKTYPVYINEFALEDVREKWTESLAKFSHVFVLTDEHVAELHKAKLDAVLADLPVVTYYVAPNGEEAKTFRV
YEDVMTKLIETGLDRKAVLIAFGGGVIGDLGGFVAATYMRGIPFYQVPTTVLAHDSAVGGKVAINHPLGKNMIGNFYQPE
AVIYDTQFFATLPEREMRSGFAEMIKHALISDQTLLRALMDTFTEPKDFYTKDLTPFLQRGIEIKANIVAQDETEQGVRA
YLNFGHTFGHALEAYGNFGKWLHGEAITYGMIYALTMSETIYGLDFDLAEFKTWLKQLGYDTTFDATVPFNKILENMRHD
KKTTFNEISMVLLEEIGKPVIFKAEDDLIFETYKRVMRNGGNGI

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; second step. [C]

COG id: COG0337

COG function: function code E; 3-dehydroquinate synthetase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dehydroquinate synthase family [H]

Homologues:

Organism=Escherichia coli, GI1789791, Length=344, Percent_Identity=40.1162790697674, Blast_Score=224, Evalue=8e-60,
Organism=Saccharomyces cerevisiae, GI6320332, Length=345, Percent_Identity=34.7826086956522, Blast_Score=170, Evalue=4e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016303
- InterPro:   IPR002658
- InterPro:   IPR016037 [H]

Pfam domain/function: PF01761 DHQ_synthase [H]

EC number: =4.2.3.4 [H]

Molecular weight: Translated: 41200; Mature: 41069

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEITVRAKSKTYPVYINEFALEDVREKWTESLAKFSHVFVLTDEHVAELHKAKLDAVLA
CCCEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHHH
DLPVVTYYVAPNGEEAKTFRVYEDVMTKLIETGLDRKAVLIAFGGGVIGDLGGFVAATYM
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHH
RGIPFYQVPTTVLAHDSAVGGKVAINHPLGKNMIGNFYQPEAVIYDTQFFATLPEREMRS
HCCCCEECCHHHEECCCCCCCEEEECCCCCCHHCCCCCCCCEEEEECHHHHHCCHHHHHH
GFAEMIKHALISDQTLLRALMDTFTEPKDFYTKDLTPFLQRGIEIKANIVAQDETEQGVR
HHHHHHHHHHHCHHHHHHHHHHHCCCCHHHHHHCCCHHHHCCCEEEEEEEECCCHHHHHH
AYLNFGHTFGHALEAYGNFGKWLHGEAITYGMIYALTMSETIYGLDFDLAEFKTWLKQLG
HHHHHCHHHHHHHHHHCCCCCHHCCCHHHHHHHHEEEHHHHHCCCCCCHHHHHHHHHHCC
YDTTFDATVPFNKILENMRHDKKTTFNEISMVLLEEIGKPVIFKAEDDLIFETYKRVMRN
CCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHC
GGNGI
CCCCC
>Mature Secondary Structure 
PEITVRAKSKTYPVYINEFALEDVREKWTESLAKFSHVFVLTDEHVAELHKAKLDAVLA
CCEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHHH
DLPVVTYYVAPNGEEAKTFRVYEDVMTKLIETGLDRKAVLIAFGGGVIGDLGGFVAATYM
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHH
RGIPFYQVPTTVLAHDSAVGGKVAINHPLGKNMIGNFYQPEAVIYDTQFFATLPEREMRS
HCCCCEECCHHHEECCCCCCCEEEECCCCCCHHCCCCCCCCEEEEECHHHHHCCHHHHHH
GFAEMIKHALISDQTLLRALMDTFTEPKDFYTKDLTPFLQRGIEIKANIVAQDETEQGVR
HHHHHHHHHHHCHHHHHHHHHHHCCCCHHHHHHCCCHHHHCCCEEEEEEEECCCHHHHHH
AYLNFGHTFGHALEAYGNFGKWLHGEAITYGMIYALTMSETIYGLDFDLAEFKTWLKQLG
HHHHHCHHHHHHHHHHCCCCCHHCCCHHHHHHHHEEEHHHHHCCCCCCHHHHHHHHHHCC
YDTTFDATVPFNKILENMRHDKKTTFNEISMVLLEEIGKPVIFKAEDDLIFETYKRVMRN
CCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHC
GGNGI
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]