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The map label for this gene is iap

Identifier: 226223211

GI number: 226223211

Start: 622600

End: 624033

Strand: Reverse

Name: iap

Synonym: Lm4b_00608

Alternate gene names: 226223211

Gene position: 624033-622600 (Counterclockwise)

Preceding gene: 226223223

Following gene: 226223210

Centisome position: 21.42

GC content: 39.26

Gene sequence:

>1434_bases
ATGAATATGAAAAAAGCAACTATCGCGGCTACAGCTGGGATTGCGGTAACAGCATTTGCTGCTCCAACAATCGCATCCGC
AAGCACTGTAGTAGTCGAAGCTGGTGATACTCTTTGGGGTATCGCACAAAGTAAAGGGACTACTGTTGACGCAATTAAAA
AAGCAAACAATTTAACAACAGATAAAATCGTACCAGGTCAAAAATTACAAGTAAATGAGGTTGCTGCTGCTGAAAAAACA
GAGAAATCTGTTAGCGCAACTTGGTTAAACGTTCGTAGTGGCGCTGGTGTTGATAACAGTATTATTACGTCAATCAAAGG
CGGAACAAAAGTAACTGTTGAATCAACCGAATCTAATGGCTGGAACAAAATTACTTACAACGACGGGGAAACTGGTTTCG
TTAACGGTAAATACTTAACTGACAAAGTAGCAAGCACTCCTGTTGCACCAACACAAGAAGTGAAAAAAGAAACTACTACT
CAACAAGCTGCACCTGCTGCAGAAACAAAAACTGAAGTAAAACAAACTACACAAGCAACTACACCTGCACCTAAAGTAGC
AGAAACGAAAGAAACTCCAGTGGTAGATCAAAATGCTACTACACACGCTGTTAAAAGCGGTGACACTATTTGGGCTTTAT
CCGTAAAATACGGTGTTTCCGTTCAAGACATTATGTCATGGAATAATTTATCTTCTTCTTCTATTTATGTAGGTCAAAAA
CTTGCTATTAAACAAACAGCCAACACAGCTACTCCAAAAGCAGAAGTGAAAAAAGAAGCTCCAGCAGCTGAAAAACAAGC
TGCACCAGTAGTTAAAGAAAATACTAACACTAACACAAATGCTACTACAGAGAAAAAAGAAACAACACAACAACAAACAG
CACCTAAAGCACCAACAGAAGCTGCAAAACCAGCTCCCGCACCATCTACAAACACAAATGCTAATAAAACGAATACGAAT
ACAAACAATACTAATACAAGTACACCATCTAAAAATACCAATACTAATACAAACTCCAATACGAATACAAACTCAAATAC
GAATGCTAATCAAGGTTCTTCTAACAATAACAGCAATTCAAGTGCGAGTGCTATTATTGCTGAAGCTCAAAAACACCTTG
GAAAAGCTTATTCATGGGGTGGTAACGGACCAACTACATTTGATTGCTCTGGTTACACTAAATATGTATTTGCTAAAGCG
GGAATCTCCCTTCCACGTACTTCTGGCGCACAATACGCTAGCACTACAAGAATCTCTGAATCTCAAGCAAAACCTGGTGA
TTTAGTATTCTTTGACTATGGTAGCGGAATTTCTCACGTTGGTATCTACGTTGGTAATGGTCAAATGATTAACGCGCAAG
ACAATGGCGTTAAATACGATAACATCCACGGCTCTGGCTGGGGTAAATATCTAGTTGGCTTCGGTCGCGTATAA

Upstream 100 bases:

>100_bases
TTTAGGTGAAAACTGGGTAAACTTAGTATTAATCAATATAAAATTAATTCTCAAATACTTAATTACGTACTGGGATTTTC
TGAAAAAAGAGAGGAGTTTT

Downstream 100 bases:

>100_bases
TTAATAACTTAAAGTAACCTGTGGAGCAAGCAGTTCGCTTCACAGGTTTTTTGTTGGAAATTTTATCTTAATGAAAGACG
GTGCATGATGAAGAATCTAG

Product: invasion associated secreted endopeptidase

Products: NA

Alternate protein names: Invasion-associated protein [H]

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MNMKKATIAATAGIAVTAFAAPTIASASTVVVEAGDTLWGIAQSKGTTVDAIKKANNLTTDKIVPGQKLQVNEVAAAEKT
EKSVSATWLNVRSGAGVDNSIITSIKGGTKVTVESTESNGWNKITYNDGETGFVNGKYLTDKVASTPVAPTQEVKKETTT
QQAAPAAETKTEVKQTTQATTPAPKVAETKETPVVDQNATTHAVKSGDTIWALSVKYGVSVQDIMSWNNLSSSSIYVGQK
LAIKQTANTATPKAEVKKEAPAAEKQAAPVVKENTNTNTNATTEKKETTQQQTAPKAPTEAAKPAPAPSTNTNANKTNTN
TNNTNTSTPSKNTNTNTNSNTNTNSNTNANQGSSNNNSNSSASAIIAEAQKHLGKAYSWGGNGPTTFDCSGYTKYVFAKA
GISLPRTSGAQYASTTRISESQAKPGDLVFFDYGSGISHVGIYVGNGQMINAQDNGVKYDNIHGSGWGKYLVGFGRV

Sequences:

>Translated_477_residues
MNMKKATIAATAGIAVTAFAAPTIASASTVVVEAGDTLWGIAQSKGTTVDAIKKANNLTTDKIVPGQKLQVNEVAAAEKT
EKSVSATWLNVRSGAGVDNSIITSIKGGTKVTVESTESNGWNKITYNDGETGFVNGKYLTDKVASTPVAPTQEVKKETTT
QQAAPAAETKTEVKQTTQATTPAPKVAETKETPVVDQNATTHAVKSGDTIWALSVKYGVSVQDIMSWNNLSSSSIYVGQK
LAIKQTANTATPKAEVKKEAPAAEKQAAPVVKENTNTNTNATTEKKETTQQQTAPKAPTEAAKPAPAPSTNTNANKTNTN
TNNTNTSTPSKNTNTNTNSNTNTNSNTNANQGSSNNNSNSSASAIIAEAQKHLGKAYSWGGNGPTTFDCSGYTKYVFAKA
GISLPRTSGAQYASTTRISESQAKPGDLVFFDYGSGISHVGIYVGNGQMINAQDNGVKYDNIHGSGWGKYLVGFGRV
>Mature_477_residues
MNMKKATIAATAGIAVTAFAAPTIASASTVVVEAGDTLWGIAQSKGTTVDAIKKANNLTTDKIVPGQKLQVNEVAAAEKT
EKSVSATWLNVRSGAGVDNSIITSIKGGTKVTVESTESNGWNKITYNDGETGFVNGKYLTDKVASTPVAPTQEVKKETTT
QQAAPAAETKTEVKQTTQATTPAPKVAETKETPVVDQNATTHAVKSGDTIWALSVKYGVSVQDIMSWNNLSSSSIYVGQK
LAIKQTANTATPKAEVKKEAPAAEKQAAPVVKENTNTNTNATTEKKETTQQQTAPKAPTEAAKPAPAPSTNTNANKTNTN
TNNTNTSTPSKNTNTNTNSNTNTNSNTNANQGSSNNNSNSSASAIIAEAQKHLGKAYSWGGNGPTTFDCSGYTKYVFAKA
GISLPRTSGAQYASTTRISESQAKPGDLVFFDYGSGISHVGIYVGNGQMINAQDNGVKYDNIHGSGWGKYLVGFGRV

Specific function: This major extracellular protein may be involved in the invasion of non-professional phagocytic cells by Listeria [H]

COG id: COG0791

COG function: function code M; Cell wall-associated hydrolases (invasion-associated proteins)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 LysM repeats [H]

Homologues:

Organism=Escherichia coli, GI1787944, Length=113, Percent_Identity=39.8230088495575, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1786421, Length=136, Percent_Identity=30.1470588235294, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1788501, Length=80, Percent_Identity=40, Blast_Score=66, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000064
- InterPro:   IPR018392
- InterPro:   IPR002482
- InterPro:   IPR003646
- InterPro:   IPR013247 [H]

Pfam domain/function: PF01476 LysM; PF00877 NLPC_P60; PF08239 SH3_3 [H]

