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The map label for this gene is gor [H]

Identifier: 226223526

GI number: 226223526

Start: 943267

End: 944616

Strand: Direct

Name: gor [H]

Synonym: Lm4b_00926

Alternate gene names: 226223526

Gene position: 943267-944616 (Clockwise)

Preceding gene: 226223525

Following gene: 226223527

Centisome position: 32.38

GC content: 42.59

Gene sequence:

>1350_bases
ATGGAAAAGCATTATGATTATATTGCGATTGGCGGCGGAAGTGGCGGAATTGCTTCGATTAATCGCGCAGCCATGCACGG
AGCAAAATGTGCATTAATTGAACCAAAATTTTTAGGTGGAACTTGTGTAAATGTTGGTTGTGTTCCGAAAAAAGTCATGT
GGTATGGCGCACAAATTAAAGAAGCGATGGATTTATACGCAGATGCTTATGGTTACCAAGTGGACGCGAGCTTCAACTTC
CAAAAACTAGTCGAAAATCGAGAAGCGTACATTGAACGGATTCGAGGTTCTTACAAAAATGGGCTGGATAATAATAAAGT
AGAATGGATTAAAGGTTATGCCGAATTTGTCGATGAAAAAACATTGCGCGTAAACGGCGAACTAGTGACAGCGGATCATA
TTTTAATTGCAACAGGCGGCGAACCAGCGCTTCCTTCCATTCCGGGCGCAGAATTTGGCATCACCTCAGATGGCTTTTTT
GCATTAAAAGAACTACCTAAAAAAGTGGCGGTTGTTGGCGCGGGATACATTGCGGTTGAACTAGCTGGTGTACTACAACA
ACTTGGCTCAGAAACGCATTTATTTGTACGGAAACATGCACCACTCCGAAATTTTGATCCACTTTTAACAGATACACTAA
CCGAAATTATTGAGCAATCGGATATGATGTTGCATAAACACGCTGTTCCTCAAAAAGTTGAAAAAAATCCAGATGGCAGT
TTGACGTTGAGCTTAGAGGATGGCCGCACAGAAACCGTTGATACGCTTATTTGGGCGATCGGACGTAAACCAGTCATCCA
AGGTCTTCAAATCGAAAAAGCGGGCGTAAAACTTCTAGAAAGCGGACATATCGCCGTAGATAAATTCCAAAACACCAATG
TAGCGGGGATTTATGCAGTTGGCGATGTAACGGGTCATTATGAATTAACTCCAGTCGCAATTGCAGCAGGGCGCCGTTTA
TCAGAACGCCTTTTCAATAACAAAAAAGATGCACATTTAAACTATGAAAATATCCCAACCGTTGTATTTAGCCATCCAGC
TATCGGAACGGTTGGTTTAACAGAACCAGAAGCAATCGAAAAATACGGCAAAGAAAATATCAAAGTGTACACTTCTAGCT
TTACCTCAATGTATACAGCCATCACAGACCACCGCGAACCTTGCCGAATGAAATTAATTTGCGAAGGGAAGACAGAGCGC
GTCATTGGCTTGCACGGGATTGGTTACGGTGTGGACGAGATGATTCAAGGATTCGCTGTTGCGATTAATATGGGCGCAAC
AAAAGCCGATTTCGACAATACGGTTGCGATTCACCCAACAGGATCCGAAGAATTTGTTACAATGAAATAG

Upstream 100 bases:

>100_bases
TGATAAAACGATACTTACCAAATCCGCGGGTTCTTGCGATTATGCGGGGCGAAGCGTATTTATAAAAACGAAAACGAAGA
AATGTTAGGAGAGATTTTGT

Downstream 100 bases:

>100_bases
AAAACAACGATGGAGGAGGAAGTACGTAATGGGAAAAAAATTATCACTTTATTTTGTAAGACATGGTCAAACCTACTTAA
ATAAAAACTTGCGCATGCAA

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MEKHYDYIAIGGGSGGIASINRAAMHGAKCALIEPKFLGGTCVNVGCVPKKVMWYGAQIKEAMDLYADAYGYQVDASFNF
QKLVENREAYIERIRGSYKNGLDNNKVEWIKGYAEFVDEKTLRVNGELVTADHILIATGGEPALPSIPGAEFGITSDGFF
ALKELPKKVAVVGAGYIAVELAGVLQQLGSETHLFVRKHAPLRNFDPLLTDTLTEIIEQSDMMLHKHAVPQKVEKNPDGS
LTLSLEDGRTETVDTLIWAIGRKPVIQGLQIEKAGVKLLESGHIAVDKFQNTNVAGIYAVGDVTGHYELTPVAIAAGRRL
SERLFNNKKDAHLNYENIPTVVFSHPAIGTVGLTEPEAIEKYGKENIKVYTSSFTSMYTAITDHREPCRMKLICEGKTER
VIGLHGIGYGVDEMIQGFAVAINMGATKADFDNTVAIHPTGSEEFVTMK

Sequences:

>Translated_449_residues
MEKHYDYIAIGGGSGGIASINRAAMHGAKCALIEPKFLGGTCVNVGCVPKKVMWYGAQIKEAMDLYADAYGYQVDASFNF
QKLVENREAYIERIRGSYKNGLDNNKVEWIKGYAEFVDEKTLRVNGELVTADHILIATGGEPALPSIPGAEFGITSDGFF
ALKELPKKVAVVGAGYIAVELAGVLQQLGSETHLFVRKHAPLRNFDPLLTDTLTEIIEQSDMMLHKHAVPQKVEKNPDGS
LTLSLEDGRTETVDTLIWAIGRKPVIQGLQIEKAGVKLLESGHIAVDKFQNTNVAGIYAVGDVTGHYELTPVAIAAGRRL
SERLFNNKKDAHLNYENIPTVVFSHPAIGTVGLTEPEAIEKYGKENIKVYTSSFTSMYTAITDHREPCRMKLICEGKTER
VIGLHGIGYGVDEMIQGFAVAINMGATKADFDNTVAIHPTGSEEFVTMK
>Mature_449_residues
MEKHYDYIAIGGGSGGIASINRAAMHGAKCALIEPKFLGGTCVNVGCVPKKVMWYGAQIKEAMDLYADAYGYQVDASFNF
QKLVENREAYIERIRGSYKNGLDNNKVEWIKGYAEFVDEKTLRVNGELVTADHILIATGGEPALPSIPGAEFGITSDGFF
ALKELPKKVAVVGAGYIAVELAGVLQQLGSETHLFVRKHAPLRNFDPLLTDTLTEIIEQSDMMLHKHAVPQKVEKNPDGS
LTLSLEDGRTETVDTLIWAIGRKPVIQGLQIEKAGVKLLESGHIAVDKFQNTNVAGIYAVGDVTGHYELTPVAIAAGRRL
SERLFNNKKDAHLNYENIPTVVFSHPAIGTVGLTEPEAIEKYGKENIKVYTSSFTSMYTAITDHREPCRMKLICEGKTER
VIGLHGIGYGVDEMIQGFAVAINMGATKADFDNTVAIHPTGSEEFVTMK

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=460, Percent_Identity=54.1304347826087, Blast_Score=464, Evalue=1e-131,
Organism=Homo sapiens, GI22035672, Length=475, Percent_Identity=39.3684210526316, Blast_Score=284, Evalue=9e-77,
Organism=Homo sapiens, GI148277071, Length=431, Percent_Identity=36.4269141531323, Blast_Score=249, Evalue=3e-66,
Organism=Homo sapiens, GI33519430, Length=431, Percent_Identity=36.4269141531323, Blast_Score=249, Evalue=4e-66,
Organism=Homo sapiens, GI33519428, Length=431, Percent_Identity=36.4269141531323, Blast_Score=249, Evalue=4e-66,
Organism=Homo sapiens, GI33519426, Length=431, Percent_Identity=36.4269141531323, Blast_Score=249, Evalue=4e-66,
Organism=Homo sapiens, GI148277065, Length=431, Percent_Identity=36.4269141531323, Blast_Score=249, Evalue=4e-66,
Organism=Homo sapiens, GI291045266, Length=431, Percent_Identity=36.4269141531323, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI291045268, Length=431, Percent_Identity=32.9466357308585, Blast_Score=195, Evalue=6e-50,
Organism=Homo sapiens, GI91199540, Length=464, Percent_Identity=29.5258620689655, Blast_Score=175, Evalue=7e-44,
Organism=Escherichia coli, GI1789915, Length=450, Percent_Identity=69.1111111111111, Blast_Score=630, Evalue=0.0,
Organism=Escherichia coli, GI1786307, Length=447, Percent_Identity=29.082774049217, Blast_Score=152, Evalue=6e-38,
Organism=Escherichia coli, GI87081717, Length=453, Percent_Identity=28.0353200883002, Blast_Score=149, Evalue=5e-37,
Organism=Escherichia coli, GI87082354, Length=461, Percent_Identity=27.5488069414317, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1787114, Length=214, Percent_Identity=29.4392523364486, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71983419, Length=450, Percent_Identity=54.6666666666667, Blast_Score=441, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI71983429, Length=450, Percent_Identity=54.6666666666667, Blast_Score=441, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI17557007, Length=469, Percent_Identity=36.6737739872068, Blast_Score=294, Evalue=8e-80,
Organism=Caenorhabditis elegans, GI71982272, Length=487, Percent_Identity=33.6755646817248, Blast_Score=221, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI32565766, Length=460, Percent_Identity=29.5652173913043, Blast_Score=178, Evalue=6e-45,
Organism=Saccharomyces cerevisiae, GI6325166, Length=464, Percent_Identity=51.5086206896552, Blast_Score=440, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6321091, Length=480, Percent_Identity=30.625, Blast_Score=174, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6325240, Length=472, Percent_Identity=24.5762711864407, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24640553, Length=470, Percent_Identity=39.5744680851064, Blast_Score=288, Evalue=6e-78,
Organism=Drosophila melanogaster, GI24640549, Length=470, Percent_Identity=39.5744680851064, Blast_Score=288, Evalue=6e-78,
Organism=Drosophila melanogaster, GI24640551, Length=470, Percent_Identity=39.5744680851064, Blast_Score=288, Evalue=7e-78,
Organism=Drosophila melanogaster, GI17737741, Length=473, Percent_Identity=36.3636363636364, Blast_Score=264, Evalue=8e-71,
Organism=Drosophila melanogaster, GI21358499, Length=462, Percent_Identity=27.9220779220779, Blast_Score=154, Evalue=1e-37,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006322
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 49023; Mature: 49023

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKHYDYIAIGGGSGGIASINRAAMHGAKCALIEPKFLGGTCVNVGCVPKKVMWYGAQIK
CCCCCCEEEEECCCCCCHHHHHHHHCCCEEEEECCCCCCCEEEECCCCCHHHHHHHHHHH
EAMDLYADAYGYQVDASFNFQKLVENREAYIERIRGSYKNGLDNNKVEWIKGYAEFVDEK
HHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCC
TLRVNGELVTADHILIATGGEPALPSIPGAEFGITSDGFFALKELPKKVAVVGAGYIAVE
EEEECCEEEEECEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHCCHHEEEEECCHHHHH
LAGVLQQLGSETHLFVRKHAPLRNFDPLLTDTLTEIIEQSDMMLHKHAVPQKVEKNPDGS
HHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCC
LTLSLEDGRTETVDTLIWAIGRKPVIQGLQIEKAGVKLLESGHIAVDKFQNTNVAGIYAV
EEEEECCCCCHHHHHHHHHHCCCHHHCCCEEEHHHHHHHHCCCEEEEECCCCCEEEEEEE
GDVTGHYELTPVAIAAGRRLSERLFNNKKDAHLNYENIPTVVFSHPAIGTVGLTEPEAIE
CCCCCCEEECEEHHHHCHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHH
KYGKENIKVYTSSFTSMYTAITDHREPCRMKLICEGKTERVIGLHGIGYGVDEMIQGFAV
HCCCCCEEEEECHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEECCCCCHHHHHCCEEE
AINMGATKADFDNTVAIHPTGSEEFVTMK
EEECCCCCCCCCCEEEEECCCCCCEEEEC
>Mature Secondary Structure
MEKHYDYIAIGGGSGGIASINRAAMHGAKCALIEPKFLGGTCVNVGCVPKKVMWYGAQIK
CCCCCCEEEEECCCCCCHHHHHHHHCCCEEEEECCCCCCCEEEECCCCCHHHHHHHHHHH
EAMDLYADAYGYQVDASFNFQKLVENREAYIERIRGSYKNGLDNNKVEWIKGYAEFVDEK
HHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCC
TLRVNGELVTADHILIATGGEPALPSIPGAEFGITSDGFFALKELPKKVAVVGAGYIAVE
EEEECCEEEEECEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHCCHHEEEEECCHHHHH
LAGVLQQLGSETHLFVRKHAPLRNFDPLLTDTLTEIIEQSDMMLHKHAVPQKVEKNPDGS
HHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCC
LTLSLEDGRTETVDTLIWAIGRKPVIQGLQIEKAGVKLLESGHIAVDKFQNTNVAGIYAV
EEEEECCCCCHHHHHHHHHHCCCHHHCCCEEEHHHHHHHHCCCEEEEECCCCCEEEEEEE
GDVTGHYELTPVAIAAGRRLSERLFNNKKDAHLNYENIPTVVFSHPAIGTVGLTEPEAIE
CCCCCCEEECEEHHHHCHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHH
KYGKENIKVYTSSFTSMYTAITDHREPCRMKLICEGKTERVIGLHGIGYGVDEMIQGFAV
HCCCCCEEEEECHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEECCCCCHHHHHCCEEE
AINMGATKADFDNTVAIHPTGSEEFVTMK
EEECCCCCCCCCCEEEEECCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3521741; 8041620; 9278503; 2006135; 8061609 [H]