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The map label for this gene is msrA [H]

Identifier: 226223539

GI number: 226223539

Start: 957153

End: 958724

Strand: Direct

Name: msrA [H]

Synonym: Lm4b_00939

Alternate gene names: 226223539

Gene position: 957153-958724 (Clockwise)

Preceding gene: 226223538

Following gene: 226223540

Centisome position: 32.86

GC content: 39.25

Gene sequence:

>1572_bases
ATGTCTACAATCGAAATAAATCAATTAAAAATAGAAGTAGCAGACAGAGTTTTAGTAGAAATCCCTCATCTGCTAGTTAG
TAAAAAAGCAAGAATCGGCATCATCGGTCAAAATGGTCTAGGAAAAACAACACTAATGGAAGTGATTGCTGGCGCTAAAG
AAGCAACATCTGGCACGGTGACTACCCAAGGAAAACTTGCTTACATCAAACAACTTTCCACTGATACAAGTACGAAAAGC
GGCGGCGAAAAAACAAGAAAAGCAATTCAACATGCGATGCGCCAAAACCCAAGTGTTCTCCTAGCAGATGAACCGACAAG
CAACCTCGATGTCGAAAGCGTCAAACATTTAGAACGTCAGTGGAGCGATTTCCACGGTGCGCTCATAATTATATCGCATG
ACCGTACCTTTTTAGATGCACTTTGTACAGAAATATGGGAAATCAAAAACCAAAAAATTCACGTATACAAAGGAAACTAC
CACGCGTATTTAGAACAAAAACAACAACAAGAAAACCAAGCGGAACTCGTATACAAAGAATTTAAAAACAAAAAGCAACA
ACTACAAGCCTCCCAAACACACCATGAAATCGAAGCAGGTCGCATTGTCAAACCTGGAAAACGCCTAAACAACAAAGAAG
CCAGCGCGTTTAAAGCCGGAAAAGGCACACAACAAAAGAAACAACACAGTACCATCAAAGCTTTAGAAAAACGAATTGAA
CGGCTCGGCAATGTCGAAAAACCACATACAACTAAACCAATCAAAATGATCACCCCAGACAATCGCGTCATAAAAAAAGG
TAATACGATACTAAGTGTCAAAGAAACAACCTACGAGATCGCAGGACGAAAACTATTTGAAACAAAAGCTTTTTCTATTA
AAGCAGGGGATAAAGTGGCGCTAATCGGTGAAAATGCGAGCGGGAAAACTACATTTTTAAAAGAAATAATCCAAGAAAAT
CCTAATCTCCTATGTAATACCCAAGCGAAAATTGCTTATTTCGACCAAGAATTGAATGGATTAAACCAAACGAAATCCCT
GTTAGAAAACATCTCGGAAATTAGCGTTCAAACCAAGCAAGTAAACAGAGAAGTACTAGGTAGCATGCATTTTAAAGAAA
GCGATTTGCATAAGGAAGTGCGCATGCTCTCTGGCGGGGAACGAGTGAAGTTGCTGCTCAGTATGCTCCTCGTTAGTGAC
GCCAATTTCTTGATTCTTGATGAACCAACCAACTATTTGGATATCTATGCAATGGAAGCGCTGGAAACGTTAATCAAACA
ATTTGCGGGGACAGTACTATTCGTTTCGCATGATAGAACTTTTGTTAACCACGTGGCAGAACAATTACTCGTCATCGAAA
ATAATGAAATGACTTTCCACCGGATGACTTTCGCGGAATATGAAGAAAGTAAAGCGCCAAGTCGCATCACAGAAGAAGAT
AAGTTGATTTTAGAAATGCGCATGTCAGAAATTGCAGCCAAGCTTATGCAACCGAATTTAAAGCCCACAGAAAAAGCCAT
GCTCGAACAAGATTATCAAGAAATTATCACAAAAAGACAACAATTTAGTTAA

Upstream 100 bases:

>100_bases
GGATTCGTATGTTCATTTCGCATGATAACTCTTGCTACAGGCCTTTTTTTGGCGTAGCCTCGCGGATTCCTCTCTGGAAA
TATTCAGGAGGTTATTTTTT

Downstream 100 bases:

>100_bases
ATTGTTGTCTTTTTATTCAAGCTAAATAAAAAATATAGTCATTTATATTTTACTTGATTTCTGCAAAAGATAGGCTTAGA
ATCAAATAGTTATTAAAAAG

Product: ABC transporter ATP-binding protein (antibiotic resistance)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 523; Mature: 522

Protein sequence:

>523_residues
MSTIEINQLKIEVADRVLVEIPHLLVSKKARIGIIGQNGLGKTTLMEVIAGAKEATSGTVTTQGKLAYIKQLSTDTSTKS
GGEKTRKAIQHAMRQNPSVLLADEPTSNLDVESVKHLERQWSDFHGALIIISHDRTFLDALCTEIWEIKNQKIHVYKGNY
HAYLEQKQQQENQAELVYKEFKNKKQQLQASQTHHEIEAGRIVKPGKRLNNKEASAFKAGKGTQQKKQHSTIKALEKRIE
RLGNVEKPHTTKPIKMITPDNRVIKKGNTILSVKETTYEIAGRKLFETKAFSIKAGDKVALIGENASGKTTFLKEIIQEN
PNLLCNTQAKIAYFDQELNGLNQTKSLLENISEISVQTKQVNREVLGSMHFKESDLHKEVRMLSGGERVKLLLSMLLVSD
ANFLILDEPTNYLDIYAMEALETLIKQFAGTVLFVSHDRTFVNHVAEQLLVIENNEMTFHRMTFAEYEESKAPSRITEED
KLILEMRMSEIAAKLMQPNLKPTEKAMLEQDYQEIITKRQQFS

Sequences:

>Translated_523_residues
MSTIEINQLKIEVADRVLVEIPHLLVSKKARIGIIGQNGLGKTTLMEVIAGAKEATSGTVTTQGKLAYIKQLSTDTSTKS
GGEKTRKAIQHAMRQNPSVLLADEPTSNLDVESVKHLERQWSDFHGALIIISHDRTFLDALCTEIWEIKNQKIHVYKGNY
HAYLEQKQQQENQAELVYKEFKNKKQQLQASQTHHEIEAGRIVKPGKRLNNKEASAFKAGKGTQQKKQHSTIKALEKRIE
RLGNVEKPHTTKPIKMITPDNRVIKKGNTILSVKETTYEIAGRKLFETKAFSIKAGDKVALIGENASGKTTFLKEIIQEN
PNLLCNTQAKIAYFDQELNGLNQTKSLLENISEISVQTKQVNREVLGSMHFKESDLHKEVRMLSGGERVKLLLSMLLVSD
ANFLILDEPTNYLDIYAMEALETLIKQFAGTVLFVSHDRTFVNHVAEQLLVIENNEMTFHRMTFAEYEESKAPSRITEED
KLILEMRMSEIAAKLMQPNLKPTEKAMLEQDYQEIITKRQQFS
>Mature_522_residues
STIEINQLKIEVADRVLVEIPHLLVSKKARIGIIGQNGLGKTTLMEVIAGAKEATSGTVTTQGKLAYIKQLSTDTSTKSG
GEKTRKAIQHAMRQNPSVLLADEPTSNLDVESVKHLERQWSDFHGALIIISHDRTFLDALCTEIWEIKNQKIHVYKGNYH
AYLEQKQQQENQAELVYKEFKNKKQQLQASQTHHEIEAGRIVKPGKRLNNKEASAFKAGKGTQQKKQHSTIKALEKRIER
LGNVEKPHTTKPIKMITPDNRVIKKGNTILSVKETTYEIAGRKLFETKAFSIKAGDKVALIGENASGKTTFLKEIIQENP
NLLCNTQAKIAYFDQELNGLNQTKSLLENISEISVQTKQVNREVLGSMHFKESDLHKEVRMLSGGERVKLLLSMLLVSDA
NFLILDEPTNYLDIYAMEALETLIKQFAGTVLFVSHDRTFVNHVAEQLLVIENNEMTFHRMTFAEYEESKAPSRITEEDK
LILEMRMSEIAAKLMQPNLKPTEKAMLEQDYQEIITKRQQFS

Specific function: Confers resistance to 14-membered ring macrolides (like erythromycin) and to B streptogramins, by acting as an ATP- dependent efflux pump [H]

COG id: COG0488

COG function: function code R; ATPase components of ABC transporters with duplicated ATPase domains

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ABC transporter domains [H]

Homologues:

Organism=Homo sapiens, GI148612853, Length=435, Percent_Identity=27.5862068965517, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI27881506, Length=411, Percent_Identity=27.007299270073, Blast_Score=139, Evalue=7e-33,
Organism=Homo sapiens, GI10947137, Length=411, Percent_Identity=27.007299270073, Blast_Score=139, Evalue=7e-33,
Organism=Homo sapiens, GI69354671, Length=405, Percent_Identity=27.1604938271605, Blast_Score=135, Evalue=8e-32,
Organism=Homo sapiens, GI10947135, Length=405, Percent_Identity=27.1604938271605, Blast_Score=135, Evalue=1e-31,
Organism=Escherichia coli, GI2367384, Length=405, Percent_Identity=34.8148148148148, Blast_Score=191, Evalue=9e-50,
Organism=Escherichia coli, GI1787182, Length=401, Percent_Identity=32.4189526184539, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1787041, Length=399, Percent_Identity=29.0726817042606, Blast_Score=171, Evalue=1e-43,
Organism=Escherichia coli, GI1789751, Length=408, Percent_Identity=26.9607843137255, Blast_Score=161, Evalue=1e-40,
Organism=Escherichia coli, GI1788506, Length=431, Percent_Identity=23.4338747099768, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1789891, Length=205, Percent_Identity=24.390243902439, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17559834, Length=435, Percent_Identity=28.0459770114943, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17553372, Length=396, Percent_Identity=28.7878787878788, Blast_Score=138, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI17555318, Length=385, Percent_Identity=25.7142857142857, Blast_Score=134, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6320874, Length=408, Percent_Identity=27.6960784313726, Blast_Score=145, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6321121, Length=402, Percent_Identity=24.6268656716418, Blast_Score=136, Evalue=7e-33,
Organism=Saccharomyces cerevisiae, GI6325030, Length=212, Percent_Identity=30.6603773584906, Blast_Score=85, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6323278, Length=188, Percent_Identity=25, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6324314, Length=183, Percent_Identity=26.775956284153, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24666836, Length=390, Percent_Identity=28.974358974359, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24641342, Length=434, Percent_Identity=28.3410138248848, Blast_Score=145, Evalue=6e-35,
Organism=Drosophila melanogaster, GI24642252, Length=398, Percent_Identity=26.1306532663317, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI18859989, Length=398, Percent_Identity=26.1306532663317, Blast_Score=143, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593
- InterPro:   IPR000014 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 59279; Mature: 59148