EC number: NA

Molecular weight: Translated: 49834; Mature: 49834

Theoretical pI: Translated: 9.82; Mature: 9.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMKKATIAATAGIAVTAFAAPTIASASTVVVEAGDTLWGIAQSKGTTVDAIKKANNLTT
CCCCCEEEEEECCEEEEEECCCCCCCCCEEEEECCCCEEEEECCCCCHHHHHHHHCCCCC
DKIVPGQKLQVNEVAAAEKTEKSVSATWLNVRSGAGVDNSIITSIKGGTKVTVESTESNG
CCCCCCCCEEHHHHHHHHHHHHCCEEEEEEECCCCCCCCHHHEEECCCEEEEEEECCCCC
WNKITYNDGETGFVNGKYLTDKVASTPVAPTQEVKKETTTQQAAPAAETKTEVKQTTQAT
CEEEEECCCCCEEECCCEECHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
TPAPKVAETKETPVVDQNATTHAVKSGDTIWALSVKYGVSVQDIMSWNNLSSSSIYVGQK
CCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEEEEEECCCHHHHHHHCCCCCCEEEECCE
LAIKQTANTATPKAEVKKEAPAAEKQAAPVVKENTNTNTNATTEKKETTQQQTAPKAPTE
EEEEECCCCCCCHHHHHHCCCCCHHHCCCCEECCCCCCCCCCCCHHHHHHHHCCCCCCCC
AAKPAPAPSTNTNANKTNTNTNNTNTSTPSKNTNTNTNSNTNTNSNTNANQGSSNNNSNS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SASAIIAEAQKHLGKAYSWGGNGPTTFDCSGYTKYVFAKAGISLPRTSGAQYASTTRISE
HHHHHHHHHHHHHCHHEECCCCCCCEEECCCCEEEEEEECCCCCCCCCCCCHHHHCCCCC
SQAKPGDLVFFDYGSGISHVGIYVGNGQMINAQDNGVKYDNIHGSGWGKYLVGFGRV
CCCCCCCEEEEECCCCCCEEEEEECCCEEECCCCCCEEECCCCCCCCHHHEEEECCC
>Mature Secondary Structure
MNMKKATIAATAGIAVTAFAAPTIASASTVVVEAGDTLWGIAQSKGTTVDAIKKANNLTT
CCCCCEEEEEECCEEEEEECCCCCCCCCEEEEECCCCEEEEECCCCCHHHHHHHHCCCCC
DKIVPGQKLQVNEVAAAEKTEKSVSATWLNVRSGAGVDNSIITSIKGGTKVTVESTESNG
CCCCCCCCEEHHHHHHHHHHHHCCEEEEEEECCCCCCCCHHHEEECCCEEEEEEECCCCC
WNKITYNDGETGFVNGKYLTDKVASTPVAPTQEVKKETTTQQAAPAAETKTEVKQTTQAT
CEEEEECCCCCEEECCCEECHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
TPAPKVAETKETPVVDQNATTHAVKSGDTIWALSVKYGVSVQDIMSWNNLSSSSIYVGQK
CCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEEEEEECCCHHHHHHHCCCCCCEEEECCE
LAIKQTANTATPKAEVKKEAPAAEKQAAPVVKENTNTNTNATTEKKETTQQQTAPKAPTE
EEEEECCCCCCCHHHHHHCCCCCHHHCCCCEECCCCCCCCCCCCHHHHHHHHCCCCCCCC
AAKPAPAPSTNTNANKTNTNTNNTNTSTPSKNTNTNTNSNTNTNSNTNANQGSSNNNSNS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SASAIIAEAQKHLGKAYSWGGNGPTTFDCSGYTKYVFAKAGISLPRTSGAQYASTTRISE
HHHHHHHHHHHHHCHHEECCCCCCCEEECCCCEEEEEEECCCCCCCCCCCCHHHHCCCCC
SQAKPGDLVFFDYGSGISHVGIYVGNGQMINAQDNGVKYDNIHGSGWGKYLVGFGRV
CCCCCCCEEEEECCCCCCEEEEEECCCEEECCCCCCEEECCCCCCCCHHHEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2111287; 1459966; 11679669 [H]