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The map label for this gene is ldh [H]

Identifier: 226223675

GI number: 226223675

Start: 1085891

End: 1086844

Strand: Direct

Name: ldh [H]

Synonym: Lm4b_01077

Alternate gene names: 226223675

Gene position: 1085891-1086844 (Clockwise)

Preceding gene: 226223674

Following gene: 226223676

Centisome position: 37.28

GC content: 36.9

Gene sequence:

>954_bases
ATGCCATCTAAGAAGAAAAAAATTGTCGTTATCGGCAGAAGTAATCTACAAAATCTCTACATTCATACAGTTCTTTTTAA
AAAAATACCAGCCGAGATTTACTTAATAGACGATCAAGCTAAAACAAGCGTACAAGATTTTGACTATGCGAGTTATTATC
ATGCAGATGCGACCATTCACGCAGGAACCTTCAACGAGTGTCGCAACGCTGATATAGTCGTCTTTTTTCAAGAAGAAATG
TCCAATCAACTCGTTTCAAAAGAAGACAATGTCACGCTAATCAAAGAAAAAGTGAAGAAAATGATGGCGAGCGGTTTCCG
AGGAATTGTCTTAGTGGCGACAGCTGAAAGTAATGTCGTTGCCGCGTTAATTAAACGTTTCTCCGGCCTACCTGCAAATC
AAATTATTACGCTTGGCACCATGCTTGCGACGTCTTATTTTCAAGTGGAAATTGCTAAATTATTTAAAATTAGCCCTAAA
AATGTACACGGATATATTATTGGCGATAATGCAGAAGATGTCATTCCTGTATGGAGTAGAGCCTTTCTTGGTGGCAAACC
AATTTTAAGTTATTTAGCTGAAGAGCAAAAAAGAATCTCAGCAGAGGATTTACAAAATTTAACAAAAATGATTACTAAAA
TTCCAGATTTTCCTTTTGAAAATAAAGATGGTTGTTCTTTTCGATTTAGCACGGTAACTGTTCTTGCTGAATTAACCGAA
GTTGTTTTGCGCGACGAAGCAAGAGTTATAACAGTTGGTGTTGAAGTGAAAGACGCATATGGTTTAGAAAATCCTGTCTT
CATTAGTGTTCCAGCTGTCATTGGCGCAGAAGGAGTCAGAGAACTACTTGAATTACATCTCTCAGACGATGAACAAAAAG
AATTAAAACAAATCGCCACAAAAACCACCGAGAAATTGGAAGAATTGCAACTTAACAAAGGAGGGATTAGTTAA

Upstream 100 bases:

>100_bases
GAATGAGCATTGCTTTTTATTTATGTGGTCAAGTTATTTTATTTTTGCCTCGGAAGCATGCTAAAATAACAATAAGAGAC
TTGATGAGGAGGAGATGCAT

Downstream 100 bases:

>100_bases
TGGAATACAGTTATCCACTAAATCCAGACTGGACAACCGAAGAAATGACGATTGTTGTGCAATTTTTAGAAGCTATTGAG
CGAGCGTATGAAAAGGGCAT

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: L-LDH [H]

Number of amino acids: Translated: 317; Mature: 316

Protein sequence:

>317_residues
MPSKKKKIVVIGRSNLQNLYIHTVLFKKIPAEIYLIDDQAKTSVQDFDYASYYHADATIHAGTFNECRNADIVVFFQEEM
SNQLVSKEDNVTLIKEKVKKMMASGFRGIVLVATAESNVVAALIKRFSGLPANQIITLGTMLATSYFQVEIAKLFKISPK
NVHGYIIGDNAEDVIPVWSRAFLGGKPILSYLAEEQKRISAEDLQNLTKMITKIPDFPFENKDGCSFRFSTVTVLAELTE
VVLRDEARVITVGVEVKDAYGLENPVFISVPAVIGAEGVRELLELHLSDDEQKELKQIATKTTEKLEELQLNKGGIS

Sequences:

>Translated_317_residues
MPSKKKKIVVIGRSNLQNLYIHTVLFKKIPAEIYLIDDQAKTSVQDFDYASYYHADATIHAGTFNECRNADIVVFFQEEM
SNQLVSKEDNVTLIKEKVKKMMASGFRGIVLVATAESNVVAALIKRFSGLPANQIITLGTMLATSYFQVEIAKLFKISPK
NVHGYIIGDNAEDVIPVWSRAFLGGKPILSYLAEEQKRISAEDLQNLTKMITKIPDFPFENKDGCSFRFSTVTVLAELTE
VVLRDEARVITVGVEVKDAYGLENPVFISVPAVIGAEGVRELLELHLSDDEQKELKQIATKTTEKLEELQLNKGGIS
>Mature_316_residues
PSKKKKIVVIGRSNLQNLYIHTVLFKKIPAEIYLIDDQAKTSVQDFDYASYYHADATIHAGTFNECRNADIVVFFQEEMS
NQLVSKEDNVTLIKEKVKKMMASGFRGIVLVATAESNVVAALIKRFSGLPANQIITLGTMLATSYFQVEIAKLFKISPKN
VHGYIIGDNAEDVIPVWSRAFLGGKPILSYLAEEQKRISAEDLQNLTKMITKIPDFPFENKDGCSFRFSTVTVLAELTEV
VLRDEARVITVGVEVKDAYGLENPVFISVPAVIGAEGVRELLELHLSDDEQKELKQIATKTTEKLEELQLNKGGIS

Specific function: Unknown

COG id: COG0039

COG function: function code C; Malate/lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH/MDH superfamily. LDH family [H]

Homologues:

Organism=Homo sapiens, GI15082234, Length=318, Percent_Identity=22.9559748427673, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI291575128, Length=312, Percent_Identity=25, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI4557032, Length=312, Percent_Identity=25, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI9257228, Length=312, Percent_Identity=23.3974358974359, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI4504973, Length=312, Percent_Identity=23.3974358974359, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI260099723, Length=317, Percent_Identity=22.397476340694, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI5031857, Length=317, Percent_Identity=22.397476340694, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI47059044, Length=313, Percent_Identity=23.0031948881789, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI221136809, Length=313, Percent_Identity=23.0031948881789, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI207028494, Length=225, Percent_Identity=23.5555555555556, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17535107, Length=292, Percent_Identity=20.2054794520548, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17136226, Length=316, Percent_Identity=24.3670886075949, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI45550422, Length=302, Percent_Identity=22.5165562913907, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001557
- InterPro:   IPR011304
- InterPro:   IPR018177
- InterPro:   IPR022383
- InterPro:   IPR001236
- InterPro:   IPR015955
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02866 Ldh_1_C; PF00056 Ldh_1_N [H]

EC number: =1.1.1.27 [H]

Molecular weight: Translated: 35320; Mature: 35189

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSKKKKIVVIGRSNLQNLYIHTVLFKKIPAEIYLIDDQAKTSVQDFDYASYYHADATIH
CCCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCCCCCHHCCCCHHEEECCCEEE
AGTFNECRNADIVVFFQEEMSNQLVSKEDNVTLIKEKVKKMMASGFRGIVLVATAESNVV
CCCCHHHCCCCEEEEEHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCHHH
AALIKRFSGLPANQIITLGTMLATSYFQVEIAKLFKISPKNVHGYIIGDNAEDVIPVWSR
HHHHHHHCCCCHHHHHHHHHHHHHHHHHEEEHHHHCCCCCCEEEEEECCCCCCHHHHHHH
AFLGGKPILSYLAEEQKRISAEDLQNLTKMITKIPDFPFENKDGCSFRFSTVTVLAELTE
HHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEHHHHHHHHHHHH
VVLRDEARVITVGVEVKDAYGLENPVFISVPAVIGAEGVRELLELHLSDDEQKELKQIAT
HHHCCCCEEEEEEEEEECCCCCCCCEEEEECHHHCHHHHHHHHHHHCCCCHHHHHHHHHH
KTTEKLEELQLNKGGIS
HHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PSKKKKIVVIGRSNLQNLYIHTVLFKKIPAEIYLIDDQAKTSVQDFDYASYYHADATIH
CCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCCCCCHHCCCCHHEEECCCEEE
AGTFNECRNADIVVFFQEEMSNQLVSKEDNVTLIKEKVKKMMASGFRGIVLVATAESNVV
CCCCHHHCCCCEEEEEHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCHHH
AALIKRFSGLPANQIITLGTMLATSYFQVEIAKLFKISPKNVHGYIIGDNAEDVIPVWSR
HHHHHHHCCCCHHHHHHHHHHHHHHHHHEEEHHHHCCCCCCEEEEEECCCCCCHHHHHHH
AFLGGKPILSYLAEEQKRISAEDLQNLTKMITKIPDFPFENKDGCSFRFSTVTVLAELTE
HHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEHHHHHHHHHHHH
VVLRDEARVITVGVEVKDAYGLENPVFISVPAVIGAEGVRELLELHLSDDEQKELKQIAT
HHHCCCCEEEEEEEEEECCCCCCCCEEEEECHHHCHHHHHHHHHHHCCCCHHHHHHHHHH
KTTEKLEELQLNKGGIS
HHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA