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The map label for this gene is manR [H]

Identifier: 226223492

GI number: 226223492

Start: 912726

End: 914744

Strand: Direct

Name: manR [H]

Synonym: Lm4b_00891

Alternate gene names: 226223492

Gene position: 912726-914744 (Clockwise)

Preceding gene: 226223491

Following gene: 226223493

Centisome position: 31.34

GC content: 37.3

Gene sequence:

>2019_bases
ATGAAACTAAATCAGCAGTGTATTCAAATTTTAGATTTTCTTATGGAGCAGGAAGATTTTAAAAATATTGGTTATATTTC
TAACGCGCTTGGTTGTTCGGAGCGAAGTGTTCGTTATAGTTTGGAAAAAATCGATATTTTTCTCCATGAGCAAACATTAC
CAGCTCTTATCAGACATACAAGGAAAGGGGTGCTACTTCCGGAAAAGAATATCGTAAATCCGGTTGTGCGTAAATTTAAG
CAACAAATTACGCCGAAAAAATATCGTTACAGCCAAGAAGAAGTGCAGCAATTTTTACTGCTAAAACTGCTTTTAAGTGA
AGAAGTGCTCCCGGTTACTTATTTTGAAGAAGTCCTGTTTATTTCCAGATCCTCTGTGCTAAATCATCTACGTGCTATTG
AAGGAGAACTTTTTTTAAATAATTTAGATTTATCGCATCAGCCTAGGCATGGCTTTCTAGTGACTGGAAATTTAATTACG
AAAACATCGCTTTTTGCTAGAAGTTTCTTGCGTTTTATTAATATCCGCGAATTTTATCAGTTTTTAGATTCGGAAAATAG
CTTATCTAAAAAAGGCGAGTTATTTTTTTATAATCTTTTTGAACTGGAGATTTTGCAGGAGGTGAATCGTGAGGCGCATT
CGGTGGAGGAGAATATGACACGTGCGATGGATGAGCAGCTTTACTTAACGCTAATTGCGATTTTACTAAAGCAGCATGAA
GCCAAACCGGATTTTCAGTTTACAGCAGATTTTATGATTAAAGATGAGCTTGATCAGGCGTTAGCAACAATTATTGGGTC
TTTGAAGCAGTATCAATATGGGCGTGAAGATGAGGCGGTAATTGAAGCATTTGTAACAGGTATTTGCGAAAAAATGGGTG
AAATTTATCAAGTGGATTTTGTGCATGGCGATACGGATTTTTTCACGCAAATCAAAGCACACATTAAATTAATGATTAGG
CGTGTTCGCGCCGGAGTCACTATCGAGAATCCGATTTTTAATGAATTTATGCGCGATAATCGAGAAATTTTTATGCGTGT
GAAGGAGAGTTTGGATGCACTCAAGCCGTTATTGCCGATTTCTGTCAGCTCTCAAGAAATTTCATTTTTAGCTATTTATT
TTGCATCTGAGGTACAACGCAATAAACAAACAGTTGAAATGAAGCCGAATTTGCTGATTATTTGCCCGGAAGGTGTCGCT
GTTTCAAAAATGATTGCGATTCAGTTAAAGCGTATGTTTGAGTTTGAATCGATTCAAACAATTGGCCTCAGAAAGTTCAA
ACGCGCGATGATGGCTGATTTTGATTTTGTGATTAGCACAGTGGATTTACCAGATATGCAAGACGCAAAAGTACTCCGGA
TTCATAGCTATTTGCAAAAAGAGGATATGGAATTACTGCAAAAGCATTTACGGATGAAACTCATCAAAAGTGATAAACAG
ATTATTAATAAGTTCAGTAAGATTTTAGCGATTATTGGCGAAAACACGCAAATTACTAATTTAAGTAAATTAGAATTCGA
TTTATTGGAAGCGCTTATATCGGATGAAGGTGAAACACCAAAAAGGCTTATACCACCGTTTCAATTTACAGAAGAAGCGA
TTGTTATGGAAGAAACATGCCCAACATGGAGGCAGGCAATTAAGCTTGGAACAAAATGTTTGGAGCATTTAGAAGTCATT
GAGCCGAGTTATCATGAAAAAATCATCCATAACTTAAAAGCATACGGGCCGTATATGGTCGTTGCGCCAGGTGTTGTCAT
TGCACATGCGGGGGCAAGTGACGGTGTTTTGATGGATGGCATTGGAGTGACGATTATTGAGGATGGCATCATGTTTTTCG
ATAGATACGAGGAGCCGGTTCATGTCATTTTCACCTTAGCTTTAAAAACAAAAGAGGCGCACTTGATCGTGGAACAATTA
ATGAAGTTAGCGCTGGACGAGGAAAAAATGCAAAAAATTAAAATGGCTAGCTCAAAACGTGATATTTATCATTACGTTAA
GTCGGCTATCTTTGAATGA

Upstream 100 bases:

>100_bases
TTTTTTTGTCCCTACGTATCTGACAAAAATAGCTATATAGCTTATTGTAAGCCCTATCATGAAAATGATAAATTGAATTT
AGAAAGAGGAGTGATACCTG

Downstream 100 bases:

>100_bases
GAGAGGGTTTCATAATGGACATAGAAAAAATATCGTTTTCATTAATTTCACTGGCGGGGGATTCGTTTTCTAAATTAATT
GAAGCCTTACATGCCGCAAA

Product: transcriptional regulator (antiterminator)

Products: NA

Alternate protein names: Putative phosphotransferase enzyme IIB component; Putative PTS system EIIB component; Putative phosphotransferase enzyme IIA component; Putative PTS system EIIA component [H]

Number of amino acids: Translated: 672; Mature: 672

Protein sequence:

>672_residues
MKLNQQCIQILDFLMEQEDFKNIGYISNALGCSERSVRYSLEKIDIFLHEQTLPALIRHTRKGVLLPEKNIVNPVVRKFK
QQITPKKYRYSQEEVQQFLLLKLLLSEEVLPVTYFEEVLFISRSSVLNHLRAIEGELFLNNLDLSHQPRHGFLVTGNLIT
KTSLFARSFLRFINIREFYQFLDSENSLSKKGELFFYNLFELEILQEVNREAHSVEENMTRAMDEQLYLTLIAILLKQHE
AKPDFQFTADFMIKDELDQALATIIGSLKQYQYGREDEAVIEAFVTGICEKMGEIYQVDFVHGDTDFFTQIKAHIKLMIR
RVRAGVTIENPIFNEFMRDNREIFMRVKESLDALKPLLPISVSSQEISFLAIYFASEVQRNKQTVEMKPNLLIICPEGVA
VSKMIAIQLKRMFEFESIQTIGLRKFKRAMMADFDFVISTVDLPDMQDAKVLRIHSYLQKEDMELLQKHLRMKLIKSDKQ
IINKFSKILAIIGENTQITNLSKLEFDLLEALISDEGETPKRLIPPFQFTEEAIVMEETCPTWRQAIKLGTKCLEHLEVI
EPSYHEKIIHNLKAYGPYMVVAPGVVIAHAGASDGVLMDGIGVTIIEDGIMFFDRYEEPVHVIFTLALKTKEAHLIVEQL
MKLALDEEKMQKIKMASSKRDIYHYVKSAIFE

Sequences:

>Translated_672_residues
MKLNQQCIQILDFLMEQEDFKNIGYISNALGCSERSVRYSLEKIDIFLHEQTLPALIRHTRKGVLLPEKNIVNPVVRKFK
QQITPKKYRYSQEEVQQFLLLKLLLSEEVLPVTYFEEVLFISRSSVLNHLRAIEGELFLNNLDLSHQPRHGFLVTGNLIT
KTSLFARSFLRFINIREFYQFLDSENSLSKKGELFFYNLFELEILQEVNREAHSVEENMTRAMDEQLYLTLIAILLKQHE
AKPDFQFTADFMIKDELDQALATIIGSLKQYQYGREDEAVIEAFVTGICEKMGEIYQVDFVHGDTDFFTQIKAHIKLMIR
RVRAGVTIENPIFNEFMRDNREIFMRVKESLDALKPLLPISVSSQEISFLAIYFASEVQRNKQTVEMKPNLLIICPEGVA
VSKMIAIQLKRMFEFESIQTIGLRKFKRAMMADFDFVISTVDLPDMQDAKVLRIHSYLQKEDMELLQKHLRMKLIKSDKQ
IINKFSKILAIIGENTQITNLSKLEFDLLEALISDEGETPKRLIPPFQFTEEAIVMEETCPTWRQAIKLGTKCLEHLEVI
EPSYHEKIIHNLKAYGPYMVVAPGVVIAHAGASDGVLMDGIGVTIIEDGIMFFDRYEEPVHVIFTLALKTKEAHLIVEQL
MKLALDEEKMQKIKMASSKRDIYHYVKSAIFE
>Mature_672_residues
MKLNQQCIQILDFLMEQEDFKNIGYISNALGCSERSVRYSLEKIDIFLHEQTLPALIRHTRKGVLLPEKNIVNPVVRKFK
QQITPKKYRYSQEEVQQFLLLKLLLSEEVLPVTYFEEVLFISRSSVLNHLRAIEGELFLNNLDLSHQPRHGFLVTGNLIT
KTSLFARSFLRFINIREFYQFLDSENSLSKKGELFFYNLFELEILQEVNREAHSVEENMTRAMDEQLYLTLIAILLKQHE
AKPDFQFTADFMIKDELDQALATIIGSLKQYQYGREDEAVIEAFVTGICEKMGEIYQVDFVHGDTDFFTQIKAHIKLMIR
RVRAGVTIENPIFNEFMRDNREIFMRVKESLDALKPLLPISVSSQEISFLAIYFASEVQRNKQTVEMKPNLLIICPEGVA
VSKMIAIQLKRMFEFESIQTIGLRKFKRAMMADFDFVISTVDLPDMQDAKVLRIHSYLQKEDMELLQKHLRMKLIKSDKQ
IINKFSKILAIIGENTQITNLSKLEFDLLEALISDEGETPKRLIPPFQFTEEAIVMEETCPTWRQAIKLGTKCLEHLEVI
EPSYHEKIIHNLKAYGPYMVVAPGVVIAHAGASDGVLMDGIGVTIIEDGIMFFDRYEEPVHVIFTLALKTKEAHLIVEQL
MKLALDEEKMQKIKMASSKRDIYHYVKSAIFE

Specific function: May regulate the expression of the mannose operon [H]

COG id: COG3711

COG function: function code K; Transcriptional antiterminator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIB type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI2367359, Length=133, Percent_Identity=25.5639097744361, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013196
- InterPro:   IPR007737
- InterPro:   IPR011608
- InterPro:   IPR016152
- InterPro:   IPR002178
- InterPro:   IPR013011
- InterPro:   IPR011991 [H]

Pfam domain/function: PF08279 HTH_11; PF05043 Mga; PF00874 PRD; PF00359 PTS_EIIA_2 [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 77896; Mature: 77896

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS51094 PTS_EIIA_TYPE_2 ; PS51099 PTS_EIIB_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLNQQCIQILDFLMEQEDFKNIGYISNALGCSERSVRYSLEKIDIFLHEQTLPALIRHT
CCCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RKGVLLPEKNIVNPVVRKFKQQITPKKYRYSQEEVQQFLLLKLLLSEEVLPVTYFEEVLF
HCCCCCCCCHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
ISRSSVLNHLRAIEGELFLNNLDLSHQPRHGFLVTGNLITKTSLFARSFLRFINIREFYQ
HHHHHHHHHHHHHCCHHEEECCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHH
FLDSENSLSKKGELFFYNLFELEILQEVNREAHSVEENMTRAMDEQLYLTLIAILLKQHE
HHCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
AKPDFQFTADFMIKDELDQALATIIGSLKQYQYGREDEAVIEAFVTGICEKMGEIYQVDF
CCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEEEEE
VHGDTDFFTQIKAHIKLMIRRVRAGVTIENPIFNEFMRDNREIFMRVKESLDALKPLLPI
EECCHHHHHHHHHHHHHHHHHHHCCCEECCHHHHHHHHCCHHHHHHHHHHHHHHCCCCCC
SVSSQEISFLAIYFASEVQRNKQTVEMKPNLLIICPEGVAVSKMIAIQLKRMFEFESIQT
CCCCCCHHHHHHHHHHHHHCCCCCEEECCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
IGLRKFKRAMMADFDFVISTVDLPDMQDAKVLRIHSYLQKEDMELLQKHLRMKLIKSDKQ
HHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IINKFSKILAIIGENTQITNLSKLEFDLLEALISDEGETPKRLIPPFQFTEEAIVMEETC
HHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHCCCCCCCHHCCCCCCCCCHHHHHHHCC
PTWRQAIKLGTKCLEHLEVIEPSYHEKIIHNLKAYGPYMVVAPGVVIAHAGASDGVLMDG
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEECCEEEEECCCCCCEEECC
IGVTIIEDGIMFFDRYEEPVHVIFTLALKTKEAHLIVEQLMKLALDEEKMQKIKMASSKR
CCEEEECCCHHHHHCCCCCEEEEEEEHHHCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
DIYHYVKSAIFE
HHHHHHHHHHCC
>Mature Secondary Structure
MKLNQQCIQILDFLMEQEDFKNIGYISNALGCSERSVRYSLEKIDIFLHEQTLPALIRHT
CCCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RKGVLLPEKNIVNPVVRKFKQQITPKKYRYSQEEVQQFLLLKLLLSEEVLPVTYFEEVLF
HCCCCCCCCHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
ISRSSVLNHLRAIEGELFLNNLDLSHQPRHGFLVTGNLITKTSLFARSFLRFINIREFYQ
HHHHHHHHHHHHHCCHHEEECCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHH
FLDSENSLSKKGELFFYNLFELEILQEVNREAHSVEENMTRAMDEQLYLTLIAILLKQHE
HHCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
AKPDFQFTADFMIKDELDQALATIIGSLKQYQYGREDEAVIEAFVTGICEKMGEIYQVDF
CCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEEEEE
VHGDTDFFTQIKAHIKLMIRRVRAGVTIENPIFNEFMRDNREIFMRVKESLDALKPLLPI
EECCHHHHHHHHHHHHHHHHHHHCCCEECCHHHHHHHHCCHHHHHHHHHHHHHHCCCCCC
SVSSQEISFLAIYFASEVQRNKQTVEMKPNLLIICPEGVAVSKMIAIQLKRMFEFESIQT
CCCCCCHHHHHHHHHHHHHCCCCCEEECCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
IGLRKFKRAMMADFDFVISTVDLPDMQDAKVLRIHSYLQKEDMELLQKHLRMKLIKSDKQ
HHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IINKFSKILAIIGENTQITNLSKLEFDLLEALISDEGETPKRLIPPFQFTEEAIVMEETC
HHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHCCCCCCCHHCCCCCCCCCHHHHHHHCC
PTWRQAIKLGTKCLEHLEVIEPSYHEKIIHNLKAYGPYMVVAPGVVIAHAGASDGVLMDG
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEECCEEEEECCCCCCEEECC
IGVTIIEDGIMFFDRYEEPVHVIFTLALKTKEAHLIVEQLMKLALDEEKMQKIKMASSKR
CCEEEECCCHHHHHCCCCCEEEEEEEHHHCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
DIYHYVKSAIFE
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]