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The map label for this gene is iap [H]

Identifier: 226223019

GI number: 226223019

Start: 418206

End: 418889

Strand: Direct

Name: iap [H]

Synonym: Lm4b_00412

Alternate gene names: 226223019

Gene position: 418206-418889 (Clockwise)

Preceding gene: 226223018

Following gene: 226223021

Centisome position: 14.36

GC content: 35.23

Gene sequence:

>684_bases
TTGAAAATAATAGCAACGAGAAGAAAGATTTTTTTTGCGTTTATAGCTTTAATGATTTCTTTTTCAGTACTATTTTTACC
AACAACTAACGCTTCAGCAGCGACTACATATAAAATGACGACAACGGCTGATGTAAATGTTCGCGCAGCAGACAACACCA
AAGGTAAAGTCATCGGTTTTTACAAAAAGGGTACAACGGTTACTTTCACTGCTAAAACAAAAAACAACTGGTATAAAACG
ACATACAAAGGCAAAGTTGGTTATGTTTCAGGTAAATGTGTGACTACATATAAAGCACCTGTTGCAACAACGCAAAGTTT
TACCGCATTAAATAACGAAGCAAGAAAACACATTGGCAAACGCTACAAAATTGGCGCTACTGGCCCAAGCTGTTTTGATT
GTTCAGGTTACACACAATATGTATACTCTAAAGGAGTTAAAAAATCCATTCCTCGTACAGCGAAGCAACAATATGCCTCT
GCTAAGAAAATTAAAGCTCAAGAACTAAAAAAAGGTGATTTGATTTTCTTCAATTATGGTAAGGGTGTTGCACATGTTGG
GATTTATGTTGGAAATGGCAAAATGCTTAATGCGCAAAATAATGGCGTAAAATACGACACAATCACATCTGGCTATTGGA
AAAAATATATTGCTGGATATGGACGAGTAGCAAATTTAAAATAA

Upstream 100 bases:

>100_bases
TCAAAACTGTTACATAATAACGCCAAGTTTTAAAATCCCTGTATTACAACTGTAACATTGACCTGCTATGCTGTGTGTAT
ATAAAAAAGGGGTGCGTGGA

Downstream 100 bases:

>100_bases
TTTTACTGAGCGTCACTTTTTAGTGATGCTTTTTTGTATGAAGGAGGAGTTAGGGATGCAATATAAAATAAAAGAAATGC
CACTGGAAGAACTAGAACCT

Product: extracellular P60 protein

Products: NA

Alternate protein names: Invasion-associated protein [H]

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MKIIATRRKIFFAFIALMISFSVLFLPTTNASAATTYKMTTTADVNVRAADNTKGKVIGFYKKGTTVTFTAKTKNNWYKT
TYKGKVGYVSGKCVTTYKAPVATTQSFTALNNEARKHIGKRYKIGATGPSCFDCSGYTQYVYSKGVKKSIPRTAKQQYAS
AKKIKAQELKKGDLIFFNYGKGVAHVGIYVGNGKMLNAQNNGVKYDTITSGYWKKYIAGYGRVANLK

Sequences:

>Translated_227_residues
MKIIATRRKIFFAFIALMISFSVLFLPTTNASAATTYKMTTTADVNVRAADNTKGKVIGFYKKGTTVTFTAKTKNNWYKT
TYKGKVGYVSGKCVTTYKAPVATTQSFTALNNEARKHIGKRYKIGATGPSCFDCSGYTQYVYSKGVKKSIPRTAKQQYAS
AKKIKAQELKKGDLIFFNYGKGVAHVGIYVGNGKMLNAQNNGVKYDTITSGYWKKYIAGYGRVANLK
>Mature_227_residues
MKIIATRRKIFFAFIALMISFSVLFLPTTNASAATTYKMTTTADVNVRAADNTKGKVIGFYKKGTTVTFTAKTKNNWYKT
TYKGKVGYVSGKCVTTYKAPVATTQSFTALNNEARKHIGKRYKIGATGPSCFDCSGYTQYVYSKGVKKSIPRTAKQQYAS
AKKIKAQELKKGDLIFFNYGKGVAHVGIYVGNGKMLNAQNNGVKYDTITSGYWKKYIAGYGRVANLK

Specific function: This major extracellular protein may be involved in the invasion of non-professional phagocytic cells by Listeria [H]

COG id: COG0791

COG function: function code M; Cell wall-associated hydrolases (invasion-associated proteins)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 LysM repeats [H]

Homologues:

Organism=Escherichia coli, GI1787944, Length=190, Percent_Identity=35.2631578947368, Blast_Score=94, Evalue=7e-21,
Organism=Escherichia coli, GI1786421, Length=115, Percent_Identity=31.304347826087, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788501, Length=98, Percent_Identity=33.6734693877551, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1788001, Length=130, Percent_Identity=31.5384615384615, Blast_Score=62, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000064
- InterPro:   IPR018392
- InterPro:   IPR002482
- InterPro:   IPR003646
- InterPro:   IPR013247 [H]

Pfam domain/function: PF01476 LysM; PF00877 NLPC_P60; PF08239 SH3_3 [H]

EC number: NA

Molecular weight: Translated: 25056; Mature: 25056

Theoretical pI: Translated: 10.71; Mature: 10.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIIATRRKIFFAFIALMISFSVLFLPTTNASAATTYKMTTTADVNVRAADNTKGKVIGF
CCEEHHHHHHHHHHHHHHHHCEEEEEECCCCCCEEEEEEEEEEEEEEEECCCCCCCEEEE
YKKGTTVTFTAKTKNNWYKTTYKGKVGYVSGKCVTTYKAPVATTQSFTALNNEARKHIGK
EECCCEEEEEEECCCCEEEEEECCEEEEECCEEEEEEECCCCCCCHHHHHHHHHHHHCCC
RYKIGATGPSCFDCSGYTQYVYSKGVKKSIPRTAKQQYASAKKIKAQELKKGDLIFFNYG
EEEECCCCCCCCCCCCCHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEEECC
KGVAHVGIYVGNGKMLNAQNNGVKYDTITSGYWKKYIAGYGRVANLK
CCEEEEEEEECCCEEEECCCCCEEEEEECCHHHHHHHHCCCEEECCC
>Mature Secondary Structure
MKIIATRRKIFFAFIALMISFSVLFLPTTNASAATTYKMTTTADVNVRAADNTKGKVIGF
CCEEHHHHHHHHHHHHHHHHCEEEEEECCCCCCEEEEEEEEEEEEEEEECCCCCCCEEEE
YKKGTTVTFTAKTKNNWYKTTYKGKVGYVSGKCVTTYKAPVATTQSFTALNNEARKHIGK
EECCCEEEEEEECCCCEEEEEECCEEEEECCEEEEEEECCCCCCCHHHHHHHHHHHHCCC
RYKIGATGPSCFDCSGYTQYVYSKGVKKSIPRTAKQQYASAKKIKAQELKKGDLIFFNYG
EEEECCCCCCCCCCCCCHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEEECC
KGVAHVGIYVGNGKMLNAQNNGVKYDTITSGYWKKYIAGYGRVANLK
CCEEEEEEEECCCEEEECCCCCEEEEEECCHHHHHHHHCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1514809; 11679669; 1459966 [H]