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The map label for this gene is treR [H]

Identifier: 226223856

GI number: 226223856

Start: 1263617

End: 1264330

Strand: Direct

Name: treR [H]

Synonym: Lm4b_01263

Alternate gene names: 226223856

Gene position: 1263617-1264330 (Clockwise)

Preceding gene: 226223854

Following gene: 226223859

Centisome position: 43.38

GC content: 37.25

Gene sequence:

>714_bases
TTGAATAAAAAAAATAAGTTTTTTGACATTTATTTAGAATTAGAGCAAGACATTACATCAGGCGTTTATCCAGCAGGCAC
ACTACTTCCAAGTGAAAATGTCCTGGCGAAGCGTTTTTCGGTATCCCGTGAGACCATTAGAAAAGCACTTGTATTATTGC
TTGAAAACGGCTGTATTCAAAAGCTCCAAGGAAAAGGATCGATTGTCATTGACCGAGAACGCTATTCTTTTCCAGTCTCT
GGTTTAACTAGTTTTAAGGAATTACAAAAATCCGAACATATGAATGCGACAACGGAAGTCATCCGAAATGAACGAACCAC
TTTACCAGATCGAATTGCTGATTTTGCTGGTCTTCCGCACGGCTCAAACTGCTTAGCTATCCTCAGAGTGCGCTATTTAG
AAGGAGAGGCAACTATTTTGGATTACGATTATTTATTAGACAAAACTGAACCAATTGCGAATGAGATTTTAGAAGACTCT
TTGTATCAATACTTAGAAAATGAGAAAGGCTATGAAATCAGTTATGCTCAAAAAGAAATAACCGTGGAACCGCTGAACGC
CGAAGATAAAAAATACTTAGCATTACATGGTGATACGCATGTAGTTGTCGTAAAAAGTACCGTGTTTTTAAAAGATACAA
CACTTTTTCAATACACAGAATCGCGTCACCGACTGGATAAATTCCGTTTTATAGATTTTGCAAGAAGACGCTAA

Upstream 100 bases:

>100_bases
TAGTGTACCAAATTTCACGTGATTTTGGTAATAAAGCGAGCTAGCAAATTTCGGTTACAATTATGGGTAAATGTGCTACA
ATAGCCTTGGGTGAGTAAAT

Downstream 100 bases:

>100_bases
AAAGCCTGAGAATTGTTTCTCAGGCTTTTTTTATCGAATTAAAGTTAATGTTTCATAAGGTGCTAATTCCAGCTCAGAAC
TGATTGTTTGACGTTCATAA

Product: transcription regulator GntR family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MNKKNKFFDIYLELEQDITSGVYPAGTLLPSENVLAKRFSVSRETIRKALVLLLENGCIQKLQGKGSIVIDRERYSFPVS
GLTSFKELQKSEHMNATTEVIRNERTTLPDRIADFAGLPHGSNCLAILRVRYLEGEATILDYDYLLDKTEPIANEILEDS
LYQYLENEKGYEISYAQKEITVEPLNAEDKKYLALHGDTHVVVVKSTVFLKDTTLFQYTESRHRLDKFRFIDFARRR

Sequences:

>Translated_237_residues
MNKKNKFFDIYLELEQDITSGVYPAGTLLPSENVLAKRFSVSRETIRKALVLLLENGCIQKLQGKGSIVIDRERYSFPVS
GLTSFKELQKSEHMNATTEVIRNERTTLPDRIADFAGLPHGSNCLAILRVRYLEGEATILDYDYLLDKTEPIANEILEDS
LYQYLENEKGYEISYAQKEITVEPLNAEDKKYLALHGDTHVVVVKSTVFLKDTTLFQYTESRHRLDKFRFIDFARRR
>Mature_237_residues
MNKKNKFFDIYLELEQDITSGVYPAGTLLPSENVLAKRFSVSRETIRKALVLLLENGCIQKLQGKGSIVIDRERYSFPVS
GLTSFKELQKSEHMNATTEVIRNERTTLPDRIADFAGLPHGSNCLAILRVRYLEGEATILDYDYLLDKTEPIANEILEDS
LYQYLENEKGYEISYAQKEITVEPLNAEDKKYLALHGDTHVVVVKSTVFLKDTTLFQYTESRHRLDKFRFIDFARRR

Specific function: Repressor for the trehalose operon (treP and treA). Binds trehalose-6-phosphate, which probably acts as an inducer [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786950, Length=238, Percent_Identity=25.6302521008403, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1790540, Length=228, Percent_Identity=26.3157894736842, Blast_Score=77, Evalue=8e-16,
Organism=Escherichia coli, GI87082252, Length=160, Percent_Identity=33.75, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1790118, Length=205, Percent_Identity=29.7560975609756, Blast_Score=64, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000524
- InterPro:   IPR012770
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 27353; Mature: 27353

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKKNKFFDIYLELEQDITSGVYPAGTLLPSENVLAKRFSVSRETIRKALVLLLENGCIQ
CCCCCCEEEEEEEEEHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHH
KLQGKGSIVIDRERYSFPVSGLTSFKELQKSEHMNATTEVIRNERTTLPDRIADFAGLPH
HHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHCCCC
GSNCLAILRVRYLEGEATILDYDYLLDKTEPIANEILEDSLYQYLENEKGYEISYAQKEI
CCCCEEEEEEEEECCCEEEEEHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCEE
TVEPLNAEDKKYLALHGDTHVVVVKSTVFLKDTTLFQYTESRHRLDKFRFIDFARRR
EEECCCCCCCEEEEEECCEEEEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNKKNKFFDIYLELEQDITSGVYPAGTLLPSENVLAKRFSVSRETIRKALVLLLENGCIQ
CCCCCCEEEEEEEEEHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHH
KLQGKGSIVIDRERYSFPVSGLTSFKELQKSEHMNATTEVIRNERTTLPDRIADFAGLPH
HHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHCCCC
GSNCLAILRVRYLEGEATILDYDYLLDKTEPIANEILEDSLYQYLENEKGYEISYAQKEI
CCCCEEEEEEEEECCCEEEEEHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCEE
TVEPLNAEDKKYLALHGDTHVVVVKSTVFLKDTTLFQYTESRHRLDKFRFIDFARRR
EEECCCCCCCEEEEEECCEEEEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8917076; 8969503; 9384377; 7651129; 8755887 [H]