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The map label for this gene is manY [H]

Identifier: 226223399

GI number: 226223399

Start: 805121

End: 805936

Strand: Reverse

Name: manY [H]

Synonym: Lm4b_00797

Alternate gene names: 226223399

Gene position: 805936-805121 (Counterclockwise)

Preceding gene: 226223400

Following gene: 226223398

Centisome position: 27.67

GC content: 42.16

Gene sequence:

>816_bases
ATGTCAGCAATACAATTAATCCTTGTATTCCTCGTATCCTGTATTAGTGGTATGGGTAGTATTTTGGATGAGTGGCAAAC
GCACCGTCCATTAATTGCCTGTACGTTAATTGGTCTTGTTCTTGGGGATATTACAACTGGTATTATTATTGGGGGAACAC
TTGAAATGATCGCGCTTGGATGGATGAATATCGGAGCTGCGGTTGCTCCAGATGCTGCCCTTGCATCCATTATTTCTACT
ATCTTAGTTATTACTGGGGGACAAGATATCAGCGTAGGTATTTCGCTTGCGATTCCTCTAGCTGCTCTTGGTCAAGTACT
TACAATTCTAGTTCGTACAATTACAGTTGCATTCCAACACATGGCTGATAAAGCTGGTAAGGAAGGTAATCTGCGAAGTC
TCGACTGGATACATGTTACAGCACTACTACTTCAAGCTATGCGTATTGCAATTCCAGCCGTTATCGTTGCGGTAACAGTT
GGTACACAAGCAGTCGAAAATTTACTCAATGCCATTCCGGACGTTATTGTTAATGGTCTAAACGTAGCTGGTGGATTTAT
CGTTGTTGTTGGTTACGCCATGGTTATTAACATGATGTCCGCTAAATATTTAATGCCTTTCTTCTTCTTAGGTTTTGTTG
TCGCAGCATTTACTGCGTTTAACTTAGTAGCACTAGGTGTTTTAGGACTAGTTGCAGCAATCATTTATATCCAACTAAAC
CCTAAATATCAATTGAAAGAAGCTATCCAACAATACGGCGGGGGCGGCGGCGGACGATCAGCGGATGATGATCTCGACGA
CGACCTTGACGACTAA

Upstream 100 bases:

>100_bases
TCATGAATAAAAGCTTATGTAATAGATGCTTAATTTATTCAGTCATCATAATGAAATTATCTTTTTTTATCATTCTAAAG
AAAAATTGGGAGGGAAATAT

Downstream 100 bases:

>100_bases
GGAAGGGGGAGAAAAATATGAGTGAACAAATTACAGTTAATGAAAAGAAAATAACGAAAAGTGACTTAATGGGCGTGTTC
ATACGTTCCAACCTCTTCCA

Product: mannose-specific phosphotransferase system (PTS) component IIC

Products: protein histidine; sugar phosphate; D-glucosamine-6-phosphate [Cytoplasm]; pyruvate; glucose-6-phosphate [Cytoplasm]; N-acetyl-D-glucosamine-6-phosphate [Cytoplasm]; mannose-6-phosphate [Cytoplasm]; fructose-6-phosphate [Cytoplasm] [C]

Alternate protein names: EII-P-Man; EIIC-Man; PTS system mannose-specific EIIC component [H]

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MSAIQLILVFLVSCISGMGSILDEWQTHRPLIACTLIGLVLGDITTGIIIGGTLEMIALGWMNIGAAVAPDAALASIIST
ILVITGGQDISVGISLAIPLAALGQVLTILVRTITVAFQHMADKAGKEGNLRSLDWIHVTALLLQAMRIAIPAVIVAVTV
GTQAVENLLNAIPDVIVNGLNVAGGFIVVVGYAMVINMMSAKYLMPFFFLGFVVAAFTAFNLVALGVLGLVAAIIYIQLN
PKYQLKEAIQQYGGGGGGRSADDDLDDDLDD

Sequences:

>Translated_271_residues
MSAIQLILVFLVSCISGMGSILDEWQTHRPLIACTLIGLVLGDITTGIIIGGTLEMIALGWMNIGAAVAPDAALASIIST
ILVITGGQDISVGISLAIPLAALGQVLTILVRTITVAFQHMADKAGKEGNLRSLDWIHVTALLLQAMRIAIPAVIVAVTV
GTQAVENLLNAIPDVIVNGLNVAGGFIVVVGYAMVINMMSAKYLMPFFFLGFVVAAFTAFNLVALGVLGLVAAIIYIQLN
PKYQLKEAIQQYGGGGGGRSADDDLDDDLDD
>Mature_270_residues
SAIQLILVFLVSCISGMGSILDEWQTHRPLIACTLIGLVLGDITTGIIIGGTLEMIALGWMNIGAAVAPDAALASIISTI
LVITGGQDISVGISLAIPLAALGQVLTILVRTITVAFQHMADKAGKEGNLRSLDWIHVTALLLQAMRIAIPAVIVAVTVG
TQAVENLLNAIPDVIVNGLNVAGGFIVVVGYAMVINMMSAKYLMPFFFLGFVVAAFTAFNLVALGVLGLVAAIIYIQLNP
KYQLKEAIQQYGGGGGGRSADDDLDDDLDD

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system i

COG id: COG3715

COG function: function code G; Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-4 domain [H]

Homologues:

Organism=Escherichia coli, GI1788121, Length=270, Percent_Identity=71.1111111111111, Blast_Score=348, Evalue=2e-97,
Organism=Escherichia coli, GI1789528, Length=240, Percent_Identity=27.5, Blast_Score=99, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004700
- InterPro:   IPR018404 [H]

Pfam domain/function: PF03609 EII-Sor [H]

EC number: NA

Molecular weight: Translated: 28302; Mature: 28171

Theoretical pI: Translated: 4.24; Mature: 4.24

Prosite motif: PS51106 PTS_EIIC_TYPE_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAIQLILVFLVSCISGMGSILDEWQTHRPLIACTLIGLVLGDITTGIIIGGTLEMIALG
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
WMNIGAAVAPDAALASIISTILVITGGQDISVGISLAIPLAALGQVLTILVRTITVAFQH
HHHCCCHHCCHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MADKAGKEGNLRSLDWIHVTALLLQAMRIAIPAVIVAVTVGTQAVENLLNAIPDVIVNGL
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NVAGGFIVVVGYAMVINMMSAKYLMPFFFLGFVVAAFTAFNLVALGVLGLVAAIIYIQLN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PKYQLKEAIQQYGGGGGGRSADDDLDDDLDD
CCHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SAIQLILVFLVSCISGMGSILDEWQTHRPLIACTLIGLVLGDITTGIIIGGTLEMIALG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
WMNIGAAVAPDAALASIISTILVITGGQDISVGISLAIPLAALGQVLTILVRTITVAFQH
HHHCCCHHCCHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MADKAGKEGNLRSLDWIHVTALLLQAMRIAIPAVIVAVTVGTQAVENLLNAIPDVIVNGL
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NVAGGFIVVVGYAMVINMMSAKYLMPFFFLGFVVAAFTAFNLVALGVLGLVAAIIYIQLN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PKYQLKEAIQQYGGGGGGRSADDDLDDDLDD
CCHHHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: protein N p -phosphohistidine; sugar; phosphoenolpyruvate; glucosamine [Periplasm]; phosphoenolpyruvate; beta-D-glucose [Periplasm]; N-acetyl-D-glucosamine [Periplasm]; mannose [Periplasm]; fructose [Periplasm] [C]

Specific reaction: protein N p -phosphohistidine + sugar = protein histidine + sugar phosphate phosphoenolpyruvate + glucosamine [Periplasm] = D-glucosamine-6-phosphate [Cytoplasm] + pyruvate phosphoenolpyruvate + beta-D-glucose [Periplasm] = glucose-6-phosphate [Cytoplasm]

General reaction: Transferring phosphorus-containing groups; Phosphotransferases with an alcohol group as acceptor [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]