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The map label for this gene is hisE

Identifier: 226223190

GI number: 226223190

Start: 604483

End: 604794

Strand: Reverse

Name: hisE

Synonym: Lm4b_00587

Alternate gene names: 226223190

Gene position: 604794-604483 (Counterclockwise)

Preceding gene: 226223191

Following gene: 226223189

Centisome position: 20.76

GC content: 36.86

Gene sequence:

>312_bases
ATGTTAAATGACCTATATGAAGAAATTAAACTGCGTAAAACTCAACCAAGAGAAGGCTCCTATACCAACTATTTGTTCGA
TAAAGGCCTTGATAAAATTCTCAAAAAGGTTGGTGAAGAAGCAACCGAAGTCGTTATTGCTGCCAAAAATAACGAGCAAG
AATTAATCGCTGAAGTATCCGATTTAACTTATCACTTGCTCGTTCTCTTAGCCGAGCAAAATATTCCATTATCAAAAATC
CAAGCAGAGCTTCAAAATCGTGAAGGAAAGCTAAGCACCACTCGCGACCGTAAAGAAATCAACGATTTATAA

Upstream 100 bases:

>100_bases
TGATAACGACACATTACTTATCCGCGTAACCCAAATCGGTCCAGCCTGCCACACCGGCAAAAAAAGCTGCTTTTTCAATC
TTATAAAGGAGGATTTTTAA

Downstream 100 bases:

>100_bases
AAACATGACATTTTCGTAAGCTTAGAGATCATTATTGTAAGAAAAAGCGCATGATTTTTAAATACATTTTTTATATACTT
GTTTACGTGGAGAGCTTTCA

Product: phosphoribosyl-ATP pyrophosphatase

Products: NA

Alternate protein names: PRA-PH

Number of amino acids: Translated: 103; Mature: 103

Protein sequence:

>103_residues
MLNDLYEEIKLRKTQPREGSYTNYLFDKGLDKILKKVGEEATEVVIAAKNNEQELIAEVSDLTYHLLVLLAEQNIPLSKI
QAELQNREGKLSTTRDRKEINDL

Sequences:

>Translated_103_residues
MLNDLYEEIKLRKTQPREGSYTNYLFDKGLDKILKKVGEEATEVVIAAKNNEQELIAEVSDLTYHLLVLLAEQNIPLSKI
QAELQNREGKLSTTRDRKEINDL
>Mature_103_residues
MLNDLYEEIKLRKTQPREGSYTNYLFDKGLDKILKKVGEEATEVVIAAKNNEQELIAEVSDLTYHLLVLLAEQNIPLSKI
QAELQNREGKLSTTRDRKEINDL

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0140

COG function: function code E; Phosphoribosyl-ATP pyrophosphohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-PH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=78, Percent_Identity=43.5897435897436, Blast_Score=60, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS2_LISMC (C1L0J0)

Other databases:

- EMBL:   FM242711
- RefSeq:   YP_002757297.1
- ProteinModelPortal:   C1L0J0
- SMR:   C1L0J0
- GeneID:   7704268
- GenomeReviews:   FM242711_GR
- KEGG:   lmc:Lm4b_00587
- OMA:   KLGEETT
- ProtClustDB:   PRK00400
- GO:   GO:0005737
- HAMAP:   MF_01020
- InterPro:   IPR008179
- InterPro:   IPR021130
- TIGRFAMs:   TIGR03188

Pfam domain/function: PF01503 PRA-PH

EC number: =3.6.1.31

Molecular weight: Translated: 11860; Mature: 11860

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNDLYEEIKLRKTQPREGSYTNYLFDKGLDKILKKVGEEATEVVIAAKNNEQELIAEVS
CCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHEEEECCCCHHHHHHHHH
DLTYHLLVLLAEQNIPLSKIQAELQNREGKLSTTRDRKEINDL
HHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCHHHHHHCCC
>Mature Secondary Structure
MLNDLYEEIKLRKTQPREGSYTNYLFDKGLDKILKKVGEEATEVVIAAKNNEQELIAEVS
CCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHEEEECCCCHHHHHHHHH
DLTYHLLVLLAEQNIPLSKIQAELQNREGKLSTTRDRKEINDL
HHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA