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The map label for this gene is holA

Identifier: 226224082

GI number: 226224082

Start: 1497957

End: 1498988

Strand: Reverse

Name: holA

Synonym: Lm4b_01491

Alternate gene names: 226224082

Gene position: 1498988-1497957 (Counterclockwise)

Preceding gene: 226224083

Following gene: 226224080

Centisome position: 51.46

GC content: 34.4

Gene sequence:

>1032_bases
ATGCTGCCAGAATGGAAACAGATACGCTCCAAAAAAATAATGCCGGTGTATTTAATCATTGGTACGGAAGATTATATTAT
TAACGAAACGAAGCAACTTTTAATAGATAACATTTTGGAAGGCGAAGAAGTAGAATTTAACTACGCTAATTTAGATTTAG
AAGAAATGCCAATAGAAGTGGTCATTCAAGAAGCAGAAAGCATGCCTTTTTTCGGTGATAAACGTTTAGTAATGGCCAAT
AATCCGCTTTTTTTAACAACTGAAAAAAGTAAAAACAAAGTGGAGCATGATACTGCAAAATTAGAGGCTTATCTCAATGA
ACCAGTGGATTATTCCGTATTATGCTTTGTAGCGCGCGTAGAAAAGTTAGATGAGCGTAAAAAGCTTACTAAGTTACTCA
AGAAAACAGCTACTGTTATAGAGGCAAAACGACCTAATGAGAATGAGTTGAAAAAATGGATTGAAGCAAAATTAAGCGAG
AACAACATGCAAATGTCACAAGAGGCTATTACTCGACTGGTGGAATTAACTAGTGGTCAGCTAACAACTGCCATGAATGA
ACTGCAAAAATTAATGCTCTATTGTTTTGATTCAAAAGAAATTACCATTCAGGATGTAGAATCTTTAGTTGTACGTTCAC
TTGAACAAAATATCTTTTTGTTACTTGATAAGATGATTGCTATGGATATCAGCGGGGCACTTCGGATTTATTACGACTTA
TTAAAACAAAAAGAAGAGCCTATCAAGATACTGGCATTAATTTCTAGTCAATTCAGGTTGTTAAACCAATTAAAGCTATT
AGAACAACAAGGTTATTCGCAACAACAAGCTGCGACTAAACTAAAAGTGCATCCATTCCGCGTTAAGTTAGCATCAAAAC
AAGCGAAGAATTTCACGGAATTACAATTAAATCAAGCTTTAAAACGATTAGCTGAAATCGACTTGGAAATGAAAACTGGC
TTTGGTGATAAAGAACAGAAACTCGAATGGTTCTTATTCGAATTACAAGATAATCGGCAAAAGAGAGTATAA

Upstream 100 bases:

>100_bases
TTTGGAAAAGGCTTTGAAGCGACTTTGAAATAAAACTTGCTATCTCTTATTTCATGTTTTACCATAGAAAGAGAAATAAG
AGTGAAGCGAGGCGAAATGA

Downstream 100 bases:

>100_bases
AAAATAGCTTTGTCATTTAAGACAAAGCTATTTTTGCAAACAAAAAACACCACACAAGGTGTGATGTTTTATACCGAACT
CGGTATTATTTAGCTAATTT

Product: DNA polymerase III subunit delta

Products: diphosphate; DNAn+1

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MLPEWKQIRSKKIMPVYLIIGTEDYIINETKQLLIDNILEGEEVEFNYANLDLEEMPIEVVIQEAESMPFFGDKRLVMAN
NPLFLTTEKSKNKVEHDTAKLEAYLNEPVDYSVLCFVARVEKLDERKKLTKLLKKTATVIEAKRPNENELKKWIEAKLSE
NNMQMSQEAITRLVELTSGQLTTAMNELQKLMLYCFDSKEITIQDVESLVVRSLEQNIFLLLDKMIAMDISGALRIYYDL
LKQKEEPIKILALISSQFRLLNQLKLLEQQGYSQQQAATKLKVHPFRVKLASKQAKNFTELQLNQALKRLAEIDLEMKTG
FGDKEQKLEWFLFELQDNRQKRV

Sequences:

>Translated_343_residues
MLPEWKQIRSKKIMPVYLIIGTEDYIINETKQLLIDNILEGEEVEFNYANLDLEEMPIEVVIQEAESMPFFGDKRLVMAN
NPLFLTTEKSKNKVEHDTAKLEAYLNEPVDYSVLCFVARVEKLDERKKLTKLLKKTATVIEAKRPNENELKKWIEAKLSE
NNMQMSQEAITRLVELTSGQLTTAMNELQKLMLYCFDSKEITIQDVESLVVRSLEQNIFLLLDKMIAMDISGALRIYYDL
LKQKEEPIKILALISSQFRLLNQLKLLEQQGYSQQQAATKLKVHPFRVKLASKQAKNFTELQLNQALKRLAEIDLEMKTG
FGDKEQKLEWFLFELQDNRQKRV
>Mature_343_residues
MLPEWKQIRSKKIMPVYLIIGTEDYIINETKQLLIDNILEGEEVEFNYANLDLEEMPIEVVIQEAESMPFFGDKRLVMAN
NPLFLTTEKSKNKVEHDTAKLEAYLNEPVDYSVLCFVARVEKLDERKKLTKLLKKTATVIEAKRPNENELKKWIEAKLSE
NNMQMSQEAITRLVELTSGQLTTAMNELQKLMLYCFDSKEITIQDVESLVVRSLEQNIFLLLDKMIAMDISGALRIYYDL
LKQKEEPIKILALISSQFRLLNQLKLLEQQGYSQQQAATKLKVHPFRVKLASKQAKNFTELQLNQALKRLAEIDLEMKTG
FGDKEQKLEWFLFELQDNRQKRV

Specific function: Unknown

COG id: COG1466

COG function: function code L; DNA polymerase III, delta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008921
- InterPro:   IPR010372
- InterPro:   IPR005790 [H]

Pfam domain/function: PF06144 DNA_pol3_delta [H]

EC number: 2.7.7.7

Molecular weight: Translated: 40013; Mature: 40013

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPEWKQIRSKKIMPVYLIIGTEDYIINETKQLLIDNILEGEEVEFNYANLDLEEMPIEV
CCCCHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHCCHHH
VIQEAESMPFFGDKRLVMANNPLFLTTEKSKNKVEHDTAKLEAYLNEPVDYSVLCFVARV
HHHHHHCCCCCCCCEEEEECCCEEEEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
EKLDERKKLTKLLKKTATVIEAKRPNENELKKWIEAKLSENNMQMSQEAITRLVELTSGQ
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCH
LTTAMNELQKLMLYCFDSKEITIQDVESLVVRSLEQNIFLLLDKMIAMDISGALRIYYDL
HHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKQKEEPIKILALISSQFRLLNQLKLLEQQGYSQQQAATKLKVHPFRVKLASKQAKNFTE
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHEECCCEEEEEHHHHCCCHHH
LQLNQALKRLAEIDLEMKTGFGDKEQKLEWFLFELQDNRQKRV
HHHHHHHHHHHHCCCCEECCCCCHHHHHHHHEEEECCCCCCCC
>Mature Secondary Structure
MLPEWKQIRSKKIMPVYLIIGTEDYIINETKQLLIDNILEGEEVEFNYANLDLEEMPIEV
CCCCHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHCCHHH
VIQEAESMPFFGDKRLVMANNPLFLTTEKSKNKVEHDTAKLEAYLNEPVDYSVLCFVARV
HHHHHHCCCCCCCCEEEEECCCEEEEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
EKLDERKKLTKLLKKTATVIEAKRPNENELKKWIEAKLSENNMQMSQEAITRLVELTSGQ
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCH
LTTAMNELQKLMLYCFDSKEITIQDVESLVVRSLEQNIFLLLDKMIAMDISGALRIYYDL
HHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKQKEEPIKILALISSQFRLLNQLKLLEQQGYSQQQAATKLKVHPFRVKLASKQAKNFTE
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHEECCCEEEEEHHHHCCCHHH
LQLNQALKRLAEIDLEMKTGFGDKEQKLEWFLFELQDNRQKRV
HHHHHHHHHHHHCCCCEECCCCCHHHHHHHHEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: deoxynucleoside triphosphate; DNAn

Specific reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]