Click here to switch to the map view.

The map label for this gene is zosA [H]

Identifier: 226223265

GI number: 226223265

Start: 679429

End: 681309

Strand: Direct

Name: zosA [H]

Synonym: Lm4b_00662

Alternate gene names: 226223265

Gene position: 679429-681309 (Clockwise)

Preceding gene: 226223264

Following gene: 226223266

Centisome position: 23.33

GC content: 43.06

Gene sequence:

>1881_bases
ATGAAGGAATGGATGAAGCAGAATTGGCAATTTATTACGACGGGTATTAGCGGGATTTTGATTGTGATAGGTTGTTTGGT
CGGCAGTGATGTTGGCGACTTTTGGACAGCGGTTATTTTCCTAAGTGCCTTTGTTATCGGTGGTTTTGAGCAAGCTAAAG
AAGGCATTCAAGCGACTATCAAAACGAAAAAGTTGAATGTGGAGCTCTTAATGATTTTAGCGGCTACCGGTGCATCTATT
ATTGGTTATTGGTTTGAAGGGGCCATACTTATTTTTATTTTCTCGGTTAGTGGCGCTTTAGAAACGTATACGACCAATAA
AAGTAAGCGCGAAATCACGAAATTAATGGCATTTCAACCAGAACGCGCCTTTCGTTTGCTTCCTAATGGAGATTTAGAGG
AAGTGGCTGCAAAGGAGTTACAACTGGATGATATGGTATTCGTTCGGCCAGGAGAAAGTGTTCCAATCGATGGAGTCATT
GTTCGAGGGTCAACCACGTTAAATGAAGCAGCCATTAATGGGGAATCAGTGCCAGCGACGAAAACAGTTGGTGCGGATGT
GTTTGGCGGGACGGTCAATGTAAGCAGCGCCATCACGGTCAAAGTAACGCAAACATTTGATAATACGATTTTTAGTAAGA
TTATTCGTTTAGTAGAATCGGCTCAAAGTGAACCTTCGAAAACCGCTCGCTTTATTGAACGATTTGAGGATGCGTATGTA
AAAGCAGTTCTATTATTTGTGTTAGTAATGATGTTCTTGCCTCATTTTGCTTTAGGGTGGTCTTGGAATGAAACATTTTA
TCGTGCGATGGTTTTGCTAACGGTTGCTTCCCCTTGTGCGCTAGTGGCTTCGGTAACGCCTGCGACTTTAGCGGCAATTT
CGAACGGTGCACGTCACGGGATTTTGTTTAAAGGCGGCGTACACTTGGAAAATTTGCGCGGTGTAAAAGCTGTTGCATTT
GATAAAACTGGGACGCTGACAAATGGTACACCAGAACTGACAGATCGGTTATTTGCTGAAAATGTCGATAAGCAACAAGT
AATCAATGTAGTTGGAGCGATGGAGCGACAATCTTTACATCCGTTAGCTGCGGCAATAACGCAAGACCTAGAGGCAGAAA
TCACCGAAAAGTTAACAGAAATTGAAGTGACGGATGTAGCTGGATGGGGAGTTCAAGCGATTTATCAAGAGGAAAATTGG
CAAGTTGGGAAAGCTGGGTTTGTTGGGAAAGAAGCAGCGGCAGCATTTTCAAATGGTGCATTTGAGCGACTTGCGGGTGA
AGGGAAAACGATTGTTTATGTAGCTAAAGACGGCGTGATTCAGGCTATGTTTGCCCTTAAAGATACATGCCGGCCTGAAG
CCATTCGTACGATTAAGGCACTTCAAGCAAAAGGGATTAAAACCATAATGGTGACGGGAGATAACGAACAAACAGGTGCA
GCGATTCAAGCCGAACTCGGAATGGACTATGTTGTTTCCGGTTGTTTACCTGAGAAAAAAGTGGATGTGTTAAAAGAATT
GTCGGTTACTTATGGCAGTGTGGCAATGGTTGGTGATGGAATTAATGATGCTCCGGCTCTTGCACATGCGGCTGTTGGAA
TTGCAATGGGCGAGGGGACGGACATTGCGATGGAAACAGCAGATGTTGTTTTAATGAAAAATGATTTGGAGAAAATCCCA
TATGCTTACAACCTTTCTGAACGGCTTCACTGGATTACTTGGCAAAATATTTGTTTTGCGATTGCGGTGATTCTTGTTTT
GATAACAGCGAATGTTTTCCAACTAATCAATTTGCCATTTGGCGTTGTGGGGCACGAGGGAAGTACTATTTTAGTTATTC
TAAATGGGCTTAGGCTCCTTCGATCTAATCGGAAAAAGTGA

Upstream 100 bases:

>100_bases
ATAATAATTATTGTTTAATCTGTTTTTCGCGGTTGCGAAAGCAGATTTTTGTGTTTTTTAGGGTAATGGGAATCATTATC
ATTTGGAGAGGATGAGCATA

Downstream 100 bases:

>100_bases
TAAATTTGACTGCTTGTCTATTCCTAGTCTAAGATGGATGAGCAGTTTCTTTTTGCGAAAAAAGGGTATTACATGATAGA
TTGGAGATGAGTGCATGAAA

Product: heavy metal-transporting ATPase

Products: NA

Alternate protein names: Zn(2+)-translocating P-type ATPase [H]

Number of amino acids: Translated: 626; Mature: 626

Protein sequence:

>626_residues
MKEWMKQNWQFITTGISGILIVIGCLVGSDVGDFWTAVIFLSAFVIGGFEQAKEGIQATIKTKKLNVELLMILAATGASI
IGYWFEGAILIFIFSVSGALETYTTNKSKREITKLMAFQPERAFRLLPNGDLEEVAAKELQLDDMVFVRPGESVPIDGVI
VRGSTTLNEAAINGESVPATKTVGADVFGGTVNVSSAITVKVTQTFDNTIFSKIIRLVESAQSEPSKTARFIERFEDAYV
KAVLLFVLVMMFLPHFALGWSWNETFYRAMVLLTVASPCALVASVTPATLAAISNGARHGILFKGGVHLENLRGVKAVAF
DKTGTLTNGTPELTDRLFAENVDKQQVINVVGAMERQSLHPLAAAITQDLEAEITEKLTEIEVTDVAGWGVQAIYQEENW
QVGKAGFVGKEAAAAFSNGAFERLAGEGKTIVYVAKDGVIQAMFALKDTCRPEAIRTIKALQAKGIKTIMVTGDNEQTGA
AIQAELGMDYVVSGCLPEKKVDVLKELSVTYGSVAMVGDGINDAPALAHAAVGIAMGEGTDIAMETADVVLMKNDLEKIP
YAYNLSERLHWITWQNICFAIAVILVLITANVFQLINLPFGVVGHEGSTILVILNGLRLLRSNRKK

Sequences:

>Translated_626_residues
MKEWMKQNWQFITTGISGILIVIGCLVGSDVGDFWTAVIFLSAFVIGGFEQAKEGIQATIKTKKLNVELLMILAATGASI
IGYWFEGAILIFIFSVSGALETYTTNKSKREITKLMAFQPERAFRLLPNGDLEEVAAKELQLDDMVFVRPGESVPIDGVI
VRGSTTLNEAAINGESVPATKTVGADVFGGTVNVSSAITVKVTQTFDNTIFSKIIRLVESAQSEPSKTARFIERFEDAYV
KAVLLFVLVMMFLPHFALGWSWNETFYRAMVLLTVASPCALVASVTPATLAAISNGARHGILFKGGVHLENLRGVKAVAF
DKTGTLTNGTPELTDRLFAENVDKQQVINVVGAMERQSLHPLAAAITQDLEAEITEKLTEIEVTDVAGWGVQAIYQEENW
QVGKAGFVGKEAAAAFSNGAFERLAGEGKTIVYVAKDGVIQAMFALKDTCRPEAIRTIKALQAKGIKTIMVTGDNEQTGA
AIQAELGMDYVVSGCLPEKKVDVLKELSVTYGSVAMVGDGINDAPALAHAAVGIAMGEGTDIAMETADVVLMKNDLEKIP
YAYNLSERLHWITWQNICFAIAVILVLITANVFQLINLPFGVVGHEGSTILVILNGLRLLRSNRKK
>Mature_626_residues
MKEWMKQNWQFITTGISGILIVIGCLVGSDVGDFWTAVIFLSAFVIGGFEQAKEGIQATIKTKKLNVELLMILAATGASI
IGYWFEGAILIFIFSVSGALETYTTNKSKREITKLMAFQPERAFRLLPNGDLEEVAAKELQLDDMVFVRPGESVPIDGVI
VRGSTTLNEAAINGESVPATKTVGADVFGGTVNVSSAITVKVTQTFDNTIFSKIIRLVESAQSEPSKTARFIERFEDAYV
KAVLLFVLVMMFLPHFALGWSWNETFYRAMVLLTVASPCALVASVTPATLAAISNGARHGILFKGGVHLENLRGVKAVAF
DKTGTLTNGTPELTDRLFAENVDKQQVINVVGAMERQSLHPLAAAITQDLEAEITEKLTEIEVTDVAGWGVQAIYQEENW
QVGKAGFVGKEAAAAFSNGAFERLAGEGKTIVYVAKDGVIQAMFALKDTCRPEAIRTIKALQAKGIKTIMVTGDNEQTGA
AIQAELGMDYVVSGCLPEKKVDVLKELSVTYGSVAMVGDGINDAPALAHAAVGIAMGEGTDIAMETADVVLMKNDLEKIP
YAYNLSERLHWITWQNICFAIAVILVLITANVFQLINLPFGVVGHEGSTILVILNGLRLLRSNRKK

Specific function: Couples the hydrolysis of ATP with the transport of zinc into the cell [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=707, Percent_Identity=29.4200848656294, Blast_Score=253, Evalue=5e-67,
Organism=Homo sapiens, GI115529486, Length=655, Percent_Identity=30.8396946564885, Blast_Score=250, Evalue=3e-66,
Organism=Homo sapiens, GI55743073, Length=547, Percent_Identity=31.8098720292505, Blast_Score=232, Evalue=8e-61,
Organism=Homo sapiens, GI48762685, Length=194, Percent_Identity=29.3814432989691, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI48762689, Length=194, Percent_Identity=29.3814432989691, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI48762691, Length=194, Percent_Identity=29.3814432989691, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI48762687, Length=194, Percent_Identity=29.3814432989691, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI4502271, Length=285, Percent_Identity=24.9122807017544, Blast_Score=69, Evalue=2e-11,
Organism=Homo sapiens, GI22748667, Length=255, Percent_Identity=24.7058823529412, Blast_Score=68, Evalue=3e-11,
Organism=Escherichia coli, GI1789879, Length=583, Percent_Identity=35.1629502572899, Blast_Score=319, Evalue=4e-88,
Organism=Escherichia coli, GI1786691, Length=564, Percent_Identity=31.0283687943262, Blast_Score=221, Evalue=9e-59,
Organism=Escherichia coli, GI1786914, Length=480, Percent_Identity=26.4583333333333, Blast_Score=132, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17556548, Length=328, Percent_Identity=28.0487804878049, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI71997262, Length=644, Percent_Identity=23.4472049689441, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71997275, Length=644, Percent_Identity=23.4472049689441, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71997269, Length=148, Percent_Identity=31.7567567567568, Blast_Score=70, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17559224, Length=285, Percent_Identity=22.8070175438596, Blast_Score=69, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6320475, Length=490, Percent_Identity=29.7959183673469, Blast_Score=208, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6319772, Length=587, Percent_Identity=23.8500851788756, Blast_Score=150, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6325221, Length=600, Percent_Identity=23.5, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6321430, Length=534, Percent_Identity=24.1573033707865, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI221329854, Length=326, Percent_Identity=29.1411042944785, Blast_Score=142, Evalue=8e-34,
Organism=Drosophila melanogaster, GI24668708, Length=183, Percent_Identity=29.5081967213115, Blast_Score=76, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24668704, Length=183, Percent_Identity=29.5081967213115, Blast_Score=76, Evalue=8e-14,
Organism=Drosophila melanogaster, GI281366617, Length=183, Percent_Identity=29.5081967213115, Blast_Score=76, Evalue=8e-14,
Organism=Drosophila melanogaster, GI161085803, Length=183, Percent_Identity=29.5081967213115, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24668696, Length=183, Percent_Identity=29.5081967213115, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR001366
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR000150 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00702 Hydrolase [H]

EC number: =3.6.3.5 [H]

Molecular weight: Translated: 67666; Mature: 67666

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00154 ATPASE_E1_E2 ; PS01229 COF_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEWMKQNWQFITTGISGILIVIGCLVGSDVGDFWTAVIFLSAFVIGGFEQAKEGIQATI
CCCHHHCCCEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHEEE
KTKKLNVELLMILAATGASIIGYWFEGAILIFIFSVSGALETYTTNKSKREITKLMAFQP
EEEECCCEEEEEEHHCCCHHHHHHHHHEEEEEEEECCCCCEEEECCCHHHHHHHHHHCCC
ERAFRLLPNGDLEEVAAKELQLDDMVFVRPGESVPIDGVIVRGSTTLNEAAINGESVPAT
CHHEEECCCCCHHHHHHHHCCCCCEEEECCCCCCCCCCEEEECCCCHHHHHCCCCCCCCC
KTVGADVFGGTVNVSSAITVKVTQTFDNTIFSKIIRLVESAQSEPSKTARFIERFEDAYV
CCCCCHHCCCEEEECCEEEEEEECHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
KAVLLFVLVMMFLPHFALGWSWNETFYRAMVLLTVASPCALVASVTPATLAAISNGARHG
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHCCCCCCC
ILFKGGVHLENLRGVKAVAFDKTGTLTNGTPELTDRLFAENVDKQQVINVVGAMERQSLH
EEEECCCCHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCH
PLAAAITQDLEAEITEKLTEIEVTDVAGWGVQAIYQEENWQVGKAGFVGKEAAAAFSNGA
HHHHHHHHHHHHHHHHHHHHEEEEEECCCCEEEEEECCCCEECCCCCCCHHHHHHHCCCH
FERLAGEGKTIVYVAKDGVIQAMFALKDTCRPEAIRTIKALQAKGIKTIMVTGDNEQTGA
HHHHCCCCCEEEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCC
AIQAELGMDYVVSGCLPEKKVDVLKELSVTYGSVAMVGDGINDAPALAHAAVGIAMGEGT
EEEECCCHHHHHHCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHEEEECCCC
DIAMETADVVLMKNDLEKIPYAYNLSERLHWITWQNICFAIAVILVLITANVFQLINLPF
CEEEECCCEEEEECCHHHCCEEECHHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GVVGHEGSTILVILNGLRLLRSNRKK
EEECCCCCEEEEEEHHHHHHHCCCCC
>Mature Secondary Structure
MKEWMKQNWQFITTGISGILIVIGCLVGSDVGDFWTAVIFLSAFVIGGFEQAKEGIQATI
CCCHHHCCCEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHEEE
KTKKLNVELLMILAATGASIIGYWFEGAILIFIFSVSGALETYTTNKSKREITKLMAFQP
EEEECCCEEEEEEHHCCCHHHHHHHHHEEEEEEEECCCCCEEEECCCHHHHHHHHHHCCC
ERAFRLLPNGDLEEVAAKELQLDDMVFVRPGESVPIDGVIVRGSTTLNEAAINGESVPAT
CHHEEECCCCCHHHHHHHHCCCCCEEEECCCCCCCCCCEEEECCCCHHHHHCCCCCCCCC
KTVGADVFGGTVNVSSAITVKVTQTFDNTIFSKIIRLVESAQSEPSKTARFIERFEDAYV
CCCCCHHCCCEEEECCEEEEEEECHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
KAVLLFVLVMMFLPHFALGWSWNETFYRAMVLLTVASPCALVASVTPATLAAISNGARHG
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHCCCCCCC
ILFKGGVHLENLRGVKAVAFDKTGTLTNGTPELTDRLFAENVDKQQVINVVGAMERQSLH
EEEECCCCHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCH
PLAAAITQDLEAEITEKLTEIEVTDVAGWGVQAIYQEENWQVGKAGFVGKEAAAAFSNGA
HHHHHHHHHHHHHHHHHHHHEEEEEECCCCEEEEEECCCCEECCCCCCCHHHHHHHCCCH
FERLAGEGKTIVYVAKDGVIQAMFALKDTCRPEAIRTIKALQAKGIKTIMVTGDNEQTGA
HHHHCCCCCEEEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCC
AIQAELGMDYVVSGCLPEKKVDVLKELSVTYGSVAMVGDGINDAPALAHAAVGIAMGEGT
EEEECCCHHHHHHCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHEEEECCCC
DIAMETADVVLMKNDLEKIPYAYNLSERLHWITWQNICFAIAVILVLITANVFQLINLPF
CEEEECCCEEEEECCHHHCCEEECHHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GVVGHEGSTILVILNGLRLLRSNRKK
EEECCCCCEEEEEEHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]