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The map label for this gene is uvrC [H]

Identifier: 226223464

GI number: 226223464

Start: 884541

End: 885641

Strand: Direct

Name: uvrC [H]

Synonym: Lm4b_00862

Alternate gene names: 226223464

Gene position: 884541-885641 (Clockwise)

Preceding gene: 226223463

Following gene: 226223465

Centisome position: 30.37

GC content: 34.97

Gene sequence:

>1101_bases
TTGGACGATAAATTACAAAAGAAATTGACCTTATTACCTGAATCACCAGGTTGTTATATTTATAGAGATGAAAATAATGA
AATTCTTTATATTGGTAAATCTAAATGTTTGAAAAACCGTGTAAAGTCTTATTTTCATAGCAAACAAATTGGGAAAACTG
CAAGACTTGTTAGGCAAATTCGAGATTTAGAATTAATTATTACAACCTCCGAAAAAGAAGCTTTACTACTCGAAATGATC
TTAATTCAAAAATACCAGCCACCTTTTAATATCCAGCTAAAAGAAGGAACGAGCTACCCATATATCAAAATTACGAACGA
AAAAAATCCGCATATCGAAGTTGTGTTTGAAGTAAAGCGAGACGGCGCGCATTATTTTGGTCCTTATCCAGGTCGTTTTT
CCGCAAGACAGACGGTGGACCTAATTGAAAAATTGTTTCCACTTTGTCGATGTGACGGTAAGCCAGGACGACCATGTTTG
TACTACCATCTTGGATTATGCTTAGGTCCATGCCAAGCCGAAATTGATCCGGCAGTTTATAAAAAACAGATCCATAAAAT
TAGTCGTTTTCTTGAAGGCGACGTGAAAAATGTGAAGGATAAACTACTGGGGGACATGTTAACTGCAACCGAAAATCTTG
AATTCGAAAGGGCGGCAGAACTTCGAGATAAAATACACGCTATTAATGAGACAATCGAAAAGCAACATATTATTTTTCCT
GGCCTAAAAAATCGGGATATCATTGGTTGCTATGAACAAGATAACCATTTAAGTGTCTTCGTTTTCTTCGTTCGAAATGG
CGCAATCAATGGAAGTAAATGGCACGTTTTCCAAATTGAAAAATCCCTTCAAGAAGATTTAGCCAAATTTCTCAATCAAT
TTTATAAAGATCCTAACAATATTCGACCAAAAGAGTTGTTAATCGCTGAAAAAATAGATAAGAGCTTACTGAATGAGCAG
CTTAGAAAAGCTTGTTTATTTCCACAAAAAGGCGGTAAGAAGAAACAAGTAGACCTGGCTATCGAAAATGCGAAAAGTGC
TTATATTGCTTACGCAAAAATGAAAGAATATGATTTTGAAATACAACTAAACAATCATTAG

Upstream 100 bases:

>100_bases
TGAGGAGAACTAGCCGAAGAGTTTGTGCTAGTTCTTTTTGTGTCTTTACAAAAAGGATGACTAGGGATAGAATAGATGTT
CTAGAAGGAGGGGGAGCCCT

Downstream 100 bases:

>100_bases
AAGCTAATTTTTAACGATTAGCTTCTTCTCTTTGTTGTGTTGAAAATCTTATCTTAAATAACTATGGTCAATAACCTACC
CTTATGGTAAAATCTTACGA

Product: excinuclease ABC, chain C (UvrC)

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 366; Mature: 366

Protein sequence:

>366_residues
MDDKLQKKLTLLPESPGCYIYRDENNEILYIGKSKCLKNRVKSYFHSKQIGKTARLVRQIRDLELIITTSEKEALLLEMI
LIQKYQPPFNIQLKEGTSYPYIKITNEKNPHIEVVFEVKRDGAHYFGPYPGRFSARQTVDLIEKLFPLCRCDGKPGRPCL
YYHLGLCLGPCQAEIDPAVYKKQIHKISRFLEGDVKNVKDKLLGDMLTATENLEFERAAELRDKIHAINETIEKQHIIFP
GLKNRDIIGCYEQDNHLSVFVFFVRNGAINGSKWHVFQIEKSLQEDLAKFLNQFYKDPNNIRPKELLIAEKIDKSLLNEQ
LRKACLFPQKGGKKKQVDLAIENAKSAYIAYAKMKEYDFEIQLNNH

Sequences:

>Translated_366_residues
MDDKLQKKLTLLPESPGCYIYRDENNEILYIGKSKCLKNRVKSYFHSKQIGKTARLVRQIRDLELIITTSEKEALLLEMI
LIQKYQPPFNIQLKEGTSYPYIKITNEKNPHIEVVFEVKRDGAHYFGPYPGRFSARQTVDLIEKLFPLCRCDGKPGRPCL
YYHLGLCLGPCQAEIDPAVYKKQIHKISRFLEGDVKNVKDKLLGDMLTATENLEFERAAELRDKIHAINETIEKQHIIFP
GLKNRDIIGCYEQDNHLSVFVFFVRNGAINGSKWHVFQIEKSLQEDLAKFLNQFYKDPNNIRPKELLIAEKIDKSLLNEQ
LRKACLFPQKGGKKKQVDLAIENAKSAYIAYAKMKEYDFEIQLNNH
>Mature_366_residues
MDDKLQKKLTLLPESPGCYIYRDENNEILYIGKSKCLKNRVKSYFHSKQIGKTARLVRQIRDLELIITTSEKEALLLEMI
LIQKYQPPFNIQLKEGTSYPYIKITNEKNPHIEVVFEVKRDGAHYFGPYPGRFSARQTVDLIEKLFPLCRCDGKPGRPCL
YYHLGLCLGPCQAEIDPAVYKKQIHKISRFLEGDVKNVKDKLLGDMLTATENLEFERAAELRDKIHAINETIEKQHIIFP
GLKNRDIIGCYEQDNHLSVFVFFVRNGAINGSKWHVFQIEKSLQEDLAKFLNQFYKDPNNIRPKELLIAEKIDKSLLNEQ
LRKACLFPQKGGKKKQVDLAIENAKSAYIAYAKMKEYDFEIQLNNH

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=369, Percent_Identity=34.1463414634146, Blast_Score=205, Evalue=4e-54,
Organism=Escherichia coli, GI1788037, Length=183, Percent_Identity=32.2404371584699, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 42499; Mature: 42499

Theoretical pI: Translated: 9.07; Mature: 9.07

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDKLQKKLTLLPESPGCYIYRDENNEILYIGKSKCLKNRVKSYFHSKQIGKTARLVRQI
CCCHHHHHHEECCCCCCEEEEECCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHH
RDLELIITTSEKEALLLEMILIQKYQPPFNIQLKEGTSYPYIKITNEKNPHIEVVFEVKR
HCEEEEEECCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEECCCCCCEEEEEEEEC
DGAHYFGPYPGRFSARQTVDLIEKLFPLCRCDGKPGRPCLYYHLGLCLGPCQAEIDPAVY
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHCCCCCCCCHHHH
KKQIHKISRFLEGDVKNVKDKLLGDMLTATENLEFERAAELRDKIHAINETIEKQHIIFP
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCEEECC
GLKNRDIIGCYEQDNHLSVFVFFVRNGAINGSKWHVFQIEKSLQEDLAKFLNQFYKDPNN
CCCCCCEEEEEECCCCEEEEEEEEECCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCC
IRPKELLIAEKIDKSLLNEQLRKACLFPQKGGKKKQVDLAIENAKSAYIAYAKMKEYDFE
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCEEEEEEEEECEEEE
IQLNNH
EEECCC
>Mature Secondary Structure
MDDKLQKKLTLLPESPGCYIYRDENNEILYIGKSKCLKNRVKSYFHSKQIGKTARLVRQI
CCCHHHHHHEECCCCCCEEEEECCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHH
RDLELIITTSEKEALLLEMILIQKYQPPFNIQLKEGTSYPYIKITNEKNPHIEVVFEVKR
HCEEEEEECCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEECCCCCCEEEEEEEEC
DGAHYFGPYPGRFSARQTVDLIEKLFPLCRCDGKPGRPCLYYHLGLCLGPCQAEIDPAVY
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHCCCCCCCCHHHH
KKQIHKISRFLEGDVKNVKDKLLGDMLTATENLEFERAAELRDKIHAINETIEKQHIIFP
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCEEECC
GLKNRDIIGCYEQDNHLSVFVFFVRNGAINGSKWHVFQIEKSLQEDLAKFLNQFYKDPNN
CCCCCCEEEEEECCCCEEEEEEEEECCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCC
IRPKELLIAEKIDKSLLNEQLRKACLFPQKGGKKKQVDLAIENAKSAYIAYAKMKEYDFE
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCEEEEEEEEECEEEE
IQLNNH
EEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA