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The map label for this gene is htpG [H]

Identifier: 226223560

GI number: 226223560

Start: 978103

End: 979908

Strand: Reverse

Name: htpG [H]

Synonym: Lm4b_00961

Alternate gene names: 226223560

Gene position: 979908-978103 (Counterclockwise)

Preceding gene: 226223565

Following gene: 226223559

Centisome position: 33.64

GC content: 35.94

Gene sequence:

>1806_bases
ATGGAAAATTATTCTCACCGCTTTCAGGTGAACTTGGCTGGTATGATTGACATTCTCTCAAACCACCTTTATGACGAAAA
AGATGTTTATATTCGCGAATTACTGCAAAATGCAACCGATGCCATTCGCGCCAGGAAAAAAATCGATTCAACTTTAGAAG
GTAAAATCCATGCATCTCTAACTGGAGATAATAATGAAAAAACATTAATTGTAGAAGACAACGGAATTGGTTTAACGGAA
GATGAGGTTCACGCTTTTCTAGCTACTATTGCTAATTCATCAAAAGGCGAAAAAAACTTTGATGGAGAAAGTTCCAATGA
CTTTATTGGTCGTTTTGGGATTGGTTTACTTTCTTGTTTTATTGTTAGTGATGAAATTGTAATGATTTCTACTTCCAAAA
AAGATGGTGGCACAACAGAATGGCGCGGAAAAGCGGACGGAACTTATTCGGTTCGGAAAATAGAAACGGAAACTCGCGAA
CCAGGTACACAAGTGTATTTGCGCTTACGAGCTGATTTAGACGAGCACCCTGAATGCGAGGACGTAGAAGAATTAATCAA
TACACTCAAAAAATATGGTTCCTCTTTGGAAAGTAATATAATAGTAGAAATTAATGGTTTAGAAGAAGAAATTAATAGTT
GGACCAAACAGTTTTCCAATAAAGAAACCTTGTCTAAACTATCAAAAGATCAAATTATTCAGTACGGCGAATATATCCTT
GGAACGCGTTTCCAAGATTATTTCTTAATTGAAAATGAGTCAGGAAGAACGTTTGGGATTGCTTATATGATTCCTCATGC
TGTTCAAATGAATGCTATCCGGAAGAACACGGTATTTTTAAATAATATGTATGTCACAAGTGAAGCAAATAATATTTTGC
CTGATTGGTCGTTTTTTGCTAAATGCGTGATTTGGACGGATGAGCTTCAACCTGTTGCTTCTCGTGAGGCGTTTTATAAA
AATGAGCGATTAACTAGTGTTGCCGACGAGCTTGGCGTTGCTTTGAAAAAAGGAATTGAAACTCTTCCAGAAGAAGCATT
GATGAAATTATTAGCTACACATTATCTTGGTTTTAAAGCACTTGCGAGTGAAGATGCACCATTTTTAAAATTAATCTATC
CTTATCTTCCAGTTCGGACTTTGAATGGCGAGGAAAAATTAGGTGATATTATCGCTAAAAATGATGTCATCTATTACACC
TACTCGGTCGATGACTTTAGACAAATTAAGGATATTGCTAGATCAAGCGGTATGACGCTTATTAACGGCGGCTATTCCTA
TGATTCGCCAATCTTAGCGCAATTAAGTTACTTTGTTGAGGGGACAGAATTTGTTTTAATCGAACCGGAAGAAATGACTA
ATAAATTACGGCCTATGACAGTGAGCGAAGAACAGGCTTACCAACCTATTTTGACAGAAATGAATAGTATGATGGCTGAA
TTTGATACAGATGTATTAATTAAACATTTTGAACCGAAAGATTTACCGATTATTTTCATCCACTCTACAGCAACACAAGA
ATTACGCGAACTAGAACGTGCTGTCGAAGAAACAAATTCTGTTTTTAGTGATATTTTAGAGAGCATCCAAAAAGAACAAG
AACCTGCACCGCTTGCTCACTTGTATTTAAATTTGGATAACGAGCTGATTAAAAGACTTTTCACTTCTGGAAAAACAGTG
AAAGAATTGTCCGTAATTGTGAATGTACTTTATATCCAAGCCTTACTATTAGGGCATTATCCGCTTAAACGGAAAGAAAT
GGTATTAATGAATCAAAATATGTTACGAATCTTAGAGATGCTATAG

Upstream 100 bases:

>100_bases
TGATATAAATTCTTAAACATCTATTATTGTTTTCTCATTATTTATCTCTTCTTTTATGATAGAATAAAAAGGACTTTTGT
ACAACTAGGAGGACCAAGCT

Downstream 100 bases:

>100_bases
GAGGAAGAAAAATGGATTATTTGAATGATTTAGAATCAGTTTGGGGAATGGATGACACGCCTGAAAAAATAAAAGTATTA
GAACGAATTATTGCTGGTGC

Product: HSP90 family protein

Products: NA

Alternate protein names: Heat shock protein htpG; High temperature protein G [H]

Number of amino acids: Translated: 601; Mature: 601

Protein sequence:

>601_residues
MENYSHRFQVNLAGMIDILSNHLYDEKDVYIRELLQNATDAIRARKKIDSTLEGKIHASLTGDNNEKTLIVEDNGIGLTE
DEVHAFLATIANSSKGEKNFDGESSNDFIGRFGIGLLSCFIVSDEIVMISTSKKDGGTTEWRGKADGTYSVRKIETETRE
PGTQVYLRLRADLDEHPECEDVEELINTLKKYGSSLESNIIVEINGLEEEINSWTKQFSNKETLSKLSKDQIIQYGEYIL
GTRFQDYFLIENESGRTFGIAYMIPHAVQMNAIRKNTVFLNNMYVTSEANNILPDWSFFAKCVIWTDELQPVASREAFYK
NERLTSVADELGVALKKGIETLPEEALMKLLATHYLGFKALASEDAPFLKLIYPYLPVRTLNGEEKLGDIIAKNDVIYYT
YSVDDFRQIKDIARSSGMTLINGGYSYDSPILAQLSYFVEGTEFVLIEPEEMTNKLRPMTVSEEQAYQPILTEMNSMMAE
FDTDVLIKHFEPKDLPIIFIHSTATQELRELERAVEETNSVFSDILESIQKEQEPAPLAHLYLNLDNELIKRLFTSGKTV
KELSVIVNVLYIQALLLGHYPLKRKEMVLMNQNMLRILEML

Sequences:

>Translated_601_residues
MENYSHRFQVNLAGMIDILSNHLYDEKDVYIRELLQNATDAIRARKKIDSTLEGKIHASLTGDNNEKTLIVEDNGIGLTE
DEVHAFLATIANSSKGEKNFDGESSNDFIGRFGIGLLSCFIVSDEIVMISTSKKDGGTTEWRGKADGTYSVRKIETETRE
PGTQVYLRLRADLDEHPECEDVEELINTLKKYGSSLESNIIVEINGLEEEINSWTKQFSNKETLSKLSKDQIIQYGEYIL
GTRFQDYFLIENESGRTFGIAYMIPHAVQMNAIRKNTVFLNNMYVTSEANNILPDWSFFAKCVIWTDELQPVASREAFYK
NERLTSVADELGVALKKGIETLPEEALMKLLATHYLGFKALASEDAPFLKLIYPYLPVRTLNGEEKLGDIIAKNDVIYYT
YSVDDFRQIKDIARSSGMTLINGGYSYDSPILAQLSYFVEGTEFVLIEPEEMTNKLRPMTVSEEQAYQPILTEMNSMMAE
FDTDVLIKHFEPKDLPIIFIHSTATQELRELERAVEETNSVFSDILESIQKEQEPAPLAHLYLNLDNELIKRLFTSGKTV
KELSVIVNVLYIQALLLGHYPLKRKEMVLMNQNMLRILEML
>Mature_601_residues
MENYSHRFQVNLAGMIDILSNHLYDEKDVYIRELLQNATDAIRARKKIDSTLEGKIHASLTGDNNEKTLIVEDNGIGLTE
DEVHAFLATIANSSKGEKNFDGESSNDFIGRFGIGLLSCFIVSDEIVMISTSKKDGGTTEWRGKADGTYSVRKIETETRE
PGTQVYLRLRADLDEHPECEDVEELINTLKKYGSSLESNIIVEINGLEEEINSWTKQFSNKETLSKLSKDQIIQYGEYIL
GTRFQDYFLIENESGRTFGIAYMIPHAVQMNAIRKNTVFLNNMYVTSEANNILPDWSFFAKCVIWTDELQPVASREAFYK
NERLTSVADELGVALKKGIETLPEEALMKLLATHYLGFKALASEDAPFLKLIYPYLPVRTLNGEEKLGDIIAKNDVIYYT
YSVDDFRQIKDIARSSGMTLINGGYSYDSPILAQLSYFVEGTEFVLIEPEEMTNKLRPMTVSEEQAYQPILTEMNSMMAE
FDTDVLIKHFEPKDLPIIFIHSTATQELRELERAVEETNSVFSDILESIQKEQEPAPLAHLYLNLDNELIKRLFTSGKTV
KELSVIVNVLYIQALLLGHYPLKRKEMVLMNQNMLRILEML

Specific function: Molecular chaperone. Has ATPase activity [H]

COG id: COG0326

COG function: function code O; Molecular chaperone, HSP90 family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heat shock protein 90 family [H]

Homologues:

Organism=Homo sapiens, GI155722983, Length=351, Percent_Identity=23.9316239316239, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI153792590, Length=200, Percent_Identity=30.5, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI154146191, Length=194, Percent_Identity=31.4432989690722, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI20149594, Length=197, Percent_Identity=31.4720812182741, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI4507677, Length=209, Percent_Identity=28.7081339712919, Blast_Score=84, Evalue=5e-16,
Organism=Escherichia coli, GI1786679, Length=648, Percent_Identity=23.9197530864198, Blast_Score=105, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI115535205, Length=344, Percent_Identity=27.6162790697674, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI115535167, Length=344, Percent_Identity=27.906976744186, Blast_Score=116, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17559162, Length=189, Percent_Identity=29.6296296296296, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17542208, Length=200, Percent_Identity=26, Blast_Score=78, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6325016, Length=197, Percent_Identity=31.4720812182741, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323840, Length=197, Percent_Identity=31.4720812182741, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24586016, Length=339, Percent_Identity=26.2536873156342, Blast_Score=102, Evalue=7e-22,
Organism=Drosophila melanogaster, GI17647529, Length=197, Percent_Identity=28.4263959390863, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI21357739, Length=203, Percent_Identity=29.064039408867, Blast_Score=84, Evalue=4e-16,

Paralogues:

None

Copy number: 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 2419 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR019805
- InterPro:   IPR001404
- InterPro:   IPR020575
- InterPro:   IPR020568 [H]

Pfam domain/function: PF02518 HATPase_c; PF00183 HSP90 [H]

EC number: NA

Molecular weight: Translated: 68431; Mature: 68431

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENYSHRFQVNLAGMIDILSNHLYDEKDVYIRELLQNATDAIRARKKIDSTLEGKIHASL
CCCCCCEEEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHCCEEEEEE
TGDNNEKTLIVEDNGIGLTEDEVHAFLATIANSSKGEKNFDGESSNDFIGRFGIGLLSCF
ECCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
IVSDEIVMISTSKKDGGTTEWRGKADGTYSVRKIETETREPGTQVYLRLRADLDEHPECE
HCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCEEEEEEECCCCCCCCHH
DVEELINTLKKYGSSLESNIIVEINGLEEEINSWTKQFSNKETLSKLSKDQIIQYGEYIL
HHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
GTRFQDYFLIENESGRTFGIAYMIPHAVQMNAIRKNTVFLNNMYVTSEANNILPDWSFFA
CCCCCEEEEEECCCCCEEEEEECCCCHHHHHHHCCCEEEEEEEEEECCCCCCCCCHHHHH
KCVIWTDELQPVASREAFYKNERLTSVADELGVALKKGIETLPEEALMKLLATHYLGFKA
EEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LASEDAPFLKLIYPYLPVRTLNGEEKLGDIIAKNDVIYYTYSVDDFRQIKDIARSSGMTL
HCCCCCCHHHHHHHHCCEEECCCHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHCCCEE
INGGYSYDSPILAQLSYFVEGTEFVLIEPEEMTNKLRPMTVSEEQAYQPILTEMNSMMAE
EECCCCCCCHHHHHHHHHHCCCEEEEECCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
FDTDVLIKHFEPKDLPIIFIHSTATQELRELERAVEETNSVFSDILESIQKEQEPAPLAH
CCCHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
LYLNLDNELIKRLFTSGKTVKELSVIVNVLYIQALLLGHYPLKRKEMVLMNQNMLRILEM
EEEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
L
C
>Mature Secondary Structure
MENYSHRFQVNLAGMIDILSNHLYDEKDVYIRELLQNATDAIRARKKIDSTLEGKIHASL
CCCCCCEEEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHCCEEEEEE
TGDNNEKTLIVEDNGIGLTEDEVHAFLATIANSSKGEKNFDGESSNDFIGRFGIGLLSCF
ECCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
IVSDEIVMISTSKKDGGTTEWRGKADGTYSVRKIETETREPGTQVYLRLRADLDEHPECE
HCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCEEEEEEECCCCCCCCHH
DVEELINTLKKYGSSLESNIIVEINGLEEEINSWTKQFSNKETLSKLSKDQIIQYGEYIL
HHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
GTRFQDYFLIENESGRTFGIAYMIPHAVQMNAIRKNTVFLNNMYVTSEANNILPDWSFFA
CCCCCEEEEEECCCCCEEEEEECCCCHHHHHHHCCCEEEEEEEEEECCCCCCCCCHHHHH
KCVIWTDELQPVASREAFYKNERLTSVADELGVALKKGIETLPEEALMKLLATHYLGFKA
EEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LASEDAPFLKLIYPYLPVRTLNGEEKLGDIIAKNDVIYYTYSVDDFRQIKDIARSSGMTL
HCCCCCCHHHHHHHHCCEEECCCHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHCCCEE
INGGYSYDSPILAQLSYFVEGTEFVLIEPEEMTNKLRPMTVSEEQAYQPILTEMNSMMAE
EECCCCCCCHHHHHHHHHHCCCEEEEECCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
FDTDVLIKHFEPKDLPIIFIHSTATQELRELERAVEETNSVFSDILESIQKEQEPAPLAH
CCCHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
LYLNLDNELIKRLFTSGKTVKELSVIVNVLYIQALLLGHYPLKRKEMVLMNQNMLRILEM
EEEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
L
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA