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The map label for this gene is yyxA [H]

Identifier: 226222928

GI number: 226222928

Start: 324621

End: 326123

Strand: Direct

Name: yyxA [H]

Synonym: Lm4b_00320

Alternate gene names: 226222928

Gene position: 324621-326123 (Clockwise)

Preceding gene: 226222927

Following gene: 226222929

Centisome position: 11.15

GC content: 39.79

Gene sequence:

>1503_bases
ATGGACGAGAAAGAAAAGAATTTAAATGAAAACAGCGAGAATGAAAGCACGCCAAAAAGAGAGGTCGAGGATACTTTACA
TACACCGGAGAGCGCGCAACCAGTCCAAGAAACTCCTATTGTAGAAGGCGTGACCCCAGAAGGGGAGAAATTTGCCGGAG
CGACAGAAGATGCAGCCGAGGCGAGTTCTACAAATGCATTTTTTGAAGAAGCAAGTAATAAAGAACCAGAACCTGCTAGA
CCGGCTCCAGGGCCAAGACGCGCTGGTACAACTGGTGGCGGGGCAGTTCCACCTAATAGAGTGAATAATGGCGGAAGTGG
TAACGGGAATGGTGAACCACCGAAACGCGGCAAACACTTTATCGGTTACTTTTTAACAGCACTTATTGGTGTTATTATCG
GAGGACTTATTATTTTCTTTGTCGCTTGGGATAATGGTGACAATGCAGATACAACTTCAAACTCAAATAATAAAGCTACC
AAAGTAGAAAAAGTTTCAGTAGATACAACATCAGATGTAACAAAAGCAGTAGACAAAGTACAAGATGCGGTAGTGAGTGT
TCTAAATTACCAATCATCTTCATCCCTTGATGGAACAACGACTTCTGAACAAGAAGCTTCCTCAGGATCTGGTGTTATTT
ATAAAAAGGCAAATGGAAAAGCCTACATCGTAACAAATAATCACGTTGTTGCTGATGCAAATAAATTAGAAGTAACTTTT
ACAAACGGTAAAAAATCCGAAGCAAAATTACTAGGGACAGACGAATGGAACGATTTAGCTGTTCTTGAAATTGATGATAA
AAATGTTACTACAGTCGCTGCATTCGGCGATTCAGATTCATTAAAACTTGGTGAACCAGCAATTGCAATTGGTAGCCCAC
TAGGAACAGAATTTTCCGGTTCTGTAACACAAGGTATTATTTCTGGTCTAAACCGTGCAGTACCAGTTGATACAAATGGC
GACGGAACAGAAGACTGGGAAGCAGATGTTATCCAAACAGATGCAGCAATTAACCCTGGTAACAGTGGTGGAGCTTTAAT
TAATATTGAAGGCCAAGTAATTGGTATTAACTCAATGAAAATTTCGATGGAAAATGTAGAAGGTATTAGCTTTGCAATTC
CAAGTAACACAGTAGAACCAATCATCGAACAACTAGAAACAAAAGGCGAAGTAGAACGTCCATCTCTAGGCGTATCCTTA
CGTGATGTTGATACAATTCCAGAAACACAACAAAAAAATATCTTGAAATTACCTGATAGCGTAGATTACGGCGCAATGGT
ACAACAAGTAGTATCCGGTTCTGCAGCAGACAAAGCAGGCTTGAAACAATACGATGTTATTGTTGAACTAAACGGCCAAA
AAGTAACAAACTCCATGACATTACGCAAAATTCTATACGGTAACGACGTGAAAATTGGCGATAAAGTCAAAGTGAAATAC
TATCGTGACGGTAAAGAAAAATCCACAGATATTAAATTAGAAGCAGCAAAAACAACCACATGA

Upstream 100 bases:

>100_bases
TAAGTTTCACCGTTTTTTTAAAGCTTTTTCATCGTTTTTTCATATTTGGGGTTTATTATGGAAGTATATAAATGCGAAAT
TTGCAGAGAGGAAGGAAGAC

Downstream 100 bases:

>100_bases
TAACAAAAAGCCATTCTCTTGAAAAAGAGGGTGGCTTTTTTTCTGTGGAAAACTTGTGGATAGCGATTTTTTTCGAATAT
AGATATGGTAGAGAACAAGA

Product: heat-shock protein htrA serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 500; Mature: 500

Protein sequence:

>500_residues
MDEKEKNLNENSENESTPKREVEDTLHTPESAQPVQETPIVEGVTPEGEKFAGATEDAAEASSTNAFFEEASNKEPEPAR
PAPGPRRAGTTGGGAVPPNRVNNGGSGNGNGEPPKRGKHFIGYFLTALIGVIIGGLIIFFVAWDNGDNADTTSNSNNKAT
KVEKVSVDTTSDVTKAVDKVQDAVVSVLNYQSSSSLDGTTTSEQEASSGSGVIYKKANGKAYIVTNNHVVADANKLEVTF
TNGKKSEAKLLGTDEWNDLAVLEIDDKNVTTVAAFGDSDSLKLGEPAIAIGSPLGTEFSGSVTQGIISGLNRAVPVDTNG
DGTEDWEADVIQTDAAINPGNSGGALINIEGQVIGINSMKISMENVEGISFAIPSNTVEPIIEQLETKGEVERPSLGVSL
RDVDTIPETQQKNILKLPDSVDYGAMVQQVVSGSAADKAGLKQYDVIVELNGQKVTNSMTLRKILYGNDVKIGDKVKVKY
YRDGKEKSTDIKLEAAKTTT

Sequences:

>Translated_500_residues
MDEKEKNLNENSENESTPKREVEDTLHTPESAQPVQETPIVEGVTPEGEKFAGATEDAAEASSTNAFFEEASNKEPEPAR
PAPGPRRAGTTGGGAVPPNRVNNGGSGNGNGEPPKRGKHFIGYFLTALIGVIIGGLIIFFVAWDNGDNADTTSNSNNKAT
KVEKVSVDTTSDVTKAVDKVQDAVVSVLNYQSSSSLDGTTTSEQEASSGSGVIYKKANGKAYIVTNNHVVADANKLEVTF
TNGKKSEAKLLGTDEWNDLAVLEIDDKNVTTVAAFGDSDSLKLGEPAIAIGSPLGTEFSGSVTQGIISGLNRAVPVDTNG
DGTEDWEADVIQTDAAINPGNSGGALINIEGQVIGINSMKISMENVEGISFAIPSNTVEPIIEQLETKGEVERPSLGVSL
RDVDTIPETQQKNILKLPDSVDYGAMVQQVVSGSAADKAGLKQYDVIVELNGQKVTNSMTLRKILYGNDVKIGDKVKVKY
YRDGKEKSTDIKLEAAKTTT
>Mature_500_residues
MDEKEKNLNENSENESTPKREVEDTLHTPESAQPVQETPIVEGVTPEGEKFAGATEDAAEASSTNAFFEEASNKEPEPAR
PAPGPRRAGTTGGGAVPPNRVNNGGSGNGNGEPPKRGKHFIGYFLTALIGVIIGGLIIFFVAWDNGDNADTTSNSNNKAT
KVEKVSVDTTSDVTKAVDKVQDAVVSVLNYQSSSSLDGTTTSEQEASSGSGVIYKKANGKAYIVTNNHVVADANKLEVTF
TNGKKSEAKLLGTDEWNDLAVLEIDDKNVTTVAAFGDSDSLKLGEPAIAIGSPLGTEFSGSVTQGIISGLNRAVPVDTNG
DGTEDWEADVIQTDAAINPGNSGGALINIEGQVIGINSMKISMENVEGISFAIPSNTVEPIIEQLETKGEVERPSLGVSL
RDVDTIPETQQKNILKLPDSVDYGAMVQQVVSGSAADKAGLKQYDVIVELNGQKVTNSMTLRKILYGNDVKIGDKVKVKY
YRDGKEKSTDIKLEAAKTTT

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=292, Percent_Identity=33.5616438356164, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI24308541, Length=300, Percent_Identity=34.3333333333333, Blast_Score=139, Evalue=7e-33,
Organism=Homo sapiens, GI22129776, Length=269, Percent_Identity=34.9442379182156, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI7019477, Length=267, Percent_Identity=35.5805243445693, Blast_Score=118, Evalue=1e-26,
Organism=Escherichia coli, GI1786356, Length=288, Percent_Identity=38.5416666666667, Blast_Score=174, Evalue=2e-44,
Organism=Escherichia coli, GI1789629, Length=288, Percent_Identity=37.5, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1789630, Length=386, Percent_Identity=28.7564766839378, Blast_Score=127, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24646839, Length=375, Percent_Identity=29.8666666666667, Blast_Score=136, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 52851; Mature: 52851

Theoretical pI: Translated: 4.35; Mature: 4.35

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEKEKNLNENSENESTPKREVEDTLHTPESAQPVQETPIVEGVTPEGEKFAGATEDAAE
CCCCHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCHHHH
ASSTNAFFEEASNKEPEPARPAPGPRRAGTTGGGAVPPNRVNNGGSGNGNGEPPKRGKHF
HCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
IGYFLTALIGVIIGGLIIFFVAWDNGDNADTTSNSNNKATKVEKVSVDTTSDVTKAVDKV
HHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHH
QDAVVSVLNYQSSSSLDGTTTSEQEASSGSGVIYKKANGKAYIVTNNHVVADANKLEVTF
HHHHHHHHHCCCCCCCCCCCCCHHHCCCCCEEEEEECCCEEEEEECCEEEECCCEEEEEE
TNGKKSEAKLLGTDEWNDLAVLEIDDKNVTTVAAFGDSDSLKLGEPAIAIGSPLGTEFSG
CCCCCCCEEEECCCCCCCEEEEEECCCCEEEEEEECCCCCCCCCCCCEEECCCCCCCCCC
SVTQGIISGLNRAVPVDTNGDGTEDWEADVIQTDAAINPGNSGGALINIEGQVIGINSMK
HHHHHHHHHCCCEECCCCCCCCCCCCCCCEEEECCCCCCCCCCCEEEEECCEEEEEEEEE
ISMENVEGISFAIPSNTVEPIIEQLETKGEVERPSLGVSLRDVDTIPETQQKNILKLPDS
EEECCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCEEECCCC
VDYGAMVQQVVSGSAADKAGLKQYDVIVELNGQKVTNSMTLRKILYGNDVKIGDKVKVKY
CCHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCEECCHHHHHHHHCCCCEEECCEEEEEE
YRDGKEKSTDIKLEAAKTTT
EECCCCCCCCEEEEECCCCC
>Mature Secondary Structure
MDEKEKNLNENSENESTPKREVEDTLHTPESAQPVQETPIVEGVTPEGEKFAGATEDAAE
CCCCHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCHHHH
ASSTNAFFEEASNKEPEPARPAPGPRRAGTTGGGAVPPNRVNNGGSGNGNGEPPKRGKHF
HCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
IGYFLTALIGVIIGGLIIFFVAWDNGDNADTTSNSNNKATKVEKVSVDTTSDVTKAVDKV
HHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHH
QDAVVSVLNYQSSSSLDGTTTSEQEASSGSGVIYKKANGKAYIVTNNHVVADANKLEVTF
HHHHHHHHHCCCCCCCCCCCCCHHHCCCCCEEEEEECCCEEEEEECCEEEECCCEEEEEE
TNGKKSEAKLLGTDEWNDLAVLEIDDKNVTTVAAFGDSDSLKLGEPAIAIGSPLGTEFSG
CCCCCCCEEEECCCCCCCEEEEEECCCCEEEEEEECCCCCCCCCCCCEEECCCCCCCCCC
SVTQGIISGLNRAVPVDTNGDGTEDWEADVIQTDAAINPGNSGGALINIEGQVIGINSMK
HHHHHHHHHCCCEECCCCCCCCCCCCCCCEEEECCCCCCCCCCCEEEEECCEEEEEEEEE
ISMENVEGISFAIPSNTVEPIIEQLETKGEVERPSLGVSLRDVDTIPETQQKNILKLPDS
EEECCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCEEECCCC
VDYGAMVQQVVSGSAADKAGLKQYDVIVELNGQKVTNSMTLRKILYGNDVKIGDKVKVKY
CCHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCEECCHHHHHHHHCCCCEEECCEEEEEE
YRDGKEKSTDIKLEAAKTTT
EECCCCCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8113162 [H]