Theoretical pI: Translated: 9.34; Mature: 9.34

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTIEINQLKIEVADRVLVEIPHLLVSKKARIGIIGQNGLGKTTLMEVIAGAKEATSGTV
CCCEEEHHEEHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCE
TTQGKLAYIKQLSTDTSTKSGGEKTRKAIQHAMRQNPSVLLADEPTSNLDVESVKHLERQ
EECCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHH
WSDFHGALIIISHDRTFLDALCTEIWEIKNQKIHVYKGNYHAYLEQKQQQENQAELVYKE
HHCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHH
FKNKKQQLQASQTHHEIEAGRIVKPGKRLNNKEASAFKAGKGTQQKKQHSTIKALEKRIE
HHHHHHHHHHHHHHHHHCCCCEECCCHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHH
RLGNVEKPHTTKPIKMITPDNRVIKKGNTILSVKETTYEIAGRKLFETKAFSIKAGDKVA
HHCCCCCCCCCCCEEEECCCCCEEECCCEEEEEEHHHHHHHCCHHHHCCEEEEECCCEEE
LIGENASGKTTFLKEIIQENPNLLCNTQAKIAYFDQELNGLNQTKSLLENISEISVQTKQ
EEECCCCCHHHHHHHHHHCCCCEEEECCCCEEEHHHHHCCCHHHHHHHHHHHHHHHHHHH
VNREVLGSMHFKESDLHKEVRMLSGGERVKLLLSMLLVSDANFLILDEPTNYLDIYAMEA
HHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHH
LETLIKQFAGTVLFVSHDRTFVNHVAEQLLVIENNEMTFHRMTFAEYEESKAPSRITEED
HHHHHHHHCCEEEEEECCHHHHHHHHHHEEEEECCCEEEEEHHHHHHHHCCCCCCCCCHH
KLILEMRMSEIAAKLMQPNLKPTEKAMLEQDYQEIITKRQQFS
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
STIEINQLKIEVADRVLVEIPHLLVSKKARIGIIGQNGLGKTTLMEVIAGAKEATSGTV
CCEEEHHEEHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCE
TTQGKLAYIKQLSTDTSTKSGGEKTRKAIQHAMRQNPSVLLADEPTSNLDVESVKHLERQ
EECCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHH
WSDFHGALIIISHDRTFLDALCTEIWEIKNQKIHVYKGNYHAYLEQKQQQENQAELVYKE
HHCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHH
FKNKKQQLQASQTHHEIEAGRIVKPGKRLNNKEASAFKAGKGTQQKKQHSTIKALEKRIE
HHHHHHHHHHHHHHHHHCCCCEECCCHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHH
RLGNVEKPHTTKPIKMITPDNRVIKKGNTILSVKETTYEIAGRKLFETKAFSIKAGDKVA
HHCCCCCCCCCCCEEEECCCCCEEECCCEEEEEEHHHHHHHCCHHHHCCEEEEECCCEEE
LIGENASGKTTFLKEIIQENPNLLCNTQAKIAYFDQELNGLNQTKSLLENISEISVQTKQ
EEECCCCCHHHHHHHHHHCCCCEEEECCCCEEEHHHHHCCCHHHHHHHHHHHHHHHHHHH
VNREVLGSMHFKESDLHKEVRMLSGGERVKLLLSMLLVSDANFLILDEPTNYLDIYAMEA
HHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHH
LETLIKQFAGTVLFVSHDRTFVNHVAEQLLVIENNEMTFHRMTFAEYEESKAPSRITEED
HHHHHHHHCCEEEEEECCHHHHHHHHHHEEEEECCCEEEEEHHHHHHHHCCCCCCCCCHH
KLILEMRMSEIAAKLMQPNLKPTEKAMLEQDYQEIITKRQQFS
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2233255 [H]