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The map label for this gene is pdhR [H]

Identifier: 226223566

GI number: 226223566

Start: 984009

End: 984698

Strand: Reverse

Name: pdhR [H]

Synonym: Lm4b_00968

Alternate gene names: 226223566

Gene position: 984698-984009 (Counterclockwise)

Preceding gene: 226223568

Following gene: 226223565

Centisome position: 33.81

GC content: 39.57

Gene sequence:

>690_bases
ATGGTAGAAAAAATTGAACGCAAATCGCTTGCAGAGCAAGTTTATGATCAAATAAAAGCAGAAATTACTAACGGTACTTG
GAAAATCGGTGAACGCATTCCGAAAGAAGCGGATTTAATGGCTGAATTTGGCATTAGTCGTAATACGCTACGTGAAGCCA
TTCGTGCCCTATCTCATATCGGTTTACTGGAAACCAAACAAGGTGACGGGACTTTTGTTCGTAACAATAGTGAACTAAAT
GCTATCATGCAGAGGCGTGTCCGCGAATCCACGGTTCAAGAAATCCTGGAAATTCGGCATGCGCTTGACAGAGAAGCAGT
TATTCTGGCCTGTGATAGACGCACGGAAGAAGATGTAAAAACACTAGAAAAATATAGACACCAATGCCAACTAGCGACGG
AAAAAAATGATGTTGGTGCTTTTGTGAAAGCTGATTCTGCCCTTCATTTAACAATTGTAAAGGCAGCTCATAACGATTTG
TTGTTAGATATGTATGTCAATATTTTAGAAGAAATACAGTTTTCCATCACGAGTACAACCGAAATGAGCCCAGAAGCTAA
TCAGCATAATGGGCACGCTGCGCTTGTCAAAGCGATTGAAAAACGAAATAAAGAACAAGCAGCTCATGAAGTAACAGAGT
ATATTACTCTTTTCAAACGAATTGATGCTAAGAATGGAGAAAAGAAATGA

Upstream 100 bases:

>100_bases
CCTTCATTTTATCATAGTTTAACAAAATAAGGTTTACAAAAAAAGAATTCTTCTGTAAAATAGAACCAATCATCCTACCT
TTAGAAATGGAGTGAATAGT

Downstream 100 bases:

>100_bases
ATTCAGATTTAACCAATAAAAAAATCCTTACACGCTCGAGTAAGGTAATGCTTGTTTTAGGAATTATTTTAATTGCGGCA
AACTTACGGACACCAATTAC

Product: transcription regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MVEKIERKSLAEQVYDQIKAEITNGTWKIGERIPKEADLMAEFGISRNTLREAIRALSHIGLLETKQGDGTFVRNNSELN
AIMQRRVRESTVQEILEIRHALDREAVILACDRRTEEDVKTLEKYRHQCQLATEKNDVGAFVKADSALHLTIVKAAHNDL
LLDMYVNILEEIQFSITSTTEMSPEANQHNGHAALVKAIEKRNKEQAAHEVTEYITLFKRIDAKNGEKK

Sequences:

>Translated_229_residues
MVEKIERKSLAEQVYDQIKAEITNGTWKIGERIPKEADLMAEFGISRNTLREAIRALSHIGLLETKQGDGTFVRNNSELN
AIMQRRVRESTVQEILEIRHALDREAVILACDRRTEEDVKTLEKYRHQCQLATEKNDVGAFVKADSALHLTIVKAAHNDL
LLDMYVNILEEIQFSITSTTEMSPEANQHNGHAALVKAIEKRNKEQAAHEVTEYITLFKRIDAKNGEKK
>Mature_229_residues
MVEKIERKSLAEQVYDQIKAEITNGTWKIGERIPKEADLMAEFGISRNTLREAIRALSHIGLLETKQGDGTFVRNNSELN
AIMQRRVRESTVQEILEIRHALDREAVILACDRRTEEDVKTLEKYRHQCQLATEKNDVGAFVKADSALHLTIVKAAHNDL
LLDMYVNILEEIQFSITSTTEMSPEANQHNGHAALVKAIEKRNKEQAAHEVTEYITLFKRIDAKNGEKK

Specific function: Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786303, Length=165, Percent_Identity=33.9393939393939, Blast_Score=86, Evalue=1e-18,
Organism=Escherichia coli, GI1790032, Length=232, Percent_Identity=27.5862068965517, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1789353, Length=188, Percent_Identity=29.2553191489362, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI48994955, Length=202, Percent_Identity=27.2277227722772, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1786950, Length=67, Percent_Identity=43.2835820895522, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 26106; Mature: 26106

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEKIERKSLAEQVYDQIKAEITNGTWKIGERIPKEADLMAEFGISRNTLREAIRALSHI
CCCHHHHHHHHHHHHHHHHHHHCCCEEHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHC
GLLETKQGDGTFVRNNSELNAIMQRRVRESTVQEILEIRHALDREAVILACDRRTEEDVK
CCCEECCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHH
TLEKYRHQCQLATEKNDVGAFVKADSALHLTIVKAAHNDLLLDMYVNILEEIQFSITSTT
HHHHHHHHHHHCCCCCCCCCEEECCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCC
EMSPEANQHNGHAALVKAIEKRNKEQAAHEVTEYITLFKRIDAKNGEKK
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MVEKIERKSLAEQVYDQIKAEITNGTWKIGERIPKEADLMAEFGISRNTLREAIRALSHI
CCCHHHHHHHHHHHHHHHHHHHCCCEEHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHC
GLLETKQGDGTFVRNNSELNAIMQRRVRESTVQEILEIRHALDREAVILACDRRTEEDVK
CCCEECCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHH
TLEKYRHQCQLATEKNDVGAFVKADSALHLTIVKAAHNDLLLDMYVNILEEIQFSITSTT
HHHHHHHHHHHCCCCCCCCCEEECCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCC
EMSPEANQHNGHAALVKAIEKRNKEQAAHEVTEYITLFKRIDAKNGEKK
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]