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The map label for this gene is coaBC [H]

Identifier: 226224428

GI number: 226224428

Start: 1887183

End: 1888382

Strand: Reverse

Name: coaBC [H]

Synonym: Lm4b_01841

Alternate gene names: 226224428

Gene position: 1888382-1887183 (Counterclockwise)

Preceding gene: 226224429

Following gene: 226224427

Centisome position: 64.83

GC content: 41.42

Gene sequence:

>1200_bases
ATGCAAGGAAAAAATATCTTACTCGCAGTGTCCGGTGGCATTGCTGTTTATAAAGCAGTCGCACTTACAAGTAAATTAAC
GCAAGCAGGAGCAAACGTCAAAGTGATGATGACAGAACATGCTCAGGAATTTGTTCCACCGCTTTCGTTTCAAGTATTAT
CTAAAAATGATGTATACACAGATACATTTGACGAAAAAAAATCAAGTGTTGTCGCACATATCGATTTAGCTGATTGGGCC
GATTTAGTAATTGTCGCACCAGCTACCGCAAATGTGATTGGCAAAATGGCAAATGGAATCGCTGATGATATGGTAACGAC
AACCATTCTTGCAACAGAGGCACCAGTTTGGGTAGCGCCAGCAATGAATGTCCACATGATTCAGCACCCAGCAGTTATTC
GGAATATTAATCGATTATACGCAGACGGTGTTCGTTTTATCGAGCCAGAAGAAGGTTACTTAGCTTGTGGCTACGTTGGT
CGCGGTCGTCTTGAAGAACCAGAAAAAATCGTTCTTCGTATTGCTGAATTTTTTCAAGAAGATAAAGATTTATTGCGCGA
CAAAAACGTGCTAGTTACAGCCGGCGCAACTCGCGAAAAATTAGATCCTGTACGCTATTTCACCAACCATTCCACGGGCA
AAATGGGATTTAGTATTGCAGAATCCGCAGCTCGTCATGGTGCAAAAGTGACGCTCGTTACGACAAGCAAAGCACTTCCC
GTACCACCTGGTGTAGAAGCAATCTATGTCGAATCGGCAGAAGAAATGTATCAAGCTGTGGATGAACATAAAGTGTCACA
AGATATCTTCGTGATGACCGCAGCAGTTGCCGATTACACGCCAGCAAAAGTATCAGACCAAAAAATTAAAAAACAGCCGG
GCGATTTTGCCATTGAAATGAAACGAACCAAAGATATTTTACTCGAAATTGGTCAACACAAAACTGCAGACCAAGTCGTG
ATTGGCTTTGCCGCTGAAACAGAAAATCTAGAAGCAAACGCACGTAAAAAATTAACATCCAAAAATGCCGATATGATTGT
CGCTAACAATATTAGCGTGGCAGGAGCAGGCTTTTCTGGTGATACAAATATCGTGACATTTTACCGGAAAGATGGTTCTA
GCAAAGCGTTACCGATACTAGATAAAAAAGAAGTTGCTGAACATATCATCAAAGAAACTGCTAACTTTTTAAGGAAGTGA

Upstream 100 bases:

>100_bases
AAATAAGCTGAAATCTAGTTTCTTCATGGTTTTGTCCTGTCTTAATTTAAGGTATAATAGAATTAATGATTTTTTATATT
AAAAATGAGGTGACTTTTCA

Downstream 100 bases:

>100_bases
ACGAATGATTAATATTGCGAAAGTAATTGTGGACGTTCCAGCCATGCAAGTGGATCGTCCATTTGACTACTATATTCCAG
AAGATTTAGAAGAACTTATT

Product: pantothenate metabolism flavoprotein

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MQGKNILLAVSGGIAVYKAVALTSKLTQAGANVKVMMTEHAQEFVPPLSFQVLSKNDVYTDTFDEKKSSVVAHIDLADWA
DLVIVAPATANVIGKMANGIADDMVTTTILATEAPVWVAPAMNVHMIQHPAVIRNINRLYADGVRFIEPEEGYLACGYVG
RGRLEEPEKIVLRIAEFFQEDKDLLRDKNVLVTAGATREKLDPVRYFTNHSTGKMGFSIAESAARHGAKVTLVTTSKALP
VPPGVEAIYVESAEEMYQAVDEHKVSQDIFVMTAAVADYTPAKVSDQKIKKQPGDFAIEMKRTKDILLEIGQHKTADQVV
IGFAAETENLEANARKKLTSKNADMIVANNISVAGAGFSGDTNIVTFYRKDGSSKALPILDKKEVAEHIIKETANFLRK

Sequences:

>Translated_399_residues
MQGKNILLAVSGGIAVYKAVALTSKLTQAGANVKVMMTEHAQEFVPPLSFQVLSKNDVYTDTFDEKKSSVVAHIDLADWA
DLVIVAPATANVIGKMANGIADDMVTTTILATEAPVWVAPAMNVHMIQHPAVIRNINRLYADGVRFIEPEEGYLACGYVG
RGRLEEPEKIVLRIAEFFQEDKDLLRDKNVLVTAGATREKLDPVRYFTNHSTGKMGFSIAESAARHGAKVTLVTTSKALP
VPPGVEAIYVESAEEMYQAVDEHKVSQDIFVMTAAVADYTPAKVSDQKIKKQPGDFAIEMKRTKDILLEIGQHKTADQVV
IGFAAETENLEANARKKLTSKNADMIVANNISVAGAGFSGDTNIVTFYRKDGSSKALPILDKKEVAEHIIKETANFLRK
>Mature_399_residues
MQGKNILLAVSGGIAVYKAVALTSKLTQAGANVKVMMTEHAQEFVPPLSFQVLSKNDVYTDTFDEKKSSVVAHIDLADWA
DLVIVAPATANVIGKMANGIADDMVTTTILATEAPVWVAPAMNVHMIQHPAVIRNINRLYADGVRFIEPEEGYLACGYVG
RGRLEEPEKIVLRIAEFFQEDKDLLRDKNVLVTAGATREKLDPVRYFTNHSTGKMGFSIAESAARHGAKVTLVTTSKALP
VPPGVEAIYVESAEEMYQAVDEHKVSQDIFVMTAAVADYTPAKVSDQKIKKQPGDFAIEMKRTKDILLEIGQHKTADQVV
IGFAAETENLEANARKKLTSKNADMIVANNISVAGAGFSGDTNIVTFYRKDGSSKALPILDKKEVAEHIIKETANFLRK

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=179, Percent_Identity=36.3128491620112, Blast_Score=100, Evalue=3e-21,
Organism=Escherichia coli, GI87082301, Length=395, Percent_Identity=44.8101265822785, Blast_Score=300, Evalue=1e-82,
Organism=Caenorhabditis elegans, GI17560194, Length=188, Percent_Identity=32.9787234042553, Blast_Score=91, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6322762, Length=183, Percent_Identity=27.3224043715847, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24657262, Length=190, Percent_Identity=33.1578947368421, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43490; Mature: 43490

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQGKNILLAVSGGIAVYKAVALTSKLTQAGANVKVMMTEHAQEFVPPLSFQVLSKNDVYT
CCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHCCCCEEEEECCCCCCC
DTFDEKKSSVVAHIDLADWADLVIVAPATANVIGKMANGIADDMVTTTILATEAPVWVAP
CCCCCCCCCEEEEEECCCCCCEEEECCCHHHHHHHHHCCHHHHHHHHHEEEECCCEEEEC
AMNVHMIQHPAVIRNINRLYADGVRFIEPEEGYLACGYVGRGRLEEPEKIVLRIAEFFQE
CCCEEEECCCHHHHHHHHHHHCCEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHH
DKDLLRDKNVLVTAGATREKLDPVRYFTNHSTGKMGFSIAESAARHGAKVTLVTTSKALP
HHHHHCCCCEEEEECCCHHHCCHHHHHCCCCCCCCCHHHHHHHHHCCCEEEEEEECCCCC
VPPGVEAIYVESAEEMYQAVDEHKVSQDIFVMTAAVADYTPAKVSDQKIKKQPGDFAIEM
CCCCCCEEEECCHHHHHHHHHHHHCCCHHEEEEEHHHCCCCCCCCHHHHHCCCCCEEEEE
KRTKDILLEIGQHKTADQVVIGFAAETENLEANARKKLTSKNADMIVANNISVAGAGFSG
HHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCHHHHHHHCCCCCEEEECCEEEEECCCCC
DTNIVTFYRKDGSSKALPILDKKEVAEHIIKETANFLRK
CCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQGKNILLAVSGGIAVYKAVALTSKLTQAGANVKVMMTEHAQEFVPPLSFQVLSKNDVYT
CCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHCCCCEEEEECCCCCCC
DTFDEKKSSVVAHIDLADWADLVIVAPATANVIGKMANGIADDMVTTTILATEAPVWVAP
CCCCCCCCCEEEEEECCCCCCEEEECCCHHHHHHHHHCCHHHHHHHHHEEEECCCEEEEC
AMNVHMIQHPAVIRNINRLYADGVRFIEPEEGYLACGYVGRGRLEEPEKIVLRIAEFFQE
CCCEEEECCCHHHHHHHHHHHCCEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHH
DKDLLRDKNVLVTAGATREKLDPVRYFTNHSTGKMGFSIAESAARHGAKVTLVTTSKALP
HHHHHCCCCEEEEECCCHHHCCHHHHHCCCCCCCCCHHHHHHHHHCCCEEEEEEECCCCC
VPPGVEAIYVESAEEMYQAVDEHKVSQDIFVMTAAVADYTPAKVSDQKIKKQPGDFAIEM
CCCCCCEEEECCHHHHHHHHHHHHCCCHHEEEEEHHHCCCCCCCCHHHHHCCCCCEEEEE
KRTKDILLEIGQHKTADQVVIGFAAETENLEANARKKLTSKNADMIVANNISVAGAGFSG
HHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCHHHHHHHCCCCCEEEECCEEEEECCCCC
DTNIVTFYRKDGSSKALPILDKKEVAEHIIKETANFLRK
CCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9534248; 9384377 [H]