Click here to switch to the map view.

The map label for this gene is gmk

Identifier: 226224430

GI number: 226224430

Start: 1888740

End: 1889357

Strand: Reverse

Name: gmk

Synonym: Lm4b_01843

Alternate gene names: 226224430

Gene position: 1889357-1888740 (Counterclockwise)

Preceding gene: 226224431

Following gene: 226224429

Centisome position: 64.87

GC content: 40.78

Gene sequence:

>618_bases
ATGACAGAAAGAGGACTGTTAATTGTACTTTCAGGTCCATCTGGAGTAGGTAAGGGAACTGTTCGGGAAGCTGTTTTTAA
AGATCCAGAAACAAGTTTTGATTATTCTATTTCCATGACAACGCGTCTTCCTCGTGAAGGCGAACAAGACGGGGTCGATT
ATTATTTTCGTTCACGAGAAGTGTTTGAACAAGCTATCAAAGACGGAAAGATGTTAGAATATGCAGAGTACGTCGGTAAT
TATTACGGCACTCCGCTTGAATATGTCGAGGAAAAATTAGCCGCAGGAGTGGATATTTTTCTCGAAATTGAAGTACAAGG
AGCAATGCAAGTTCGAAAAGCGATGCCAGAAGGAATTTTCATTTTCTTAACGCCACCAGATTTGTCTGAGCTTAAAAACC
GGATTATCGGTCGCGGTACAGAATCGATGGAAGTTGTCGAGGAACGCATGGAAACAGCGAAGAAAGAAATCGAAATGATG
GCGTCTTATGATTATGCTGTGGTGAATGATGTAGTTGCAAACGCCGTACAAAAAATCAAAGGCATCGTCGAAACAGAACA
CTTAAAAACTGAGCGAGTAATTCATCGCTACAAAAAAATGTTGGAGGGATTACAATGA

Upstream 100 bases:

>100_bases
TTCTCTAAAAATCACTGAACAAGTGGTAGAAATGAAAACGACGCTTGAAAAAATTCGAGAACAAGTGCAAAATGTGGAAT
GATATGCAGGAGGGGAAATG

Downstream 100 bases:

>100_bases
TGTTATATCCATCAATTGATAATTTATTGTTAAAAATCGACTCAAAATATTCGCTAGTTACAGTGGCCGCTAAACGCGCA
CGCTACATGCAACTGGAAAA

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 205; Mature: 204

Protein sequence:

>205_residues
MTERGLLIVLSGPSGVGKGTVREAVFKDPETSFDYSISMTTRLPREGEQDGVDYYFRSREVFEQAIKDGKMLEYAEYVGN
YYGTPLEYVEEKLAAGVDIFLEIEVQGAMQVRKAMPEGIFIFLTPPDLSELKNRIIGRGTESMEVVEERMETAKKEIEMM
ASYDYAVVNDVVANAVQKIKGIVETEHLKTERVIHRYKKMLEGLQ

Sequences:

>Translated_205_residues
MTERGLLIVLSGPSGVGKGTVREAVFKDPETSFDYSISMTTRLPREGEQDGVDYYFRSREVFEQAIKDGKMLEYAEYVGN
YYGTPLEYVEEKLAAGVDIFLEIEVQGAMQVRKAMPEGIFIFLTPPDLSELKNRIIGRGTESMEVVEERMETAKKEIEMM
ASYDYAVVNDVVANAVQKIKGIVETEHLKTERVIHRYKKMLEGLQ
>Mature_204_residues
TERGLLIVLSGPSGVGKGTVREAVFKDPETSFDYSISMTTRLPREGEQDGVDYYFRSREVFEQAIKDGKMLEYAEYVGNY
YGTPLEYVEEKLAAGVDIFLEIEVQGAMQVRKAMPEGIFIFLTPPDLSELKNRIIGRGTESMEVVEERMETAKKEIEMMA
SYDYAVVNDVVANAVQKIKGIVETEHLKTERVIHRYKKMLEGLQ

