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The map label for this gene is inlH

Identifier: 226222897

GI number: 226222897

Start: 289067

End: 290713

Strand: Direct

Name: inlH

Synonym: Lm4b_00289

Alternate gene names: 226222897

Gene position: 289067-290713 (Clockwise)

Preceding gene: 226222896

Following gene: 226222898

Centisome position: 9.92

GC content: 37.28

Gene sequence:

>1647_bases
ATGAAAAAACGATGGAATTCTGTATTTAAACTAGTTTTAATGGTAGCTGCTATTCTCGGTATTAGTCTATATGTAACGAC
AAGTCAAGGTGCGGAGGTTCGCGCGGAAAGCATTGCGCAGCCAACCCCAATTAATGTTATTTTCCCTGATCCGGCTCTTG
CGAATGCAGTTAAAACAGCGACTGGAAAATCTAATGTAACAGACGCTGTTACGCAAGCAGATTTAGATGGAATAGCTACT
TTATCAGCATTTAATACTGGAGTAACAACGATAGAAGGAATACAATACTTAAATAATTTGATAGGGTTAGAACTTAAAGA
TAACCAAATAACTGATTTAACTCCTCTTAAAAATTTAACGAAAATAACAGAGCTTGAATTATCTGGAAATCCGTTAAAAA
ATGTGAGCGCGATTGCTGGGTTACAAAGCATTAAAACGCTAGATTTAACTTCTACACAAATTACAGATGTGACTCCACTT
GCAGGTCTTTCCAATTTGCAGGTATTATATTTGGACCTCAATCAAATAACCAATATAAGTCCGCTCGCAGGACTAACTAA
TTTACAATACTTATCAATCGGAAATAACCAAGTAAATGATTTAACCCCACTTGCTAATTTATCTAAACTAACGACTTTAA
GAGCTGATGATAATAAAATAAGTGATATTTCGCCACTTGCGAGTTTACCTAACCTTATAGAAGTTCATTTGAAAGATAAT
CAAATTAGTGATGTCAGCCCACTTGCTAATTTATCGAACTTATTTATAGTCACTTTAACAAATCAAACAATTACCAACCA
ACCCGTGTATTATCAAAATAATCTTGTCGTTCCTAATGTAGTAAAAGGTTCTTCTGGCGCGCCTATTGCACCTGCTACTA
TTAGCGACAATGGAACATACGCTAGTCCAAATTTAACATGGAATTTAACTAGTTTTATTAATAATGTTAGCTACACGTTT
AACCAATCAGTCGCTTTCAAAAATACAACGGTTCCTTTCAGTGGAACAGTTACCCAACCATTAACAGAAGCTTACACTGC
GGTTTTTGATGTGGATGGAAAACAAACAAGTGTGACAGTCGGCGCGAATGAATTAATTAAAGAACCAACAGCACCAACGA
AAGAAGGTTACACATTCACAGGCTGGTATGATGCCAAAACTGGCGGGAATAAATGGGATTTCAGCACGGACAAAATGCCA
GCAGAAAATATCACATTGTATGCGCAGTTCACGATTAATAGCTATACTGCCACATTTGACAATGATGGAAAAATAACGAC
GCAAAAAGTCACTTATCAAAGTCTGTTAGAAGAACCAGCAGCGCCAACGAAAGCAGGTTATACGTTCAAAGGTTGGTACG
ATGCTAAAACGGGTGGAACTAAATGGGATTTTGCTACTGGTAAAATGCCGGCGGGAAATATTACACTATATGCCCAATTC
ACTAAAAATGATAGCCCAAATCCAAATGATCCAACTCCTAATACCCCAACAGGAAATGGTGATGGTACAAGTAATCCAAG
TGATTCAGGCGGTAATACCACACTTCCAACAGCTGGGGACGAAAATACTATGCTTCCAATTTTTATCGGAGTTTTCTTGT
TAGGGACAGCAACGCTAATTCTCCGCAAAACAATCAAAGTGAAATAA

Upstream 100 bases:

>100_bases
AATCCCTTTTTTTGTTAAGTAAATCTAAAAAAGGGTATCTAATATTAACGATTTATTTAGAACAATTAATGGTTTTAATT
TAAATAAAAGGAGAGAGACT

Downstream 100 bases:

>100_bases
CAACAAAAACAGCTGCGGTTTATAGTTTCTTTATAGACTTCAGCTGTTTTTTGTTAATAGGGGAATTCATCTAAATGTCA
CAACTAATCAATAATGAGTC

Product: internalin H (LPXTG motif)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 548; Mature: 548

Protein sequence:

>548_residues
MKKRWNSVFKLVLMVAAILGISLYVTTSQGAEVRAESIAQPTPINVIFPDPALANAVKTATGKSNVTDAVTQADLDGIAT
LSAFNTGVTTIEGIQYLNNLIGLELKDNQITDLTPLKNLTKITELELSGNPLKNVSAIAGLQSIKTLDLTSTQITDVTPL
AGLSNLQVLYLDLNQITNISPLAGLTNLQYLSIGNNQVNDLTPLANLSKLTTLRADDNKISDISPLASLPNLIEVHLKDN
QISDVSPLANLSNLFIVTLTNQTITNQPVYYQNNLVVPNVVKGSSGAPIAPATISDNGTYASPNLTWNLTSFINNVSYTF
NQSVAFKNTTVPFSGTVTQPLTEAYTAVFDVDGKQTSVTVGANELIKEPTAPTKEGYTFTGWYDAKTGGNKWDFSTDKMP
AENITLYAQFTINSYTATFDNDGKITTQKVTYQSLLEEPAAPTKAGYTFKGWYDAKTGGTKWDFATGKMPAGNITLYAQF
TKNDSPNPNDPTPNTPTGNGDGTSNPSDSGGNTTLPTAGDENTMLPIFIGVFLLGTATLILRKTIKVK

Sequences:

>Translated_548_residues
MKKRWNSVFKLVLMVAAILGISLYVTTSQGAEVRAESIAQPTPINVIFPDPALANAVKTATGKSNVTDAVTQADLDGIAT
LSAFNTGVTTIEGIQYLNNLIGLELKDNQITDLTPLKNLTKITELELSGNPLKNVSAIAGLQSIKTLDLTSTQITDVTPL
AGLSNLQVLYLDLNQITNISPLAGLTNLQYLSIGNNQVNDLTPLANLSKLTTLRADDNKISDISPLASLPNLIEVHLKDN
QISDVSPLANLSNLFIVTLTNQTITNQPVYYQNNLVVPNVVKGSSGAPIAPATISDNGTYASPNLTWNLTSFINNVSYTF
NQSVAFKNTTVPFSGTVTQPLTEAYTAVFDVDGKQTSVTVGANELIKEPTAPTKEGYTFTGWYDAKTGGNKWDFSTDKMP
AENITLYAQFTINSYTATFDNDGKITTQKVTYQSLLEEPAAPTKAGYTFKGWYDAKTGGTKWDFATGKMPAGNITLYAQF
TKNDSPNPNDPTPNTPTGNGDGTSNPSDSGGNTTLPTAGDENTMLPIFIGVFLLGTATLILRKTIKVK
>Mature_548_residues
MKKRWNSVFKLVLMVAAILGISLYVTTSQGAEVRAESIAQPTPINVIFPDPALANAVKTATGKSNVTDAVTQADLDGIAT
LSAFNTGVTTIEGIQYLNNLIGLELKDNQITDLTPLKNLTKITELELSGNPLKNVSAIAGLQSIKTLDLTSTQITDVTPL
AGLSNLQVLYLDLNQITNISPLAGLTNLQYLSIGNNQVNDLTPLANLSKLTTLRADDNKISDISPLASLPNLIEVHLKDN
QISDVSPLANLSNLFIVTLTNQTITNQPVYYQNNLVVPNVVKGSSGAPIAPATISDNGTYASPNLTWNLTSFINNVSYTF
NQSVAFKNTTVPFSGTVTQPLTEAYTAVFDVDGKQTSVTVGANELIKEPTAPTKEGYTFTGWYDAKTGGNKWDFSTDKMP
AENITLYAQFTINSYTATFDNDGKITTQKVTYQSLLEEPAAPTKAGYTFKGWYDAKTGGTKWDFATGKMPAGNITLYAQF
TKNDSPNPNDPTPNTPTGNGDGTSNPSDSGGNTTLPTAGDENTMLPIFIGVFLLGTATLILRKTIKVK

Specific function: Mediates the entry of Listeria monocytogenes into cells [H]

COG id: COG4886

COG function: function code S; Leucine-rich repeat (LRR) protein

Gene ontology:

Cell location: Secreted, cell wall; Peptidoglycan-anchor [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 14 LRR (leucine-rich) repeats [H]

Homologues:

Organism=Homo sapiens, GI4506013, Length=176, Percent_Identity=34.0909090909091, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI157694513, Length=187, Percent_Identity=33.1550802139037, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI55743114, Length=156, Percent_Identity=32.0512820512821, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI21389483, Length=204, Percent_Identity=29.9019607843137, Blast_Score=67, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17536161, Length=245, Percent_Identity=28.5714285714286, Blast_Score=89, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17554124, Length=229, Percent_Identity=27.5109170305677, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17531555, Length=223, Percent_Identity=27.8026905829596, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21358617, Length=233, Percent_Identity=28.755364806867, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014755
- InterPro:   IPR019948
- InterPro:   IPR014756
- InterPro:   IPR001611
- InterPro:   IPR013378
- InterPro:   IPR019931
- InterPro:   IPR012569
- InterPro:   IPR001899 [H]

Pfam domain/function: PF09479 Flg_new; PF00746 Gram_pos_anchor; PF00560 LRR_1; PF08191 LRR_adjacent [H]

EC number: NA

Molecular weight: Translated: 58675; Mature: 58675

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKRWNSVFKLVLMVAAILGISLYVTTSQGAEVRAESIAQPTPINVIFPDPALANAVKTA
CCCHHHHHHHHHHHHHHHHCEEEEEEECCCCHHHHHHCCCCCCEEEECCCHHHHHHHHHC
TGKSNVTDAVTQADLDGIATLSAFNTGVTTIEGIQYLNNLIGLELKDNQITDLTPLKNLT
CCCCCCHHHHHHHCCCCEEEEHHHCCCCHHHHHHHHHHHHHCEEECCCCCCCCCCHHHHH
KITELELSGNPLKNVSAIAGLQSIKTLDLTSTQITDVTPLAGLSNLQVLYLDLNQITNIS
EEEEEEECCCCCCHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCEEEEEEHHHCCCCC
PLAGLTNLQYLSIGNNQVNDLTPLANLSKLTTLRADDNKISDISPLASLPNLIEVHLKDN
CCCCCCCEEEEEECCCCCCCCCCHHHHHHHEEEECCCCCCCCCCHHHHCCCEEEEEECCC
QISDVSPLANLSNLFIVTLTNQTITNQPVYYQNNLVVPNVVKGSSGAPIAPATISDNGTY
CCCCCCHHCCCCCEEEEEEECCCCCCCCEEEECCEEECCEEECCCCCCCCCEEECCCCCE
ASPNLTWNLTSFINNVSYTFNQSVAFKNTTVPFSGTVTQPLTEAYTAVFDVDGKQTSVTV
ECCCEEEEHHHHHCCCEEEECCEEEEECCCCCCCCCCCHHHHHHEEEEEECCCCCEEEEE
GANELIKEPTAPTKEGYTFTGWYDAKTGGNKWDFSTDKMPAENITLYAQFTINSYTATFD
CHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEEEEEEEEEEC
NDGKITTQKVTYQSLLEEPAAPTKAGYTFKGWYDAKTGGTKWDFATGKMPAGNITLYAQF
CCCCEEEEHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCEEEECCCCCCCCCEEEEEEE
TKNDSPNPNDPTPNTPTGNGDGTSNPSDSGGNTTLPTAGDENTMLPIFIGVFLLGTATLI
ECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHH
LRKTIKVK
HHHHHCCC
>Mature Secondary Structure
MKKRWNSVFKLVLMVAAILGISLYVTTSQGAEVRAESIAQPTPINVIFPDPALANAVKTA
CCCHHHHHHHHHHHHHHHHCEEEEEEECCCCHHHHHHCCCCCCEEEECCCHHHHHHHHHC
TGKSNVTDAVTQADLDGIATLSAFNTGVTTIEGIQYLNNLIGLELKDNQITDLTPLKNLT
CCCCCCHHHHHHHCCCCEEEEHHHCCCCHHHHHHHHHHHHHCEEECCCCCCCCCCHHHHH
KITELELSGNPLKNVSAIAGLQSIKTLDLTSTQITDVTPLAGLSNLQVLYLDLNQITNIS
EEEEEEECCCCCCHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCEEEEEEHHHCCCCC
PLAGLTNLQYLSIGNNQVNDLTPLANLSKLTTLRADDNKISDISPLASLPNLIEVHLKDN
CCCCCCCEEEEEECCCCCCCCCCHHHHHHHEEEECCCCCCCCCCHHHHCCCEEEEEECCC
QISDVSPLANLSNLFIVTLTNQTITNQPVYYQNNLVVPNVVKGSSGAPIAPATISDNGTY
CCCCCCHHCCCCCEEEEEEECCCCCCCCEEEECCEEECCEEECCCCCCCCCEEECCCCCE
ASPNLTWNLTSFINNVSYTFNQSVAFKNTTVPFSGTVTQPLTEAYTAVFDVDGKQTSVTV
ECCCEEEEHHHHHCCCEEEECCEEEEECCCCCCCCCCCHHHHHHEEEEEECCCCCEEEEE
GANELIKEPTAPTKEGYTFTGWYDAKTGGNKWDFSTDKMPAENITLYAQFTINSYTATFD
CHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEEEEEEEEEEC
NDGKITTQKVTYQSLLEEPAAPTKAGYTFKGWYDAKTGGTKWDFATGKMPAGNITLYAQF
CCCCEEEEHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCEEEECCCCCCCCCEEEEEEE
TKNDSPNPNDPTPNTPTGNGDGTSNPSDSGGNTTLPTAGDENTMLPIFIGVFLLGTATLI
ECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHH
LRKTIKVK
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9541569 [H]