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The map label for this gene is pyrD

Identifier: 226224436

GI number: 226224436

Start: 1894171

End: 1895085

Strand: Reverse

Name: pyrD

Synonym: Lm4b_01849

Alternate gene names: 226224436

Gene position: 1895085-1894171 (Counterclockwise)

Preceding gene: 226224437

Following gene: 226224435

Centisome position: 65.06

GC content: 45.03

Gene sequence:

>915_bases
ATGAACCGATTAGCAGTAGAAATTCCTGGATTATCGCTCAAAAACCCGATTATGCCAGCATCAGGATGTTTTGGCTTCGG
ACAAGAATATAGCAAATACTATGATTTAAATGAACTTGGTGCGATTATGGCCAAAGCCGTGACGCCAGAACCTAGACTTG
GGAATCCCACTCCGCGAGTAGCAGAAACCGCGAGCGGGATGCTGAATGCAATCGGCTTACAAAATCCAGGTCTAGAGCAT
GTTTTGGCGCACGAACTGCCATTTTTAGAACAATTTGAAACACCGATTATCGCTAATGTGGCGGGTGCGACGGAGGATGA
TTATGTCCAAGTCTGCGCCAGAATTGGGGAATCGAAAGCAGTGAAAGCCATCGAACTTAATATTTCCTGTCCCAATGTGA
AACATGGGGGTATCGCATTTGGAACAGATCCGGATGTTGCGCATCGTTTAACGAAAGCCGTGAAAAATGTCGCAACTGTG
CCAGTTTACGTGAAATTATCACCGAATGTAGCGGATATTGTTTCCATCGCGCAAGCAATTGAAGCCGCTGGTGCGGACGG
ACTCACAATGATAAATACCTTACTCGGCATGCGTATTGATTTAAAAACAAGAAAACCAATCATCGCAAATGGAACAGGTG
GACTTTCTGGCCCAGCGATTAAACCGGTGGCTATTCGGATGATTCACCAAGTCCGCGAGGTAAGCAATATCCCTATCATT
GGCATGGGCGGCGTGCAAACTGTAGATGACGTATTAGAATTCTTGATTGCCGGAGCAGATGCAGTCGCAGTAGGCACGAT
GAATTTTACCGACCCATTTATTTGTCCGAAATTAATTAGCGAACTACCAAAACGAATGGATGAACTCGGTATTTCTTCCC
TACAAGAACTTAAAAAGGAGCGAACAAATCAATGA

Upstream 100 bases:

>100_bases
GGGCTTGCTACGCTTGTGTTTGTCCAAAAGCAGATGATGCGAAAAAACAATTTAAAGTGTGCGAAGACGGCCCAGTATTT
CGTGCGGATGAGGTGAGTTT

Downstream 100 bases:

>100_bases
ATAAACCAATTATCGCGCTAGATTTCCAGACTTACGAAGAAGTAGAGACCTTTTTAGCCAAATTTTCGGGAGAAACGCTA
TCCGTGAAAGTCGGCATGGA

Product: dihydroorotate dehydrogenase 1B

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MNRLAVEIPGLSLKNPIMPASGCFGFGQEYSKYYDLNELGAIMAKAVTPEPRLGNPTPRVAETASGMLNAIGLQNPGLEH
VLAHELPFLEQFETPIIANVAGATEDDYVQVCARIGESKAVKAIELNISCPNVKHGGIAFGTDPDVAHRLTKAVKNVATV
PVYVKLSPNVADIVSIAQAIEAAGADGLTMINTLLGMRIDLKTRKPIIANGTGGLSGPAIKPVAIRMIHQVREVSNIPII
GMGGVQTVDDVLEFLIAGADAVAVGTMNFTDPFICPKLISELPKRMDELGISSLQELKKERTNQ

Sequences:

>Translated_304_residues
MNRLAVEIPGLSLKNPIMPASGCFGFGQEYSKYYDLNELGAIMAKAVTPEPRLGNPTPRVAETASGMLNAIGLQNPGLEH
VLAHELPFLEQFETPIIANVAGATEDDYVQVCARIGESKAVKAIELNISCPNVKHGGIAFGTDPDVAHRLTKAVKNVATV
PVYVKLSPNVADIVSIAQAIEAAGADGLTMINTLLGMRIDLKTRKPIIANGTGGLSGPAIKPVAIRMIHQVREVSNIPII
GMGGVQTVDDVLEFLIAGADAVAVGTMNFTDPFICPKLISELPKRMDELGISSLQELKKERTNQ
>Mature_304_residues
MNRLAVEIPGLSLKNPIMPASGCFGFGQEYSKYYDLNELGAIMAKAVTPEPRLGNPTPRVAETASGMLNAIGLQNPGLEH
VLAHELPFLEQFETPIIANVAGATEDDYVQVCARIGESKAVKAIELNISCPNVKHGGIAFGTDPDVAHRLTKAVKNVATV
PVYVKLSPNVADIVSIAQAIEAAGADGLTMINTLLGMRIDLKTRKPIIANGTGGLSGPAIKPVAIRMIHQVREVSNIPII
GMGGVQTVDDVLEFLIAGADAVAVGTMNFTDPFICPKLISELPKRMDELGISSLQELKKERTNQ

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=183, Percent_Identity=35.5191256830601, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI45006951, Length=318, Percent_Identity=26.7295597484277, Blast_Score=84, Evalue=1e-16,
Organism=Escherichia coli, GI87082059, Length=318, Percent_Identity=29.874213836478, Blast_Score=119, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI71984108, Length=178, Percent_Identity=31.4606741573034, Blast_Score=92, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6322633, Length=302, Percent_Identity=28.476821192053, Blast_Score=100, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24640763, Length=187, Percent_Identity=35.2941176470588, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI18858217, Length=187, Percent_Identity=35.2941176470588, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI281361352, Length=319, Percent_Identity=28.8401253918495, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI17137316, Length=319, Percent_Identity=28.8401253918495, Blast_Score=81, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.3.1 [H]

Molecular weight: Translated: 32312; Mature: 32312

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRLAVEIPGLSLKNPIMPASGCFGFGQEYSKYYDLNELGAIMAKAVTPEPRLGNPTPRV
CCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCHH
AETASGMLNAIGLQNPGLEHVLAHELPFLEQFETPIIANVAGATEDDYVQVCARIGESKA
HHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHCCCCEEEECCCCCHHHHHHHHHHCCCCC
VKAIELNISCPNVKHGGIAFGTDPDVAHRLTKAVKNVATVPVYVKLSPNVADIVSIAQAI
EEEEEEEEECCCCCCCCEEECCCHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHH
EAAGADGLTMINTLLGMRIDLKTRKPIIANGTGGLSGPAIKPVAIRMIHQVREVSNIPII
HHCCCCCHHHHHHHHCCEEEECCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCEE
GMGGVQTVDDVLEFLIAGADAVAVGTMNFTDPFICPKLISELPKRMDELGISSLQELKKE
ECCCHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHH
RTNQ
HCCC
>Mature Secondary Structure
MNRLAVEIPGLSLKNPIMPASGCFGFGQEYSKYYDLNELGAIMAKAVTPEPRLGNPTPRV
CCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCHH
AETASGMLNAIGLQNPGLEHVLAHELPFLEQFETPIIANVAGATEDDYVQVCARIGESKA
HHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHCCCCEEEECCCCCHHHHHHHHHHCCCCC
VKAIELNISCPNVKHGGIAFGTDPDVAHRLTKAVKNVATVPVYVKLSPNVADIVSIAQAI
EEEEEEEEECCCCCCCCEEECCCHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHH
EAAGADGLTMINTLLGMRIDLKTRKPIIANGTGGLSGPAIKPVAIRMIHQVREVSNIPII
HHCCCCCHHHHHHHHCCEEEECCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCEE
GMGGVQTVDDVLEFLIAGADAVAVGTMNFTDPFICPKLISELPKRMDELGISSLQELKKE
ECCCHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHH
RTNQ
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]