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=189, Percent_Identity=34.3915343915344, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI4504221, Length=189, Percent_Identity=34.3915343915344, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI226874831, Length=189, Percent_Identity=34.3915343915344, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI14780902, Length=193, Percent_Identity=28.4974093264249, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI38570142, Length=176, Percent_Identity=29.5454545454545, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI4505237, Length=173, Percent_Identity=29.4797687861272, Blast_Score=81, Evalue=7e-16,
Organism=Homo sapiens, GI262118259, Length=173, Percent_Identity=29.4797687861272, Blast_Score=81, Evalue=7e-16,
Organism=Homo sapiens, GI21361598, Length=194, Percent_Identity=27.319587628866, Blast_Score=81, Evalue=7e-16,
Organism=Homo sapiens, GI262118255, Length=173, Percent_Identity=29.4797687861272, Blast_Score=81, Evalue=8e-16,
Organism=Homo sapiens, GI262118263, Length=173, Percent_Identity=29.4797687861272, Blast_Score=80, Evalue=9e-16,
Organism=Homo sapiens, GI111154074, Length=158, Percent_Identity=28.4810126582279, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI186700627, Length=182, Percent_Identity=24.7252747252747, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI186700629, Length=182, Percent_Identity=24.7252747252747, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI21536464, Length=123, Percent_Identity=30.8943089430894, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI186972120, Length=182, Percent_Identity=24.7252747252747, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI52630447, Length=193, Percent_Identity=26.4248704663212, Blast_Score=68, Evalue=6e-12,
Organism=Escherichia coli, GI1790080, Length=202, Percent_Identity=41.5841584158416, Blast_Score=162, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17508835, Length=189, Percent_Identity=34.9206349206349, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI193203132, Length=189, Percent_Identity=34.9206349206349, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17556244, Length=124, Percent_Identity=36.2903225806452, Blast_Score=74, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71988041, Length=177, Percent_Identity=25.4237288135593, Blast_Score=71, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71988048, Length=177, Percent_Identity=25.4237288135593, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17557440, Length=121, Percent_Identity=29.7520661157025, Blast_Score=67, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6320662, Length=183, Percent_Identity=38.7978142076503, Blast_Score=135, Evalue=3e-33,
Organism=Drosophila melanogaster, GI21356141, Length=166, Percent_Identity=39.1566265060241, Blast_Score=120, Evalue=7e-28,
Organism=Drosophila melanogaster, GI161077626, Length=188, Percent_Identity=29.2553191489362, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI45554489, Length=188, Percent_Identity=29.2553191489362, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24640542, Length=188, Percent_Identity=29.2553191489362, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI116007136, Length=188, Percent_Identity=29.2553191489362, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI85724806, Length=188, Percent_Identity=29.2553191489362, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI45554481, Length=188, Percent_Identity=29.2553191489362, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI221330162, Length=185, Percent_Identity=31.3513513513514, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221330164, Length=185, Percent_Identity=31.3513513513514, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221330166, Length=185, Percent_Identity=31.3513513513514, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45551002, Length=129, Percent_Identity=31.7829457364341, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI85816106, Length=129, Percent_Identity=31.7829457364341, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI85816281, Length=129, Percent_Identity=31.7829457364341, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 23282; Mature: 23151

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTERGLLIVLSGPSGVGKGTVREAVFKDPETSFDYSISMTTRLPREGEQDGVDYYFRSRE
CCCCCEEEEEECCCCCCCHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHH
VFEQAIKDGKMLEYAEYVGNYYGTPLEYVEEKLAAGVDIFLEIEVQGAMQVRKAMPEGIF
HHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEEEEHHHHHHHHCCCCCEE
IFLTPPDLSELKNRIIGRGTESMEVVEERMETAKKEIEMMASYDYAVVNDVVANAVQKIK
EEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
GIVETEHLKTERVIHRYKKMLEGLQ
HHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TERGLLIVLSGPSGVGKGTVREAVFKDPETSFDYSISMTTRLPREGEQDGVDYYFRSRE
CCCCEEEEEECCCCCCCHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHH
VFEQAIKDGKMLEYAEYVGNYYGTPLEYVEEKLAAGVDIFLEIEVQGAMQVRKAMPEGIF
HHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEEEEHHHHHHHHCCCCCEE
IFLTPPDLSELKNRIIGRGTESMEVVEERMETAKKEIEMMASYDYAVVNDVVANAVQKIK
EEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
GIVETEHLKTERVIHRYKKMLEGLQ
HHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]