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The map label for this gene is nhaK [H]

Identifier: 226223420

GI number: 226223420

Start: 830732

End: 832780

Strand: Direct

Name: nhaK [H]

Synonym: Lm4b_00818

Alternate gene names: 226223420

Gene position: 830732-832780 (Clockwise)

Preceding gene: 226223419

Following gene: 226223423

Centisome position: 28.52

GC content: 39.73

Gene sequence:

>2049_bases
TTGGAGATATTTTTATATGTTTTAGCATTACTTGTGGCCATCTTTATTTCTAATTTACTCAACCGGTTTGTTCCCTTTGT
TTCGGTACCACTAATCCAAATTGGCCTTGGTGTATTAATTGCCATTATGCCGATTACGTTTGATTTGCAATTAAATCCAG
AACTTTTTCTAGTGATGTTTATTGCGCCATTGCTATTTAATGACGGAAGACAGACGGACAAAGCAGCTCTTTGGGGTATG
CGAATGCCGATTTTAGTATTAGCGCTCGGACTTGTATTTGCAACGGTTGTCGTGATTGGATATTTTGTCCACTGGATGAT
TCCGACGATTCCACTAGCAGCAGCTTTTGCCTTAGCAGCGGCTCTTGCGCCAACGGATGCTGTAGCAGTTAGTTCTCTTT
CTGGGCGGATTAATTTACCGAAACGAATTATGAATTTGCTCGAAGGTGAGGCATTAATCAACGACGCGTCAGGACTCGTG
GCATTCCAGTTCGCGATTGCAGCGATGGTGACCGGCGTTTTCAGTTTTATGGATGCAAGTATTAGCTTTTTTGTCATTGC
GATTGGTGGTATTTTAGTTGGGCTCATTTTGAGTTGGTTAAAATTCCGATTGTTAAAATGGGTTCGCGGCCTTGGCATGG
AAGATGTTACGTTTCATATGCTTATCCAAATTTTAACACCATTTATTATTTACTTAGCGGCAGAAGAAATCCATGTTTCT
GGGATTTTGGCAGTTGTTGCAGCCGGAATTATGCACTCGATGGAACAAAAGAAAATGGATCCTCAGTCGGTGAAATTAAA
TGTCGTTTCGCAAAGTACTTGGTCGGTGATCATTTTTGTTTTAAATGGTTTAGTATTTTTACTTTTAGGCACACAACTTC
CTGCGATTACAGAAGTAGTTTGGAATGATTCAGGAAGTAGTAATTTACAAGTGATGGCTTACATTTTGTCTATCACAGCT
GCCTTAATTTTACTGCGCTTTTTATGGGTATACATATCGTGGAGCATCGGCGCAAAACAAAGACAGAAACAAAATAAAAA
AACACAGCTACCTAAGTTTAGACCCGTTGTACTTACATCGCTTTCTGGTGTTCGCGGGGCAGTTACACTTGCCAGTGCGC
TCGCAATCCCGTTTTTCTTAGATGACGGATCACTATTTCCGCAGCGCTCGCTAATTATTTTTATCGCATCAGGTGTTATT
CTTTGTACATTAGTGATTGCGACATTTATTTTACCGTTACTTGCCAAAAGTGAAGAAGTGACAACGGAAGATGAACGAGC
TGAAACTGCAACCCGGATTCGAATCCTGAGAAACGTAATCAGGGAATTAAAAGAACAGACGCTACCTGAAACGAAAGCGG
CAACGGATGAAGTAATTGAAGATTATCGCAGACGAATTTACGATTTACAGCAAAATAATAGTTCGAATCGAGGCATGGAT
GAAAGAGAACGTGCCAAACGATTAGAGATCATCCAGTGGGAACGTGAAAACACCCAAAAAATGACCGATGAAGGACGCAT
TGTTGCTACAGATAGCTATCGTTATCAACACTATCTTAATATGATGGAACAAGCGATCAAACAGCGCTTCCGGACAAAAA
TAAAAACAGCCTGGATGTTCCTTTATCGTCTAATAATGCTTGTCATTCACCCGAAAAAATGGGGTAGAATCACGCATAAA
GTGAAAAAAGGTATTTCTAAAGACAGCGAACGATTCCAAGCAATTCGCCAATTACGCGAAGAAAATGAAGTACTCATTAT
TTCTAAACTCAAAGAACAACTAACGAAAGAGAATGTTGATATCATTGGCCCATTAATTACCGAACATACTATTTTCCTGG
AACGCGTAAGAAAAGAGCACAGTCCAAGAGGTAAGCGAGCAAAATTCGAACAGAAAAAACGCGAAGTCCAAGTGCTGGCT
TTCCAATTAGAACGTGATATTATTCAGAATATGTTTGAAAAAGGCGGGATCTCGAGAGACTTAGCCCGAGACTTACGCCA
AAATTTAAATATGATTGAAACATATTTATATGATGATTTTTTAGAATGA

Upstream 100 bases:

>100_bases
GCGGGATGGATGCATAGAAATAAAGCTGTTTTATATTTGCGAGTTAGGTTATTTTGCTTCATAATAATATAGGAGAAAAA
ACGAAAGGGGACGATACATA

Downstream 100 bases:

>100_bases
CAAAAAGCCCTAAGAACAGTGTCTTGTTCTTAGGGCTTTCTATTTAGCTTGTATTTTTTTTAATTGTTCGGCGAGATTTA
CTATTTCTAAATGGAAGTTC

Product: Na+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 682; Mature: 682

Protein sequence:

>682_residues
MEIFLYVLALLVAIFISNLLNRFVPFVSVPLIQIGLGVLIAIMPITFDLQLNPELFLVMFIAPLLFNDGRQTDKAALWGM
RMPILVLALGLVFATVVVIGYFVHWMIPTIPLAAAFALAAALAPTDAVAVSSLSGRINLPKRIMNLLEGEALINDASGLV
AFQFAIAAMVTGVFSFMDASISFFVIAIGGILVGLILSWLKFRLLKWVRGLGMEDVTFHMLIQILTPFIIYLAAEEIHVS
GILAVVAAGIMHSMEQKKMDPQSVKLNVVSQSTWSVIIFVLNGLVFLLLGTQLPAITEVVWNDSGSSNLQVMAYILSITA
ALILLRFLWVYISWSIGAKQRQKQNKKTQLPKFRPVVLTSLSGVRGAVTLASALAIPFFLDDGSLFPQRSLIIFIASGVI
LCTLVIATFILPLLAKSEEVTTEDERAETATRIRILRNVIRELKEQTLPETKAATDEVIEDYRRRIYDLQQNNSSNRGMD
ERERAKRLEIIQWERENTQKMTDEGRIVATDSYRYQHYLNMMEQAIKQRFRTKIKTAWMFLYRLIMLVIHPKKWGRITHK
VKKGISKDSERFQAIRQLREENEVLIISKLKEQLTKENVDIIGPLITEHTIFLERVRKEHSPRGKRAKFEQKKREVQVLA
FQLERDIIQNMFEKGGISRDLARDLRQNLNMIETYLYDDFLE

Sequences:

>Translated_682_residues
MEIFLYVLALLVAIFISNLLNRFVPFVSVPLIQIGLGVLIAIMPITFDLQLNPELFLVMFIAPLLFNDGRQTDKAALWGM
RMPILVLALGLVFATVVVIGYFVHWMIPTIPLAAAFALAAALAPTDAVAVSSLSGRINLPKRIMNLLEGEALINDASGLV
AFQFAIAAMVTGVFSFMDASISFFVIAIGGILVGLILSWLKFRLLKWVRGLGMEDVTFHMLIQILTPFIIYLAAEEIHVS
GILAVVAAGIMHSMEQKKMDPQSVKLNVVSQSTWSVIIFVLNGLVFLLLGTQLPAITEVVWNDSGSSNLQVMAYILSITA
ALILLRFLWVYISWSIGAKQRQKQNKKTQLPKFRPVVLTSLSGVRGAVTLASALAIPFFLDDGSLFPQRSLIIFIASGVI
LCTLVIATFILPLLAKSEEVTTEDERAETATRIRILRNVIRELKEQTLPETKAATDEVIEDYRRRIYDLQQNNSSNRGMD
ERERAKRLEIIQWERENTQKMTDEGRIVATDSYRYQHYLNMMEQAIKQRFRTKIKTAWMFLYRLIMLVIHPKKWGRITHK
VKKGISKDSERFQAIRQLREENEVLIISKLKEQLTKENVDIIGPLITEHTIFLERVRKEHSPRGKRAKFEQKKREVQVLA
FQLERDIIQNMFEKGGISRDLARDLRQNLNMIETYLYDDFLE
>Mature_682_residues
MEIFLYVLALLVAIFISNLLNRFVPFVSVPLIQIGLGVLIAIMPITFDLQLNPELFLVMFIAPLLFNDGRQTDKAALWGM
RMPILVLALGLVFATVVVIGYFVHWMIPTIPLAAAFALAAALAPTDAVAVSSLSGRINLPKRIMNLLEGEALINDASGLV
AFQFAIAAMVTGVFSFMDASISFFVIAIGGILVGLILSWLKFRLLKWVRGLGMEDVTFHMLIQILTPFIIYLAAEEIHVS
GILAVVAAGIMHSMEQKKMDPQSVKLNVVSQSTWSVIIFVLNGLVFLLLGTQLPAITEVVWNDSGSSNLQVMAYILSITA
ALILLRFLWVYISWSIGAKQRQKQNKKTQLPKFRPVVLTSLSGVRGAVTLASALAIPFFLDDGSLFPQRSLIIFIASGVI
LCTLVIATFILPLLAKSEEVTTEDERAETATRIRILRNVIRELKEQTLPETKAATDEVIEDYRRRIYDLQQNNSSNRGMD
ERERAKRLEIIQWERENTQKMTDEGRIVATDSYRYQHYLNMMEQAIKQRFRTKIKTAWMFLYRLIMLVIHPKKWGRITHK
VKKGISKDSERFQAIRQLREENEVLIISKLKEQLTKENVDIIGPLITEHTIFLERVRKEHSPRGKRAKFEQKKREVQVLA
FQLERDIIQNMFEKGGISRDLARDLRQNLNMIETYLYDDFLE

Specific function: Transporter involved in the efflux of sodium, potassium, lithium and rubidium [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. Nhak (TC 2.A.36.3.2) subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790501, Length=543, Percent_Identity=37.5690607734807, Blast_Score=304, Evalue=1e-83,
Organism=Caenorhabditis elegans, GI25150332, Length=495, Percent_Identity=24.4444444444444, Blast_Score=78, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71980847, Length=358, Percent_Identity=22.6256983240223, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71992107, Length=338, Percent_Identity=22.4852071005917, Blast_Score=69, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71992101, Length=338, Percent_Identity=22.4852071005917, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71987545, Length=409, Percent_Identity=22.4938875305623, Blast_Score=66, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI71987559, Length=403, Percent_Identity=22.5806451612903, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6320663, Length=368, Percent_Identity=22.8260869565217, Blast_Score=67, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR018417
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 77468; Mature: 77468

Theoretical pI: Translated: 9.96; Mature: 9.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIFLYVLALLVAIFISNLLNRFVPFVSVPLIQIGLGVLIAIMPITFDLQLNPELFLVMF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCHHHHHHH
IAPLLFNDGRQTDKAALWGMRMPILVLALGLVFATVVVIGYFVHWMIPTIPLAAAFALAA
HHHHHHCCCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALAPTDAVAVSSLSGRINLPKRIMNLLEGEALINDASGLVAFQFAIAAMVTGVFSFMDAS
HHCCCHHHHHHHCCCCCCCHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
ISFFVIAIGGILVGLILSWLKFRLLKWVRGLGMEDVTFHMLIQILTPFIIYLAAEEIHVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GILAVVAAGIMHSMEQKKMDPQSVKLNVVSQSTWSVIIFVLNGLVFLLLGTQLPAITEVV
HHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHH
WNDSGSSNLQVMAYILSITAALILLRFLWVYISWSIGAKQRQKQNKKTQLPKFRPVVLTS
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHH
LSGVRGAVTLASALAIPFFLDDGSLFPQRSLIIFIASGVILCTLVIATFILPLLAKSEEV
HCCHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TTEDERAETATRIRILRNVIRELKEQTLPETKAATDEVIEDYRRRIYDLQQNNSSNRGMD
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
ERERAKRLEIIQWERENTQKMTDEGRIVATDSYRYQHYLNMMEQAIKQRFRTKIKTAWMF
HHHHHHHHHHHHCCHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYRLIMLVIHPKKWGRITHKVKKGISKDSERFQAIRQLREENEVLIISKLKEQLTKENVD
HHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEHHHHHHHHHHCCCH
IIGPLITEHTIFLERVRKEHSPRGKRAKFEQKKREVQVLAFQLERDIIQNMFEKGGISRD
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
LARDLRQNLNMIETYLYDDFLE
HHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEIFLYVLALLVAIFISNLLNRFVPFVSVPLIQIGLGVLIAIMPITFDLQLNPELFLVMF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCHHHHHHH
IAPLLFNDGRQTDKAALWGMRMPILVLALGLVFATVVVIGYFVHWMIPTIPLAAAFALAA
HHHHHHCCCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALAPTDAVAVSSLSGRINLPKRIMNLLEGEALINDASGLVAFQFAIAAMVTGVFSFMDAS
HHCCCHHHHHHHCCCCCCCHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
ISFFVIAIGGILVGLILSWLKFRLLKWVRGLGMEDVTFHMLIQILTPFIIYLAAEEIHVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GILAVVAAGIMHSMEQKKMDPQSVKLNVVSQSTWSVIIFVLNGLVFLLLGTQLPAITEVV
HHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHH
WNDSGSSNLQVMAYILSITAALILLRFLWVYISWSIGAKQRQKQNKKTQLPKFRPVVLTS
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHH
LSGVRGAVTLASALAIPFFLDDGSLFPQRSLIIFIASGVILCTLVIATFILPLLAKSEEV
HCCHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TTEDERAETATRIRILRNVIRELKEQTLPETKAATDEVIEDYRRRIYDLQQNNSSNRGMD
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
ERERAKRLEIIQWERENTQKMTDEGRIVATDSYRYQHYLNMMEQAIKQRFRTKIKTAWMF
HHHHHHHHHHHHCCHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYRLIMLVIHPKKWGRITHKVKKGISKDSERFQAIRQLREENEVLIISKLKEQLTKENVD
HHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEHHHHHHHHHHCCCH
IIGPLITEHTIFLERVRKEHSPRGKRAKFEQKKREVQVLAFQLERDIIQNMFEKGGISRD
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
LARDLRQNLNMIETYLYDDFLE
HHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]